Organization profile

Introduction / mission

The Precision Medicine group focuses on designing and evaluating nanotherapeutics that regulate the immune response to treat a range of conditions, including cancer, cardiovascular and autoimmune diseases.

Highlighted phrase

Nanotechnology for immunotherapy

Organisational profile

Nanotechnology can be applied to empower the immune system’s ability to fight disease, by promoting or inhibiting an immune response, by polarizing macrophage function, or by targeting myeloid cell dynamics. The innovation cascade involves developing biocompatible nanoimmunotherapeutics from natural molecular building blocks and comprises an innovative translational workflow, involving noninvasive imaging for testing on small and large animal disease models.

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Medical nanotechnology Chemical Compounds

Nanoparticles Chemical Compounds

Atherosclerosis Medicine & Life Sciences

Lipids Chemical Compounds

Inflammation Medicine & Life Sciences

Tropoelastin Medicine & Life Sciences

Small Interfering RNA Chemical Compounds

Myeloid Cells Medicine & Life Sciences

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Profiles

Ewelina Kluza, PhD

e.kluza@tue.nl

Department of Biomedical Engineering, Precision Medicine - Postdoc

Person: PD : Postdoc

Roy van der Meel, MSc

r.v.d.meel@tue.nl

Department of Biomedical Engineering, Precision Medicine - Assistant Professor

Person: UD : Assistant Professor

Willem J.W. Mulder

W.J.M.Mulder@tue.nl

Department of Biomedical Engineering, Precision Medicine - Full Professor

Person: HGL : Professor

Research Output 2007 2020

7 Article
5 Review article
1 Chapter
1 Comment/Letter to the editor
1 More
- 1 Editorial

Modular lipid nanoparticle platform technology for siRNA and lipophilic prodrug delivery

van der Meel, R., Chen, S., Zaifman, J., Kulkarni, J. A., Zhang, X. R. S., Tam, Y. K., Bally, M. B., Schiffelers, R. M., Ciufolini, M. A., Cullis, P. R. & Tam, Y. Y. C., 16 Jan 2020, In : bioRxiv. 20 p.

Research output: Contribution to journal › Article › Academic

Open Access

File

Prodrugs

Nanoparticles

Small Interfering RNA

Technology

Lipids

5 Downloads (Pure)

An iterative sparse deconvolution method for simultaneous multicolor ¹⁹F-MRI of multiple contrast agents

Schoormans, J., Calcagno, C., Daal, M. R. R., Wüst, R. C. I., Faries, C., Maier, A., Teunissen, A. J. P., Naidu, S., Sanchez-Gaytan, B. L., Nederveen, A. J., Fayad, Z. A., Mulder, W. J. M., Coolen, B. F. & Strijkers, G. J., 10 Jul 2019, In : Magnetic Resonance in Medicine. 83, 1, p. 228-239 12 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

Contrast Media

Artifacts

Fluorine

Noise

Cell Tracking

7 Citations (Scopus)

Fusion-dependent formation of lipid nanoparticles containing macromolecular payloads

Kulkarni, J. A., Witzigmann, D., Leung, J., van der Meel, R., Zaifman, J., Darjuan, M. M., Grisch-Chan, H. M., Thöny, B., Tam, Y. Y. C. & Cullis, P. R., 14 May 2019, In : Nanoscale. 11, 18, p. 9023-9031 9 p.

Research output: Contribution to journal › Article › Academic › peer-review

Lipids

Fusion reactions

Nanoparticles

Polyethylene glycols

Gene therapy