Department of Biomedical Engineering

Research Output 1962 2019

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2019

Allosteric small molecule modulators of nuclear receptors

Meijer, F. A., Leijten-van de Gevel, I. A., de Vries, R. M. J. M. & Brunsveld, L., 1 Apr 2019, In : Molecular and Cellular Endocrinology. 485, p. 20-34 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Cytoplasmic and Nuclear Receptors
Allosteric Site
Ligands
Drug Discovery
Pathology
Open Access
Intravenous Administration
Theoretical Models
Clinical Decision Support Systems
Mathematical models
Fluids

A multilayer microfluidic platform for the conduction of prolonged cell-free gene expression

van der Linden, A., Pieters, P., Yelleswarapu, M., Swank, Z., Huck, W. T. S., Maerkl, S. & de Greef, T., 2019, (Accepted/In press) In : Journal of Visualized Experiments (JoVE).

Research output: Contribution to journalArticleAcademicpeer-review

File
Lab-On-A-Chip Devices
Microfluidics
Transcription
Gene expression
Multilayers

A new class of supramolecular ligands stabilizes 14-3-3 protein-protein interactions by up to two orders of magnitude

Gigante, A., Grad, J. N., Briels, J., Bartel, M., Hoffmann, D., Ottmann, C. & Schmuck, C., 1 Jan 2019, In : Chemical Communications. 55, 1, p. 111-114 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Neurodegenerative diseases
14-3-3 Proteins
Signal transduction
Ligands
Proteins

A novel hybrid silk-fibroin/polyurethane three-layered vascular graft: towards in situ tissue-engineered vascular accesses for haemodialysis

van Uden, S., Vanerio, N., Catto, V., Bonandrini, B., Tironi, M., Figliuzzi, M., Remuzzi, A., Kock, L., Redaelli, A. C. L., Greco, F. G. & Riboldi, S. A., 30 Jan 2019, In : Biomedical Materials. 14, 2, p. 025007 18 p.

Research output: Contribution to journalArticleAcademicpeer-review

Fibroins
Polyurethanes
Silk
Blood Vessels
Renal Dialysis

A stirring system using suspended magnetically-actuated pillars for controlled cell clustering

Saberi, A., Zhang, S., van den Bersselaar, C., Kandail, H., den Toonder, J. M. J. & Kurniawan, N. A., 1 Jan 2019, In : Soft Matter. 15, 6, p. 1435-1443 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

stirring
Magnetic scales
Colloids
Research laboratories
cells

A survey of crowdsourcing in medical image analysis

Ørting, S., Doyle, A., Hirth, M., van Hilten, A., Inel, O., Madan, C. R., Mavridis, P., Spiers, H. & Cheplygina, V., 25 Feb 2019, In : arXiv. 12 p., 1902.09159

Research output: Contribution to journalArticleAcademic

Open Access
File
Image analysis
Astrophysics
Medical imaging
Metadata
Learning algorithms

A value proposition for trough level-based anti-TNFα drug dosing

Scharnhorst, V., Schmitz, E. M. H., van de Kerkhof, D., Derijks, L. J. J. & Broeren, M. A. C., 1 Feb 2019, In : Clinica Chimica Acta. 489, p. 89-95 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Drug Monitoring
Pharmaceutical Preparations
Cost-Benefit Analysis
Therapeutics
Critical Pathways

A versatile protocol for studying anterior cruciate ligament reconstruction in a rabbit model

Hevesi, M., Crispim, J. F., Paggi, C. A., Dudakovic, A., van Genechten, W., Hewett, T., Kakar, S., Krych, A. J., van Wijnen, A. J. & Saris, D., 19 Mar 2019, In : Tissue Engineering Part C: Methods. 25, 4, p. 191-196 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Anterior Cruciate Ligament Reconstruction
Ligaments
Anterior Cruciate Ligament
Rabbits
Animal Care Committees

Benchmark on automatic 6-month-old infant brain segmentation algorithms: The iSeg-2017 Challenge

Wang, L., Nie, D., Li, G., Puybareau, E., Dolz, J., Zhang, Q., Wang, F., Xia, J., Wu, Z., Chen, J., Thung, K-H., Bui, T. D., Shin, J., Zeng, G., Zheng, G., Fonov, V. S., Doyle, A., Xu, Y., Moeskops, P., Pluim, J. P. W. & 9 othersDesrosiers, C., Ayed, I. B., Sanroma, G., Benkarim, O. M., Casamitjana, A., Vilaplana, V., Lin, W., Li, G. & Shen, D., 27 Feb 2019, In : IEEE Transactions on Medical Imaging.

Research output: Contribution to journalArticleAcademicpeer-review

Benchmarking
Brain
Magnetic resonance
Magnetic Resonance Spectroscopy
Cerebrospinal fluid

Biomorphic engineering of multifunctional polylactide stomatocytes toward therapeutic nano-red blood cells

Shao, J., Pijpers, I. A. B., Cao, S., Williams, D. S., Yan, X., Li, J., Abdelmohsen, L. K. E. A. & van Hest, J. C. M., 1 Jan 2019, (Accepted/In press) In : Advanced Science.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
erythrocytes
Blood
Erythrocytes
Cells
engineering
1 Citation (Scopus)

Carbon nanotube reinforced supramolecular hydrogels for bioapplications

Mihajlovic, M., Mihajlovic, M., Dankers, P. Y. W., Masereeuw, R. & Sijbesma, R. P., 1 Jan 2019, In : Macromolecular Bioscience. 19, 12 p., 1800173

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Carbon Nanotubes
Hydrogels
Nanocomposites
Carbon nanotubes
Hydrogel

Computational modelling of energy balance in individuals with Metabolic Syndrome

Rozendaal, Y., Wang, Y., Hilbers, P. & van Riel, N., 26 Feb 2019, In : BMC Systems Biology. 13, 24, 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Computational Modeling
Energy Balance
Energy balance
Energy Metabolism
Energy

Cooperativity basis for small-molecule stabilization of protein-protein interactions

de Vink, P. J., Andrei, S. A., Higuchi, Y., Ottmann, C., Milroy, L-G. & Brunsveld, L., 2019, In : Chemical Science. 10, 10, p. 2869-2874 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Stabilization
Molecules
Proteins
14-3-3 Proteins
Fluorescence
3 Citations (Scopus)

Cortical and trabecular bone microarchitecture as an independent predictor of incident fracture risk in older women and men in the Bone Microarchitecture International Consortium (BoMIC): a prospective study

Samelson, E. J., Broe, K. E., Xu, H., Yang, L., Boyd, S., Biver, E., Szulc, P., Adachi, J., Amin, S., Atkinson, E., Berger, C., Burt, L., Chapurlat, R., Chevalley, T., Ferrari, S., Goltzman, D., Hanley, D. A., Hannan, M. T., Khosla, S., Liu, C-T. & 13 othersLorentzon, M., Mellstrom, D., Merle, B., Nethander, M., Rizzoli, R., Sornay-Rendu, E., van Rietbergen, B., Sundh, D., Wong, A. K. O., Ohlsson, C., Demissie, S., Kiel, D. P. & Bouxsein, M. L., 1 Jan 2019, In : Lancet Diabetes & Endocrinology. 7, 1, p. 34-43 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Bone Density
Prospective Studies
Bone and Bones
Femur Neck
Tibia

Counterion dependent mechanisms of DNA origami nanostructure stabilization revealed by atomistic molecular simulation

Roodhuizen, J., Hendrikx, P. J. T. M., Hilbers, P. A. J., de Greef, T. & Markvoort, B., 2019, (Accepted/In press) In : ACS Nano.

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Development of morphologically discrete PEG-PDLLA nanotubes for precision nanomedicine

Wauters, A. C., Pijpers, I. A. B., Mason, A. F., Williams, D. S., Tel, J., Abdelmohsen, L. K. E. A. & van Hest, J. C. M., 1 Jan 2019, In : Biomacromolecules. 20, 1, p. 177-183

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Medical nanotechnology
Nanotubes
Polyethylene glycols
Particle interactions
Nanostructures

DNA-based communication in populations of synthetic protocells

Joesaar, A. H., Yang, S., Bögels, B. W. A., van der Linden, A. J., Pieters, P. A., Kumar, P., Dachau, N., Phillips, A., Mann, S. & de Greef, T. F. A., 1 Apr 2019, In : Nature Nanotechnology. 14, p. 369-378

Research output: Contribution to journalArticleAcademicpeer-review

DNA
deoxyribonucleic acid
communication
Communication
Networks (circuits)
2 Citations (Scopus)

Epileptic seizure detection in EEG signals using sparse multiscale radial basis function networks and the Fisher vector approach

Li, Y., Cui, W. G., Huang, H., Guo, Y. Z., Li, K. & Tan, T., 15 Jan 2019, In : Knowledge-Based Systems. 164, p. 96-106

Research output: Contribution to journalArticleAcademicpeer-review

Radial basis function networks
Electroencephalography
Statistical tests
Model structures
Particle swarm optimization (PSO)
1 Citation (Scopus)

Fourier transform on the homogeneous space of 3D positions and orientations for exact solutions to linear PDEs

Duits, R., Bekkers, E. J. & Mashtakov, A., 8 Jan 2019, In : Entropy. 21, 1, 38 p., 38

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
pulse detonation engines
quotients
rigid structures
robotics
image analysis

Identification of topographical architectures supporting the phenotype of rat tenocytes

Vermeulen, S., Vasilevich, A., Tsiapalis, D., Roumans, N., Vroemen, P., Beijer, N. R. M., Dede Eren, A., Zeugolis, D. & de Boer, J., 1 Jan 2019, In : Acta Biomaterialia. 83, p. 277-290 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Topography
Rats
Tendons
Phenotype
Screening

Impairment of cyclo-oxygenase-2 function results in abnormal growth plate development and bone microarchitecture but does not affect longitudinal growth of the long bones in skeletally immature mice

Caron, M. M. J., Castermans, T. M. R., van Rietbergen, B., Haartmans, M. J. J., van Rhijn, L. W., Witlox, A. M. A. & Welting, T. J. M., 1 Jan 2019, In : Cartilage.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Celecoxib
Growth Plate
Bone Development
Prostaglandin-Endoperoxide Synthases
Growth and Development

Including surrounding tissue improves ultrasound-based 3D mechanical characterization of abdominal aortic aneurysms

Petterson, N. J., van Disseldorp, E. M. J., van Sambeek, M. R. H. M., van de Vosse, F. N. & Lopata, R. G. P., 6 Mar 2019, In : Journal of Biomechanics. 85, p. 126-133

Research output: Contribution to journalArticleAcademicpeer-review

Abdominal Aortic Aneurysm
Spine
Ultrasonics
Tissue
Aorta

Increased cell traction-induced prestress in dynamically cultured microtissues

van Kelle, M. A. J., Khalil, N., Foolen, J., Loerakker, S. & Bouten, C. V. C., 12 Mar 2019, In : Frontiers in Bioengineering and Biotechnology. 7, 11 p., 41

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File

Insights into the kinetics of supramolecular copolymerization in water

Lafleur, R., Schoenmakers, S., Madhikar, P., Bochicchio, D., Baumeier, B., Palmans, A., Pavan, G. & Meijer, B., 2019, (Accepted/In press) In : Macromolecules.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Copolymerization
Polymers
Kinetics
Water
Monomers

In vitro test-retest repeatability of invasive physiological indices to assess coronary flow

Picard, F., Alansari, O., Mogi, S., van 't Veer, M., Varenne, O. & Adjedj, J., 6 Mar 2019, In : Catheterization and Cardiovascular Interventions.

Research output: Contribution to journalArticleAcademicpeer-review

Reproducibility of Results
Blood Vessels
Pathologic Constriction
Catheters
In Vitro Techniques

Maternal hemoglobin level and its relation to fetal distress, mode of delivery, and short-term neonatal outcome: a retrospective cohort study

Bullens, L. M., Smith, J. S., Truijens, S. E. M., van der Hout-van der Jagt, M. B., van Runnard Heimel, P. J. & Oei, S. G., 31 Jan 2019, In : Journal of Maternal-Fetal and Neonatal Medicine. p. 1-7 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Fetal Distress
Hemoglobins
Cohort Studies
Retrospective Studies
Mothers
Open Access
File
Micellization
Surface-Active Agents
self consistent fields
Surface active agents
Salts

Micro-scaled topographies direct differentiation of human epidermal stem cells

Zijl, S., Vasilevich, A. S., Viswanathan, P., Helling, A. L., Beijer, N. R. M., Walko, G., Chiappini, C., de Boer, J. & Watt, F. M., 15 Jan 2019, In : Acta Biomaterialia. 84, p. 133-145 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
1 Citation (Scopus)

Mimicking active biopolymer networks with a synthetic hydrogel

Fernández-Castano Romera, M., Göstl, R., Shaikh, H., ter Huurne, G., Schill, J., Voets, I. K., Storm, C. & Sijbesma, R. P., 6 Feb 2019, In : Journal of the American Chemical Society. 141, 5, p. 1989-1997 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Biopolymers
Hydrogel
Hydrogels
Collagen
Residual stresses

Multivalency in a dendritic host-guest system

Smeijers, A. F., Pieterse, K., Hilbers, P. A. J. & Markvoort, A. J., 9 Apr 2019, In : Macromolecules. 52, 7, p. 2778-2788 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Dendrimers
Supramolecular chemistry
Binding sites
Urea
Self assembly

Nanoimmunotherapy to treat ischaemic heart disease

Duivenvoorden, R., Senders, M. L., van Leent, M. M. T., Pérez-Medina, C., Nahrendorf, M., Fayad, Z. A. & Mulder, W. J. M., 2019, In : Nature Reviews. Cardiology. 16, p. 21-32

Research output: Contribution to journalArticleAcademicpeer-review

Myocardial Ischemia
Atherosclerosis
Inflammation
Lipids
Recurrence

On the relationship between dynamic contrast-enhanced ultrasound parameters and the underlying vascular architecture extracted from acoustic angiography

Panfilova, A., Shelton, S. E., Caresio, C., van Sloun, R. J. G., Molinari, F., Wijkstra, H., Dayton, P. A. & Mischi, M., Feb 2019, In : Ultrasound in Medicine and Biology. 45, 2, p. 539-548

Research output: Contribution to journalArticleAcademicpeer-review

angiography
Acoustics
Blood Vessels
Angiography
Perfusion

Optimized ChIP-seq method facilitates transcription factor profiling in human tumors

Singh, A. A., Schuurman, K., Nevedomskaya, E., Stelloo, S., Linder, S., Droog, M., Kim, Y., Sanders, J., van der Poel, H., Bergman, A. M., Wessels, L. F. A. & Zwart, W., 1 Jan 2019, In : Life Science Alliance. 2, 1, 12 p., e201800115

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Chromatin Immunoprecipitation
tumor
Chromatin
chromatin
Tumors

Predicting breast tumor proliferation from whole-slide images: The TUPAC16 challenge

Veta, M., Heng, Y. J., Stathonikos, N., Bejnordi, B. E., Beca, F., Wollmann, T., Rohr, K., Shah, M. A., Wang, D., Rousson, M., Hedlund, M., Tellez, D., Ciompi, F., Zerhouni, E., Lanyi, D., Viana, M., Kovalev, V., Liauchuk, V., Phoulady, H. A., Qaiser, T. & 13 othersGraham, S., Rajpoot, N., Sjöblom, E., Molin, J., Paeng, K., Hwang, S., Park, S., Jia, Z., Chang, E. I-C., Xu, Y., Beck, A. H., van Diest, P. J. & Pluim, J. P. W., 27 Feb 2019, In : Medical Image Analysis. 54, p. 111-121 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Tumors
Breast Neoplasms
Neoplasms
Mitosis
Image analysis

Prospective follow-Up of cortical interruptions, bone density, and micro-structure detected on HR-pQCT: A study in patients with rheumatoid arthritis and healthy subjects

Peters, M., van den Bergh, J. P., Geusens, P., Scharmga, A., Loeffen, D., Weijers, R., van Rietbergen, B. & van Tubergen, A., 1 Feb 2019, In : Calcified Tissue International.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Bone Density
Antirheumatic Agents
Rheumatoid Arthritis
Healthy Volunteers
Tomography
2 Citations (Scopus)
Vascular Stiffness
Abdominal Aortic Aneurysm
Healthy Volunteers
Volunteers
Aortic Rupture

Quantifying guest–host dynamics in supramolecular assemblies to analyze their robustness

Bastings, M. M. C., Hermans, T. M., Spiering, A. J. H., Kemps, E. W. L., Albertazzi, L., Kurisinkal, E. E. & Dankers, P. Y. W., 1 Jan 2019, In : Macromolecular Bioscience. 19, 1, 11 p., 1800296

Research output: Contribution to journalArticleAcademicpeer-review

Pyrimidinones
Fluorescence Recovery After Photobleaching
Photobleaching
Fluorescence Resonance Energy Transfer
Microfluidics

Reducing distortions in echo-planar breast imaging at ultrahigh field with high-resolution off-resonance maps

van Rijssel, M. J., Zijlstra, F., Seevinck, P. R., Luijten, P. R., Gilhuijs, K. G. A., Klomp, D. W. J. & Pluim, J. P. W., 1 Mar 2019, In : Magnetic Resonance in Medicine.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Echo-Planar Imaging
Breast
Nonparametric Statistics
Artifacts
Healthy Volunteers

RegressionExplorer: Interactive exploration of logistic regression models with subgroup analysis

Dingen, D., van 't Veer, M., Houthuizen, P., Mestrom, E. H. J., Korsten, E. H. H. M., Bouwman, A. R. A. & van Wijk, J., 1 Jan 2019, In : IEEE Transactions on Visualization and Computer Graphics. 25, 1, p. 246-255 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Logistics

Renal epithelial monolayer formation on monomeric and polymeric catechol functionalized supramolecular biomaterials

van Gaal, R. C., Fedecostante, M., Fransen, P. P. K. H., Masereeuw, R. & Dankers, P. Y. W., 2019, In : Macromolecular Bioscience. 19, 2, 7 p., 1800300

Research output: Contribution to journalArticleAcademicpeer-review

Pyrimidinones
Biocompatible Materials
Biomaterials
Catechols
Monolayers

Robust non-rigid motion compensation of free-breathing myocardial perfusion MRI data

Scannell, C. M., Villa, A. D. M., Lee, J., Breeuwer, M. & Chiribiri, A., 1 Feb 2019, In : IEEE Transactions on Medical Imaging.

Research output: Contribution to journalArticleAcademicpeer-review

Motion compensation
Magnetic Resonance Angiography
Magnetic resonance
Compensation and Redress
Respiration

Site-directed fragment-based screening for the discovery of protein-protein interaction stabilizers

Sijbesma, E., Hallenbeck, K. K., Leysen, S., de Vink, P. J., Skóra, L., Jahnke, W., Brunsveld, L., Arkin, M. R. & Ottmann, C., 27 Feb 2019, In : Journal of the American Chemical Society. 141, 8, p. 3524–3531 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Screening
Proteins
Estrogen Receptor alpha
Stabilization
Phosphorylation

Structural connectivity analysis using Finsler geometry

Dela Haije, T., Savadjiev, P., Fuster, A., Schultz, R. T., Verma, R., Florack, L. & Westin, C-F., 2019, In : SIAM Journal on Imaging Sciences. 12, 1, p. 551-575

Research output: Contribution to journalArticleAcademicpeer-review

Super-resolution microscopy reveals significant impact of M2e-specific monoclonal antibodies on influenza A virus filament formation at the host cell surface

Kolpe, A., Arista-Romero, M., Schepens, B., Pujals, S., Saelens, X. & Albertazzi, L., 1 Dec 2019, In : Scientific Reports. 9, 1, 4450

Research output: Contribution to journalArticleAcademicpeer-review

Influenza A virus
Microscopy
Monoclonal Antibodies
Virus Replication
Viruses
antifouling
Scaffolds
Adhesives
adhesives
casts

Tetrazine - trans-cyclooctene chemistry applied to fabricate self-assembled fluorescent and radioactive nanoparticles for in vivo dual mode imaging

van Onzen, A. H. A. M., Rossin, R., Schenning, A. P. H. J., Nicolay, K., Milroy, L. G., Robillard, M. S. & Brunsveld, L., 1 Jan 2019, In : Bioconjugate Chemistry. 30, 3, p. 547–551 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Nanoparticles
Imaging techniques
Molecules
Multimodal Imaging
Radioactivity

The dual-mode dipole: A new array element for 7T body imaging with reduced SAR

Solomakha, G., Leeuwen, C. V., Raaijmakers, A., Simovski, C., Popugaev, A., Abdeddaim, R., Melchakova, I. & Glybovski, S., 1 Feb 2019, In : Magnetic Resonance in Medicine. 81, 2, p. 1459-1469

Research output: Contribution to journalArticleAcademicpeer-review

Prostate
Volunteers
Open Access
File
Pathologic Constriction
Geometry
Hydrodynamics
Uncertainty
Dynamic models
Open Access
Finite Element Analysis