Research Output per year
Personal profile
Research profile
Alex Mason received his BSc (Honours) in Nanotechnology from the University of New South Wales, located in Sydney, Australia (2012). He continued his studies there, working in the group of Prof. Pall Thordarson where he received his PhD in chemistry for the thesis entitled, “Polymersomes as Synthetic Cell Scaffolds” (2016). His interests and expertise in self-assembly, chemical biology, and artificial cells have brought him to TU/e, working in the van Hest group as a postdoctoral researcher.
Research Themes
1. Artificial cells
This project utilizes the self-assembly chemically accessible materials such as block copolymers and proteins to construct complex systems that begin to resemble the natural cell in both structure and function, or so called “protocells”. The de novo synthesis of a cell will undoubtedly have significant impacts on our knowledge of the natural cell and lead to the development of “living” technology, but will also contribute to understanding the precise chemical conditions required for the origin of life. There is significant scope for expansion of this project, for example exploring communication between populations of protocells and using these protocells as a framework to study membrane proteins.
2. Nanomedicine
The delivery of nanoscopically “large” objects to the cytosol of the cell is not a trivial task if you want to avoid the low pH environment of the endo-/lysosomal pathway. Polymersomes present an ideal system for cytosolic delivery as we can significantly alter their surface chemistry and design delivery pathways for sensitive cargoes such as protein drugs.
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Research Output 2017 2019
ATP-mediated transient behavior of stomatocyte nanosystems
Che, H., Zhu, J., Song, S., Mason, A. F., Cao, S., Pijpers, I. A. B., Abdelmohsen, L. K. E. A. & van Hest, J. C. M., 9 Sep 2019, In : Angewandte Chemie - International Edition. 58, 37, p. 13113-13118 6 p.Research output: Contribution to journal › Review article › Academic › peer-review
Development of morphologically discrete PEG-PDLLA nanotubes for precision nanomedicine
Wauters, A. C., Pijpers, I. A. B., Mason, A. F., Williams, D. S., Tel, J., Abdelmohsen, L. K. E. A. & van Hest, J. C. M., 14 Jan 2019, In : Biomacromolecules. 20, 1, p. 177-183 7 p.Research output: Contribution to journal › Article › Academic › peer-review
Mimicking cellular compartmentalization in a hierarchical protocell through spontaneous spatial organization
Mason, A. F., Yewdall, A., Welzen, P. L. W., Shao, J., van Stevendaal, M., van Hest, J. C. M., Williams, D. S. & Abdelmohsen, L. K. E. A., 28 Aug 2019, In : ACS Central Science. 5, 8, p. 1360-1365 6 p.Research output: Contribution to journal › Article › Academic › peer-review
Physicochemical characterization of polymer-stabilized coacervate protocells
Yewdall, N. A., Buddingh, B. C., Altenburg, W. J., Timmermans, S. B. P. E., Vervoort, D. F. M., Abdelmohsen, L. K. E. A., Mason, A. F. & van Hest, J., 15 Oct 2019, In : ChemBioChem. 20, 20, p. 2643-2652 10 p.Research output: Contribution to journal › Article › Academic › peer-review
Tandem catalysis in multicomponent solvent-free biofluids
Atkins, D. L., Berrocal, J. A., Mason, A. F. & Voets, I. K., 14 Nov 2019, In : Nanoscale. 11, 42, p. 19797-19805 9 p.Research output: Contribution to journal › Article › Academic › peer-review
Press / Media
Plastic nanoparticles inspired by nature could improve cancer drug delivery
1/11/17 → 9/11/17
6 items of Media coverage
Press/Media: Expert Comment
Plastic Nanoparticles Inspired by Nature Could Improve Cancer Drug Delivery
3/11/17
1 item of Media coverage
Press/Media: Expert Comment
Nanoparticles for Drug Delivery to Tumors Developed
2/11/17
1 item of Media coverage
Press/Media: Expert Comment
Nature Inspires Non-spherical Drug Delivery Nanoparticles
1/11/17
1 item of Media coverage
Press/Media: Expert Comment