Research output per year
Research output per year
Groene Loper 19, Flux
5612 AE Eindhoven
Netherlands
P.O.Box 513, Department of Biomedical Engineering & Department of Applied Physics
5600 MB Eindhoven
Netherlands
The MBx group develops technologies based on micro- and nanoparticles for monitoring patients and for treating diseases. Towards this goal, the unique approach of MBx is to use advanced optical imaging techniques that quantify molecular processes with single molecule resolution within complex biomacromolecular environments.
Quantify molecular processes with single molecule resolution
The MBx group creates concepts in the field of molecular biosensing with diagnostic and therapeutic healthcare perspectives. Combining nanotechnology, molecular engineering and single molecule imaging technologies we aim to measure with ultimate sensitivity biomolecules implicated in a variety of diseases, such as cancer, immunology, and cardiology.
Single-molecule imaging and manipulation enables measurements with high sensitivity and gives access to molecular characteristics such as variations in space and in time, distributions of kinetic properties, molecular torsion constants, enzymatic activity, and conformational dynamics.
Furthermore, super-resolution microscopies unveil the interactions of nanostructures with living matter and guide the rational design of novel nanomedicines and diagnostic colloidal particles.
The diagnostic potential and fundamental understanding arising from these biophysical methods leads to novel solutions for patient monitoring and patient treatment. From the work in the group a startup company has been created, Helia Biomonitoring (www.heliabiomonitoring.com). Furthermore, the group has founded and organizes SensUs (www.sensus.org), the international student competition in the field of Sensors for Health, which provides students with training in multidisciplinary technological design and entrepreneurship.
The MBx group is based in the Department of Biomedical Engineering, the Department of Applied Physics, and the Institute for Complex Molecular Systems.
Person: UHD : Associate Professor
Person: Prom. : doctoral candidate (PhD)
Person: Prom. : doctoral candidate (PhD)
Research output: Contribution to journal › Review article › Academic › peer-review
Research output: Contribution to journal › Article › Academic › peer-review
Research output: Thesis › Phd Thesis 1 (Research TU/e / Graduation TU/e)
C.C.M.M. Schot (Manager) & A.M. de Jong (Manager)
Molecular BiosensingFacility/equipment: Research lab
Lanckohr, C. (Creator), Boeing, C. (Creator), De Waele, J. J. (Creator), de Lange, D. W. (Creator), Schouten, J. (Creator), Prins, M. W. J. (Creator), Nijsten, M. (Creator), Povoa, P. (Creator), Morris, A. C. (Creator) & Bracht, H. (Creator), Figshare, 27 Aug 2021
DOI: 10.6084/m9.figshare.c.5585799
Dataset
Pacassoni, G. (Contributor), Albertazzi, L. (Creator), Pujals, S. (Contributor), Glinkowska Mares, A. (Contributor) & Samitier Marti, J. (Contributor), 4TU.Centre for Research Data, 31 May 2021
DOI: 10.4121/14572362
Dataset
Albertazzi, Lorenzo (Recipient), 2017
Prize: ERC › Starting › Scientific
Albertazzi, Lorenzo (Recipient), 2014
Prize: NWO › Veni › Scientific
Zijlstra, Peter (Recipient), 2013
Prize: NWO › Vidi › Scientific
Yuyang Wang (Speaker)
Activity: Talk or presentation types › Contributed talk › Scientific
Yuyang Wang (Speaker)
Activity: Talk or presentation types › Contributed talk › Scientific
Yuyang Wang (Speaker) & P. Zijlstra (Member)
Activity: Talk or presentation types › Contributed talk › Scientific
23/11/21
1 item of Media coverage
Press/Media: Expert Comment
23/11/21
1 item of Media coverage
Press/Media: Expert Comment
Leo J. van IJzendoorn & Menno W.J. Prins
8/11/21
1 item of Media coverage
Press/Media: Expert Comment
Rianne Sanders (Content manager)
Impact: Research Topic/Theme (at group level)
Rianne Sanders (Content manager)
Impact: Research Topic/Theme (at group level)
Rianne Sanders (Content manager)
Impact: Research Topic/Theme (at group level)
Supervisor: Koenraad, P. M. (Supervisor 1), Geelhaar, L. (External person) (External coach), Bakkers, E. P. A. M. (Supervisor 2), Nijdam, S. (Supervisor 2) & Zijlstra, P. (Supervisor 2)
Student thesis: Master
Supervisor: Prins, M. W. J. (Supervisor 1) & Wimberger-Friedl, R. (External person) (External coach)
Student thesis: Master
Supervisor: Ellenbroek, W. G. (Supervisor 1) & Zijlstra, P. (Supervisor 2)
Student thesis: Bachelor