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Research profile

Bas Rosier (1990, The Netherlands) is a postdoctoral researcher in the group of prof. Maarten Merkx in the Department of Chemical Biology and the Institute for Complex Molecular Systems, in collaboration with the group of dr. Javier Ramón Azcón at the Institute of Bioengineering of Catalonia. He develops antibody-based nanoswitches using DNA nanotechnology for continuous monitoring of analytes and biomarkers in organ-on-a-chip microfluidic devices.

Academic background

After completing his secondary education in 2007 at Trevianum in Sittard (The Netherlands), Bas Rosier received his BSc and MSc in biomedical engineering at Eindhoven University of Technology (The Netherlands). As part of his master’s degree, he performed a five-month internship at the Wyss Institute for Biologically Inspired Engineering at Harvard University (USA), working in the group of dr. W.M. Shih on the development of a fluorescence barcoding system for a microfluidic DNA origami-scaffolded, SNARE-mediated vesicle fusion assay. For his master thesis he worked in the group of prof. E.W. Meijer, under supervision of prof. T.F.A. de Greef, and investigated the use of microfluidic gradient-generating devices in the fields of supramolecular chemistry and chemical biology. After graduating cum laude in 2014, he started his PhD research at the Institute for Complex Molecular Systems (ICMS) and the laboratory of Chemical Biology at Eindhoven University of Technology (The Netherlands) under supervision of prof. T.F.A. de Greef and prof. L. Brunsveld and obtained his doctoral degree in 2019. The main focus of his research was to use DNA origami-based nanoscaffolds as biomolecular organizing platforms for studying proximity-driven interactions of relevant biomolecules, in particular proteins.

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  • 7 Similar Profiles
Antibodies Engineering & Materials Science
DNA Engineering & Materials Science
Apoptosomes Medicine & Life Sciences
Proteins Chemical Compounds
Caspase 9 Medicine & Life Sciences
Scaffolds Chemical Compounds
Networks (circuits) Chemical Compounds
Chemical reactions Chemical Compounds

Research Output 2015 2020

  • 67 Citations
  • 5 Article
  • 1 Chapter
  • 1 Phd Thesis 1 (Research TU/e / Graduation TU/e)
4 Downloads (Pure)

Proximity-induced caspase-9 activation on a DNA origami-based synthetic apoptosome

Rosier, B., Markvoort, B., Gumi Audenis, B., Roodhuizen, J., den Hamer, A., Brunsveld, L. & de Greef, T. F. A., 6 Jan 2020, In : Nature Catalysis. 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Apoptosomes
Caspase 9
DNA
Protein Engineering
Multiprotein Complexes

DNA origami-based biomolecular organizing platforms

Rosier, B. J. H. M., 12 Dec 2019, Eindhoven: Technische Universiteit Eindhoven. 190 p.

Research output: ThesisPhd Thesis 1 (Research TU/e / Graduation TU/e)

Open Access
File
1 Citation (Scopus)
14 Downloads (Pure)

Efficient small-scale conjugation of DNA to primary antibodies for multiplexed cellular targeting

Cremers, G., Rosier, B., Riera Brillas, R., Albertazzi, L. & de Greef, T., 18 Sep 2019, In : Bioconjugate Chemistry. 30, 9, p. 2384-2392 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Antibodies
DNA
Labeling
Fluorescence
Affinity Labels
11 Citations (Scopus)
77 Downloads (Pure)
Open Access
File
Antibodies
Nanostructures
DNA
Fusion reactions
Proteins
3 Downloads (Pure)

Protein scaffolds and higher-order complexes in synthetic biology

den Hamer, A., Rosier, B. J. H. M., Brunsveld, L. & de Greef, T. F. A., 29 Nov 2017, Synthetic Biology : Volume 2. Ryadnov, M., Brunsveld, L. & Suga, H. (eds.). Cambridge: Royal Society of Chemistry, p. 65-96

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Scaffolds
Proteins
Metabolic engineering
Mathematical models
Engineers

Student theses

A microfluidic toolbox for supramolecular chemistry and chemical biology

Author: Rosier, B., 31 Oct 2014

Supervisor: de Greef, T. (Supervisor 1) & Meijer, E. (Supervisor 2)

Student thesis: Master

Towards in vitro spatial organization of caspase-9

Author: van der Zon, N., 22 Feb 2018

Supervisor: Rosier, B. (Supervisor 1) & de Greef, T. (Supervisor 2)

Student thesis: Master