Organization profile

Introduction / mission

The Precision Medicine group focuses on designing and evaluating nanotherapeutics that regulate the immune response to treat a range of conditions, including cancer, cardiovascular and autoimmune diseases.

Highlighted phrase

Nanotechnology for immunotherapy

Organisational profile

Nanotechnology can be applied to empower the immune system’s ability to fight disease, by promoting or inhibiting an immune response, by polarizing macrophage function, or by targeting myeloid cell dynamics. The innovation cascade involves developing biocompatible nanoimmunotherapeutics from natural molecular building blocks and comprises an innovative translational workflow, involving noninvasive imaging for testing on small and large animal disease models.

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Profiles

Anne de Dreu

a.d.dreu@tue.nl

Department of Biomedical Engineering, Precision Medicine - Doctoral Candidate
Department of Biomedical Engineering

Person: Prom. : doctoral candidate (PhD), Student

Ewelina Kluza, PhD

e.kluza@tue.nl

Department of Biomedical Engineering, Precision Medicine - Education/Research Officer

Person: OBP : Supportive and management staff

Roy van der Meel, MSc

r.v.d.meel@tue.nl

Department of Biomedical Engineering, Precision Medicine - Assistant Professor

Person: UD : Assistant Professor

Research Output

7 Article
6 Review article
2 Editorial
1 Chapter
1 More
- 1 Comment/Letter to the editor

Defining trained immunity and its role in health and disease

Netea, M. G., Domínguez-Andrés, J., Barreiro, L. B., Chavakis, T., Divangahi, M., Fuchs, E., Joosten, L. A. B., van der Meer, J. W. M., Mhlanga, M. M., Mulder, W. J. M., Riksen, N. P., Schlitzer, A., Schultze, J. L., Stabell Benn, C., Sun, J. C., Xavier, R. J. & Latz, E., 4 Mar 2020, In : Nature Reviews Immunology. 20, p. 375–388 14 p.

Research output: Contribution to journal › Review article › Academic › peer-review

Open Access

11 Citations (Scopus)

Modular lipid nanoparticle platform technology for siRNA and lipophilic prodrug delivery

van der Meel, R., Chen, S., Zaifman, J., Kulkarni, J. A., Zhang, X. R. S., Tam, Y. K., Bally, M. B., Schiffelers, R. M., Ciufolini, M. A., Cullis, P. R. & Tam, Y. Y. C., 16 Jan 2020, In : bioRxiv. 20 p.

Research output: Contribution to journal › Article › Academic

Open Access

File

15 Downloads (Pure)

Multimodal positron emission tomography imaging to quantify uptake of ⁸⁹Zr-labeled liposomes in the atherosclerotic vessel wall

Lobatto, M. E., Binderup, T., Robson, P. M., Giesen, L. F. P., Calcagno, C., Witjes, J., Fay, F., Baxter, S., Wessel, C. H., Eldib, M., Bini, J., Carlin, S. D., Stroes, E. S. G., Storm, G., Kjaer, A., Lewis, J. S., Reiner, T., Fayad, Z. A., Mulder, W. J. M. & Pérez-Medina, C., 19 Feb 2020, In : Bioconjugate Chemistry. 31, 2, p. 360-368 9 p.

Research output: Contribution to journal › Article › Academic › peer-review