• 2200 Citations
19962020

Research output per year

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Personal profile

Quote

Molecular simulations can act as a digital microscope. They allow us to observe how simple interactions between atoms and molecules give rise to intricate dynamics of molecular systems.

Research profile

Bart Markvoort is assistant professor in the Computational Biology group of the TU/e department of Biomedical Engineering. His research focuses on molecular simulations of self-assembly and self-organization processes in biologically relevant systems, with focus on both method development and application. His current research projects include molecular dynamics simulations of phospholipid membranes, proteins and DNA, as well as the modeling of supramolecular (co)polymerizations and nanoparticles using Monte Carlo techniques. He is also active in the fields of synthetic biology, DNA nanotechnology, bioinformatics, and multi-scale modeling.

Academic background

Bart Markvoort studied Applied Physics at Eindhoven University of Technology (TU/e, The Netherlands), where he obtained his Master's degree in the Theoretical Physics group on the subject of small angle x-ray scattering on asphaltenes. He then started PhD research in the Parallel Systems group of the TU/e department of Mathematics and Computer Science on the application of wavelets in parallelized density functional theory calculations. In 2006, he obtained his PhD for his thesis 'Towards Hybrid Molecular Simulations' under the supervision of professors Peter Hilbers and Thijs Michels. He then was appointed in his current position as assistant professor in the Computational Biology group of the TU/e, heading the molecular simulations subgroup. As of 2010 he is also a member of the Institute for Complex Molecular Systems at TU/e.

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Research Output

Open Access
  • Photodynamic control of the chain length in supramolecular polymers: switching an intercalator into a chain capper

    Weyandt, E., ter Huurne, G. M., Vantomme, G., Markvoort, A. J., Palmans, A. R. A. & Meijer, E. W., 1 Apr 2020, In : Journal of the American Chemical Society. 142, 13, p. 6295-6303 9 p.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    File
  • 7 Downloads (Pure)

    Proximity-induced caspase-9 activation on a DNA origami-based synthetic apoptosome

    Rosier, B., Markvoort, A. J., Gumi Audenis, B., Roodhuizen, J., den Hamer, A., Brunsveld, L. & de Greef, T. F. A., 1 Mar 2020, In : Nature Catalysis. 3, 3, p. 295-306 12 p.

    Research output: Contribution to journalArticleAcademicpeer-review

  • 6 Downloads (Pure)

    Counterion-dependent mechanisms of DNA origami nanostructure stabilization revealed by atomistic molecular simulation

    Roodhuizen, J., Hendrikx, P. J. T. M., Hilbers, P. A. J., de Greef, T. & Markvoort, B., 10 Sep 2019, In : ACS Nano. 13, 9, p. 10798-10809 12 p.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    File
  • 1 Citation (Scopus)
    24 Downloads (Pure)
    Open Access
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  • 2 Citations (Scopus)
    15 Downloads (Pure)

    Courses

    DBL Gene expression

    1/09/13 → …

    Course

    Molecular modeling

    1/09/15 → …

    Course

    Programming and genomics

    1/09/15 → …

    Course

    Project Computational biology

    1/09/1431/08/20

    Course

    Press / Media

    What Does Atp Mean In Biology

    A.J. Markvoort & T.F.A. de Greef

    26/04/17

    1 item of Media coverage

    Press/Media: Expert Comment

    Definition Of Cohesion In Biology

    A.J. Markvoort & T.F.A. de Greef

    26/04/17

    1 item of Media coverage

    Press/Media: Expert Comment

    Resolution Definition Biology

    A.J. Markvoort & T.F.A. de Greef

    26/04/17

    1 item of Media coverage

    Press/Media: Expert Comment

    Student theses

    File

    Cationic stabilization of DNA origami investigated through atomistic simulations

    Author: Hendrikx, P., 29 Nov 2018

    Supervisor: Roodhuizen, J. (Supervisor 1), Markvoort, B. (Supervisor 2), de Greef, T. (Supervisor 2) & Hilbers, P. (Supervisor 2)

    Student thesis: Master

    Cholesterol and bio-membranes influence on membrane dynamics and stability

    Author: van den Heuvel, F., 28 Feb 2005

    Supervisor: Hilbers, P. (Supervisor 1), Markvoort, A. (Supervisor 2), Pieterse, K. (Supervisor 2), van Steenhoven, A. (Supervisor 2) & Kuijpers, N. (Supervisor 2)

    Student thesis: Master

    Dynamic behaviour of the ß2-adrenergic receptor: approach and study using molecular dynamics

    Author: Spijker, P., 31 Dec 2004

    Supervisor: Hilbers, P. (Supervisor 1), Meijer, E. (Supervisor 2), van Santen, R. (Supervisor 2), Vaidehi, N. (External person) (External coach), Merkx, M. (Supervisor 2), Pieterse, K. (Supervisor 2) & Markvoort, A. (Supervisor 2)

    Student thesis: Master

    Mapping the homunculus in sensorimotor cortex using fMRI

    Author: Bakker, C., 28 Sep 2017

    Supervisor: Pluim, J. (Supervisor 1), Cheplygina, V. (Supervisor 2), Markvoort, A. (Supervisor 2) & Schellekens, W. (External person) (External coach)

    Student thesis: Master