Precision Medicine

2025

A modular nanoparticle vaccine platform for tailored antigen and adjuvant delivery

de Dreu, A., Schrijver, D. P., Cremers, G. A. O., de Bruin, K., Vos, B. N., Anbergen, T., van Elsas, Y., Versteeg, I., Zwolsman, R., Deckers, J., Timmers, M., Roelofs, S., Darwish, Y., van der Staak, M., Priem, B., Maas, R. J. F., de Leeuw, P., Ros, G., Bartelet, B. & Hendrikx, M. & 14 others, Verhalle, L., Hokke, A. M., Van Zundert, I., van Dongen, J. L. J., Kreijtz, J., Netea, M., Beldman, T. J., Merkx, M., Kluza, E., Toner, Y. C., van der Meel, R., de Greef, T. F. A., Mulder, W. J. M. & Makri Pistikou, A.-M., 2025, (Submitted) In: Nature Nanotechnology. XX, X

Research output: Contribution to journal › Article › Academic › peer-review

Autonomous and tunable control of synthetic receptor activation using microRNAs

Nathalia, B. L., Meuleman, T. J., Makri Pistikou, A.-M., Doensen, W. H. M., Nijenhuis, W., Schrijver, D. P., Kapitein, L. C. & de Greef, T. F. A., 17 Mar 2025, (Submitted).

Research output: Contribution to conference › Abstract › Academic

Bioengineered Therapeutic Strategies to Rebalance the Immune System

Schrijver, D. P., 29 Jan 2025, Eindhoven: Eindhoven University of Technology. 205 p.

Research output: Thesis › Phd Thesis 1 (Research TU/e / Graduation TU/e)

Imaging-guided high-throughput formulation and screening of nanoparticles

Ortiz Pérez, A., 19 Mar 2025, Eindhoven: Eindhoven University of Technology. 178 p.

Research output: Thesis › Phd Thesis 1 (Research TU/e / Graduation TU/e)

Open Access

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Nature-inspired platform nanotechnology for RNA delivery to myeloid cells and their bone marrow progenitors

Hofstraat, S. R. J., Anbergen, T., Zwolsman, R., Deckers, J., van Elsas, Y., Trines, M. M., Versteeg, I., Hoorn, D., Ros, G., Bartelet, B., Hendrikx, M., Darwish, Y., Kleuskens, T. M. A., Borges, F., Maas, R., Verhalle, L., Tielemans, W., Vader, P., de Jong, O. & Tabaglio, T. & 14 others, Wee, D. K. B., Teunissen, A. J. P., Brechbühl, E., Janssen, H. M., Fransen, M., de Dreu, A., Schrijver, D. P., Priem, B., Toner, Y. C., Beldman, T. J., Netea, M., Mulder, W. J. M., Kluza, E. & van der Meel, R. (Corresponding author), 3 Feb 2025, (E-pub ahead of print) In: Nature Nanotechnology. XX, X, 4493.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

2 Citations (Scopus)

Targeting mTOR in myeloid cells prevents infection-associated inflammation

Toner, Y. C., Munitz, J., Prevot, G., Morla-Folch, J., Wang, W., van Elsas, Y., Priem, B., Deckers, J., Anbergen, T., Beldman, T. J., Brechbühl, E. E. S., Aksu, M. D., Ziogas, A., Sarlea, S. A., Ozturk, M., Zhang, Z., Li, W., Li, Y., Maier, A. & Fernandes, J. C. & 23 others, Cremers, G. A. O., van Genabeek, B., Kreijtz, J. H. C. M., Lutgens, E., Riksen, N. P., Janssen, H. M., Söntjens, S. H. M., Hoeben, F. J. M., Kluza, E., Singh, G., Giamarellos-Bourboulis, E. J., Schotsaert, M., Duivenvoorden, R., van der Meel, R., Joosten, L. A. B., Cai, L., Temel, R. E., Fayad, Z. A., Mhlanga, M. M., van Leent, M. M. T., Teunissen, A. J. P., Netea, M. G. & Mulder, W. J. M. (Corresponding author), 18 Apr 2025, In: iScience. 28, 4, 18 p., 112163.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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2024

Author Correction: Ultrafast light-activated polymeric nanomotors (Nature communications (2024) 15 1 DOI: 10.1038/s41467-024-49217-w)

Wang, J., Wu, H., Zhu, X., Zwolsman, R., Hofstraat, S. R. J., Li, Y., Luo, Y., Joosten, R. R. M., Friedrich, H., Cao, S., Abdelmohsen, L. K. E. A., Shao, J. (Corresponding author) & van Hest, J. C. M. (Corresponding author), 11 Nov 2024, In: Nature Communications. 15, 1, 1 p., 9735.

Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

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Circulatory Inflammatory Proteins as Early Diagnostic Biomarkers for Invasive Aspergillosis in Patients with Hematologic Malignancies: an Exploratory Study

ECMM Immunologic Markers for Treatment Monitoring and Diagnosis in Invasive Mold Infection Working Group Contributors, Aerts, R. (Corresponding author), Netea, M. G. & Hoenigl, M. (Corresponding author), Apr 2024, In: Mycopathologia. 189, 2, 12 p., 24.

Research output: Contribution to journal › Article › Academic › peer-review

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5 Citations (Scopus)

22 Downloads (Pure)

Cortico-limbic interactions and carotid atherosclerotic burden during chronic stress exposure

Gharios, C., van Leent, M. M. T., Chang, H. L., Abohashem, S., O’Connor, D., Osborne, M. T., Tang, C. Y., Kaufman, A. E., Robson, P. M., Ramachandran, S., Calcagno, C., Mani, V., Trivieri, M. G., Seligowski, A. V., Dekel, S., Mulder, W. J. M., Murrough, J. W., Shin, L. M., Tawakol, A. & Fayad, Z. A., 14 May 2024, In: European Heart Journal. 45, 19, p. 1753-1764 12 p.

Research output: Contribution to journal › Article › Academic › peer-review

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11 Citations (Scopus)

5 Downloads (Pure)

Engineering synthetic receptor systems for mammalian cell-based therapeutics

Makri Pistikou, A.-M., 29 May 2024, Eindhoven: Eindhoven University of Technology. 295 p.

Research output: Thesis › Phd Thesis 1 (Research TU/e / Graduation TU/e)

Lipid discovery for mRNA delivery guided by machine learning

van der Meel, R. (Corresponding author), Grisoni, F. & Mulder, W. J. M., Jul 2024, In: Nature Materials. 23, 7, p. 880-881 2 p.

Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

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2 Citations (Scopus)

29 Downloads (Pure)

Machine learning-guided high throughput nanoparticle design

Ortiz-Perez, A., van Tilborg, D., van der Meel, R., Grisoni, F. (Corresponding author) & Albertazzi, L. (Corresponding author), 1 Jul 2024, In: Digital Discovery. 3, 7, p. 1280-1291 12 p.

Research output: Contribution to journal › Article › Academic › peer-review

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13 Citations (Scopus)

41 Downloads (Pure)

Macrophage PET imaging in mouse models of cardiovascular disease and cancer with an apolipoprotein-inspired radiotracer

Toner, Y. C., Prévot, G., van Leent, M. M. T., Munitz, J., Oosterwijk, R. S., Verschuur, A. V. D., van Elsas, Y., Perić, V., Maas, R. J. F., Ranzenigo, A., Morla-Folch, J., Wang, W., Umali, M., de Dreu, A., Fernandes, J. C., Sullivan, N. A. T., Maier, A., Mason, C. A., Fayad, Z. A. & Mulder, W. J. M. & 2 others, Teunissen, A. J. P. (Corresponding author) & Pérez-Medina, C. (Corresponding author), 15 May 2024, In: npj Imaging. 10 p., 12.

Research output: Contribution to journal › Article › Academic › peer-review

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Polymersomes with splenic avidity target red pulp myeloid cells for cancer immunotherapy

Wauters, A. C., Scheerstra, J. F., van Leent, M. M. T., Teunissen, A. J. P., Priem, B., Beldman, T. J., Rother, N., Duivenvoorden, R., Prévot, G., Munitz, J., Toner, Y. C., Deckers, J., van Elsas, Y., Mora-Raimundo, P., Chen, G., Nauta, S. A., Verschuur, A. V. D., Griffioen, A. W., Schrijver, D. P. & Anbergen, T. & 15 others, Li, Y., Wu, H., Mason, A. F., van Stevendaal, M. H. M. E., Kluza, E., Post, R. A. J., Joosten, L. A. B., Netea, M. G., Calcagno, C., Fayad, Z. A., van der Meel, R., Schroeder, A., Abdelmohsen, L. K. E. A. (Corresponding author), Mulder, W. J. M. (Corresponding author) & van Hest, J. C. M. (Corresponding author), Nov 2024, In: Nature Nanotechnology. 19, 11, p. 1735-1744 10 p.

Research output: Contribution to journal › Article › Academic › peer-review

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5 Citations (Scopus)

23 Downloads (Pure)

The immunostimulatory nature of mRNA lipid nanoparticles

Sharma, P., Hoorn, D., Aitha, A., Breier, D. & Peer, D. (Corresponding author), 1 Feb 2024, In: Advanced Drug Delivery Reviews. 205, 22 p., 115175.

Research output: Contribution to journal › Review article › peer-review

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36 Citations (Scopus)

391 Downloads (Pure)

Trained immunity is regulated by T cell-induced CD40-TRAF6 signaling

Jacobs, M. M. E., Maas, R. J. F., Jonkman, I., Negishi, Y., Tielemans Zamora, W., Yanginlar, C., van Heck, J., Matzaraki, V., Martens, J. H. A., Baltissen, M., Vermeulen, M., Morla-Folch, J., Ranzenigo, A., Wang, W., Umali, M., Ochando, J., van der Vlag, J., Hilbrands, L. B., Joosten, L. A. B. & Netea, M. G. & 6 others, Mulder, W. J. M., van Leent, M. M. T., Mhlanga, M. M., Teunissen, A. J. P., Rother, N. & Duivenvoorden, R. (Corresponding author), 24 Sept 2024, In: Cell Reports. 43, 9, 27 p., 114664.

Research output: Contribution to journal › Article › Academic › peer-review

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1 Citation (Scopus)

11 Downloads (Pure)

Trained immunity suppression determines kidney allograft survival

Jonkman, I., Jacobs, M. M. E., Negishi, Y., Yanginlar, C., Martens, J. H. A., Baltissen, M., Vermeulen, M., van den Hoogen, M. W. F., Baas, M., van der Vlag, J., Fayad, Z. A., Teunissen, A. J. P., Madsen, J. C., Ochando, J., Joosten, L. A. B., Netea, M. G., Mulder, W. J. M., Mhlanga, M. M., Hilbrands, L. B. & Rother, N. & 1 others, Duivenvoorden, R. (Corresponding author), Nov 2024, In: American Journal of Transplantation. 24, 11, p. 2022-2033 12 p.

Research output: Contribution to journal › Article › Academic › peer-review

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2 Citations (Scopus)

12 Downloads (Pure)

Ultrafast light-activated polymeric nanomotors

Wang, J., Wu, H., Zhu, X., Zwolsman, R., Hofstraat, S. R. J., Li, Y., Luo, Y., Joosten, R. R. M., Friedrich, H., Cao, S., Abdelmohsen, L. K. E. A., Shao, J. (Corresponding author) & van Hest, J. C. M. (Corresponding author), 7 Jun 2024, In: Nature Communications. 15, 1, 11 p., 4878.

Research output: Contribution to journal › Article › Academic › peer-review

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16 Citations (Scopus)

38 Downloads (Pure)

2023

Acid ceramidase regulates innate immune memory

Rother, N., Yanginlar, C., Prévot, G., Jonkman, I., Jacobs, M., van Leent, M. M. T., van Heck, J., Matzaraki, V., Azzun, A., Morla-Folch, J., Ranzenigo, A., Wang, W., van der Meel, R., Fayad, Z. A., Riksen, N. P., Hilbrands, L. B., Lindeboom, R. G. H., Martens, J. H. A., Vermeulen, M. & Joosten, L. A. B. & 5 others, Netea, M. G., Mulder, W. J. M., van der Vlag, J., Teunissen, A. J. P. & Duivenvoorden, R. (Corresponding author), 26 Dec 2023, In: Cell Reports. 42, 12, 25 p., 113458.

Research output: Contribution to journal › Article › Academic › peer-review

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3 Citations (Scopus)

54 Downloads (Pure)

A nature-inspired nanodelivery platform for gene silencing in hematopoietic stem and progenitor cells

Hofstraat, S. R. J., Anbergen, T., Zwolsman, R., Deckers, J., van Elsas, Y., Trines, M. M., Versteeg, I., Priem, B., B. Darwish, Y., Kleuskens, T. M. A., Borges, F., Maas, R., Verhalle, L., Tielemans, W., Vader, P., de Jong, O., Teunissen, A. J. P., Brechbühl, E., Janssen, H. M. & Fransen, P. M. & 8 others, de Dreu, A., Schrijver, D. P., Toner, Y. C., Beldman, T. J., Netea, M., Mulder, W. J. M., Kluza, E. & van der Meel, R., 27 Oct 2023, Research Square.

Research output: Working paper › Preprint › Academic

Author Correction: Engineering cytokine therapeutics: Engineering cytokine therapeutics (Nature Reviews Bioengineering, (2023), 1, 4, (286-303), 10.1038/s44222-023-00030-y)

Deckers, J., Anbergen, T., Hokke, A. M., de Dreu, A., Schrijver, D. P., de Bruin, K., Toner, Y. C., Beldman, T. J., Spangler, J. B., de Greef, T. F. A., Grisoni, F., van der Meel, R., Joosten, L. A. B., Merkx, M., Netea, M. G. (Corresponding author-nrf) & Mulder, W. J. M. (Corresponding author), Apr 2023, In: Nature Reviews Bioengineering. 1, 4, 1 p., 304.

Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

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DNA storage in thermoresponsive microcapsules for repeated random multiplexed data access

Bögels, B. W. A., Nguyen, B. H., Ward, D., Gascoigne, L., Schrijver, D. P., Makri Pistikou, A. M., Joesaar, A., Yang, S., Voets, I. K., Mulder, W. J. M., Phillips, A., Mann, S., Seelig, G., Strauss, K., Chen, Y. J. (Corresponding author) & de Greef, T. F. A. (Corresponding author), Aug 2023, In: Nature Nanotechnology. 18, 8, p. 912-921 10 p.

Research output: Contribution to journal › Article › Academic › peer-review

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30 Citations (Scopus)

101 Downloads (Pure)

Engineering a Scalable and Orthogonal Platform for Synthetic Communication in Mammalian Cells

Makri Pistikou, A.-M., Cremers, G. A. O., Nathalia, B. L., Meuleman, T., Bögels, B., Eijkens, B. V., de Dreu, A., Bezembinder, M., Stassen, O. M. J. A., Bouten, C. V. C., Merkx, M., Jerala, R. & de Greef, T. F. A. (Corresponding author), Dec 2023, In: Nature Communications. 14, 1, 16 p., 7001.

Research output: Contribution to journal › Article › Academic › peer-review

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8 Citations (Scopus)

62 Downloads (Pure)

Engineering cytokine therapeutics

Deckers, J., Anbergen, T., Hokke, A. M., de Dreu, A., Schrijver, D. P., de Bruin, K., Toner, Y. C., Beldman, T., Spangler, J. B., de Greef, T. F. A., Grisoni, F., van der Meel, R., Joosten, L. A. B., Merkx, M., Netea, M. G. (Corresponding author) & Mulder, W. J. M. (Corresponding author), Apr 2023, In: Nature Reviews. Bioengineering. 1, 4, p. 286-303 18 p., e206.

Research output: Contribution to journal › Article › Academic › peer-review

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108 Citations (Scopus)

171 Downloads (Pure)

In vivo imaging of cerebral glucose metabolism informs on subacute to chronic post-stroke tissue status – A pilot study combining PET and deuterium metabolic imaging

Meerwaldt, A. E., Straathof, M., Oosterveld, W., van Heijningen, C. L., van Leent, M. M. T., Toner, Y. C., Munitz, J., Teunissen, A. J. P., Daemen, C. C., van der Toorn, A., van Vliet, G., van Tilborg, G. A. F., De Feyter, H. M., de Graaf, R. A., Hol, E. M., Mulder, W. J. M. & Dijkhuizen, R. M. (Corresponding author), May 2023, In: Journal of Cerebral Blood Flow and Metabolism. 43, 5, p. 778-790 13 p.

Research output: Contribution to journal › Article › Academic › peer-review

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6 Citations (Scopus)

95 Downloads (Pure)

Nanomedicine approaches for in vivo cancer immunotherapy

Hofstraat, S. R. J., Anbergen, T. & van der Meel, R. (Corresponding author), 1 Oct 2023, In: Nanomedicine. 18, 23, p. 1607-1611 5 p.

Research output: Contribution to journal › Article › Academic › peer-review

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1 Citation (Scopus)

107 Downloads (Pure)

Resolving sepsis-induced immunoparalysis via trained immunity by targeting interleukin-4 to myeloid cells

Schrijver, D. P., Röring, R. J., Deckers, J., de Dreu, A., Toner, Y. C., Prevot, G., Priem, B., Munitz, J., Nugraha, E. G., van Elsas, Y., Azzun, A., Anbergen, T., Groh, L. A., Becker, A. M. D., Pérez-Medina, C., Oosterwijk, R. S., Novakovic, B., Moorlag, S. J. C. F. M., Jansen, A. & Pickkers, P. & 12 others, Kox, M., Beldman, T. J., Kluza, E., van Leent, M. M. T., Teunissen, A. J. P., van der Meel, R., Fayad, Z. A., Joosten, L. A. B., Fisher, E. A., Merkx, M., Netea, M. G. (Corresponding author) & Mulder, W. J. M. (Corresponding author), 1 Sept 2023, In: Nature Biomedical Engineering. 7, 9, p. 1097-1112 16 p.

Research output: Contribution to journal › Article › Academic › peer-review

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33 Citations (Scopus)

86 Downloads (Pure)

Spatial Transcriptional Mapping Reveals Site-Specific Pathways Underlying Human Atherosclerotic Plaque Rupture

Sun, J., Singh, P., Shami, A., Kluza, E., Pan, M., Djordjevic, D., Michaelsen, N. B., Kennbäck, C., van der Wel, N. N., Orho-Melander, M., Nilsson, J., Formentini, I., Conde-Knape, K., Lutgens, E., Edsfeldt, A. & Gonçalves, I. (Corresponding author), 13 Jun 2023, In: Journal of the American College of Cardiology. 81, 23, p. 2213-2227 15 p.

Research output: Contribution to journal › Article › Academic › peer-review

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36 Citations (Scopus)

337 Downloads (Pure)

Trained immunity: Target for prophylaxis and therapy

Ziogas, A. (Corresponding author), Bruno, M., van der Meel, R., Mulder, W. J. M. & Netea, M. G., 8 Nov 2023, In: Cell Host and Microbe. 31, 11, p. 1776-1791 16 p.

Research output: Contribution to journal › Review article › peer-review

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25 Citations (Scopus)

323 Downloads (Pure)

Transport by circulating myeloid cells drives liposomal accumulation in inflamed synovium

Deprez, J., Verbeke, R., Meulewaeter, S., Aernout, I., Dewitte, H., Decruy, T., Coudenys, J., Van Duyse, J., Van Isterdael, G., Peer, D., van der Meel, R., De Smedt, S. C., Jacques, P., Elewaut, D. (Corresponding author) & Lentacker, I. (Corresponding author), Nov 2023, In: Nature Nanotechnology. 18, 11, p. 1341-1350 10 p.

Research output: Contribution to journal › Article › Academic › peer-review

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21 Citations (Scopus)

13 Downloads (Pure)

2022

Hoe weet een medicijn waar het heen moet?

van der Meel, R., 2022

Research output: Non-textual form › Digital or Visual Products › Popular

Lipid nanoparticles to silence androgen receptor variants for prostate cancer therapy

Quick, J., Santos, N. D., Cheng, M. H. Y., Chander, N., Brimacombe, C. A., Kulkarni, J., van der Meel, R., Tam, Y. Y. C., Witzigmann, D. & Cullis, P. R. (Corresponding author), Sept 2022, In: Journal of Controlled Release. 349, p. 174-183 10 p.

Research output: Contribution to journal › Article › Academic › peer-review

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13 Citations (Scopus)

231 Downloads (Pure)

Regulating trained immunity with nanomedicine

van Leent, M. M. T., Priem, B., Schrijver, D. P., de Dreu, A., Hofstraat, S. R. J., Zwolsman, R., Beldman, T. J., Netea, M. G. (Corresponding author) & Mulder, W. J. M. (Corresponding author), Jun 2022, In: Nature Reviews. Materials. 7, 6, p. 465-481 17 p.

Research output: Contribution to journal › Review article › peer-review

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71 Citations (Scopus)

89 Downloads (Pure)

2021

A modular approach toward producing nanotherapeutics targeting the innate immune system

van Leent, M. M. T., Meerwaldt, A. E., Berchouchi, A., Toner, Y. C., Burnett, M., Klein, E. D., Vera Verschuur, A., Nauta, S. A., Munitz, J., Prévot, G., van Leeuwen, E. M., Ordikhani, F., Mourits, V. P., Calcagno, C., Robson, P. M., Soultanidis, G., Reiner, T., Joosten, R., Friedrich, H. & Madsen, J. C. & 9 others, Kluza, E., van der Meel, R., Joosten, L. A. B., Netea, M., Ochando, J., Fayad, Z. A., Pérez-Medina, C., Mulder, W. J. M. (Corresponding author) & Teunissen, A. J. P. (Corresponding author), 5 Mar 2021, In: Science Advances. 7, 10, 13 p., eabe7853.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

27 Citations (Scopus)

Applications of elastin-like polypeptides in nanomedicine

Abdelghani, M., 9 Feb 2021, Eindhoven: Technische Universiteit Eindhoven. 153 p.

Research output: Thesis › Phd Thesis 1 (Research TU/e / Graduation TU/e)

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Author Correction: Trained immunity, tolerance, priming and differentiation: distinct immunological processes (Nature Immunology, (2021), 22, 1, (2-6), 10.1038/s41590-020-00845-6)

Divangahi, M. (Corresponding author), Aaby, P., Khader, S. A., Barreiro, L. B., Bekkering, S., Chavakis, T., van Crevel, R., Curtis, N., DiNardo, A. R., Dominguez-Andres, J., Duivenvoorden, R., Fanucchi, S., Fayad, Z., Fuchs, E., Hamon, M., Jeffrey, K. L., Khan, N., Joosten, L. A. B., Kaufmann, E. & Latz, E. & 24 others, Matarese, G., van der Meer, J. W. M., Mhlanga, M., Moorlag, S. J. C. F. M., Mulder, W. J. M., Naik, S., Novakovic, B., O’Neill, L., Ochando, J., Ozato, K., Riksen, N. P., Sauerwein, R., Sherwood, E. R., Schlitzer, A., Schultze, J. L., Sieweke, M. H., Benn, C. S., Stunnenberg, H., Sun, J., van de Veerdonk, F. L., Weis, S., Williams, D. L., Xavier, R. & Netea, M. G., Jul 2021, In: Nature Immunology. 22, 7, p. 928 1 p.

Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

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9 Citations (Scopus)

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Author Correction: The current landscape of nucleic acid therapeutics (Nature Nanotechnology, (2021), 16, 6, (630-643), 10.1038/s41565-021-00898-0)

Kulkarni, J. A., Witzigmann, D., Thomson, S. B., Chen, S., Leavitt, B. R., Cullis, P. R. & van der Meel, R. (Corresponding author), Jul 2021, In: Nature Nanotechnology. 16, 7, p. 841 1 p.

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15 Citations (Scopus)

54 Downloads (Pure)

Characterization of Lipid Nanoparticles Containing Ionizable Cationic Lipids Using Design-of-Experiments Approach

Terada, T. (Corresponding author), Kulkarni, J. A., Huynh, A., Chen, S., van der Meel, R., Tam, Y. Y. C. & Cullis, P. R., 26 Jan 2021, In: Langmuir. 37, 3, p. 1120-1128 9 p.

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70 Citations (Scopus)

1613 Downloads (Pure)

Diverse ultrastructural landscape of atherosclerotic endothelium

Kluza, E. (Corresponding author), Beldman, T. J., Shami, A., Scholl, E. R., Malinova, T. S., Grootemaat, A. E., van der Wel, N. N., Gonçalves, I., Huveneers, S., Mulder, W. J. M. & Lutgens, E., Dec 2021, In: Atherosclerosis. 339, p. 35-45 11 p.

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8 Citations (Scopus)

78 Downloads (Pure)

Embracing nanomaterials' interactions with the innate immune system

Teunissen, A. J. P. (Corresponding author), Burnett, M. E., Prévot, G., Klein, E. D., Bivona, D. & Mulder, W. J. M. (Corresponding author), Nov 2021, In: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology. 13, 6, 22 p., e1719.

Research output: Contribution to journal › Review article › peer-review

12 Citations (Scopus)

2 Downloads (Pure)

Imaging-guided nanomedicine development

Bernal, A., Calcagno, C., Mulder, W. J. M. & Pérez-Medina, C. (Corresponding author), Aug 2021, In: Current Opinion in Chemical Biology. 63, p. 78-85 8 p.

Research output: Contribution to journal › Review article › peer-review

18 Citations (Scopus)

Modular Lipid Nanoparticle Platform Technology for siRNA and Lipophilic Prodrug Delivery

van der Meel, R. (Corresponding author), Chen, S., Zaifman, J., Kulkarni, J. A., Zhang, X. R. S., Tam, Y. K., Bally, M. B., Schiffelers, R. M., Ciufolini, M. A., Cullis, P. R. & Tam, Y. Y. C., 16 Sept 2021, In: Small : Nano Micro. 17, 37, 2103025.

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34 Citations (Scopus)

132 Downloads (Pure)

Nanoengineering Apolipoprotein A1-Based Immunotherapeutics

Schrijver, D. P., de Dreu, A., Hofstraat, S. R. J., Kluza, E., Zwolsman, R., Deckers, J., Anbergen, T., de Bruin, K., Trines, M. M., Nugraha, E. G., Ummels, F., Röring, R. J., Beldman, T. J., Teunissen, A. J. P., Fayad, Z. A., van der Meel, R. & Mulder, W. J. M. (Corresponding author), Aug 2021, In: Advanced Therapeutics. 4, 8, 16 p., 2100083.

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10 Citations (Scopus)

336 Downloads (Pure)

Prosaposin mediates inflammation in atherosclerosis

van Leent, M. M. T., Beldman, T. J., Toner, Y. C., Lameijer, M., Rother, N., Bekkering, S., Teunissen, A. J. P., Zhou, X., van der Meel, R., Malkus, J., Nauta, S. A., Klein, E. D., Fay, F., Sanchez-Gaytan, B. L., Pérez-Medina, C., Kluza, E., Ye, Y.-X., Wojtkiewicz, G., Fisher, E. A. & Swirski, F. K. & 13 others, Nahrendorf, M., Zhang, B., Li, Y., Zhang, B., Joosten, L. A. B., Pasterkamp, G., Boltjes, A., Fayad, Z. A., Lutgens, E., Netea, M., Riksen, N. P., Mulder, W. J. M. & Duivenvoorden, R. (Corresponding author), 10 Mar 2021, In: Science Translational Medicine. 13, 584, eabe1433.

Research output: Contribution to journal › Article › Academic › peer-review

51 Citations (Scopus)

RNA vaccines – from code to cure

van der Meel, R., 2021

Research output: Non-textual form › Digital or Visual Products › Popular

Roadmap on Nanomedicine

Decuzzi, P. (Corresponding author), Peer, D. (Corresponding author), Di Mascolo, D., Palange, A. L., Manghnani, P. N., Moghimi, S. M., Farhangrazi, Z. S., Howard, K. A., Rosenblum, D., Liang, T., Chen, Z., Wang, Z., Zhu, J.-J., Gu, Z., Korin, N., Letourneur, D., Chauvierre, C., van der Meel, R., Kiessling, F. & Lammers, T., 1 Jan 2021, In: Nanotechnology. 32, 1, 26 p., 012001.

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23 Citations (Scopus)

100 Downloads (Pure)

Sound of Science #25

van der Meel, R., 2021

Research output: Non-textual form › Digital or Visual Products › Popular

The current landscape of nucleic acid therapeutics

Kulkarni, J. A., Witzigmann, D., Thomson, S. B., Chen, S., Leavitt, B. R., Cullis, P. R. & van der Meel, R. (Corresponding author), Jun 2021, In: Nature Nanotechnology. 16, 6, p. 630-643 14 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

865 Citations (Scopus)

Trained immunity, tolerance, priming and differentiation: distinct immunological processes

Divangahi, M. (Corresponding author), Aaby, P., Khader, S. A., Barreiro, L. B., Bekkering, S., Chavakis, T., van Crevel, R., Curtis, N., DiNardo, A. R., Dominguez-Andres, J., Duivenwoorden, R., Fanucchi, S., Fayad, Z., Fuchs, E., Hamon, M., Jeffrey, K. L., Khan, N., Joosten, L. A. B., Kaufmann, E. & Latz, E. & 24 others, Matarese, G., van der Meer, J. W. M., Mhlanga, M., Moorlag, S. J. C. F. M., Mulder, W. J. M., Naik, S., Novakovic, B., O’Neill, L., Ochando, J., Ozato, K., Riksen, N. P., Sauerwein, R., Sherwood, E. R., Schlitzer, A., Schultze, J. L., Sieweke, M. H., Benn, C. S., Stunnenberg, H., Sun, J., van de Veerdonk, F. L., Weis, S., Williams, D. L., Xavier, R. & Netea, M. G. (Corresponding author), 1 Jan 2021, In: Nature Immunology. 22, 1, p. 2-6 5 p.

Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

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341 Citations (Scopus)

What does the success of mRNA vaccines tell us about the future of biological therapeutics?

Karikó, K., Whitehead, K. & van der Meel, R., 18 Aug 2021, In: Cell Systems. 12, 8, p. 757-758 2 p.

Research output: Contribution to journal › Comment/Letter to the editor › Academic

11 Citations (Scopus)

Precision Medicine

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