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Personal profile

Research profile

Bas Rosier (1990) received his MSc degree in Biomedical Engineering cum laude in 2014 at Eindhoven University of Technology. For his Master thesis he investigated the use of microfluidic devices in the fields of supramolecular chemistry and chemical biology and developed a microfluidic gradient generator to determine kinetic parameters of enzymes. During an internship at the Wyss Institute for Biologically Inspired Engineering at Harvard University, he worked in the group of dr. W.M. Shih on the development of a fluorescence barcoding system for a microfluidic DNA origami-scaffolded, SNARE-mediated vesicle fusion assay.

Currently, he is a PhD candidate under supervision of dr. T.F.A. de Greef and prof. L. Brunsveld and aims to use DNA origami as scaffolds to study kinetics of multi-enzyme complexes and cascades.

Fingerprint Dive into the research topics where Bas J.H.M. Rosier is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 2 Similar Profiles
Antibodies Engineering & Materials Science
Chemical reactions Chemical Compounds
Nanostructures Chemical Compounds
engineering Agriculture & Biology
DNA Engineering & Materials Science
Fusion reactions Chemical Compounds
Cells Chemical Compounds
multienzyme complexes Agriculture & Biology

Research Output 2015 2019

  • 62 Citations
  • 5 Article
  • 1 Chapter
  • 1 Phd Thesis 1 (Research TU/e / Graduation TU/e)

A DNA-based synthetic apoptosome

Rosier, B., Markvoort, B., Gumi Audenis, B., Roodhuizen, J., Brunsveld, L. & de Greef, T. F. A., 2019, (Accepted/In press) In : Nature Catalysis.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Apoptosomes
Caspase 9
DNA
Proteins
Enzymes

DNA origami-based biomolecular organizing platforms

Rosier, B., 12 Dec 2019, (Accepted/In press) Eindhoven: Technische Universiteit Eindhoven.

Research output: ThesisPhd Thesis 1 (Research TU/e / Graduation TU/e)Academic

Efficient small-scale conjugation of DNA to primary antibodies for multiplexed cellular targeting

Cremers, G., Rosier, B., Riera Brillas, R., Albertazzi, L. & de Greef, T., 22 Aug 2019, In : Bioconjugate Chemistry. 30, 9, p. 2384-2392

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Antibodies
DNA
Labeling
Fluorescence
Affinity Labels
9 Citations (Scopus)
Open Access
File
Antibodies
Nanostructures
DNA
Fusion reactions
Proteins

Protein scaffolds and higher-order complexes in synthetic biology

den Hamer, A., Rosier, B. J. H. M., Brunsveld, L. & de Greef, T. F. A., 29 Nov 2017, Synthetic Biology : Volume 2. Ryadnov, M., Brunsveld, L. & Suga, H. (eds.). Cambridge: Royal Society of Chemistry, p. 65-96

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Scaffolds
Proteins
Metabolic engineering
Mathematical models
Engineers

Student theses

A microfluidic toolbox for supramolecular chemistry and chemical biology

Author: Rosier, B., 31 Oct 2014

Supervisor: de Greef, T. (Supervisor 1) & Meijer, E. (Supervisor 2)

Student thesis: Master

Towards in vitro spatial organization of caspase-9

Author: van der Zon, N., 22 Feb 2018

Supervisor: Rosier, B. (Supervisor 1) & de Greef, T. (Supervisor 2)

Student thesis: Master