• Department of Biomedical Engineering Eindhoven University of Technology, P.O. Box 513

    5600 MB Eindhoven

    Netherlands

  • Eindhoven University of Technology, Building 15, Gemini-South (room 4.115) Groene Loper

    5612 AZ Eindhoven

    Netherlands

Organization profile

Introduction / mission

At STEM we aim to understand and predict how mechanical factors influence soft tissue growth, remodelling, damage, and repair. We use this knowledge to (re)build soft tissues and organs within the human body, and to find ways to prevent mechanically-induced soft tissue degeneration.

Highlighted phrase

Modelling and experimentation at length scales from molecule to man

Organisational profile

While performing our research at the forefront of soft tissue biomechanics, mechanobiology, and the engineering of living soft biological tissues and organs, we strive to provide a stimulating educational environment for graduate and post-graduate students. Our research is multi-disciplinary at heart, combining concepts from molecular, cell and tissue biology, (patho)physiology, immunology, biomechanics, physics, engineering, and materials science. To translate our fundamental knowledge to (bio)medical applications we actively collaborate with clinical partners, industry, and patient organizations.

Research themes at the STEM group include: i) cardiovascular in situ tissue engineering, ii) tissue growth and remodelling, iii) the biophysical cellular niche, iv) tissue and organ morphogenesis, v) hybrid organs, vi) scaffold design, and vii) soft tissue mechanics. Emphasis is given to the integration of computational modelling with experimentation at length scales from molecule to man.

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1981 2019

A computational model to predict cell traction-mediated prestretch in the mitral valve

van Kelle, M. A. J., Rausch, M. K., Kuhl, E. & Loerakker, S., 2019, In : Computer Methods in Biomechanics and Biomedical Engineering. 22, 15, p. 1174-1185

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Tissue
Actins
Structural properties
Anisotropy
Fibers
2 Citations (Scopus)

Analysis of chemical exchange saturation transfer contributions from brain metabolites to the Z-spectra at various field strengths and pH

Khlebnikov, V., van der Kemp, W. J. M., Hoogduin, H., Klomp, D. W. J. & Prompers, J. J., 31 Jan 2019, In : Scientific Reports. 9, 11 p., 1089

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File

A stirring system using suspended magnetically-actuated pillars for controlled cell clustering

Saberi, A., Zhang, S., van den Bersselaar, C., Kandail, H., den Toonder, J. M. J. & Kurniawan, N. A., 1 Jan 2019, In : Soft Matter. 15, 6, p. 1435-1443 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

stirring
Magnetic scales
Colloids
Research laboratories
cells

Equipment

Bioreactors
Blood Vessels
spinners
heart valves
tissue engineering
high voltages
polymers
mechanical properties
glass
cells

Prizes

Annual BME Research Day Poster Prize

Mathieu van Kelle (Recipient), 8 Apr 2016

Recognition: OtherCareer, activity or publication related prizes (lifetime, best paper, poster etc.)Scientific

Control cell communication and tissue regeneration

Nicholas Kurniawan (Recipient), 2019

Recognition: ERCStartingScientific

Cell Communication
Regeneration
Extracellular Matrix
Cardiomyopathies
Communication

Dekker Junior 2014T013

Noortje Bax (Recipient), Mar 2015

Recognition: OtherDiscipline relatedScientific

Stem Cells

Activities 1993 2018

  • 6 Contributed talk
  • 3 Editorial activity
  • 1 Membership of board
  • 1 Membership of committee

Young@Heart Institute (External organisation)

Anthal I.P.M. Smits (Chair)
Sep 2018 → …

Activity: Membership typesMembership of boardScientific

Young@Heart Institute (External organisation)

Anthal I.P.M. Smits (Contributor)
Sep 2018 → …

Activity: Membership typesMembership of committeeProfessional

Unraveling the mechanisms behind cellular anisotropy sensing

Antonetta B.C. Buskermolen (Speaker)
4 Oct 2016

Activity: Talk or presentation typesContributed talkScientific

Press / Media

Detecting pressure ulcers in sweat and sebum

Dan Bader

17/06/19

1 item of media coverage

Press/Media: Expert Comment

PhD dissertation - Public Summary

Valentina Bonito

13/09/18

1 media contribution

Press/Media: Research

Research areas

Cell-Matrix Interactions

Yvon Biemans (Content manager), Lieke van Gorp (Content manager), Amy Broeders (Content manager)

Impact: Research Topic/Theme (at group level)

Cell-Matrix Mechanobiology

Yvon Biemans (Content manager), Lieke van Gorp (Content manager), Amy Broeders (Content manager)

Impact: Research Topic/Theme (at group level)

Cell Signaling in Tissue Formation and Malformation

Yvon Biemans (Content manager), Lieke van Gorp (Content manager), Amy Broeders (Content manager)

Impact: Research Topic/Theme (at group level)

Student theses

A brain chip to investigate neurite outgrowth by trapping cell-laden hydrogel beads in microsieves

Author: Labeur, T., 29 Aug 2019

Supervisor: Bouten, C. (Supervisor 1), Luttge, R. (Supervisor 2), Kurniawan, N. (Supervisor 2) & Bastiaens, A. (Supervisor 2)

Student thesis: Master

A constitutive material model to describe the mechanical behavior of human skin in shear, tensile and indentation tests

Author: Rooijakkers, T., 31 Aug 2017

Supervisor: Oomens, C. (Supervisor 1), Loerakker, S. (Supervisor 2), Lopata, R. (Supervisor 2) & Soetens, J. (Supervisor 2)

Student thesis: Master

An in-silico imaging system based on k-Wave for multi-perspective ultrasound imaging of abdominal aortic aneurysms

Author: Nooijens, S., 31 Jan 2019

Supervisor: van de Vosse, F. (Supervisor 1), Lopata, R. (Supervisor 2), Oomens, C. (Supervisor 2), Petterson, N. (Supervisor 2) & Bouwman, R. (Supervisor 2)

Student thesis: Master