Department of Biomedical Engineering

Research Output 1962 2020

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Review article
2020
7 Downloads (Pure)

Fiber scaffold patterning for mending hearts: 3D organization bringing the next step

Kristen, M., Ainsworth, M. J., Chirico, N., van der Ven, C. F. T., Doevendans, P. A., Sluijter, J. P. G., Malda, J., van Mil, A. & Castilho, M., Jan 2020, In : Advanced Healthcare Materials. 9, 1, p. e1900775 21 p., 1900775.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
File
Scaffolds
Organizations
Technology
Fibers
Tissue Engineering
2019
1 Citation (Scopus)
12 Downloads (Pure)

Adaptive polymeric assemblies for applications in biomimicry and nanomedicine

Altay, Y., Che, H., Cao, S., Abdelmohsen, L. & van Hest, J., 11 Nov 2019, In : Biomacromolecules. 20, 11, p. 4053-4064 12 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
File
Medical nanotechnology
Nanostructured materials
Self assembly
Intelligent networks
Complex networks
5 Citations (Scopus)
109 Downloads (Pure)

Allosteric small molecule modulators of nuclear receptors

Meijer, F. A., Leijten-van de Gevel, I. A., de Vries, R. M. J. M. & Brunsveld, L., 5 Apr 2019, In : Molecular and Cellular Endocrinology. 485, p. 20-34 15 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
File
Cytoplasmic and Nuclear Receptors
Allosteric Site
Ligands
Drug Discovery
Pathology
1 Citation (Scopus)
2 Downloads (Pure)

ATP-mediated transient behavior of stomatocyte nanosystems

Che, H., Zhu, J., Song, S., Mason, A. F., Cao, S., Pijpers, I. A. B., Abdelmohsen, L. K. E. A. & van Hest, J. C. M., 9 Sep 2019, In : Angewandte Chemie - International Edition. 58, 37, p. 13113-13118 6 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
Nanosystems
Adenosine Triphosphate
Polylysine
Nanoreactors
Molecular interactions
3 Citations (Scopus)
1 Downloads (Pure)

Bone-adhesive materials: clinical requirements, mechanisms of action, and future perspective

Sánchez-Fernández, M. J., Hammoudeh, H., Félix Lanao, R. P., van Erk, M., van Hest, J. C. M. & Leeuwenburgh, S. C. G., 22 Feb 2019, In : Advanced Materials Interfaces. 6, 4, 11 p., 1802021.

Research output: Contribution to journalReview articleAcademicpeer-review

Adhesives
Bone
Biomaterials
Glues
Tissue
1 Citation (Scopus)
14 Downloads (Pure)

Cats or CAT scans: transfer learning from natural or medical image source data sets?

Cheplygina, V., Mar 2019, In : Current Opinion in Biomedical Engineering. 9, p. 21-27 7 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
File
learning
tomography
image analysis
train
5 Citations (Scopus)
52 Downloads (Pure)

Cell-free microcompartmentalised transcription-translation for the prototyping of synthetic communication networks

Dubuc, E., Pieters, P. A., van der Linden, A. J., van Hest, J. C. M., Huck, W. T. S. & de Greef, T. F. A., 1 Aug 2019, In : Current Opinion in Biotechnology. 58, p. 72-80 9 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
File
Transcription
Telecommunication networks
Communication
Cells
Networks (circuits)
2 Citations (Scopus)
1 Downloads (Pure)

Clinical candidates modulating protein-protein interactions: the fragment-based experience

Valenti, D., Hristeva, S., Tzalis, D. & Ottmann, C., 1 Apr 2019, In : European Journal of Medicinal Chemistry. 167, p. 76-95 20 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Proteins
Modulators
Lead compounds
Drug Discovery
Chemical properties
5 Downloads (Pure)

Decoding the PTM-switchboard of Notch

Antfolk, D., Antila, C., Kemppainen, K., Landor, S. K. J. & Sahlgren, C., 1 Dec 2019, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1866, 12, 21 p., 118507.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
File
Post Translational Protein Processing
Nimodipine
Translational Medical Research
Glycosylation
Half-Life
2 Citations (Scopus)
34 Downloads (Pure)

DNA-functionalized supramolecular polymers: dynamic multicomponent assemblies with emergent properties

Wijnands, S. P. W., Meijer, E. W. & Merkx, M., 17 Jul 2019, In : Bioconjugate Chemistry. 30, 7, p. 1905-1914 10 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
File
Polymers
DNA
Hybrid systems
1 Citation (Scopus)

Emerging modes-of-action in drug discovery

Valeur, E., Narjes, F., Ottmann, C. & Plowright, A. T., 1 Oct 2019, In : MedChemComm. 10, 9, p. 1550-1568 19 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Drug Discovery
Arsenals
Biological Phenomena
Pharmaceutical Preparations
Degradation
1 Citation (Scopus)

Lipid nanoparticle technology for clinical translation of siRNA therapeutics

Kulkarni, J. A., Witzigmann, D., Chen, S., Cullis, P. R. & van der Meel, R., 17 Sep 2019, In : Accounts of Chemical Research. 52, 9, p. 2435-2444 10 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Small Interfering RNA
Nanoparticles
Lipids
Genes
Prealbumin
1 Citation (Scopus)
3 Downloads (Pure)

Modulating protein–protein interaction networks in protein homeostasis

Zhong, M., Lee, G. M., Sijbesma, E., Ottmann, C. & Arkin, M. R., 1 Jun 2019, In : Current Opinion in Chemical Biology. 50, p. 55-65 11 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Protein Interaction Maps
Complex networks
Homeostasis
Molecules
Virus Diseases
3 Citations (Scopus)

Nanoimmunotherapy to treat ischaemic heart disease

Duivenvoorden, R., Senders, M. L., van Leent, M. M. T., Pérez-Medina, C., Nahrendorf, M., Fayad, Z. A. & Mulder, W. J. M., Jan 2019, In : Nature Reviews. Cardiology. 16, 1, p. 21-32 12 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Myocardial Ischemia
Atherosclerosis
Inflammation
Lipids
Recurrence
1 Citation (Scopus)

Review on factors influencing physician guideline adherence in cardiology

Hoorn, C. J. G. M., Crijns, H. J. G. M., Dierick-van Daele, A. T. M. & Dekker, L. R. C., 1 Mar 2019, In : Cardiology in Review. 27, 2, p. 80-86 7 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Guideline Adherence
Cardiology
Physicians
Secondary Care Centers
Patient Compliance
6 Citations (Scopus)
26 Downloads (Pure)

Rotating magnetic particles for lab-on-chip applications-a comprehensive review

Moerland, C. P., van IJzendoorn, L. J. & Prins, M. W. J., 21 Mar 2019, In : Lab on a Chip. 19, 6, p. 919-933 15 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
File
Magnetic Fields
Magnetic fields
Torque
Molecules
Biomolecules
1 Citation (Scopus)
1 Downloads (Pure)

Smart cancer nanomedicine

van der Meel, R., Sulheim, E., Shi, Y., Kiessling, F., Mulder, W. & Lammers, T., 6 Nov 2019, In : Nature Nanotechnology. 14, 11, p. 1007–1017 11 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Medical nanotechnology
cancer
therapy
drugs
stratification
10 Citations (Scopus)

Super-resolution microscopy as a powerful tool to study complex synthetic materials

Pujals, S., Feiner-Gracia, N., Delcanale, P., Voets, I. & Albertazzi, L., 1 Feb 2019, In : Nature Reviews Chemistry. 3, 2, p. 68-84 17 p.

Research output: Contribution to journalReview articleAcademicpeer-review

File
Microscopic examination
Nanotechnology
Biocompatible Materials
Materials science
Biomaterials
6 Downloads (Pure)

Super-resolution microscopy for nanomedicine research

Pujals, S. & Albertazzi, L., 24 Sep 2019, In : ACS Nano. 13, 9, p. 9707-9712 6 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
File
Medical nanotechnology
Microscopic examination
Cytology
microscopy
Nanotechnology
14 Citations (Scopus)

Therapeutic targeting of trained immunity

Mulder, W. J. M., Ochando, J., Joosten, L. A. B., Fayad, Z. A. & Netea, M. G., 9 Apr 2019, In : Nature Reviews Drug Discovery. 18, 7, p. 553-566 14 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Immunity
Immunotherapy
Immune System
Immune System Diseases
Myeloid Cells
2018
5 Citations (Scopus)
37 Downloads (Pure)

14-3-3: A case study in ppi modulation

Ballone, A., Centorrino, F. & Ottmann, C., 1 Jan 2018, In : Molecules. 23, 6, 14 p., 1386.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
File
14-3-3 Proteins
Complex networks
Drug Discovery
Protein Binding
Neurodegenerative Diseases
2 Citations (Scopus)
50 Downloads (Pure)

Comparison between in vitro and in vivo cartilage overloading studies based on a systematic literature review

Nickien, M., Heuijerjans, A., Ito, K. & van Donkelaar, C. C., 1 Aug 2018, In : Journal of Orthopaedic Research. 36, 8, p. 2076-2086 11 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
File
Cartilage
Articular Cartilage
In Vitro Techniques
Osteoarthritis
Cell Survival
2 Citations (Scopus)
114 Downloads (Pure)

Integrating immunology and microfluidics for single immune cell analysis

Sinha, N., Subedi, N. & Tel, J., 16 Oct 2018, In : Frontiers in Immunology. 9, 16 p., 2373.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
File
Single-Cell Analysis
Microfluidics
Allergy and Immunology
Immune System
Point-of-Care Systems
15 Citations (Scopus)

Investigating supramolecular systems using Förster resonance energy transfer

Teunissen, A. J. P., Pérez-Medina, C., Meijerink, A. & Mulder, W. J. M., 21 Sep 2018, In : Chemical Society Reviews. 47, 18, p. 7027-7044 18 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Energy transfer
Medical nanotechnology
Biochemistry
Materials science
Conformations
4 Citations (Scopus)
93 Downloads (Pure)

Mechanobiology of the cell–matrix interplay: catching a glimpse of complexity via minimalistic models

Kurniawan, N. A. & Bouten, C. V. C., 1 Apr 2018, In : Extreme Mechanics Letters. 20, p. 59-64 6 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
File
Tissue
Tissue regeneration
Biomechanics
Biocompatible Materials
Biomaterials
15 Citations (Scopus)
171 Downloads (Pure)

Metastasis in context: modeling the tumor microenvironment with cancer-on-a-chip approaches

Sleeboom, J. J. F., Amirabadi, H. E., Nair, P., Sahlgren, C. M. & Den Toonder, J. M. J., 1 Mar 2018, In : Disease Models & Mechanisms. 11, 3, 033100.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
File
Tumor Microenvironment
Tumors
Neoplasm Metastasis
Neoplasms
Mechanics
12 Citations (Scopus)
51 Downloads (Pure)

Multi-omics profiling of the tumor microenvironment: Paving the way to precision immuno-oncology

Finotello, F. & Eduati, F., 5 Oct 2018, In : Frontiers in Oncology. 8, OCT, 9 p., 430.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
File
Tumor Microenvironment
Neoplasms
Ecosystem
Immunity
Therapeutics
3 Citations (Scopus)
1 Downloads (Pure)

Polymers at the interface with biology

Deming, T. J., Klok, H. A., Armes, S. P., Becker, M. L., Champion, J. A., Chen, E. Y. X., Heilshorn, S. C., van Hest, J. C. M., Irvine, D. J., Johnson, J. A., Kiessling, L. L., Maynard, H. D., De La Cruz, M. O., Sullivan, M. O., Tirrell, M. V., Anseth, K. S., Lecommandoux, S., Percec, S., Zhong, Z. & Albertsson, A. C., 13 Aug 2018, In : Biomacromolecules. 19, 8, p. 3151-3162 12 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
Polymers
13 Citations (Scopus)
65 Downloads (Pure)

Self-assembled nanoreactors based on peptides and proteins

Timmermans, S. B. P. E. & van Hest, J. C. M., 1 May 2018, In : Current Opinion in Colloid and Interface Science. 35, p. 26-35 10 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
File
Nanoreactors
Peptides
peptides
proteins
Proteins
40 Citations (Scopus)
390 Downloads (Pure)

Synthetic immune niches for cancer immunotherapy

Weiden, J., Tel, J. & Figdor, C. G., 1 Mar 2018, In : Nature Reviews Immunology. 18, 3, p. 212-219 8 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
File
Immunotherapy
Immunomodulation
Immunity
Neoplasms
Cancer Vaccines
11 Citations (Scopus)
721 Downloads (Pure)

The future of heart valve replacement: recent developments and translational challenges for heart valve tissue engineering

Fioretta, E. S., Dijkman, P. E., Emmert, M. Y. & Hoerstrup, S. P., 1 Jan 2018, In : Journal of Tissue Engineering and Regenerative Medicine. 12, 1, p. e323-e335

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
File
Heart Valves
Tissue Engineering
Tissue engineering
Heart Valve Diseases
Starters
8 Citations (Scopus)
58 Downloads (Pure)

The hallmarks of living systems: Towards creating artificial cells

Amy Yewdall, N., Mason, A. F. & Van Hest, J. C. M., 6 Oct 2018, In : Interface Focus. 8, 5, 15 p., 20180023.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
File
Artificial Cells
Earth (planet)
Biological Phenomena
Automatic Data Processing
Transplantation
2017
14 Citations (Scopus)
1 Downloads (Pure)

14-3-3 adaptor protein-protein interactions as therapeutic targets for CNS diseases

Kaplan, A., Ottmann, C. & Fournier, A. E., 1 Nov 2017, In : Pharmacological Research. 125, part B, p. 114-121 8 p.

Research output: Contribution to journalReview articleAcademicpeer-review

14-3-3 Proteins
Central Nervous System Diseases
Proteins
Therapeutics
Therapeutic Uses
46 Citations (Scopus)

Bio-inks for 3D bioprinting: recent advances and future prospects

Donderwinkel, I., van Hest, J. C. M. & Cameron, N. R., 20 Aug 2017, In : Polymer Chemistry. 8, 31, p. 4451-4471 21 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Bioprinting
Printing
Ink
Polymers
Biocompatible Materials
5 Citations (Scopus)
48 Downloads (Pure)

Current challenges in translating tissue-engineered heart valves

Stassen, O. M. J. A., Muylaert, D. E. P., Bouten, C. V. C. & Hjortnaes, J., 1 Sep 2017, In : Current Treatment Options in Cardiovascular Medicine. 19, 9, 13 p., 71.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
File
Heart Valves
Heart Valve Diseases
Biocompatible Materials
Bioreactors
Complex Mixtures
73 Citations (Scopus)
196 Downloads (Pure)

From supramolecular polymers to multi-component biomaterials

Goor, O. J. G. M., Hendrikse, S. I. S., Dankers, P. Y. W. & Meijer, E. W., 7 Nov 2017, In : Chemical Society Reviews. 46, 21, p. 6621-6637 17 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
File
Biocompatible Materials
Polymers
Bearings (structural)
Hydrogels
Hydrogel
10 Citations (Scopus)
2 Downloads (Pure)

How not to drown in data: a guide for biomaterial engineers

Vasilevich, A. S., Carlier, A., de Boer, J. & Singh, S., Aug 2017, In : Trends in Biotechnology. 35, 8, p. 743-755 13 p.

Research output: Contribution to journalReview articleAcademicpeer-review

3 Citations (Scopus)

How to define the hemodynamic significance of an equivocal iliofemoral artery stenosis: review of literature and outcomes of an international questionnaire

de Boer, S. W., Heinen, S. G. H., van den Heuvel, D. A. F., van de Vosse, F. N. & de Vries, J. P. P. M., 1 Dec 2017, In : Vascular. 25, 6, p. 598-608 11 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Pathologic Constriction
Arteries
Hemodynamics
Arterial Pressure
Surveys and Questionnaires
9 Citations (Scopus)

Joining forces: the chemical biology–medicinal chemistry continuum

Plowright, A. T., Ottmann, C., Arkin, M., Auberson, Y. P., Timmerman, H. & Waldmann, H., 21 Sep 2017, In : Cell Chemical Biology. 24, 9, p. 1058-1065 8 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Joining
Biological systems
Drug Discovery
Medicine
Lead compounds
20 Citations (Scopus)
21 Downloads (Pure)

Subthalamic nucleus deep brain stimulation: Basic concepts and novel perspectives

Hamani, C., Florence, G., Heinsen, H., Plantinga, B. R., Temel, Y., Uludag, K., Alho, E., Teixeira, M. J., Amaro, E. & Fonoff, E. T., 1 Sep 2017, In : eNeuro. 4, 5, e0140-17.2017.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
File
Subthalamic Nucleus
Deep Brain Stimulation
Parkinson Disease
Motor Cortex
Neuroimaging
12 Citations (Scopus)

Tailored approaches in drug development and diagnostics: from molecular design to biological model systems

Sahlgren, C. M., Meinander, A., Zhang, H., Cheng, F., Preis, M., Xu, C., Salminen, T. A., Toivola, D. M., Abankwa, D., Rosling, A., Karaman, D. Ş., Salo-Ahen, O. M. H., Österbacka, R., Eriksson, J. E., Willför, S., Petre, I., Peltonen, J., Leino, R., Johnson, M., Rosenholm, J. & 1 others, Sandler, N., 8 Nov 2017, In : Advanced Healthcare Materials. 6, 21, p. 1-34 1700258.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
Biological Models
Molecular Pathology
Drug delivery
Pharmaceutical Preparations
Pharmacokinetics
4 Citations (Scopus)
47 Downloads (Pure)

The available evidence on demineralised bone matrix in trauma and orthopaedic surgery: a systematic review

van der Stok, J., Hartholt, K. A., Schoenmakers, D. A. L. & Arts, J. J. C., 1 Jul 2017, In : Bone and Joint Research. 6, 7, p. 423-432 10 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
File
Bone Matrix
Orthopedics
Wounds and Injuries
Manuscripts
Randomized Controlled Trials
17 Citations (Scopus)

Tumour-vessel-on-a-chip models for drug delivery

Caballero, D., Blackburn, S. M., De Pablo, M., Samitier, J. & Albertazzi, L., 1 Jan 2017, In : Lab on a Chip. 17, 22, p. 3760-3771 12 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Drug delivery
Microfluidics
Tumors
Pharmaceutical Preparations
Neoplasms
155 Downloads (Pure)

Vascular mechanobiology: towards control of in situ regeneration

van Haaften, E. E., Bouten, C. V. C. & Kurniawan, N. A., 3 Jul 2017, In : Cells. 6, 3, p. 1-24 19.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
File
Biophysics
Blood Vessels
Regeneration
Tissue
Tissue engineering
2016
7 Citations (Scopus)
46 Downloads (Pure)

7 T renal MRI: challenges and promises

de Boer, A., Hoogduin, J. M., Blankestijn, P. J., Li, X., Luijten, P. R., Metzger, G. J., Raaijmakers, A. J. E., Umutlu, L., Visser, F. & Leiner, T., Jun 2016, In : Magnetic Resonance Materials in Physics, Biology and Medicine (MAGMA). 29, 3, p. 417-433 17 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
File
Magnetic Resonance Imaging
Kidney
Signal-To-Noise Ratio
Angiography
Sodium
103 Citations (Scopus)
103 Downloads (Pure)

Adipose tissue-derived stem cells in regenerative medicine

Frese, L., Dijkman, P. E. & Hoerstrup, S. P., 1 Jul 2016, In : Transfusion Medicine and Hemotherapy. 43, 4, p. 268-274 7 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
File
Regenerative Medicine
Adipose Tissue
Stem Cells
Multipotent Stem Cells
Osteocytes

Current practices and challenges in ruptured abdominal aortic aneurysm repair

't Mannetje, Y. W., Broos, P. P. H. L., van Sambeek, M. R. H. M., Cuypers, P. W. M. & Teijink, J. A. W., 1 Mar 2016, In : Italian Journal of Vascular and Endovascular Surgery. 23, 1, p. 34-45 12 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Aortic Rupture
Abdominal Aortic Aneurysm
Preoperative Care
Patient Selection
Aneurysm
14 Citations (Scopus)
59 Downloads (Pure)

Heart valve replacements with regenerative capacity

Dijkman, P. E., Fioretta, E. S., Frese, L., Pasqualini, F. S. & Hoerstrup, S. P., 1 Jul 2016, In : Transfusion Medicine and Hemotherapy. 43, 4, p. 282-290 9 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
File
Heart Valves
Tissue Engineering
Pathologic Constriction
Technology
Incidence
23 Citations (Scopus)
1 Downloads (Pure)

MRI methods for the evaluation of high intensity focused ultrasound tumor treatment: current status and future needs

Hectors, S. J. C. G., Jacobs, I., Moonen, C. T. W., Strijkers, G. J. & Nicolaij, K., 1 Jan 2016, In : Magnetic Resonance in Medicine. 75, 1, p. 302-317 16 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
Neoplasms
Therapeutics
High-Intensity Focused Ultrasound Ablation
Hot Temperature
207 Citations (Scopus)
143 Downloads (Pure)

Silk fibroin as biomaterial for bone tissue engineering

Melke, J., Midha, S., Ghosh, S., Ito, K. & Hofmann, S., Feb 2016, In : Acta Biomaterialia. 31, p. 1-16 16 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
File
Fibroins
Silk
Biocompatible Materials
Tissue Engineering
Tissue engineering