Projects per year
Organization profile
Introduction / mission
Our mission is to make things move at small scales: fluids, particles, molecules, solid structures. We do this by carrying out research in our Microfab/lab, where we develop innovative technological concepts and fabrication methods to create novel microfluidic devices and microactuators, serving a wide range of applications.
Highlighted phrase
We make things move at small scales!
Organisational profile
In microfluidic systems, active control of fluids and species is essential. Examples are fluid pumping, mixing, mechanical actuation, sorting of cells and particles, and biomolecule capture for diagnostics. We develop and apply micro-actuators, responsive surfaces, and magnetic bead actuation systems, to realize these functions. Our approaches are often biologically inspired, translating principles from nature into technological innovations.
As an important application of our microfluidic systems, and in collaboration with biological, biomedical, and clinical groups, we develop biomedical microdevices to study and understand the behavior of cells, tissues, and organs. This work is aimed at learning about health and disease, and eventually developing novel therapies and medicines. Specifically, we develop organs-on-chips as in-vitro disease models focusing on cancer, we study mechanical properties of single cells, and we develop technologies for in-vitro diagnostics. In addition, we develop biomedical devices that can be applied to treat patients non-invasively, such as a glaucoma eye implant.
We also develop new concepts for microactuators that combine electrical, optical and/or mechanical functionalities, for other applications, from lithography machines to new display principles to air quality monitoring to microrobotics.
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Network
Profiles
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Eva A. van Aalen
- Biomedical Engineering, Protein Engineering - Doctoral Candidate
- Mechanical Engineering, Microsystems - Doctoral Candidate
- Mechanical Engineering, Group Den Toonder - Doctoral Candidate
Person: Prom. : doctoral candidate (PhD)
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Liesbeth van Ballegooij
- Mechanical Engineering, Group Den Toonder - Administrative Secretary
- Mechanical Engineering, Microsystems - Administrative Secretary
Person: Secr. : Secretary
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Zhiwei Cui
- Mechanical Engineering, Microsystems - Doctoral Candidate
- Mechanical Engineering, Group Den Toonder - Doctoral Candidate
Person: Prom. : doctoral candidate (PhD)
Projects
- 1 Finished
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Magnetic control of micro-particles and integrated micro-actuators for high precision handheld diagnostics
den Toonder, J. M. J. & Shanko, E.
1/11/16 → 31/10/20
Project: Research direct
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Fully Transparent, Ultrathin Flexible Organic Electrochemical Transistors with Additive Integration for Bioelectronic Applications
Takemoto, A., Araki, T., Nishimura, K., Akiyama, M., Uemura, T., Kiriyama, K., Koot, J. M., Kasai, Y., Kurihira, N., Osaki, S., Wakida, S. I., den Toonder, J. M. J. & Sekitani, T., 13 Jan 2023, In: Advanced Science. 10, 2, 11 p., 2204746.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile3 Downloads (Pure) -
Real-time monitoring of low-concentration pollen in the air
Yang, J., 20 Jan 2023, Eindhoven: Eindhoven University of Technology. 136 p.Research output: Thesis › Phd Thesis 1 (Research TU/e / Graduation TU/e)
Open AccessFile -
Acoustic characterization of tissue-mimicking materials for ultrasound perfusion imaging research
Chen, P., Pollet, A. M. A. O., Panfilova, A., Zhou, M., Turco, S., den Toonder, J. M. J. & Mischi, M., Jan 2022, In: Ultrasound in Medicine and Biology. 48, 1, p. 124-142 19 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile6 Citations (Scopus)114 Downloads (Pure)
Datasets
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Data underlying the publication "Vimentin regulates Notch signaling strength and arterial remodeling in response to hemodynamic stress"
van Engeland, N. C. A. (Creator), Suarez Rodriguez, F. (Creator), Rivero-Müller, A. (Creator), Ristori, T. (Creator), Duran, C. L. (Creator), Stassen, O. M. J. A. (Creator), Antfolk, D. (Creator), Driessen, R. C. H. (Creator), Ruohonen, S. (Creator), Ruohonen, S. T. (Creator), Nuutinen, S. (Creator), Savontaus, E. (Creator), Loerakker, S. (Creator), Bayless, K. J. (Contributor), Sjöqvist, M. (Creator), Bouten, C. V. C. (Creator), Eriksson, J. E. (Creator) & Sahlgren, C. M. (Creator), 4TU.Centre for Research Data, 10 Sep 2020
DOI: 10.4121/12854801
Dataset
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Data underlying the publication "A biomimetic microfluidic model to study signalling between endothelial and vascular smooth muscle cells under hemodynamic conditions"
Van Engeland, N. C. A. (Contributor), Pollet, A. (Creator), den Toonder, J. M. J. (Contributor), Bouten, C. V. C. (Creator), Stassen, O. M. J. A. (Creator) & Sahlgren, C. M. (Creator), 4TU.Centre for Research Data, 2020
DOI: 10.4121/12854756.v1, https://data.4tu.nl/articles/_/12854756/1
Dataset
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Microfluidic Models of Metastasis: In vitro approaches to study the tumor microenvironment - supplementary design and video files
Sleeboom, J. J. F. (Creator), Sahlgren, C. M. (Creator) & den Toonder, J. M. J. (Creator), 4TU.Centre for Research Data, 2020
DOI: 10.4121/uuid:08ac69b6-6430-4ffa-a33e-40da88821dc6, https://data.4tu.nl/articles/_/12764378/1
Dataset
Prizes
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Famelab Heat 2021(Audience's choice award)
Jouy Bar, Mohammad (Recipient), 29 Apr 2021
Prize: Other › Career, activity or publication related prizes (lifetime, best paper, poster etc.) › Scientific
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FameLab National Final 2021
Jouy Bar, Mohammad (Recipient), 1 Jun 2021
Prize: Other › Career, activity or publication related prizes (lifetime, best paper, poster etc.) › Scientific
Press / Media
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Microsatellite Innovation Res Institute of Chinese Academy of Sciences and Shanghai Microsatellite Eng Center File Chinese Patent Application for High-Energy Light Beam Energy Collecting Device in Vacuum Environment
Ye Wang & Yue Wang
21/01/23
1 item of Media coverage
Press/Media: Expert Comment
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University of Chinese Academy of Sciences Researchers Yield New Study Findings on Liver Metastasis (Diagnostic value of an enhanced MRI combined with serum CEA, CA19-9, CA125 and CA72-4 in the liver metastasis of colorectal cancer)
Ye Wang & Yue Wang
5/01/23
1 item of Media coverage
Press/Media: Expert Comment
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Microelectronic Res Institute of Chinese Academy of Sciences Applies for Patent on P-Channel Type Logic Storage Unit and Nonvolatile Memory
Ye Wang & Yue Wang
24/12/22
1 item of Media coverage
Press/Media: Expert Comment
Student theses
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A microfluidic platform for multiplexed continuous monitoring using bioluminescent immunoassays
Author: Jansen, T. P. A., 2022Supervisor: Rosier, B. J. H. M. (Supervisor 1), van Aalen, E. A. (Supervisor 2) & Merkx, M. (Supervisor 2)
Student thesis: Master
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Analysis of liquid crystal actuation towards a light-driven amphibious soft microrobot
Author: van Beek, J. C., 19 Jan 2021Supervisor: den Toonder, J. M. J. (Supervisor 1), Schenning, A. P. H. J. (Supervisor 2), Pilz Da Cunha, M. (Supervisor 2) & Wang, Y. (Supervisor 2)
Student thesis: Master
File -
An integrated approach to study the aerotaxis of breast cancer cells in a 3D environment using an oxygen diffusion chip
Author: Selhorst, L., 27 Aug 2020Supervisor: Sleeboom, J. J. F. (Supervisor 1) & Sahlgren, C. M. (Supervisor 2)
Student thesis: Master