Soft Tissue Biomechanics & Tissue Engineering

  • Department of Biomedical Engineering Eindhoven University of Technology, P.O. Box 513

    5600 MB Eindhoven

    Netherlands

  • Eindhoven University of Technology, Building 15, Gemini-South (room 4.115) Groene Loper

    5612 AZ Eindhoven

    Netherlands

Organization profile

Introduction / mission

At STEM we aim to understand and predict how mechanical factors influence soft tissue growth, remodelling, damage, and repair. We use this knowledge to (re)build soft tissues and organs within the human body, and to find ways to prevent mechanically-induced soft tissue degeneration.

Highlighted phrase

Modelling and experimentation at length scales from molecule to man

Organisational profile

While performing our research at the forefront of soft tissue biomechanics, mechanobiology, and the engineering of living soft biological tissues and organs, we strive to provide a stimulating educational environment for graduate and post-graduate students. Our research is multi-disciplinary at heart, combining concepts from molecular, cell and tissue biology, (patho)physiology, immunology, biomechanics, physics, engineering, and materials science. To translate our fundamental knowledge to (bio)medical applications we actively collaborate with clinical partners, industry, and patient organizations.

Research themes at the STEM group include: i) cardiovascular in situ tissue engineering, ii) tissue growth and remodelling, iii) the biophysical cellular niche, iv) tissue and organ morphogenesis, v) hybrid organs, vi) scaffold design, and vii) soft tissue mechanics. Emphasis is given to the integration of computational modelling with experimentation at length scales from molecule to man.

Fingerprint Dive into the research topics where Soft Tissue Biomechanics & Tissue Engineering is active. These topic labels come from the works of this organisation's members. Together they form a unique fingerprint.

  • Network Recent external collaboration on country level. Dive into details by clicking on the dots.

    Research Output

    Cellular Contact Guidance Emerges from Gap Avoidance

    Buskermolen, A. B. C. G., Ristori, T., Mostert, D., van Turnhout, M. C., Shishvan, S. S., Loerakker, S., Kurniawan, N. A., Deshpande, V. S. & Bouten, C. V. C., 20 May 2020, In : Cell Reports. Physical Science. 1, 5, 100055.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
  • Cellular geometry sensing at different length scales and its implications for scaffold design

    Werner, M., Kurniawan, N. A. & Bouten, C. V. C., 1 Feb 2020, In : Materials. 13, 4, 18 p., 963.

    Research output: Contribution to journalReview articleAcademicpeer-review

    Open Access
    File
  • 1 Citation (Scopus)
    23 Downloads (Pure)
    Open Access
  • Equipment

  • Prizes

    Annual BME Research Day Poster Prize

    Mathieu van Kelle (Recipient), 8 Apr 2016

    Prize: OtherCareer, activity or publication related prizes (lifetime, best paper, poster etc.)Scientific

    Control cell communication and tissue regeneration

    Nicholas Kurniawan (Recipient), 2019

    Prize: ERCStartingScientific

  • Dekker Junior 2014T013

    Noortje A.M. Bax (Recipient), Mar 2015

    Prize: OtherDiscipline relatedScientific

  • Activities

    • 6 Contributed talk
    • 3 Editorial activity
    • 1 Membership of board
    • 1 Membership of committee

    Young@Heart Institute (External organisation)

    Anthal I.P.M. Smits (Chair)
    Sep 2018 → …

    Activity: Membership typesMembership of boardScientific

    Young@Heart Institute (External organisation)

    Anthal I.P.M. Smits (Contributor)
    Sep 2018 → …

    Activity: Membership typesMembership of committeeProfessional

    Unraveling the mechanisms behind cellular anisotropy sensing

    Antonetta B.C. Buskermolen (Speaker)
    4 Oct 2016

    Activity: Talk or presentation typesContributed talkScientific

    Research areas

    Cell-Matrix Interactions

    Yvon Biemans (Content manager), Lieke van Gorp (Content manager), Amy Broeders (Content manager)

    Impact: Research Topic/Theme (at group level)

    Cell-Matrix Mechanobiology

    Yvon Biemans (Content manager), Lieke van Gorp (Content manager), Amy Broeders (Content manager)

    Impact: Research Topic/Theme (at group level)

    Cell Signaling in Tissue Formation and Malformation

    Yvon Biemans (Content manager), Lieke van Gorp (Content manager), Amy Broeders (Content manager)

    Impact: Research Topic/Theme (at group level)

    Student theses

    A brain chip to investigate neurite outgrowth by trapping cell-laden hydrogel beads in microsieves

    Author: Labeur, T., 29 Aug 2019

    Supervisor: Bouten, C. (Supervisor 1), Luttge, R. (Supervisor 2), Kurniawan, N. (Supervisor 2) & Bastiaens, A. (Supervisor 2)

    Student thesis: Master

    A constitutive material model to describe the mechanical behavior of human skin in shear, tensile and indentation tests

    Author: Rooijakkers, T., 31 Aug 2017

    Supervisor: Oomens, C. (Supervisor 1), Loerakker, S. (Supervisor 2), Lopata, R. (Supervisor 2) & Soetens, J. (Supervisor 2)

    Student thesis: Master

    An in-silico imaging system based on k-Wave for multi-perspective ultrasound imaging of abdominal aortic aneurysms

    Author: Nooijens, S., 31 Jan 2019

    Supervisor: van de Vosse, F. (Supervisor 1), Lopata, R. (Supervisor 2), Oomens, C. (Supervisor 2), Petterson, N. (Supervisor 2) & Bouwman, R. (Supervisor 2)

    Student thesis: Master