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Personal profile

Biography

Short biography:

Anat Akiva is a postdoc fellow at theLaboratory of Materials and Interface Chemistry in Eindhoven University of Technology, working on mineralization of collagen which is the basic building block of our bones.
She received her B.Sc, and M.Sc degree (cum laude) in Chemistry from the Technion – Israel Institute of Technology. Her major was in physical chemistry and solid state NMR.  During her master degree she was first introduced to the world of biomineralization (formation of minerals by organisms) and she continued in this field as a Ph.D student in the biomineralization group of Prof Lia Addadi and Prof Steve Weiner from the Weizmann Institute of Science, Israel. Her Ph.D thesis was on structural and dynamic investigation of bone mineralization processes in the zebrafish larva.
In October 2016 she joined the laboratory of Materials and Interfaces Chemistry as a postdoc fellow.

 

 

Research profile

Research interest:

 

The mineralized collagen fibril is the basic building block of our bones. The fibrils are hierarchically ordered from the nanometer to the macroscopic scale. The mineralization of collagen involves the deposition of oriented carbonated hydroxyapatite (cHAP) platelets in a process that is thought to be directed by the collagen together with a family of acidic non-collagenous proteins (NCPs). During the mineralization process, small cHAP platelets (25x4x50 nm) are embedded between two adjacent collagen fibrils. The detailed analysis of the mineralized collagen fibril structure has proven difficult, mainly due to its highly complex organization, its nanoscopic dimensions and the fact that bone consists of both hard and soft components. It is an even more challenging task to unravel the mechanism by which collagen is mineralized, as this occurs on the nanometer scale, through a multistep process, and in a complex aqueous multicomponent environment.  To address those questions, we perform in vitro mineralization experiments on early-deposited collagen produced in an osteoblast cell culture. Using in situ liquid phase electron microscopy with (3D) cryo-TEM, electron diffraction and fluorescence microscopy we visualize – with unprecedented spatial/temporal resolution – both the structural development of the mineral phase and the associated interactions between the different organic, inorganic and cellular components that lead to collagen mineralization.

 

Education and Teaching

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

Minerals Medicine & Life Sciences
Calcium Carbonate Medicine & Life Sciences
Zebrafish Medicine & Life Sciences
Bone and Bones Medicine & Life Sciences
Blood Vessels Medicine & Life Sciences
calcium carbonates Physics & Astronomy
Larva Medicine & Life Sciences
Physiologic Calcification Medicine & Life Sciences

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Research Output 2011 2018

  • 164 Citations
  • 9 Article
2 Citations

Microscopic structure of the polymer-induced liquid precursor for calcium carbonate

Xu, Y., Tijssen, K. C. H., Bomans, P. H. H., Akiva, A., Friedrich, H., Kentgens, A. P. M. & Sommerdijk, N. A. J. M., 1 Dec 2018, In : Nature Communications. 9, 1, 2582

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Calcium Carbonate
calcium carbonates
Polymers
polymers
Liquids
1 Citations

Minerals in the pre-settled coral Stylophora pistillata crystallize via protein and ion changes

Akiva, A., Neder, M., Kahil, K., Gavriel, R., Pinkas, I., Goobes, G. & Mass, T., 1 Dec 2018, In : Nature Communications. 9, 1, 1880

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
aragonite
Anthozoa
Calcium Carbonate
musculoskeletal system
Biomineralization
12 Citations

Cryo-FIB-SEM serial milling and block face imaging: Large volume structural analysis of biological tissues preserved close to their native state

Vidavsky, N., Akiva, A., Kaplan-Ashiri, I., Rechav, K., Addadi, L., Weiner, S. & Schertel, A., 1 Dec 2016, In : Journal of Structural Biology. 196, 3, p. 487-495 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Zebrafish
Minerals
Tail
Electrons
Nuclear Pore
12 Citations

Deposition of collagen type I onto skeletal endothelium reveals a new role for blood vessels in regulating bone morphology

Shoham, A. B., Rot, C., Stern, T., Krief, S., Akiva, A., Dadosh, T., Sabany, H., Lu, Y., Kadler, K. E. & Zelzer, E., 1 Nov 2016, In : Development (Cambridge). 143, 21, p. 3933-3943 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Collagen Type I
Endothelium
Blood Vessels
Bone and Bones
Morphogenesis
8 Citations

Mineral formation in the Larval Zebrafish tail bone occurs via an acidic disordered calcium phosphate phase

Akiva, A., Kerschnitzki, M., Pinkas, I., Wagermaier, W., Yaniv, K., Fratzl, P., Addadi, L. & Weiner, S., 2 Nov 2016, In : Journal of the American Chemical Society. 138, 43, p. 14481-14487 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Calcium phosphate
Zebrafish
Raman Spectrum Analysis
Minerals
Tail

Courses