Organisation profile
Introduction / mission
Our mission is to make things move at small scales: fluids, particles, molecules, solid structures. We do this by carrying out research in our Microfab/lab, where we develop innovative technological concepts and fabrication methods to create novel microfluidic devices and microactuators, serving a wide range of applications.
Highlighted phrase
We make things move at small scales!
Organisation profile
In microfluidic systems, active control of fluids and species is essential. Examples are fluid pumping, mixing, mechanical actuation, sorting of cells and particles, and biomolecule capture for diagnostics. We develop and apply micro-actuators, responsive surfaces, and magnetic bead actuation systems, to realize these functions. Our approaches are often biologically inspired, translating principles from nature into technological innovations.
As an important application of our microfluidic systems, and in collaboration with biological, biomedical, and clinical groups, we develop biomedical microdevices to study and understand the behavior of cells, tissues, and organs. This work is aimed at learning about health and disease, and eventually developing novel therapies and medicines. Specifically, we develop organs-on-chips as in-vitro disease models focusing on cancer, we study mechanical properties of single cells, and we develop technologies for in-vitro diagnostics. In addition, we develop biomedical devices that can be applied to treat patients non-invasively, such as a glaucoma eye implant.
We also develop new concepts for microactuators that combine electrical, optical and/or mechanical functionalities, for other applications, from lithography machines to new display principles to air quality monitoring to microrobotics.
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Collaborations and top research areas from the last five years
Profiles
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Angie Carola Alarcon Rios, MSc
- Mechanical Engineering, Group Den Toonder - Postdoc
Person: PD : Postdoc
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Tommaso Bo
- Mechanical Engineering, Group Den Toonder - Doctoral Candidate
Person: Prom. : doctoral candidate (PhD)
Projects
- 1 Finished
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Magnetic control of micro-particles and integrated micro-actuators for high precision handheld diagnostics
den Toonder, J. M. J. (Project Manager) & Shanko, E. (Project member)
1/11/16 → 31/10/20
Project: Research direct
Research output
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Artificial cilia controlled modulation of biochemical microenvironments to study cellular responses
Sun, Y., 16 Jun 2026, (Accepted/In press) Eindhoven: Eindhoven University of Technology. 104 p.Research output: Thesis › Phd Thesis 1 (Research TU/e / Graduation TU/e)
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Artificial embryonic node elucidates the role of flow in left-right symmetry breaking in vertebrates
ul Islam, T., Aggarwal, I., Bellouard, Y., Onck, P. R. (Corresponding author) & den Toonder, J. M. J. (Corresponding author), 27 Mar 2026, In: Science Advances. 12, 13, 11 p., eaec2328.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile7 Downloads (Pure) -
Controllable Dynamic Mechanical Cell Stimulation using Magnetically Actuated Artificial Cilia
Kooi, R., Ul Islam, T., Stassen, O. M. J. A., Amsing, N., de Boer, J. & den Toonder, J. M. J. (Corresponding author), 15 May 2026, In: Advanced Healthcare Materials. 15, 18, 15 p., e00001.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile9 Downloads (Pure)
Datasets
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Source data for the publication: Curved Surfaces Induce Metachronal Motion of Microscopic Magnetic Cilia
Cui, Z. (Creator), Ul Islam, T. (Creator), Wang, Y. (Creator) & den Toonder, J. M. J. (Creator), 4TU.Centre for Research Data, 15 Nov 2024
DOI: 10.4121/49513019-dc6d-4f6e-9bc5-36bc4d8db1a7, https://data.4tu.nl/datasets/49513019-dc6d-4f6e-9bc5-36bc4d8db1a7 and one more link, https://data.4tu.nl/datasets/49513019-dc6d-4f6e-9bc5-36bc4d8db1a7/1 (show fewer)
Dataset
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Source data for the publication: Enhancement of microalgae growth using magnetic artificial cilia
Verburg, T. H. C. M. (Creator), Schaap, A. (Creator), Zhang, S. (Creator), den Toonder, J. (Creator) & Wang, Y. (Creator), 4TU.Centre for Research Data, 15 Nov 2024
DOI: 10.4121/90b75bcc-fe98-4c92-bfd1-97d1801d2cdc, https://data.4tu.nl/datasets/90b75bcc-fe98-4c92-bfd1-97d1801d2cdc and one more link, https://data.4tu.nl/datasets/90b75bcc-fe98-4c92-bfd1-97d1801d2cdc/1 (show fewer)
Dataset
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Source data for the publication: A Cell Pre-Wrapping Seeding Technique for Hydrogel-Based Tubular Organ-On-A-Chip
Nie, J. (Creator), Lou, S. (Creator), Pollet, A. (Creator), van Vegchel, M. (Creator), Bouten, C. V. C. (Creator) & den Toonder, J. M. J. (Creator), 4TU.Centre for Research Data, 15 Nov 2024
DOI: 10.4121/6b6afa04-cf9c-4273-8150-8eb34c22b138, https://data.4tu.nl/datasets/6b6afa04-cf9c-4273-8150-8eb34c22b138 and one more link, https://data.4tu.nl/datasets/6b6afa04-cf9c-4273-8150-8eb34c22b138/1 (show fewer)
Dataset
Prizes
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Famelab Heat 2021(Audience's choice award)
Jouy Bar, M. (Recipient), 29 Apr 2021
Prize: Other › Career, activity or publication related prizes (lifetime, best paper, poster etc.) › Scientific
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FameLab National Final 2021
Jouy Bar, M. (Recipient), 1 Jun 2021
Prize: Other › Career, activity or publication related prizes (lifetime, best paper, poster etc.) › Scientific
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Netherlands Academy of Engineering Fellow
den Toonder, J. M. J. (Recipient), 2023
Prize: Other › Fellowships & memberships › Scientific
Activities
- 6 Editorial activity
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Bio-Design and Manufacturing (Journal)
den Toonder, J. M. J. (Editorial board member)
2024 → …Activity: Publication peer-review and editorial work types › Editorial activity › Scientific
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Biomicrofluidics (Journal)
den Toonder, J. M. J. (Editorial board member)
2018 → …Activity: Publication peer-review and editorial work types › Editorial activity › Scientific
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Micromachines (Journal)
den Toonder, J. M. J. (Editorial board member)
2018 → …Activity: Publication peer-review and editorial work types › Editorial activity › Scientific
Press/Media
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GLOBAL ROUND UP SECTOR WEEKLY: UNIVERSITY NEWSLETTER OF WEEK-ENDED NOV 05, 2023
Baaijens, F. P. T., Steinbuch, M., Mulder, W. J. M., den Toonder, J. M. J. & Lüttge, R.
6/11/23
1 item of Media coverage
Press/Media: Expert Comment
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Six TU/e researchers appointed fellows of the new Netherlands Academy of Engineering
Baaijens, F. P. T., Steinbuch, M., Mulder, W. J. M., den Toonder, J. M. J., Lüttge, R. & Fitzgerald, B.
2/11/23 → 3/11/23
2 items of Media coverage
Press/Media: Expert Comment
Student theses
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A microfluidic platform for multiplexed continuous monitoring using bioluminescent immunoassays
Jansen, T. P. A. (Author), Rosier, B. J. H. M. (Supervisor 1), van Aalen, E. A. (Supervisor 2) & Merkx, M. (Supervisor 2), 31 Aug 2023Student thesis: Master
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Analysis of liquid crystal actuation towards a light-driven amphibious soft microrobot
van Beek, J. C. (Author), den Toonder, J. M. J. (Supervisor 1), Schenning, A. P. H. J. (Supervisor 2), Pilz Da Cunha, M. (Supervisor 2) & Wang, Y. (Supervisor 2), 19 Jan 2021Student thesis: Master
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An integrated approach to study the aerotaxis of breast cancer cells in a 3D environment using an oxygen diffusion chip
Selhorst, L. (Author), Sleeboom, J. J. F. (Supervisor 1) & Sahlgren, C. M. (Supervisor 2), 27 Aug 2020Student thesis: Master