Research Output per year
Organization profile
Introduction / mission
At the protein engineering group we develop new proteins for applications in therapy and diagnosis, while critically testing our understanding of protein function.
Highlighted phrase
Beyond the already impressive functional diversity of natural proteins
Organisational profile
Our group operates at the interface of chemical biology and synthetic biology. Combining protein engineering and DNA nanotechnology, we develop intelligent biomolecular sensors and switches for applications in intracellular imaging, optogenetics, point-of-care diagnostics and antibody-based therapies. An important research theme is to develop generic engineering concepts for the development of protein-based switches, which include fluorescent sensors for intracellular imaging of metal ions, photo-switchable proteins, and protein-based sensors for antibody detection and actuation. We have an active policy of sharing our protein building blocks by depositing our plasmids to AddGene and promote their use by writing dedicated protocols and tutorial reviews. In education, our main goal is to train bachelor, masters and PhD students to become creative biomolecular engineers and independent critical scientists.
Fingerprint Dive into the research topics where Protein Engineering is active. These topic labels come from the works of this organisation's members. Together they form a unique fingerprint.
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Profiles
Eva A. van Aalen
- Department of Biomedical Engineering, Protein Engineering - Doctoral Candidate
- den Toonder
Person: Prom. : doctoral candidate (PhD)
Lieuwe Biewenga, MSc
- Department of Biomedical Engineering, Protein Engineering - University Researcher
Person: OWP : University Teacher / Researcher
Research Output
Continuous small-molecule monitoring with a digital single particle switch
Yan, J., van Smeden, L., Merkx, M., Zijlstra, P. & Prins, M. W. J., 24 Apr 2020, In : ACS Sensors. 5, 4, p. 1168-1176 9 p.Research output: Contribution to journal › Article › Academic › peer-review
Dynamic modulation of proximity-induced enzyme activity using supramolecular polymers
Magdalena Estirado, E., Rosier, B. J. H. M., de Greef, T. F. A. & Brunsveld, L., 22 Apr 2020, In : Chemical Communications.Research output: Contribution to journal › Article › Academic › peer-review
Open Access
Engineered living materials based on adhesin-mediated trapping of programmable cells
Guo, S., Dubuc, E., Rave, Y., Verhagen, M., Twisk, S. A. E., van der Hek, T., Oerlemans, G. J. M., van den Oetelaar, M. C. M., van Hazendonk, L. S., Brüls, M., Eijkens, B. V., Joostens, P. L., Keij, S. R., Xing, W., Nijs, M., Stalpers, J., Sharma, M., Gerth, M., Boonen, R. J. E. A., Verduin, K. & 3 others, , 20 Mar 2020, In : ACS Synthetic Biology. 9, 3, p. 475-485 11 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access
File
Prizes
Engineering protein switches: sensors and regulators for biology and diagnostics
M. Merkx (Recipient), 2011
Prize: ERC › Starting › Scientific
Exploring the diagnostics market for simple and fast point-of-care antibody detection
M. Merkx (Recipient), 2013
Prize: ERC › Proof of concept › Scientific
NWO Vidi Award : Pieces of plastic with biological properties?
P.Y.W. Dankers (Recipient), 2016
Prize: NWO › Vidi › Scientific
Activities
- 1 Editorial activity
Nature Methods (Journal)
Jan Vinkenborg (Editorial board member)2009
Activity: Publication peer-review and editorial work types › Editorial activity › Scientific
Press / Media
DNA computer brings ‘intelligent drugs‘ a step closer
17/12/19
1 item of Media coverage
Press/Media: Expert Comment
Running DNA Like a Computer Could Help You Fight Viruses One Day
17/12/19
1 item of Media coverage
Press/Media: Expert Comment
Professor Maarten Merkx new Dean of the Department of Biomedical Engineering at TU/e
Frank P.T. Baaijens, Peter A.J. Hilbers, Maarten Merkx, Keita Ito & Josien P.W. Pluim
21/10/19
1 item of Media coverage
Press/Media: Expert Comment
Research areas
Bioluminescent sensors for point-of-care diagnostics
Marjo van Hoof (Content manager), Lieke van Gorp (Content manager), Amy Broeders (Content manager)
Impact: Research Topic/Theme (at group level)
FRET and BRET sensors for intracellular imaging
Marjo van Hoof (Content manager), Lieke van Gorp (Content manager), Amy Broeders (Content manager)
Impact: Research Topic/Theme (at group level)
Protein sensing and actuation using DNA-based molecular circuits
Marjo van Hoof (Content manager), Lieke van Gorp (Content manager), Amy Broeders (Content manager)
Impact: Research Topic/Theme (at group level)
Student theses
Benzene-1,3,5-tricarboxamides as supramolecular ordering moieties in polymeric materials
Author: Mes, T., May 2007Supervisor: Palmans, A. (Supervisor 1), Roosma, J. (Supervisor 2) & Meijer, B. (Supervisor 2)
Student thesis: Master
Bioactivation of electrospun UPy-based supramolecular polymer meshes: towards an improved treatment of pelvic floor dysfunctions
Author: Arts, B., 18 Dec 2017Supervisor: Dankers, P. (Supervisor 1), Zaccaria, S. (Supervisor 2) & Meijer, B. (Supervisor 2)
Student thesis: Master
Bioluminescent antibody conjugates for direct detection of analytes in solution
Author: van Aalen, E., 28 Mar 2019Supervisor: Ni, Y. (Supervisor 1) & Merkx, M. (Supervisor 2)
Student thesis: Master