Projects per year
Organisation profile
Introduction / mission
Our mission is to make things move at small scales: fluids, particles, molecules, solid structures. We do this by carrying out research in our Microfab/lab, where we develop innovative technological concepts and fabrication methods to create novel microfluidic devices and microactuators, serving a wide range of applications.
Highlighted phrase
We make things move at small scales!
Organisation profile
In microfluidic systems, active control of fluids and species is essential. Examples are fluid pumping, mixing, mechanical actuation, sorting of cells and particles, and biomolecule capture for diagnostics. We develop and apply micro-actuators, responsive surfaces, and magnetic bead actuation systems, to realize these functions. Our approaches are often biologically inspired, translating principles from nature into technological innovations.
As an important application of our microfluidic systems, and in collaboration with biological, biomedical, and clinical groups, we develop biomedical microdevices to study and understand the behavior of cells, tissues, and organs. This work is aimed at learning about health and disease, and eventually developing novel therapies and medicines. Specifically, we develop organs-on-chips as in-vitro disease models focusing on cancer, we study mechanical properties of single cells, and we develop technologies for in-vitro diagnostics. In addition, we develop biomedical devices that can be applied to treat patients non-invasively, such as a glaucoma eye implant.
We also develop new concepts for microactuators that combine electrical, optical and/or mechanical functionalities, for other applications, from lithography machines to new display principles to air quality monitoring to microrobotics.
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Collaborations and top research areas from the last five years
Profiles
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Willem-Jan H. Berghuis, MSc
- Applied Physics and Science Education, Plasma & Materials Processing - University Researcher
- Applied Physics and Science Education, Atomic scale processing
- Mechanical Engineering, Group Den Toonder - University Researcher
Person: Prom. : doctoral candidate (PhD), OWP : University Teacher / Researcher
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Tommaso Bo
- Mechanical Engineering, Group Den Toonder - Doctoral Candidate
Person: Prom. : doctoral candidate (PhD)
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Irene Dobbelaer-Bosboom
- Mechanical Engineering, Microsystems - Education/Research Officer
- Mechanical Engineering, Group Den Toonder - Education/Research Officer
Person: OBP : Supportive and management staff
Projects
- 1 Finished
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Magnetic control of micro-particles and integrated micro-actuators for high precision handheld diagnostics
den Toonder, J. M. J. (Project Manager) & Shanko, E. (Project member)
1/11/16 → 31/10/20
Project: Research direct
Research output
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Cancer-on-Chip Technologies: Models of Tumor Microenvironments, Metastasis, and Therapeutic Testing
Jouybar, M., 7 Feb 2025, Eindhoven: Eindhoven University of Technology. 214 p.Research output: Thesis › Phd Thesis 1 (Research TU/e / Graduation TU/e)
Open AccessFile -
Charge injection mediated by inverse micelles in nonpolar solvents: A microscopic model
Liu, W., Liu, W., Dekkers, M. H. J., Henzen, A., den Toonder, J. M. J., Yuan, D. (Corresponding author), Groenewold, J. (Corresponding author), Zhou, G. & Wyss, H. M. (Corresponding author), 15 Jan 2025, In: Journal of Colloid and Interface Science. 678, Part C, p. 449-459 11 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile22 Downloads (Pure) -
A Cell Pre-Wrapping Seeding Technique for Hydrogel-Based Tubular Organ-On-A-Chip
Nie, J., Lou, S., Pollet, A. M. A. O., van Vegchel, M., Bouten, C. V. C. & den Toonder, J. M. J. (Corresponding author), 14 Aug 2024, In: Advanced Science. 11, 30, 15 p., 2400970.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile37 Downloads (Pure)
Datasets
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Source data for the publication: Curved Surfaces Induce Metachronal Motion of Microscopic Magnetic Cilia
Cui, Z. (Creator), Ul Islam, T. (Creator), Wang, Y. (Creator) & den Toonder, J. M. J. (Creator), 4TU.Centre for Research Data, 15 Nov 2024
DOI: 10.4121/49513019-dc6d-4f6e-9bc5-36bc4d8db1a7, https://data.4tu.nl/datasets/49513019-dc6d-4f6e-9bc5-36bc4d8db1a7 and one more link, https://data.4tu.nl/datasets/49513019-dc6d-4f6e-9bc5-36bc4d8db1a7/1 (show fewer)
Dataset
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Source data for the publication: Enhancement of microalgae growth using magnetic artificial cilia
Verburg, T. H. C. M. (Creator), Schaap, A. (Creator), Zhang, S. (Creator), den Toonder, J. (Creator) & Wang, Y. (Creator), 4TU.Centre for Research Data, 15 Nov 2024
DOI: 10.4121/90b75bcc-fe98-4c92-bfd1-97d1801d2cdc, https://data.4tu.nl/datasets/90b75bcc-fe98-4c92-bfd1-97d1801d2cdc and one more link, https://data.4tu.nl/datasets/90b75bcc-fe98-4c92-bfd1-97d1801d2cdc/1 (show fewer)
Dataset
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Source data for the publication: A Cell Pre-Wrapping Seeding Technique for Hydrogel-Based Tubular Organ-On-A-Chip
Nie, J. (Creator), Lou, S. (Creator), Pollet, A. (Creator), van Vegchel, M. (Creator), Bouten, C. V. C. (Creator) & den Toonder, J. M. J. (Creator), 4TU.Centre for Research Data, 15 Nov 2024
DOI: 10.4121/6b6afa04-cf9c-4273-8150-8eb34c22b138, https://data.4tu.nl/datasets/6b6afa04-cf9c-4273-8150-8eb34c22b138 and one more link, https://data.4tu.nl/datasets/6b6afa04-cf9c-4273-8150-8eb34c22b138/1 (show fewer)
Dataset
Prizes
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Famelab Heat 2021(Audience's choice award)
Jouy Bar, M. (Recipient), 29 Apr 2021
Prize: Other › Career, activity or publication related prizes (lifetime, best paper, poster etc.) › Scientific
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FameLab National Final 2021
Jouy Bar, M. (Recipient), 1 Jun 2021
Prize: Other › Career, activity or publication related prizes (lifetime, best paper, poster etc.) › Scientific
Press/Media
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New Findings from Eindhoven University of Technology in the Area of Science Published (Miniaturized metachronal magnetic artificial cilia)
Wang, T., Cui, Z., den Toonder, J. M. J. & Wang, Y.
7/09/23
1 item of Media coverage
Press/Media: Expert Comment
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TU/e starts joint research institute with Zhejiang University
Wyss, H. M., Hu, J., Jiao, Y. & Lu, Y.
2/12/19
1 item of Media coverage
Press/Media: Expert Comment
Student theses
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A microfluidic platform for multiplexed continuous monitoring using bioluminescent immunoassays
Jansen, T. P. A. (Author), Rosier, B. J. H. M. (Supervisor 1), van Aalen, E. A. (Supervisor 2) & Merkx, M. (Supervisor 2), 31 Aug 2023Student thesis: Master
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Analysis of liquid crystal actuation towards a light-driven amphibious soft microrobot
van Beek, J. C. (Author), den Toonder, J. M. J. (Supervisor 1), Schenning, A. P. H. J. (Supervisor 2), Pilz Da Cunha, M. (Supervisor 2) & Wang, Y. (Supervisor 2), 19 Jan 2021Student thesis: Master
File -
An integrated approach to study the aerotaxis of breast cancer cells in a 3D environment using an oxygen diffusion chip
Selhorst, L. (Author), Sleeboom, J. J. F. (Supervisor 1) & Sahlgren, C. M. (Supervisor 2), 27 Aug 2020Student thesis: Master