• Department of Biomedical Engineering Eindhoven University of Technology, P.O. Box 513

    5600 MB Eindhoven

    Netherlands

  • Eindhoven University of Technology, Building 15, Gemini-South (room 4.115) Groene Loper

    5612 AZ Eindhoven

    Netherlands

Organization profile

Introduction / mission

At STEM we aim to understand and predict how mechanical factors influence soft tissue growth, remodelling, damage, and repair. We use this knowledge to (re)build soft tissues and organs within the human body, and to find ways to prevent mechanically-induced soft tissue degeneration.

Highlighted phrase

Modelling and experimentation at length scales from molecule to man

Organisational profile

While performing our research at the forefront of soft tissue biomechanics, mechanobiology, and the engineering of living soft biological tissues and organs, we strive to provide a stimulating educational environment for graduate and post-graduate students. Our research is multi-disciplinary at heart, combining concepts from molecular, cell and tissue biology, (patho)physiology, immunology, biomechanics, physics, engineering, and materials science. To translate our fundamental knowledge to (bio)medical applications we actively collaborate with clinical partners, industry, and patient organizations.

Research themes at the STEM group include: i) cardiovascular in situ tissue engineering, ii) tissue growth and remodelling, iii) the biophysical cellular niche, iv) tissue and organ morphogenesis, v) hybrid organs, vi) scaffold design, and vii) soft tissue mechanics. Emphasis is given to the integration of computational modelling with experimentation at length scales from molecule to man.

Fingerprint Dive into the research topics where Soft Tissue Engineering and Mechanobiology is active. These topic labels come from the works of this organisation's members. Together they form a unique fingerprint.

Tissue Engineering & Materials Science
Tissue Engineering Medicine & Life Sciences
Heart Valves Medicine & Life Sciences
Tissue engineering Engineering & Materials Science
Collagen Engineering & Materials Science
Scaffolds Engineering & Materials Science
Blood Vessels Medicine & Life Sciences
Scaffolds (biology) Engineering & Materials Science

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1981 2020

6 Downloads (Pure)
Open Access
File
Tissue Engineering
Tissue engineering
Scaffolds
Tissue
Gastrin-Secreting Cells
1 Citation (Scopus)
3 Downloads (Pure)

Differential leaflet remodeling of bone marrow cell pre-seeded versus nonseeded bioresorbable transcatheter pulmonary valve replacements

Fioretta, E., Lintas, V., Mallone, A., Motta, S. E., von Boehmer, L., Dijkman, P. E., Cesarovic, N., Caliskan, E., Rodriguez Cetina Biefer, H., Lipiski, M., Sauer, M., Putti, M., Janssen, H. M., Söntjens, S. H. M., Smits, A. I. P. M., Bouten, C. V. C., Emmert, M. Y. & Hoerstrup, S. P., 1 Jan 2020, In : JACC: Basic to Translational Science. 5, 1, p. 15-31 17 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Pulmonary Valve
Heart Valves
Bone Marrow Cells
polycarbonate
Sheep

Early cost-utility analysis of tissue-engineered heart valves compared to bioprostheses in the aortic position in elderly patients

Huygens, S. A., Ramos, I. C., Bouten, C. V. C., Kluin, J., Chiu, S. T., Grunkemeier, G. L., Takkenberg, J. J. M. & Rutten-van Mölken, M. P. M. H., 25 Jan 2020, In : European Journal of Health Economics.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Bioprosthesis
Heart Valves
Cost-Benefit Analysis
Quality-Adjusted Life Years
Costs and Cost Analysis

Equipment

Bioreactors
Blood Vessels
spinners
heart valves
tissue engineering
high voltages
polymers
mechanical properties
glass
cells

Prizes

Annual BME Research Day Poster Prize

Mathieu van Kelle (Recipient), 8 Apr 2016

Prize: OtherCareer, activity or publication related prizes (lifetime, best paper, poster etc.)Scientific

Control cell communication and tissue regeneration

Nicholas Kurniawan (Recipient), 2019

Prize: ERCStartingScientific

Cell Communication
Regeneration
Extracellular Matrix
Cardiomyopathies
Communication

Dekker Junior 2014T013

Noortje A.M. Bax (Recipient), Mar 2015

Prize: OtherDiscipline relatedScientific

Stem Cells

Activities 1993 2018

  • 6 Contributed talk
  • 3 Editorial activity
  • 1 Membership of board
  • 1 Membership of committee

Young@Heart Institute (External organisation)

Anthal I.P.M. Smits (Chair)
Sep 2018 → …

Activity: Membership typesMembership of boardScientific

Young@Heart Institute (External organisation)

Anthal I.P.M. Smits (Contributor)
Sep 2018 → …

Activity: Membership typesMembership of committeeProfessional

Unraveling the mechanisms behind cellular anisotropy sensing

Antonetta B.C. Buskermolen (Speaker)
4 Oct 2016

Activity: Talk or presentation typesContributed talkScientific

Research areas

Cell-Matrix Interactions

Yvon Biemans (Content manager), Lieke van Gorp (Content manager), Amy Broeders (Content manager)

Impact: Research Topic/Theme (at group level)

Cell-Matrix Mechanobiology

Yvon Biemans (Content manager), Lieke van Gorp (Content manager), Amy Broeders (Content manager)

Impact: Research Topic/Theme (at group level)

Cell Signaling in Tissue Formation and Malformation

Yvon Biemans (Content manager), Lieke van Gorp (Content manager), Amy Broeders (Content manager)

Impact: Research Topic/Theme (at group level)

Student theses

A brain chip to investigate neurite outgrowth by trapping cell-laden hydrogel beads in microsieves

Author: Labeur, T., 29 Aug 2019

Supervisor: Bouten, C. (Supervisor 1), Luttge, R. (Supervisor 2), Kurniawan, N. (Supervisor 2) & Bastiaens, A. (Supervisor 2)

Student thesis: Master

A constitutive material model to describe the mechanical behavior of human skin in shear, tensile and indentation tests

Author: Rooijakkers, T., 31 Aug 2017

Supervisor: Oomens, C. (Supervisor 1), Loerakker, S. (Supervisor 2), Lopata, R. (Supervisor 2) & Soetens, J. (Supervisor 2)

Student thesis: Master

An in-silico imaging system based on k-Wave for multi-perspective ultrasound imaging of abdominal aortic aneurysms

Author: Nooijens, S., 31 Jan 2019

Supervisor: van de Vosse, F. (Supervisor 1), Lopata, R. (Supervisor 2), Oomens, C. (Supervisor 2), Petterson, N. (Supervisor 2) & Bouwman, R. (Supervisor 2)

Student thesis: Master