Molecular Biosensing for Medical Diagnostics

  • Groene Loper 19, Flux

    5612 AE Eindhoven

    Netherlands

  • P.O.Box 513, Department of Biomedical Engineering & Department of Applied Physics

    5600 MB Eindhoven

    Netherlands

Organization profile

Introduction / mission

The MBx group develops technologies based on micro- and nanoparticles for monitoring patients and for treating diseases. Towards this goal, the unique approach of MBx is to use advanced optical imaging techniques that quantify molecular processes with single molecule resolution within complex biomacromolecular environments.

Highlighted phrase

Quantify molecular processes with single molecule resolution

Organisational profile

The MBx group creates concepts in the field of molecular biosensing with diagnostic and therapeutic healthcare perspectives. Combining nanotechnology, molecular engineering and single molecule imaging technologies we aim to measure with ultimate sensitivity biomolecules implicated in a variety of diseases, such as cancer, immunology, and cardiology.

Single-molecule imaging and manipulation enables measurements with high sensitivity and gives access to molecular characteristics such as variations in space and in time, distributions of kinetic properties, molecular torsion constants, enzymatic activity, and conformational dynamics.

Furthermore, super-resolution microscopies unveil the interactions of nanostructures with living matter and guide the rational design of novel nanomedicines and diagnostic colloidal particles.

The diagnostic potential and fundamental understanding arising from these biophysical methods leads to novel solutions for patient monitoring and patient treatment. From the work in the group a startup company has been created, Helia Biomonitoring (www.heliabiomonitoring.com). Furthermore, the group has founded and organizes SensUs (www.sensus.org), the international student competition in the field of Sensors for Health, which provides students with training in multidisciplinary technological design and entrepreneurship. 

The MBx group is based in the Department of Biomedical Engineering, the Department of Applied Physics, and the Institute for Complex Molecular Systems.

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1980 2019

3 Citations (Scopus)

A stochastic view on surface inhomogeneity of nanoparticles

Post, R. A. J., van der Zwaag, D., Bet, G., Wijnands, S. P. W., Albertazzi, L., Meijer, E. W. & van der Hofstad, R. W., 10 Apr 2019, In : Nature Communications. 10, 1, 11 p., 1663

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Nanoparticles
inhomogeneity
nanoparticles
Microscopy
Microscopic examination

Conformation switching of single native proteins revealed by nanomechanical probing without a pulling force

Gutierrez Mejia, F. A., Moerland, C., van Ijzendoorn, L. & Prins, M., 24 Sep 2019, In : Nanoscale.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Conformations
Proteins
Calcium
Antibodies
Troponin

Efficient small-scale conjugation of DNA to primary antibodies for multiplexed cellular targeting

Cremers, G., Rosier, B., Riera Brillas, R., Albertazzi, L. & de Greef, T., 22 Aug 2019, In : Bioconjugate Chemistry. 30, 9, p. 2384-2392

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Antibodies
DNA
Labeling
Fluorescence
Affinity Labels

Prizes

Nanostructured materials
Imaging techniques
Microscopic examination
Drug delivery
Nanostructures
Nanorobots
Intelligent materials
Viruses
Robots
Gold
Biochemical Phenomena
Enzymes
Nanoparticles
Research Personnel

Activities 2010 2018

  • 21 Contributed talk
  • 4 Invited talk
  • 1 Poster presentation

Plasmon-enhanced enzymatic turnovers by single metal particles

Yuyang Wang (Speaker)
2 Oct 2018

Activity: Talk or presentation typesContributed talkScientific

Plasmon-enhanced Single-molecule enzymology

Yuyang Wang (Speaker)
18 Jul 2018

Activity: Talk or presentation typesContributed talkScientific

Plasmon-enhanced Single-molecule Enzymology

Yuyang Wang (Speaker), P. Zijlstra (Member)
23 Jan 2018

Activity: Talk or presentation typesContributed talkScientific

Press / Media

Biology becomes digital

Menno Prins

1/01/14

1 media contribution

Press/Media: Public Engagement Activities

Research areas

Particle Actuation for Integrated Biosensing

Rianne Sanders (Content manager)

Impact: Research Topic/Theme (at group level)

Particle Functionalization and Characterization

Rianne Sanders (Content manager)

Impact: Research Topic/Theme (at group level)

Single-Molecule Biosensing

Rianne Sanders (Content manager)

Impact: Research Topic/Theme (at group level)