• Groene Loper , Building 14, Helix (room STO 3.39)

    5612 AP Eindhoven


  • P.O. Box 513, Department of Biomedical Engineering

    5600 MB Eindhoven


Organization profile

Introduction / mission

At the protein engineering group we develop new proteins for applications in therapy and diagnosis, while critically testing our understanding of protein function.

Highlighted phrase

Beyond the already impressive functional diversity of natural proteins

Organisational profile

Our group operates at the interface of chemical biology and synthetic biology. Combining protein engineering and DNA nanotechnology, we develop intelligent biomolecular sensors and switches for applications in intracellular imaging, optogenetics, point-of-care diagnostics and antibody-based therapies. An important research theme is to develop generic engineering concepts for the development of protein-based switches, which include fluorescent sensors for intracellular imaging of metal ions, photo-switchable proteins, and protein-based sensors for antibody detection and actuation. We have an active policy of sharing our protein building blocks by depositing our plasmids to AddGene and promote their use by writing dedicated protocols and tutorial reviews. In education, our main goal is to train bachelor, masters and PhD students to become creative biomolecular engineers and independent critical scientists.

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1996 2019

2 Citations (Scopus)

DNA-functionalized supramolecular polymers: dynamic multicomponent assemblies with emergent properties

Wijnands, S. P. W., Meijer, E. W. & Merkx, M., 2019, In : Bioconjugate Chemistry. 30, 7, p. 1905-1914

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
Hybrid systems

DNA origami-based biomolecular organizing platforms

Rosier, B., 12 Dec 2019, (Accepted/In press) Eindhoven: Technische Universiteit Eindhoven.

Research output: ThesisPhd Thesis 1 (Research TU/e / Graduation TU/e)Academic

Optical control of antibody activity using photocleavable bivalent peptide-DNA locks

Wouters, S., Wijker, E. & Merkx, M., 10 May 2019, In : ChemBioChem.

Research output: Contribution to journalArticleAcademicpeer-review



Engineering protein switches: sensors and regulators for biology and diagnostics

Maarten Merkx (Recipient), 2011

Recognition: ERCStartingScientific

Protein Engineering
Synthetic Biology

Exploring the diagnostics market for simple and fast point-of-care antibody detection

Maarten Merkx (Recipient), 2013

Recognition: ERCProof of conceptScientific


NWO Vidi Award : Pieces of plastic with biological properties?

Patricia Dankers (Recipient), 2016

Recognition: NWOVidiScientific

Bearings (structural)

Activities 2009 2009

  • 1 Editorial activity

Nature Methods (Journal)

Jan Vinkenborg (Editorial board member)

Activity: Publication peer-review and editorial work typesEditorial activityScientific

Research areas

Bioluminescent sensors for point-of-care diagnostics

Marjo van Hoof (Content manager), Lieke van Gorp (Content manager), Amy Broeders (Content manager)

Impact: Research Topic/Theme (at group level)

FRET and BRET sensors for intracellular imaging

Marjo van Hoof (Content manager), Lieke van Gorp (Content manager), Amy Broeders (Content manager)

Impact: Research Topic/Theme (at group level)

Protein sensing and actuation using DNA-based molecular circuits

Marjo van Hoof (Content manager), Lieke van Gorp (Content manager), Amy Broeders (Content manager)

Impact: Research Topic/Theme (at group level)

Student theses

Benzene-1,3,5-tricarboxamides as supramolecular ordering moieties in polymeric materials

Author: Mes, T., May 2007

Supervisor: Palmans, A. (Supervisor 1), Roosma, J. (Supervisor 2) & Meijer, B. (Supervisor 2)

Student thesis: Master

Bioactivation of electrospun UPy-based supramolecular polymer meshes: towards an improved treatment of pelvic floor dysfunctions

Author: Arts, B., 18 Dec 2017

Supervisor: Dankers, P. (Supervisor 1), Zaccaria, S. (Supervisor 2) & Meijer, B. (Supervisor 2)

Student thesis: Master

Bioluminescent antibody conjugates for direct detection of analytes in solution

Author: van Aalen, E., 28 Mar 2019

Supervisor: Ni, Y. (Supervisor 1) & Merkx, M. (Supervisor 2)

Student thesis: Master