Content available in repository
Content available in repository
Organisation profile
Introduction / mission
We explore and develop (regenerative) treatment strategies for orthopaedic injuries and disorders based on a thorough understanding of musculoskeletal tissue mechanobiology and biomechanical function.
Highlighted phrase
Novel treatment strategies for an ever-active ageing population
Organisation profile
Human cells produce, maintain and adapt musculoskeletal tissues such as bone and cartilage as a response to their biophysical environment, both in health and disease. In our ever-aging population, orthopaedic injuries and degenerative diseases have become more prevalent, with an increasing socioeconomic impact. Current treatment methods with purely synthetic devices may be limited in view of the increasing longevity and high level of activity of modern day humans. The Orthopaedic Biomechanics research group combines engineering and biology to expand our understanding of musculoskeletal tissues and to develop (regenerative) treatment strategies. These are currently applied to bone, articular cartilage, intervertebral disc and tendons/ligaments.
UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. Our work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Profiles
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Florencia Abinzano
- Biomedical Engineering, Orthopaedic Biomechanics - University Researcher
Person: OWP : University Teacher / Researcher
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Parisa Akhlaghi
- Biomedical Engineering, Orthopaedic Biomechanics - Doctoral Candidate
Person: Prom. : doctoral candidate (PhD)
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J.J.C. (Chris) Arts
- Biomedical Engineering, Orthopaedic Biomechanics - Full Professor
Person: HGL : Professor
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A small notch width index, steeper medial and lateral tibial slope and higher lateral/medial tibial slope ratio are relevant knee morphological factors for ACL injuries in skeletally immature patients: A systematic review
Voskuilen, R. (Corresponding author), Dietvorst, M., van der Steen, M. C. & Janssen, R. P., Jan 2025, In: Journal of Experimental Orthopaedics. 12, 1, 16 p., e70211.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile -
Biomimetic design of articular cartilage tissue engineering constructs: A focus on the cell microenvironment
van Mourik, M., 30 Jan 2025, Eindhoven: Eindhoven University of Technology. 160 p.Research output: Thesis › Phd Thesis 1 (Research TU/e / Graduation TU/e)
Open AccessFile -
Cartilage Organoids from Articular Chondroprogenitor Cells and Their Potential to Produce Neo-Hyaline Cartilage
Menssen, D. M. A., Feenstra, J., Janssen, R. P., Abinzano, F. (Corresponding author) & Ito, K., 10 Feb 2025, (E-pub ahead of print) In: Cartilage. XX, XResearch output: Contribution to journal › Article › Academic › peer-review
Open Access
Equipment
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Biomaterials Design & Processing Lab
Castilho, M. (Manager), Maenhout-van Haag, M. (Operator) & Gorginkaraji, Z. (Education/research technician)
Biomedical EngineeringFacility/equipment: Research lab
Datasets
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Translation and transcultural validation of the Dutch hospital for special surgery paediatric functional activity brief scale (HSS Pedi-FABS)
Dietvorst, M. (Creator), Janssen, R. P. A. (Creator), van den Berg, L. E. (Creator), van de Kerkhof, T. M. (Creator) & van der Steen, M. C. (Creator), Figshare, 7 Oct 2021
DOI: 10.6084/m9.figshare.c.5651026, https://springernature.figshare.com/collections/Translation_and_transcultural_validation_of_the_Dutch_hospital_for_special_surgery_paediatric_functional_activity_brief_scale_HSS_Pedi-FABS_/5651026
Dataset
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Data underlying the publication "Computational characterization of the dish-in-a-dish, a high yield culture platform for endothelial shear stress studies on the orbital shaker"
Driessen, R. (Creator), Zhao, F. (Creator), Hofmann, S. (Contributor), Bouten, C. (Creator), Sahlgren, C. (Creator) & Stassen, O. (Creator), 4TU.Centre for Research Data, 22 Jun 2020
DOI: 10.4121/uuid:817dbbc8-f3d7-4b91-b809-1ea25214bd3c
Dataset
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Additional file 2 of Identifying potential patient-specific predictors for anterior cruciate ligament reconstruction outcome – a diagnostic in vitro tissue remodeling platform
van Vijven, M. (Contributor), van Groningen, B. (Contributor), Kimenai, J. N. (Creator), van der Steen, M. C. (Contributor), van Doeselaar, M. (Contributor), Janssen, R. P. A. (Creator), Ito, K. (Creator) & Foolen, J. (Creator), Figshare, 5 Jul 2020
DOI: 10.6084/m9.figshare.12611684, https://springernature.figshare.com/articles/Additional_file_2_of_Identifying_potential_patient-specific_predictors_for_anterior_cruciate_ligament_reconstruction_outcome_a_diagnostic_in_vitro_tissue_remodeling_platform/12611684
Dataset
Prizes
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An ex vivo platform to screen drug effects on bone
Hofmann, S. (Recipient), 20 Apr 2020
Prize: ERC › Proof of concept › Scientific
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ASIA / IPD 2017 (KIVI) Educational Knee Simulator
van Lith, M. (Recipient), Tielen, R. (Recipient), Faber, T. (Recipient), Custers, T. (Recipient), Römkens, D. D. I. A. (Recipient), Peters, S. (Recipient), Beljaars, T. (Recipient), Voorn, S. (Recipient) & Janssen, R. P. A. (Recipient), 5 Jul 2017
Prize: Other › Career, activity or publication related prizes (lifetime, best paper, poster etc.) › Scientific
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Best Oral Presentation
Remmers, S. (Recipient), 4 Dec 2015
Prize: Other › Career, activity or publication related prizes (lifetime, best paper, poster etc.) › Scientific
Activities
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Janne MH Spierings. Improving ACL reconstruction: understanding and mitigating postoperative complications. PhD Thesis (Event)
Janssen, R. P. A. (Member)
23 Jun 2025Activity: Membership types › Membership of jury › Scientific
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Masterclass ACL & BIomedical Engineering
Janssen, R. P. A. (Speaker)
9 Apr 2025Activity: Talk or presentation types › Keynote talk › Scientific
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Roby Weeteling. Realistic Ultrasound Simulations of Articular Cartilage. MSc Thesis (Event)
Janssen, R. P. A. (Member)
26 Feb 2025Activity: Membership types › Membership of jury › Scientific
Courses
Press/Media
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Diagnose en behandeling van kruisbandletsel bij kinderen anders dan bij volwassenen. Orthopedisch chirurg Rob Janssen: ‘liever niet opereren voor kinderen zijn uitgegroeid’
11/07/24
1 item of Media coverage
Press/Media: Expert Comment
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Studenten doen ervaring op met medisch-technische vraagstukken. Fontys start programma Applied Biomedical Sciences & Engineering
12/06/24
1 Media contribution
Press/Media: Public Engagement Activities
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Botcast De Kruisband, met Rob Janssen
24/10/23
1 Media contribution
Press/Media: Public Engagement Activities
Research areas
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Bone Function and Structure
Arts-Arts, E. (Content manager), Broeders, A. E. J. A. (Content manager) & van Gorp, L. (Content manager)
Impact: Research Topic/Theme (at group level)
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Bone Tissue Engineering
Arts-Arts, E. (Content manager), Broeders, A. E. J. A. (Content manager) & van Gorp, L. (Content manager)
Impact: Research Topic/Theme (at group level)
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Intervertebral Disc
Arts-Arts, E. (Content manager), Broeders, A. E. J. A. (Content manager) & van Gorp, L. (Content manager)
Impact: Research Topic/Theme (at group level)
Student theses
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3D human osteoblast - osteoclast in vitro co-culture
Mayer, D. (Author), Remmers, S. (Supervisor 2), Melke, J. (Supervisor 2), Hofmann, S. (Supervisor 2), Ito, K. (Supervisor 2) & Teuschl, A. (External coach), 2019Student thesis: Master
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3D reconstruction of coronary artery centerlines from two 2D angiography-based planar projections
Berendsen, A. J. (Author), van de Vosse, F. N. (Supervisor 1), van 't Veer, M. (Supervisor 2), van Rietbergen, B. (Supervisor 2) & Bakker, L. M. M. L. (Supervisor 2), 11 Oct 2021Student thesis: Master
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A 3D co-culture model of mesenchymal stem cells and endothelial cells to promote vascularization and osteogenesis in bone tissue engineering
Cramer, E. (Author), Melke, J. (Supervisor 1) & Hofmann, S. (Supervisor 2), 29 Nov 2018Student thesis: Master