Precision Medicine

2025

A modular nanoparticle vaccine platform for tailored antigen and adjuvant delivery

de Dreu, A., Schrijver, D. P., Cremers, G. A. O., de Bruin, K., Vos, B. N., Anbergen, T., van Elsas, Y., Versteeg, I., Zwolsman, R., Deckers, J., Timmers, M., Roelofs, S., Darwish, Y., van der Staak, M., Priem, B., Maas, R. J. F., de Leeuw, P., Ros, G., Bartelet, B. & Hendrikx, M. & 14 others, Verhalle, L., Hokke, A. M., Van Zundert, I., van Dongen, J. L. J., Kreijtz, J., Netea, M., Beldman, T. J., Merkx, M., Kluza, E., Toner, Y. C., van der Meel, R., de Greef, T. F. A., Mulder, W. J. M. & Makri Pistikou, A.-M., 2025, (Submitted) In: Nature Nanotechnology. XX, X

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Nature-inspired platform nanotechnology for RNA delivery to myeloid cells and their bone marrow progenitors

Hofstraat, S. R. J., Anbergen, T., Zwolsman, R., Deckers, J., van Elsas, Y., Trines, M. M., Versteeg, I., Hoorn, D., Ros, G., Bartelet, B., Hendrikx, M., Darwish, Y., Kleuskens, T. M. A., Borges, F., Maas, R., Verhalle, L., Tielemans, W., Vader, P., de Jong, O. & Tabaglio, T. & 14 others, Wee, D. K. B., Teunissen, A. J. P., Brechbühl, E., Janssen, H. M., Fransen, M., de Dreu, A., Schrijver, D. P., Priem, B., Toner, Y. C., Beldman, T. J., Netea, M., Mulder, W. J. M., Kluza, E. & van der Meel, R. (Corresponding author), 3 Feb 2025, (E-pub ahead of print) In: Nature Nanotechnology. XX, X, 4493.

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2 Citations (Scopus)

Targeting mTOR in myeloid cells prevents infection-associated inflammation

Toner, Y. C., Munitz, J., Prevot, G., Morla-Folch, J., Wang, W., van Elsas, Y., Priem, B., Deckers, J., Anbergen, T., Beldman, T. J., Brechbühl, E. E. S., Aksu, M. D., Ziogas, A., Sarlea, S. A., Ozturk, M., Zhang, Z., Li, W., Li, Y., Maier, A. & Fernandes, J. C. & 23 others, Cremers, G. A. O., van Genabeek, B., Kreijtz, J. H. C. M., Lutgens, E., Riksen, N. P., Janssen, H. M., Söntjens, S. H. M., Hoeben, F. J. M., Kluza, E., Singh, G., Giamarellos-Bourboulis, E. J., Schotsaert, M., Duivenvoorden, R., van der Meel, R., Joosten, L. A. B., Cai, L., Temel, R. E., Fayad, Z. A., Mhlanga, M. M., van Leent, M. M. T., Teunissen, A. J. P., Netea, M. G. & Mulder, W. J. M. (Corresponding author), 18 Apr 2025, In: iScience. 28, 4, 18 p., 112163.

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2024

Circulatory Inflammatory Proteins as Early Diagnostic Biomarkers for Invasive Aspergillosis in Patients with Hematologic Malignancies: an Exploratory Study

ECMM Immunologic Markers for Treatment Monitoring and Diagnosis in Invasive Mold Infection Working Group Contributors, Aerts, R. (Corresponding author), Netea, M. G. & Hoenigl, M. (Corresponding author), Apr 2024, In: Mycopathologia. 189, 2, 12 p., 24.

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5 Citations (Scopus)

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Cortico-limbic interactions and carotid atherosclerotic burden during chronic stress exposure

Gharios, C., van Leent, M. M. T., Chang, H. L., Abohashem, S., O’Connor, D., Osborne, M. T., Tang, C. Y., Kaufman, A. E., Robson, P. M., Ramachandran, S., Calcagno, C., Mani, V., Trivieri, M. G., Seligowski, A. V., Dekel, S., Mulder, W. J. M., Murrough, J. W., Shin, L. M., Tawakol, A. & Fayad, Z. A., 14 May 2024, In: European Heart Journal. 45, 19, p. 1753-1764 12 p.

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11 Citations (Scopus)

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Machine learning-guided high throughput nanoparticle design

Ortiz-Perez, A., van Tilborg, D., van der Meel, R., Grisoni, F. (Corresponding author) & Albertazzi, L. (Corresponding author), 1 Jul 2024, In: Digital Discovery. 3, 7, p. 1280-1291 12 p.

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Macrophage PET imaging in mouse models of cardiovascular disease and cancer with an apolipoprotein-inspired radiotracer

Toner, Y. C., Prévot, G., van Leent, M. M. T., Munitz, J., Oosterwijk, R. S., Verschuur, A. V. D., van Elsas, Y., Perić, V., Maas, R. J. F., Ranzenigo, A., Morla-Folch, J., Wang, W., Umali, M., de Dreu, A., Fernandes, J. C., Sullivan, N. A. T., Maier, A., Mason, C. A., Fayad, Z. A. & Mulder, W. J. M. & 2 others, Teunissen, A. J. P. (Corresponding author) & Pérez-Medina, C. (Corresponding author), 15 May 2024, In: npj Imaging. 10 p., 12.

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Polymersomes with splenic avidity target red pulp myeloid cells for cancer immunotherapy

Wauters, A. C., Scheerstra, J. F., van Leent, M. M. T., Teunissen, A. J. P., Priem, B., Beldman, T. J., Rother, N., Duivenvoorden, R., Prévot, G., Munitz, J., Toner, Y. C., Deckers, J., van Elsas, Y., Mora-Raimundo, P., Chen, G., Nauta, S. A., Verschuur, A. V. D., Griffioen, A. W., Schrijver, D. P. & Anbergen, T. & 15 others, Li, Y., Wu, H., Mason, A. F., van Stevendaal, M. H. M. E., Kluza, E., Post, R. A. J., Joosten, L. A. B., Netea, M. G., Calcagno, C., Fayad, Z. A., van der Meel, R., Schroeder, A., Abdelmohsen, L. K. E. A. (Corresponding author), Mulder, W. J. M. (Corresponding author) & van Hest, J. C. M. (Corresponding author), Nov 2024, In: Nature Nanotechnology. 19, 11, p. 1735-1744 10 p.

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Trained immunity is regulated by T cell-induced CD40-TRAF6 signaling

Jacobs, M. M. E., Maas, R. J. F., Jonkman, I., Negishi, Y., Tielemans Zamora, W., Yanginlar, C., van Heck, J., Matzaraki, V., Martens, J. H. A., Baltissen, M., Vermeulen, M., Morla-Folch, J., Ranzenigo, A., Wang, W., Umali, M., Ochando, J., van der Vlag, J., Hilbrands, L. B., Joosten, L. A. B. & Netea, M. G. & 6 others, Mulder, W. J. M., van Leent, M. M. T., Mhlanga, M. M., Teunissen, A. J. P., Rother, N. & Duivenvoorden, R. (Corresponding author), 24 Sept 2024, In: Cell Reports. 43, 9, 27 p., 114664.

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1 Citation (Scopus)

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Trained immunity suppression determines kidney allograft survival

Jonkman, I., Jacobs, M. M. E., Negishi, Y., Yanginlar, C., Martens, J. H. A., Baltissen, M., Vermeulen, M., van den Hoogen, M. W. F., Baas, M., van der Vlag, J., Fayad, Z. A., Teunissen, A. J. P., Madsen, J. C., Ochando, J., Joosten, L. A. B., Netea, M. G., Mulder, W. J. M., Mhlanga, M. M., Hilbrands, L. B. & Rother, N. & 1 others, Duivenvoorden, R. (Corresponding author), Nov 2024, In: American Journal of Transplantation. 24, 11, p. 2022-2033 12 p.

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2 Citations (Scopus)

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Ultrafast light-activated polymeric nanomotors

Wang, J., Wu, H., Zhu, X., Zwolsman, R., Hofstraat, S. R. J., Li, Y., Luo, Y., Joosten, R. R. M., Friedrich, H., Cao, S., Abdelmohsen, L. K. E. A., Shao, J. (Corresponding author) & van Hest, J. C. M. (Corresponding author), 7 Jun 2024, In: Nature Communications. 15, 1, 11 p., 4878.

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2023

Acid ceramidase regulates innate immune memory

Rother, N., Yanginlar, C., Prévot, G., Jonkman, I., Jacobs, M., van Leent, M. M. T., van Heck, J., Matzaraki, V., Azzun, A., Morla-Folch, J., Ranzenigo, A., Wang, W., van der Meel, R., Fayad, Z. A., Riksen, N. P., Hilbrands, L. B., Lindeboom, R. G. H., Martens, J. H. A., Vermeulen, M. & Joosten, L. A. B. & 5 others, Netea, M. G., Mulder, W. J. M., van der Vlag, J., Teunissen, A. J. P. & Duivenvoorden, R. (Corresponding author), 26 Dec 2023, In: Cell Reports. 42, 12, 25 p., 113458.

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3 Citations (Scopus)

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DNA storage in thermoresponsive microcapsules for repeated random multiplexed data access

Bögels, B. W. A., Nguyen, B. H., Ward, D., Gascoigne, L., Schrijver, D. P., Makri Pistikou, A. M., Joesaar, A., Yang, S., Voets, I. K., Mulder, W. J. M., Phillips, A., Mann, S., Seelig, G., Strauss, K., Chen, Y. J. (Corresponding author) & de Greef, T. F. A. (Corresponding author), Aug 2023, In: Nature Nanotechnology. 18, 8, p. 912-921 10 p.

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Engineering a Scalable and Orthogonal Platform for Synthetic Communication in Mammalian Cells

Makri Pistikou, A.-M., Cremers, G. A. O., Nathalia, B. L., Meuleman, T., Bögels, B., Eijkens, B. V., de Dreu, A., Bezembinder, M., Stassen, O. M. J. A., Bouten, C. V. C., Merkx, M., Jerala, R. & de Greef, T. F. A. (Corresponding author), Dec 2023, In: Nature Communications. 14, 1, 16 p., 7001.

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8 Citations (Scopus)

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Engineering cytokine therapeutics

Deckers, J., Anbergen, T., Hokke, A. M., de Dreu, A., Schrijver, D. P., de Bruin, K., Toner, Y. C., Beldman, T., Spangler, J. B., de Greef, T. F. A., Grisoni, F., van der Meel, R., Joosten, L. A. B., Merkx, M., Netea, M. G. (Corresponding author) & Mulder, W. J. M. (Corresponding author), Apr 2023, In: Nature Reviews. Bioengineering. 1, 4, p. 286-303 18 p., e206.

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In vivo imaging of cerebral glucose metabolism informs on subacute to chronic post-stroke tissue status – A pilot study combining PET and deuterium metabolic imaging

Meerwaldt, A. E., Straathof, M., Oosterveld, W., van Heijningen, C. L., van Leent, M. M. T., Toner, Y. C., Munitz, J., Teunissen, A. J. P., Daemen, C. C., van der Toorn, A., van Vliet, G., van Tilborg, G. A. F., De Feyter, H. M., de Graaf, R. A., Hol, E. M., Mulder, W. J. M. & Dijkhuizen, R. M. (Corresponding author), May 2023, In: Journal of Cerebral Blood Flow and Metabolism. 43, 5, p. 778-790 13 p.

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6 Citations (Scopus)

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Nanomedicine approaches for in vivo cancer immunotherapy

Hofstraat, S. R. J., Anbergen, T. & van der Meel, R. (Corresponding author), 1 Oct 2023, In: Nanomedicine. 18, 23, p. 1607-1611 5 p.

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1 Citation (Scopus)

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Resolving sepsis-induced immunoparalysis via trained immunity by targeting interleukin-4 to myeloid cells

Schrijver, D. P., Röring, R. J., Deckers, J., de Dreu, A., Toner, Y. C., Prevot, G., Priem, B., Munitz, J., Nugraha, E. G., van Elsas, Y., Azzun, A., Anbergen, T., Groh, L. A., Becker, A. M. D., Pérez-Medina, C., Oosterwijk, R. S., Novakovic, B., Moorlag, S. J. C. F. M., Jansen, A. & Pickkers, P. & 12 others, Kox, M., Beldman, T. J., Kluza, E., van Leent, M. M. T., Teunissen, A. J. P., van der Meel, R., Fayad, Z. A., Joosten, L. A. B., Fisher, E. A., Merkx, M., Netea, M. G. (Corresponding author) & Mulder, W. J. M. (Corresponding author), 1 Sept 2023, In: Nature Biomedical Engineering. 7, 9, p. 1097-1112 16 p.

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33 Citations (Scopus)

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Spatial Transcriptional Mapping Reveals Site-Specific Pathways Underlying Human Atherosclerotic Plaque Rupture

Sun, J., Singh, P., Shami, A., Kluza, E., Pan, M., Djordjevic, D., Michaelsen, N. B., Kennbäck, C., van der Wel, N. N., Orho-Melander, M., Nilsson, J., Formentini, I., Conde-Knape, K., Lutgens, E., Edsfeldt, A. & Gonçalves, I. (Corresponding author), 13 Jun 2023, In: Journal of the American College of Cardiology. 81, 23, p. 2213-2227 15 p.

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36 Citations (Scopus)

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Transport by circulating myeloid cells drives liposomal accumulation in inflamed synovium

Deprez, J., Verbeke, R., Meulewaeter, S., Aernout, I., Dewitte, H., Decruy, T., Coudenys, J., Van Duyse, J., Van Isterdael, G., Peer, D., van der Meel, R., De Smedt, S. C., Jacques, P., Elewaut, D. (Corresponding author) & Lentacker, I. (Corresponding author), Nov 2023, In: Nature Nanotechnology. 18, 11, p. 1341-1350 10 p.

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21 Citations (Scopus)

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2022

Lipid nanoparticles to silence androgen receptor variants for prostate cancer therapy

Quick, J., Santos, N. D., Cheng, M. H. Y., Chander, N., Brimacombe, C. A., Kulkarni, J., van der Meel, R., Tam, Y. Y. C., Witzigmann, D. & Cullis, P. R. (Corresponding author), Sept 2022, In: Journal of Controlled Release. 349, p. 174-183 10 p.

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2021

A modular approach toward producing nanotherapeutics targeting the innate immune system

van Leent, M. M. T., Meerwaldt, A. E., Berchouchi, A., Toner, Y. C., Burnett, M., Klein, E. D., Vera Verschuur, A., Nauta, S. A., Munitz, J., Prévot, G., van Leeuwen, E. M., Ordikhani, F., Mourits, V. P., Calcagno, C., Robson, P. M., Soultanidis, G., Reiner, T., Joosten, R., Friedrich, H. & Madsen, J. C. & 9 others, Kluza, E., van der Meel, R., Joosten, L. A. B., Netea, M., Ochando, J., Fayad, Z. A., Pérez-Medina, C., Mulder, W. J. M. (Corresponding author) & Teunissen, A. J. P. (Corresponding author), 5 Mar 2021, In: Science Advances. 7, 10, 13 p., eabe7853.

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27 Citations (Scopus)

Characterization of Lipid Nanoparticles Containing Ionizable Cationic Lipids Using Design-of-Experiments Approach

Terada, T. (Corresponding author), Kulkarni, J. A., Huynh, A., Chen, S., van der Meel, R., Tam, Y. Y. C. & Cullis, P. R., 26 Jan 2021, In: Langmuir. 37, 3, p. 1120-1128 9 p.

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70 Citations (Scopus)

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Diverse ultrastructural landscape of atherosclerotic endothelium

Kluza, E. (Corresponding author), Beldman, T. J., Shami, A., Scholl, E. R., Malinova, T. S., Grootemaat, A. E., van der Wel, N. N., Gonçalves, I., Huveneers, S., Mulder, W. J. M. & Lutgens, E., Dec 2021, In: Atherosclerosis. 339, p. 35-45 11 p.

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8 Citations (Scopus)

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Modular Lipid Nanoparticle Platform Technology for siRNA and Lipophilic Prodrug Delivery

van der Meel, R. (Corresponding author), Chen, S., Zaifman, J., Kulkarni, J. A., Zhang, X. R. S., Tam, Y. K., Bally, M. B., Schiffelers, R. M., Ciufolini, M. A., Cullis, P. R. & Tam, Y. Y. C., 16 Sept 2021, In: Small : Nano Micro. 17, 37, 2103025.

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34 Citations (Scopus)

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Nanoengineering Apolipoprotein A1-Based Immunotherapeutics

Schrijver, D. P., de Dreu, A., Hofstraat, S. R. J., Kluza, E., Zwolsman, R., Deckers, J., Anbergen, T., de Bruin, K., Trines, M. M., Nugraha, E. G., Ummels, F., Röring, R. J., Beldman, T. J., Teunissen, A. J. P., Fayad, Z. A., van der Meel, R. & Mulder, W. J. M. (Corresponding author), Aug 2021, In: Advanced Therapeutics. 4, 8, 16 p., 2100083.

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Prosaposin mediates inflammation in atherosclerosis

van Leent, M. M. T., Beldman, T. J., Toner, Y. C., Lameijer, M., Rother, N., Bekkering, S., Teunissen, A. J. P., Zhou, X., van der Meel, R., Malkus, J., Nauta, S. A., Klein, E. D., Fay, F., Sanchez-Gaytan, B. L., Pérez-Medina, C., Kluza, E., Ye, Y.-X., Wojtkiewicz, G., Fisher, E. A. & Swirski, F. K. & 13 others, Nahrendorf, M., Zhang, B., Li, Y., Zhang, B., Joosten, L. A. B., Pasterkamp, G., Boltjes, A., Fayad, Z. A., Lutgens, E., Netea, M., Riksen, N. P., Mulder, W. J. M. & Duivenvoorden, R. (Corresponding author), 10 Mar 2021, In: Science Translational Medicine. 13, 584, eabe1433.

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51 Citations (Scopus)

2020

An ⁸⁹Zr-HDL PET Tracer Monitors Response to a CSF1R Inhibitor

Mason, C. A., Kossatz, S., Carter, L. M., Pirovano, G., Brand, C., Guru, N., Pérez-Medina, C., Lewis, J. S., Mulder, W. J. M. & Reiner, T. (Corresponding author), 1 Mar 2020, In: Journal of Nuclear Medicine. 61, 3, p. 433-436 4 p.

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27 Citations (Scopus)

An iterative sparse deconvolution method for simultaneous multicolor ¹⁹F-MRI of multiple contrast agents

Schoormans, J. (Corresponding author), Calcagno, C., Daal, M. R. R., Wüst, R. C. I., Faries, C., Maier, A., Teunissen, A. J. P., Naidu, S., Sanchez-Gaytan, B. L., Nederveen, A. J., Fayad, Z. A., Mulder, W. J. M., Coolen, B. F. & Strijkers, G. J., 1 Jan 2020, In: Magnetic Resonance in Medicine. 83, 1, p. 228-239 12 p.

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Antibody-Mediated Inhibition of CTLA4 Aggravates Atherosclerotic Plaque Inflammation and Progression in Hyperlipidemic Mice

Poels, K., van Leent, M. M. T., Reiche, M. E., Kusters, P. J. H., Huveneers, S., de Winther, M. P. J., Mulder, W. J. M., Lutgens, E. & Seijkens, T. T. P. (Corresponding author), 29 Aug 2020, In: Cells. 9, 9, 13 p., 1987.

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61 Citations (Scopus)

EVQuant; high-throughput quantification and characterization of extracellular vesicle (sub)populations

Hartjes, T. A., Slotman, J. A., Vredenbregt, M. S., Dits, N., van der Meel, R., Duijvesz, D., Kulkarni, J. A., French, P. J., Van Capellen, W. A., Schiffelers, R. M., Houtsmuller, A. B., Jenster, G. W. & Van Royen, M. E., 21 Oct 2020, In: bioRxiv.

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Hydroxychloroquine Inhibits the Trained Innate Immune Response to Interferons

Rother, N., Yanginlar, C., Lindeboom, R. G. H., Bekkering, S., van Leent, M. M. T., Buijsers, B., Jonkman, I., de Graaf, M., Baltissen, M., Lamers, L. A., Riksen, N. P., Fayad, Z. A., Mulder, W. J. M., Hilbrands, L. B., Joosten, L. A. B., Netea, M. G., Vermeulen, M., van der Vlag, J. & Duivenvoorden, R. (Corresponding author), 22 Dec 2020, In: Cell Reports. Medicine. 1, 9, 20 p., 100146.

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29 Citations (Scopus)

Imaging Cardiovascular and Lung Macrophages With the Positron Emission Tomography Sensor ⁶⁴Cu-Macrin in Mice, Rabbits, and Pigs

Nahrendorf, M. (Corresponding author), Hoyer, F. F., Meerwaldt, A. E., van Leent, M. M. T., Senders, M. L., Calcagno, C., Robson, P. M., Soultanidis, G., Pérez-Medina, C., Teunissen, A. J. P., Toner, Y. C., Ishikawa, K., Fish, K., Sakurai, K., van Leeuwen, E. M., Klein, E. D., Sofias, A. M., Reiner, T., Rohde, D. & Aguirre, A. D. & 8 others, Wojtkiewicz, G., Schmidt, S., Iwamoto, Y., Izquierdo-Garcia, D., Caravan, P., Swirski, F. K., Weissleder, R. & Mulder, W. J. M., 1 Oct 2020, In: Circulation. Cardiovascular Imaging. 13, 10, e010586.

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39 Citations (Scopus)

Immune Checkpoint Inhibitor Therapy Aggravates T Cell–Driven Plaque Inflammation in Atherosclerosis

Poels, K., van Leent, M. M. T., Boutros, C., Tissot, H., Roy, S., Meerwaldt, A. E., Toner, Y. C. A., Reiche, M. E., Kusters, P. J. H., Malinova, T., Huveneers, S., Kaufman, A. E., Mani, V., Fayad, Z. A., de Winther, M. P. J., Marabelle, A., Mulder, W. J. M., Robert, C., Seijkens, T. T. P. & Lutgens, E. (Corresponding author), Nov 2020, In: JACC: CardioOncology. 2, 4, p. 599-610 12 p.

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100 Citations (Scopus)

Modular lipid nanoparticle platform technology for siRNA and lipophilic prodrug delivery

van der Meel, R. (Corresponding author), Chen, S., Zaifman, J., Kulkarni, J. A., Zhang, X. R. S., Tam, Y. K., Bally, M. B., Schiffelers, R. M., Ciufolini, M. A., Cullis, P. R. & Tam, Y. Y. C., 16 Jan 2020, In: bioRxiv. 20 p.

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Multimodal imaging of bacterial-host interface in mice and piglets with Staphylococcus aureus endocarditis

Panizzi, P., Krohn-Grimberghe, M., Keliher, E., Ye, Y. X., Grune, J., Frodermann, V., Sun, Y., Muse, C. G., Bushey, K., Iwamoto, Y., van Leent, M. M. T., Meerwaldt, A., Toner, Y. C., Munitz, J., Maier, A., Soultanidis, G., Calcagno, C., Pérez-Medina, C., Carlucci, G. & Riddell, K. P. & 14 others, Barney, S., Horne, G., Anderson, B., Maddur-Appajaiah, A., Verhamme, I. M., Bock, P. E., Wojtkiewicz, G. R., Courties, G., Swirski, F. K., Church, W. R., Walz, P. H., Tillson, D. M., Mulder, W. J. M. & Nahrendorf, M. (Corresponding author), 4 Nov 2020, In: Science Translational Medicine. 12, 568, 15 p., eaay2104.

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Open Access

8 Citations (Scopus)

Multimodal positron emission tomography imaging to quantify uptake of ⁸⁹Zr-labeled liposomes in the atherosclerotic vessel wall

Lobatto, M. E., Binderup, T., Robson, P. M., Giesen, L. F. P., Calcagno, C., Witjes, J., Fay, F., Baxter, S., Wessel, C. H., Eldib, M., Bini, J., Carlin, S. D., Stroes, E. S. G., Storm, G., Kjaer, A., Lewis, J. S., Reiner, T., Fayad, Z. A., Mulder, W. J. M. (Corresponding author) & Pérez-Medina, C. (Corresponding author), 19 Feb 2020, In: Bioconjugate Chemistry. 31, 2, p. 360-368 9 p.

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30 Citations (Scopus)

Probing myeloid cell dynamics in ischaemic heart disease by nanotracer hot-spot imaging

Senders, M. L., Meerwaldt, A. E., van Leent, M. M. T., Sanchez-Gaytan, B. L., van de Voort, J. C., Toner, Y. C., Maier, A., Klein, E. D., Sullivan, N. A. T., Sofias, A. M., Groenen, H., Faries, C., Oosterwijk, R. S., van Leeuwen, E. M., Fay, F., Chepurko, E., Reiner, T., Duivenvoorden, R., Zangi, L. & Dijkhuizen, R. M. & 9 others, Hak, S., Swirski, F. K., Nahrendorf, M., Pérez-Medina, C., Teunissen, A. J. P., Fayad, Z. A., Calcagno, C., Strijkers, G. J. & Mulder, W. J. M. (Corresponding author), 1 May 2020, In: Nature Nanotechnology. 15, 5, p. 398-405 8 p.

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47 Citations (Scopus)

Sustained Depletion of FXIII-A by Inducing Acquired FXIII-B Deficiency

Strilchuk, A., Meixner, S. C., Leung, J., Safikhan, N., Kulkarni, J. A., Russel, H. M., van der Meel, R., Sutherland, M. R., Owens III, A. P., Palumbo, J., Conway, E. M., Pryzdial, E. L. G., Cullis, P. R. & Kastrup, C. J. (Corresponding author), 17 Dec 2020, In: Blood : the Journal of Hematology. 136, 25, p. 2946-2954 9 p.

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23 Citations (Scopus)

78 Downloads (Pure)

Trained Immunity-Promoting Nanobiologic Therapy Suppresses Tumor Growth and Potentiates Checkpoint Inhibition

Priem, B., van Leent, M. M. T., Teunissen, A. J. P., Sofias, A. M., Mourits, V. P., Willemsen, L., Klein, E. D., Oosterwijk, R. S., Meerwaldt, A. E., Munitz, J., Prévot, G., Vera Verschuur, A., Nauta, S. A., van Leeuwen, E. M., Fisher, E. L., de Jong, K. A. M., Zhao, Y., Toner, Y. C., Soultanidis, G. & Calcagno, C. & 25 others, Bomans, P. H. H., Friedrich, H., Sommerdijk, N., Reiner, T., Duivenvoorden, R., Zupančič, E., Di Martino, J. S., Kluza, E., Rashidian, M., Ploegh, H. L., Dijkhuizen, R. M., Hak, S., Pérez-Medina, C., Bravo-Cordero, J. J., de Winther, M. P. J., Joosten, L. A. B., van Elsas, A., Fayad, Z. A., Rialdi, A., Torre, D., Guccione, E., Ochando, J., Netea, M. G., Griffioen, A. W. & Mulder, W. J. M. (Corresponding author), 29 Oct 2020, In: Cell. 183, 3, p. 786-801.e19 16 p.

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127 Citations (Scopus)

Tumor Targeting by α_vβ₃-Integrin-Specific Lipid Nanoparticles Occurs via Phagocyte Hitchhiking

Sofias, A. M. (Corresponding author), Toner, Y. C., Meerwaldt, A. E., van Leent, M. M. T., Soultanidis, G., Elschot, M., Gonai, H., Grendstad, K., Flobak, Å., Neckmann, U., Wolowczyk, C., Fisher, E. L., Reiner, T., de Lange Davies, C., Bjørkøy, G., Teunissen, A. J. P., Ochando, J., Pérez-Medina, C., Mulder, W. J. M. & Hak, S. (Corresponding author), 28 Jul 2020, In: ACS Nano. 14, 7, p. 7832-7846 15 p.

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Open Access

84 Citations (Scopus)

2019

Fusion-dependent formation of lipid nanoparticles containing macromolecular payloads

Kulkarni, J. A. (Corresponding author), Witzigmann, D., Leung, J., van der Meel, R., Zaifman, J., Darjuan, M. M., Grisch-Chan, H. M., Thöny, B., Tam, Y. Y. C. & Cullis, P. R. (Corresponding author), 14 May 2019, In: Nanoscale. 11, 18, p. 9023-9031 9 p.

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107 Citations (Scopus)

351 Downloads (Pure)

Imaging-assisted nanoimmunotherapy for atherosclerosis in multiple species

Binderup, T. (Corresponding author), Duivenvoorden, R. (Corresponding author), Fay, F., van Leent, M. M. T., Malkus, J., Baxter, S., Ishino, S., Zhao, Y., Sanchez-Gaytan, B., Teunissen, A. J. P., Frederico, Y. C. A., Tang, J., Carlucci, G., Lyashchenko, S., Calcagno, C., Karakatsanis, N., Soultanidis, G., Senders, M. L., Robson, P. M. & Mani, V. & 12 others, Ramachandran, S., Lobatto, M. E., Hutten, B. A., Granada, J. F., Reiner, T., Swirski, F. K., Nahrendorf, M., Kjaer, A., Fisher, E. A., Fayad, Z. A., Pérez-Medina, C. & Mulder, W. J. M., 21 Aug 2019, In: Science Translational Medicine. 11, 506, eaaw7736.

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56 Citations (Scopus)

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Nanoparticle-Aided Characterization of Arterial Endothelial Architecture during Atherosclerosis Progression and Metabolic Therapy

Beldman, T. J., Malinova, T. S., Desclos, E., Grootemaat, A. E., Misiak, A. L. S., van der Velden, S., van Roomen, C. P. A. A., Beckers, L., van Veen, H. A., Krawczyk, P. M., Hoebe, R. A., Sluimer, J. C., Neele, A. E., de Winther, M. P. J., van der Wel, N. N., Lutgens, E., Mulder, W. J. M., Huveneers, S. & Kluza, E. (Corresponding author), 24 Dec 2019, In: ACS Nano. 13, 12, p. 13759-13774 16 p.

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Open Access

79 Citations (Scopus)

2018

Inhibiting inflammation with Myeloid cell-specific nanobiologics promotes organ transplant acceptance

Braza, M. S., van Leent, M. M. T., Lameijer, M., Sanchez-Gaytan, B. L., Arts, R. J. W., Pérez-Medina, C., Conde, P., Garcia, M. R., Gonzalez-Perez, M., Brahmachary, M., Fay, F., Kluza, E., Kossatz, S., Dress, R. J., Salem, F., Rialdi, A., Reiner, T., Boros, P., Strijkers, G. J. & Calcagno, C. C. & 13 others, Ginhoux, F., Marazzi, I., Lutgens, E., Nicolaes, G. A. F., Weber, C., Swirski, F. K., Nahrendorf, M., Fisher, E. A., Duivenvoorden, R., Fayad, Z. A., Netea, M. G., Mulder, W. J. M. & Ochando, J., 20 Nov 2018, In: Immunity. 49, 5, p. 819-828.e6 17 p.

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Open Access

196 Citations (Scopus)

5 Downloads (Pure)

Nanoemulsion-based delivery of fluorescent PARP inhibitors in mouse models of small cell lung cancer

Gonzales, J., Kossatz, S., Roberts, S., Pirovano, G., Brand, C., Pérez-Medina, C., Donabedian, P., de la Cruz, M. J., Mulder, W. J. M. & Reiner, T., 21 Nov 2018, In: Bioconjugate Chemistry. 29, 11, p. 3776-3782 7 p.

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17 Citations (Scopus)

1 Downloads (Pure)

2009

Magnetic quantum dots for multimodal imaging

Koole, R., Mulder, W. J. M., Van Schooneveld, M. M., Strijkers, G. J., Meijerink, A. & Nicolay, K., 2009, In: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology. 1, 5, p. 475-491 17 p.

Research output: Contribution to journal › Article › Academic › peer-review

94 Citations (Scopus)

2008

Improved biocompatibility and pharmacokinetics of silica nanoparticles by means of a lipid coating: A multimodality investigation

Van Schooneveld, M. M., Vucic, E., Koole, R., Zhou, Y., Stocks, J., Cormode, D. P., Tang, C. Y., Gordon, R. E., Nicolay, K., Meijerink, A., Fayad, Z. A. & Mulder, W. J. M., Aug 2008, In: Nano Letters. 8, 8, p. 2517-2525 9 p.

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218 Citations (Scopus)

Multimodality nanotracers for cardiovascular applications

Mulder, W. J. M., Cormode, D. P., Hak, S., Lobatto, M. E., Silvera, S. & Fayad, Z. A., Aug 2008, In: Nature Clinical Practice. Cardiovascular Medicine. 5, SUPPL. 2, p. S103-S111 9 p.

Research output: Contribution to journal › Article › Academic › peer-review

44 Citations (Scopus)

2007

Anginex-conjugated liposomes for targeting of angiogenic endothelial cells

Brandwijk, R. J. M. G. E., Mulder, W. J. M., Nicolay, K., Mayo, K. H., Thijssen, V. L. J. L. & Griffioen, A. W., May 2007, In: Bioconjugate Chemistry. 18, 3, p. 785-790 6 p.

Research output: Contribution to journal › Article › Academic › peer-review

41 Citations (Scopus)

Precision Medicine

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