Organization profile

Introduction / mission

Our mission is to understand and predict how biophysical factors influence biological tissue damage, repair, growth, and adaptation in order to (re)build soft tissues and prevent mechanically-induced soft tissue degeneration.

Highlighted phrase

From laboratory experiment to a permanent part of the healthcare package: from hype to hope 

Organisational profile

Living tissues show an intriguing, active response to mechanical loading. Not only is the intrinsic mechanical response complicated, the ability of living tissues to adapt to mechanical loading by changing their structure and composition is fascinating. For example, tissue proliferation and differentiation is significantly affected by mechanical loading. A quantitative understanding of these phenomena, through experimentation and numerical modeling, is of crucial importance for many biomedical applications. 

 

Within our group we include five lines of research: (all links) 

 

Cell-Matrix Interactions in Tissue Regeneration 

Biomechanics of Soft Biological Tissues 

Modeling tissue growth and remodeling 

In Situ Cardiovascular Tissue Engineering 

Cell–Matrix Mechanobiology 

Want to know more about our ambitions? 

Read this interview with Carlijn Bouten (Slash, okt 2017) 

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1981 2019

Engineered cardiac microenvironments based on supramolecular biomaterials

Spaans, S., 13 Mar 2019, (Accepted/In press) Eindhoven: Technische Universiteit Eindhoven. 175 p.

Research output: ThesisPhd Thesis 1 (Research TU/e / Graduation TU/e)Academic

Evaluating aetiological processes for monitoring and detection of deep tissue injury

Traa, W. A., 19 Feb 2019, Eindhoven: Technische Universiteit Eindhoven. 140 p.

Research output: ThesisPhd Thesis 1 (Research TU/e / Graduation TU/e)Academic

Open Access
File

Mechanically driven adaptation in engineered cardiovascular tissues

van Kelle, A. J., 31 Jan 2019, Eindhoven: Technische Universiteit Eindhoven. 134 p.

Research output: ThesisPhd Thesis 1 (Research TU/e / Graduation TU/e)Academic

Heart Valves
Blood Vessels

Equipment

Bioreactors
Blood Vessels
spinners
heart valves
tissue engineering
high voltages
polymers
mechanical properties
glass
cells

Prizes

Annual BME Research Day Poster Prize

Mathieu van Kelle (Recipient), 8 Apr 2016

Recognition: OtherCareer, activity or publication related prizes (lifetime, best paper, poster etc.)Scientific

Dekker Junior 2014T013

Noortje Bax (Recipient), Mar 2015

Recognition: OtherDiscipline relatedScientific

Stem Cells

Grant Application ASTF 497-2012

Noortje Bax (Recipient), May 2013

Recognition: OtherFellowships & membershipsScientific

Colombia
grant
engineering

Activities 1993 2016

  • 6 Contributed talk
  • 3 Editorial activity

Unraveling the mechanisms behind cellular anisotropy sensing

Antonetta B.C. Buskermolen (Speaker)
4 Oct 2016

Activity: Talk or presentation typesContributed talkScientific

International Congress of Cell Biology

Rob Driessen (Speaker)
23 Jul 2016

Activity: Talk or presentation typesContributed talkScientific

Tissue Engineering. Part B, reviews (Journal)

Anthal Smits (Editorial board member)
1 Feb 2016

Activity: Publication peer-review and editorial work typesEditorial activityScientific

Press / Media

PhD dissertation - Public Summary

Valentina Bonito

13/09/18

1 media contribution

Press/Media: Research

Rebuilding tissues inside the human body

Carlijn Bouten

11/09/18

1 item of media coverage

Press/Media: Expert Comment

Home Stretch. Implants and Immune Cells

Valentina Bonito

5/09/18

1 item of media coverage

Press/Media: Public Engagement Activities

Research areas

Cell-Matrix Interactions

Lieke van Gorp (Content manager), Amy Broeders (Content manager)

Impact: Research Topic/Theme (at group level)

Cell-Matrix Mechanobiology

Lieke van Gorp (Content manager), Amy Broeders (Content manager)

Impact: Research Topic/Theme (at group level)

Cell Signaling in Tissue Formation and Malformation

Lieke van Gorp (Content manager), Amy Broeders (Content manager)

Impact: Research Topic/Theme (at group level)

Student theses

A constitutive material model to describe the mechanical behavior of human skin in shear, tensile and indentation tests

Author: Rooijakkers, T., 31 Aug 2017

Supervisor: Oomens, C. (Supervisor 1), Loerakker, S. (Supervisor 2), Lopata, R. (Supervisor 2) & Soetens, J. (Supervisor 2)

Student thesis: Master

An in-silico imaging system based on k-Wave for multi-perspective ultrasound imaging of abdominal aortic aneurysms

Author: Nooijens, S., 31 Jan 2019

Supervisor: van de Vosse, F. (Supervisor 1), Lopata, R. (Supervisor 2), Oomens, C. (Supervisor 2), Petterson, N. (Supervisor 2) & Bouwman, R. (Supervisor 2)

Student thesis: Master

Design of a DNA-based tension probe for the quantification of cellular traction forces at a molecular level

Author: van der Putten, C., 25 Jan 2018

Supervisor: Kurniawan, N. (Supervisor 1), de Greef, T. (Supervisor 2) & Bouten, C. (Supervisor 2)

Student thesis: Master