Molecular Biosensing for Medical Diagnostics

  • Groene Loper 19, Flux

    5612 AE Eindhoven

    Netherlands

  • P.O.Box 513, Department of Biomedical Engineering & Department of Applied Physics

    5600 MB Eindhoven

    Netherlands

Organization profile

Introduction / mission

The MBx group develops technologies based on micro- and nanoparticles for monitoring patients and for treating diseases. Towards this goal, the unique approach of MBx is to use advanced optical imaging techniques that quantify molecular processes with single molecule resolution within complex biomacromolecular environments.

Highlighted phrase

Quantify molecular processes with single molecule resolution

Organisational profile

The MBx group creates concepts in the field of molecular biosensing with diagnostic and therapeutic healthcare perspectives. Combining nanotechnology, molecular engineering and single molecule imaging technologies we aim to measure with ultimate sensitivity biomolecules implicated in a variety of diseases, such as cancer, immunology, and cardiology.

Single-molecule imaging and manipulation enables measurements with high sensitivity and gives access to molecular characteristics such as variations in space and in time, distributions of kinetic properties, molecular torsion constants, enzymatic activity, and conformational dynamics.

Furthermore, super-resolution microscopies unveil the interactions of nanostructures with living matter and guide the rational design of novel nanomedicines and diagnostic colloidal particles.

The diagnostic potential and fundamental understanding arising from these biophysical methods leads to novel solutions for patient monitoring and patient treatment. From the work in the group a startup company has been created, Helia Biomonitoring (www.heliabiomonitoring.com). Furthermore, the group has founded and organizes SensUs (www.sensus.org), the international student competition in the field of Sensors for Health, which provides students with training in multidisciplinary technological design and entrepreneurship. 

The MBx group is based in the Department of Biomedical Engineering, the Department of Applied Physics, and the Institute for Complex Molecular Systems.

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    Research Output

    Coarse-grained modeling of cell division in 3D: influence of density, medium viscosity, and inter-membrane friction on cell growth and nearest neighbor distribution

    Madhikar, P., Astrom, J., Westerholm, J., Baumeier, B. & Karttunen, M., 5 Jan 2020, In : Soft Materials.

    Research output: Contribution to journalArticleAcademicpeer-review

    Continuous small-molecule monitoring with a digital single particle switch

    Yan, J., van Smeden, L., Merkx, M., Zijlstra, P. & Prins, M. W. J., 19 Mar 2020, In : ACS Sensors.

    Research output: Contribution to journalArticleAcademicpeer-review

  • Dynamic single-molecule counting for the quantification and optimization of nanoparticle functionalization protocols

    Horáček, M., Engels, D. J. & Zijlstra, P., 14 Feb 2020, In : Nanoscale. 12, 6, p. 4128-4136 9 p.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
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    Prizes

  • Activities

    • 21 Contributed talk
    • 4 Invited talk
    • 1 Poster presentation

    Plasmon-enhanced enzymatic turnovers by single metal particles

    Yuyang Wang (Speaker)
    2 Oct 2018

    Activity: Talk or presentation typesContributed talkScientific

    Plasmon-enhanced Single-molecule enzymology

    Yuyang Wang (Speaker)
    18 Jul 2018

    Activity: Talk or presentation typesContributed talkScientific

    Plasmon-enhanced Single-molecule Enzymology

    Yuyang Wang (Speaker), P. Zijlstra (Member)
    23 Jan 2018

    Activity: Talk or presentation typesContributed talkScientific

    Research areas

    Particle Actuation for Integrated Biosensing

    Rianne Sanders (Content manager)

    Impact: Research Topic/Theme (at group level)

    Particle Functionalization and Characterization

    Rianne Sanders (Content manager)

    Impact: Research Topic/Theme (at group level)

    Single-Molecule Biosensing

    Rianne Sanders (Content manager)

    Impact: Research Topic/Theme (at group level)

    Student theses

    (In,Ga)N heterostructures in self-assembled GaN nanowires grown on TiN by molecular beam epitaxy

    Author: Goertz, J. J., 2016

    Supervisor: Koenraad, P. M. (Supervisor 1), Geelhaar, L. (External person) (External coach), Bakkers, E. P. (Supervisor 2), Nijdam, S. (Supervisor 2) & Zijlstra, P. (Supervisor 2)

    Student thesis: Master

    File

    A magnetic bead actuator: design and experimental analysis of a sub-microliter actuation device for superparamagnetic beads applicable on biosensing

    Author: Derks, R., 2005

    Supervisor: Prins, M. (Supervisor 1) & Wimberger-Friedl, R. (External person) (External coach)

    Student thesis: Master

    Binding kinetics in tethered particle biosensors

    Author: Almass, H., 2018

    Supervisor: Ellenbroek, W. G. (Supervisor 1) & Zijlstra, P. (Supervisor 2)

    Student thesis: Bachelor

    File