Department of Biomedical Engineering

Research Output 1962 2019

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2019

A multilayer microfluidic platform for the conduction of prolonged cell-free gene expression

van der Linden, A., Pieters, P., Yelleswarapu, M., Swank, Z., Huck, W. T. S., Maerkl, S. & de Greef, T., 2019, (Accepted/In press) In : Journal of Visualized Experiments (JoVE).

Research output: Contribution to journalArticleAcademicpeer-review

File

A new class of supramolecular ligands stabilizes 14-3-3 protein-protein interactions by up to two orders of magnitude

Gigante, A., Grad, J. N., Briels, J., Bartel, M., Hoffmann, D., Ottmann, C. & Schmuck, C., 1 Jan 2019, In : Chemical Communications. 55, 1, p. 111-114 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Neurodegenerative diseases
14-3-3 Proteins
Signal transduction
Ligands
Proteins

A value proposition for trough level-based anti-TNFα drug dosing

Scharnhorst, V., Schmitz, E. M. H., van de Kerkhof, D., Derijks, L. J. J. & Broeren, M. A. C., 1 Feb 2019, In : Clinica Chimica Acta. 489, p. 89-95 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Drug Monitoring
Pharmaceutical Preparations
Cost-Benefit Analysis
Therapeutics
Critical Pathways

Biomorphic engineering of multifunctional polylactide stomatocytes toward therapeutic nano-red blood cells

Shao, J., Pijpers, I. A. B., Cao, S., Williams, D. S., Yan, X., Li, J., Abdelmohsen, L. K. E. A. & van Hest, J. C. M., 1 Jan 2019, (Accepted/In press) In : Advanced Science.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
erythrocytes
Blood
Erythrocytes
Cells
engineering

Carbon nanotube reinforced supramolecular hydrogels for bioapplications

Mihajlovic, M., Mihajlovic, M., Dankers, P. Y. W., Masereeuw, R. & Sijbesma, R. P., 1 Jan 2019, In : Macromolecular Bioscience. 19, 12 p., 1800173

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Carbon Nanotubes
Hydrogels
Nanocomposites
Carbon nanotubes
Hydrogel
1 Citations

Cortical and trabecular bone microarchitecture as an independent predictor of incident fracture risk in older women and men in the Bone Microarchitecture International Consortium (BoMIC): a prospective study

Samelson, E. J., Broe, K. E., Xu, H., Yang, L., Boyd, S., Biver, E., Szulc, P., Adachi, J., Amin, S., Atkinson, E., Berger, C., Burt, L., Chapurlat, R., Chevalley, T., Ferrari, S., Goltzman, D., Hanley, D. A., Hannan, M. T., Khosla, S., Liu, C-T. & 13 othersLorentzon, M., Mellstrom, D., Merle, B., Nethander, M., Rizzoli, R., Sornay-Rendu, E., van Rietbergen, B., Sundh, D., Wong, A. K. O., Ohlsson, C., Demissie, S., Kiel, D. P. & Bouxsein, M. L., 1 Jan 2019, In : Lancet Diabetes & Endocrinology. 7, 1, p. 34-43 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Bone Density
Prospective Studies
Bone and Bones
Femur Neck
Tibia

Counterion dependent mechanisms of DNA origami nanostructure stabilization revealed by atomistic molecular simulation

Roodhuizen, J., Hendrikx, P. J. T. M., Hilbers, P. A. J., de Greef, T. & Markvoort, B., 2019, (Accepted/In press) In : ACS Nano.

Research output: Contribution to journalArticleAcademicpeer-review

1 Citations

Development of morphologically discrete PEG-PDLLA nanotubes for precision nanomedicine

Wauters, A. C., Pijpers, I. A. B., Mason, A. F., Williams, D. S., Tel, J., Abdelmohsen, L. K. E. A. & van Hest, J. C. M., 1 Jan 2019, In : Biomacromolecules. 20, 1, p. 177-183

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Medical nanotechnology
Nanotubes
Polyethylene glycols
Particle interactions
Nanostructures

DNA-based communication in populations of synthetic protocells

Joesaar, A. H., Yang, S., Bögels, B. W. A., van der Linden, A. J., Pieters, P. A., Kumar, P., Dachau, N., Phillips, A., Mann, S. & de Greef, T. F. A., 2019, (Accepted/In press) In : Nature Nanotechnology.

Research output: Contribution to journalArticleAcademicpeer-review

1 Citations

Epileptic seizure detection in EEG signals using sparse multiscale radial basis function networks and the Fisher vector approach

Li, Y., Cui, W. G., Huang, H., Guo, Y. Z., Li, K. & Tan, T., 15 Jan 2019, In : Knowledge-Based Systems. 164, p. 96-106

Research output: Contribution to journalArticleAcademicpeer-review

Radial basis function networks
Electroencephalography
Statistical tests
Model structures
Particle swarm optimization (PSO)

Fourier transform on the homogeneous space of 3D positions and orientations for exact solutions to linear PDEs

Duits, R., Bekkers, E. J. & Mashtakov, A., 8 Jan 2019, In : Entropy. 21, 1, 38 p., 38

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
pulse detonation engines
quotients
rigid structures
robotics
image analysis

Identification of topographical architectures supporting the phenotype of rat tenocytes

Vermeulen, S., Vasilevich, A., Tsiapalis, D., Roumans, N., Vroemen, P., Beijer, N. R. M., Dede Eren, A., Zeugolis, D. & de Boer, J., 1 Jan 2019, In : Acta Biomaterialia. 83, p. 277-290

Research output: Contribution to journalArticleAcademicpeer-review

Topography
Rats
Tendons
Phenotype
Screening

Maternal hemoglobin level and its relation to fetal distress, mode of delivery, and short-term neonatal outcome: a retrospective cohort study

Bullens, L. M., Smith, J. S., Truijens, S. E. M., van der Hout-van der Jagt, M. B., van Runnard Heimel, P. J. & Oei, S. G., 31 Jan 2019, In : Journal of Maternal-Fetal and Neonatal Medicine. p. 1-7 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Fetal Distress
Hemoglobins
Cohort Studies
Retrospective Studies
Mothers
Open Access
File
Micellization
Surface-Active Agents
self consistent fields
Surface active agents
Salts

Mimicking Active Biopolymer Networks with a Synthetic Hydrogel

Fernández-Castano Romera, M., Göstl, R., Shaikh, H., Ter Huurne, G., Schill, J., Voets, I. K., Storm, C. & Sijbesma, R. P., 6 Feb 2019, In : Journal of the American Chemical Society. 141, 5, p. 1989-1997 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Biopolymers
Hydrogel
Hydrogels
Collagen
Residual stresses

Nanoimmunotherapy to treat ischaemic heart disease

Duivenvoorden, R., Senders, M. L., van Leent, M. M. T., Pérez-Medina, C., Nahrendorf, M., Fayad, Z. A. & Mulder, W. J. M., 2019, In : Nature Reviews. Cardiology. 16, p. 21-32

Research output: Contribution to journalArticleAcademicpeer-review

Myocardial Ischemia
Atherosclerosis
Inflammation
Lipids
Recurrence

On the relationship between dynamic contrast-enhanced ultrasound parameters and the underlying vascular architecture extracted from acoustic angiography

Panfilova, A., Shelton, S. E., Caresio, C., van Sloun, R. J. G., Molinari, F., Wijkstra, H., Dayton, P. A. & Mischi, M., Feb 2019, In : Ultrasound in Medicine and Biology. 45, 2, p. 539-548

Research output: Contribution to journalArticleAcademicpeer-review

angiography
Acoustics
Blood Vessels
Angiography
Perfusion

Prospective follow-Up of cortical interruptions, bone density, and micro-structure detected on HR-pQCT: A study in patients with rheumatoid arthritis and healthy subjects

Peters, M., van den Bergh, J. P., Geusens, P., Scharmga, A., Loeffen, D., Weijers, R., van Rietbergen, B. & van Tubergen, A., 1 Feb 2019, In : Calcified Tissue International.

Research output: Contribution to journalArticleAcademicpeer-review

Bone Density
Antirheumatic Agents
Rheumatoid Arthritis
Healthy Volunteers
Tomography

Quantifying guest–host dynamics in supramolecular assemblies to analyze their robustness

Bastings, M. M. C., Hermans, T. M., Spiering, A. J. H., Kemps, E. W. L., Albertazzi, L., Kurisinkal, E. E. & Dankers, P. Y. W., 1 Jan 2019, In : Macromolecular Bioscience. 19, 1, 11 p., 1800296

Research output: Contribution to journalArticleAcademicpeer-review

Pyrimidinones
Fluorescence Recovery After Photobleaching
Photobleaching
Fluorescence Resonance Energy Transfer
Microfluidics

RegressionExplorer: Interactive exploration of logistic regression models with subgroup analysis

Dingen, D., van 't Veer, M., Houthuizen, P., Mestrom, E. H. J., Korsten, E. H. H. M., Bouwman, A. R. A. & van Wijk, J., 1 Jan 2019, In : IEEE Transactions on Visualization and Computer Graphics. 25, 1, p. 246-255 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Logistics

Robust non-rigid motion compensation of free-breathing myocardial perfusion MRI data

Scannell, C. M., Villa, A. D. M., Lee, J., Breeuwer, M. & Chiribiri, A., 1 Feb 2019, In : IEEE Transactions on Medical Imaging.

Research output: Contribution to journalArticleAcademicpeer-review

Motion compensation
Magnetic Resonance Angiography
Magnetic resonance
Compensation and Redress
Respiration
antifouling
Scaffolds
Adhesives
adhesives
casts

The dual-mode dipole: A new array element for 7T body imaging with reduced SAR

Solomakha, G., Leeuwen, C. V., Raaijmakers, A., Simovski, C., Popugaev, A., Abdeddaim, R., Melchakova, I. & Glybovski, S., 1 Feb 2019, In : Magnetic Resonance in Medicine. 81, 2, p. 1459-1469

Research output: Contribution to journalArticleAcademicpeer-review

Prostate
Volunteers
Open Access
File
Pathologic Constriction
Geometry
Hydrodynamics
Uncertainty
Dynamic models
2018
3 Citations
Open Access
File
Biomimetics
Microfluidics
Endothelial cells
Hemodynamics
Vascular Smooth Muscle

Accelerated 4D phase contrast MRI in skeletal muscle contraction

Mazzoli, V., Gottwald, L. M., Peper, E. S., Froeling, M., Coolen, B. F., Verdonschot, N., Sprengers, A. M., van Ooij, P., Strijkers, G. J. & Nederveen, A. J., 1 Nov 2018, In : Magnetic Resonance in Medicine. 80, 5, p. 1799-1811 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Muscle Contraction
Skeletal Muscle
Muscles
Volunteers
Leg
1 Citations

Accelerating DNA-based computing on a supramolecular polymer

Engelen, W., Wijnands, S. P. W. & Merkx, M., 1 Aug 2018, In : Journal of the American Chemical Society. 140, 30, p. 9758-9767 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Polymers
DNA
Benzene
Networks (circuits)
Molecular Computers
3 Citations

Adaptation of a MR imaging protocol into a real-time clinical biometric ultrasound protocol for persons with spinal cord injury at risk for deep tissue injury: A reliability study

Swaine, J. M., Moe, A., Breidahl, W., Bader, D. L., Oomens, C. W. J., Lester, L., O'Loughlin, E., Santamaria, N. & Stacey, M. C., 1 Feb 2018, In : Journal of Tissue Viability. 27, 1, p. 2-9 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Spinal Cord Injuries
Tendons
Skin
Spinal Cord
Wounds and Injuries

Adaptive polymersome and micelle morphologies in anticancer nanomedicine: from design rationale to fabrication and proof-of-concept studies

Pijpers, I. A. B., Abdelmohsen, L. K. E. A., Xia, Y., Cao, S., Williams, D. S., Meng, F., van Hest, J. C. M. & Zhong, Z., 1 Dec 2018, In : Advanced Therapeutics. 1, 8, 14 p., 1800068

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Medical nanotechnology
Micelles
Nanoparticles
Fabrication
Drug delivery

A filter-free blood-brain barrier model to quantitatively study transendothelial delivery of nanoparticles by fluorescence spectroscopy

De Jong, E., Williams, D. S., Abdelmohsen, L. K. E. A., van Hest, J. C. M. & Zuhorn, I. S., 10 Nov 2018, In : Journal of Controlled Release. 289, p. 14-22 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Fluorescence Spectrometry
Blood-Brain Barrier
Nanoparticles
Transcytosis
Brain
2 Citations

Afivo: a framework for quadtree/octree AMR with shared-memory parallelization and geometric multigrid methods

Teunissen, J. & Ebert, U., 1 Dec 2018, In : Computer Physics Communications. 233, p. 156-166

Research output: Contribution to journalArticleAcademicpeer-review

multigrid methods
Data storage equipment
files
simulation
grids
3 Citations

AFM-detected apoptosis of hepatocellular carcinoma cells induced by American ginseng root water extract

Qu, Y., Wang, Z., Zhao, F., Liu, J., Zhang, W., Li, J., Song, Z. & Xu, H., 1 Jan 2018, In : Micron. 104, p. 1-7 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Panax
Hepatocellular Carcinoma
Apoptosis
Water
Elastic Modulus
Open Access
Biomarkers
Blood Vessels
Retina
Retinal Vessels
Pipelines
1 Citations

A liquid chromatography/mass spectrometry method for screening disulfide tethering fragments

Hallenbeck, K. K., Davies, J. L., Merron, C., Ogden, P., Sijbesma, E., Ottmann, C., Renslo, A. R., Wilson, C. & Arkin, M. R., 2018, In : SLAS Discovery. 23, 2, p. 183-192 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Liquid chromatography
Disulfides
Mass spectrometry
Screening
Pipelines
4 Citations

All-optical imaging of gold nanoparticle geometry using super-resolution microscopy

Taylor, A., Verhoef, R., Beuwer, M., Wang, Y. & Zijlstra, P., 1 Feb 2018, In : Journal of Physical Chemistry C. 122, 4, p. 2336-2342 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Gold
Microscopic examination
gold
Nanoparticles
microscopy

All-printed cell counting chambers with on-chip sample preparation for point-of-care CD4 counting

Wasserberg, D., Zhang, X., Breukers, C., Connell, B. J., Baeten, E., van den Blink, D., Solà Benet, È., Bloem, A. C., Nijhuis, M., Wensing, A. M. J., Terstappen, L. W. M. M. & Beck, M., 15 Oct 2018, In : Biosensors and Bioelectronics. 117, p. 659-668 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Point-of-Care Systems
Antibodies
Microfluidics
Tissue Donors
HIV
7 Citations

A microfluidics platform for combinatorial drug screening on cancer biopsies

Eduati, F., Utharala, R., Madhavan, D., Neumann, U. P., Longerich, T., Cramer, T., Saez-Rodriguez, J. & Merten, C. A., 22 Jun 2018, In : Nature Communications. 9, 1, 13 p., 2434

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Preclinical Drug Evaluations
Microfluidics
Biopsy
Drug Combinations
Tumors

A model of human skin under large amplitude oscillatory shear

Soetens, J. F. J., van Vijven, M., Bader, D. L., Peters, G. W. M. & Oomens, C. W. J., 1 Oct 2018, In : Journal of the Mechanical Behavior of Biomedical Materials. 86, p. 423-432 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Skin
Constitutive models
Shear thinning
Parameter estimation
Shear deformation
3 Citations

Amphiphilic poly(α)glutamate polymeric micelles for systemic administration of siRNA to tumors

Krivitsky, A., Polyak, D., Scomparin, A., Eliyahu, S., Ofek, P., Tiram, G., Kalinski, H., Avkin-Nachum, S., Feiner Gracia, N., Albertazzi, L. & Satchi-Fainaro, R., 1 Feb 2018, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 14, 2, p. 303-315 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Micelles
Small Interfering RNA
Tumors
Glutamic Acid
Bearings (structural)

A multi-gram-scale stereoselective synthesis of Z-endoxifen

Milroy, L. G., Koning, B., Scheppingen, D. S. V., Jager, N. G. L., Beijnen, J. H., Koek, J. & Brunsveld, L., 2018, In : Bioorganic and Medicinal Chemistry Letters. 28, 8, p. 1352-1356

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Clinical Trials, Phase I
Tamoxifen
Metabolites
Pharmaceutical Preparations
Pharmacology
4 Citations

An 8-channel Tx/Rx dipole array combined with 16 Rx loops for high-resolution functional cardiac imaging at 7 T

Steensma, B. R., Voogt, I. J., Leiner, T., Luijten, P. R., Habets, J., Klomp, D. W. J., van den Berg, C. A. T. & Raaijmakers, A. J. E., 1 Feb 2018, In : Magnetic Resonance Materials in Physics, Biology and Medicine. 31, 1, p. 7-18 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Signal-To-Noise Ratio
Electromagnetic Phenomena
Healthy Volunteers
3 Citations

An advanced magnetic resonance imaging perspective on the etiology of deep tissue injury

Nelissen, J. L., Traa, W. A., de Boer, H. H., de Graaf, L., Mazzoli, V., Savci-Heijink, C. D., Nicolay, K., Froeling, M., Bader, D. L., Nederveen, A. J., Oomens, C. W. J. & Strijkers, G. J., 1 Jun 2018, In : Journal of Applied Physiology. 124, 6, p. 1580-1596 17 p.

Research output: Contribution to journalArticleAcademicpeer-review

Magnetic Resonance Imaging
Wounds and Injuries
Muscles
Edema
Angiography
1 Citations

An automated algorithm for the detection of cortical interruptions and its underlying loss of trabecular bone; A reproducibility study

Peters, M., de Jong, J., Scharmga, A., van Tubergen, A., Geusens, P., Loeffen, D., Weijers, R., Boyd, S. K., Barnabe, C., Stok, K. S., van Rietbergen, B. & van den Bergh, J., 15 May 2018, In : BMC Medical Imaging. 18, 1, 10 p., 13

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Joints
Arthritis
Tomography
Finger Joint
Metacarpophalangeal Joint

An automated quantitative analysis of cell, nucleus and focal adhesion morphology

Buskermolen, A. B. C., Kurniawan, N. A. & Bouten, C. V. C., 1 Mar 2018, In : PLoS ONE. 13, 3, 16 p., e0195201

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Focal Adhesions
cell nucleus
Cell Nucleus
Cell Adhesion
adhesion
9 Citations

Angiography versus hemodynamics to predict the natural history of coronary stenoses: Fractional flow reserve versus angiography in multivessel evaluation 2 substudy

Ciccarelli, G., Barbato, E., Toth, G. G., Gahl, B., Xaplanteris, P., Fournier, S., Milkas, A., Bartunek, J., Vanderheyden, M., Pijls, N., Tonino, P., Fearon, W. F., Jüni, P. & De Bruyne, B., 3 Apr 2018, In : Circulation. 137, 14, p. 1475-1485 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Coronary Stenosis
Angiography
Pathologic Constriction
Hemodynamics
Confidence Intervals
7 Citations

A novel angiographic quantification of aortic regurgitation after TAVR provides an accurate estimation of regurgitation fraction derived from cardiac magnetic resonance imaging

Abdel-Wahab, M., Abdelghani, M., Miyazaki, Y., Holy, E. W., Merten, C., Zachow, D., Tonino, W. A. L., Rutten, M. C. M., van de Vosse, F. N., Morel, M. A., Onuma, Y., Serruys, P. W., Richardt, G. & Soliman, O. I., 12 Feb 2018, In : JACC: Cardiovascular Interventions. 11, 3, p. 287-297 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Aortic Valve Insufficiency
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Area Under Curve
Sensitivity and Specificity

Antimicrobial peptide modification of biomaterials using supramolecular additives

Zaccaria, S., van Gaal, R. C., Riool, M., Zaat, S. A. J. & Dankers, P. Y. W., 1 Sep 2018, In : Journal of Polymer Science, Part A: Polymer Chemistry. 56, 17, p. 1926-1934

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Pyrimidinones
Biocompatible Materials
Biomaterials
Peptides
Polymers

A numerical simulation of heartassist5 blood pump using an advanced turbulence model

Drešar, P., Rutten, M. C. M., GregorIč, I. D. & Duhovnik, J., 1 Sep 2018, In : ASAIO journal. 64, 5, p. 673-679 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Heart-Assist Devices
Turbulence models
Blood
Pumps
Computer simulation
4 Citations

Artery/vein classification using reflection features in retina fundus images

Huang, F., Dasht Bozorg, B. & ter Haar Romeny, B. M., 1 Jan 2018, In : Machine Vision and Applications. 29, 1, p. 23-34 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Biomarkers
Image analysis
Classifiers
Pixels
Association reactions

Assembly of protein stacks with in situ synthesized nanoparticle cargo

Manuguri, S., Webster, K., Yewdall, N. A., An, Y., Venugopal, H., Bhugra, V., Turner, A., Domigan, L. J., Gerrard, J. A., Williams, D. E. & Malmström, J., 8 Aug 2018, In : Nano Letters. 18, 8, p. 5138-5145 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

cargo
assembly
Iron
Nanoparticles
proteins