Department of Biomedical Engineering

Research Output 1962 2020

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Article
2020

A metamodeling approach for instant severity assessment and uncertainty quantification of iliac artery stenoses

Heinen, S. G. H., Gashi, K., van den Heuvel, D. A. F., de Vries, J. P. P. M., van de Vosse, F. N., Delhaas, T. & Huberts, W., 1 Jan 2020, In : Journal of Biomechanical Engineering. 142, 1, 8 p., 011010

Research output: Contribution to journalArticleAcademicpeer-review

Iliac Artery
Uncertainty
Pathologic Constriction
Pressure drop
Pressure
2019

Accelerating implant RF safety assessment using a low-rank inverse update method

Stijnman, P. R. S., Tokaya, J. P., van Gemert, J., Luijten, P. R., Pluim, J. P. W., Brink, W. M., Remis, R. F., van den Berg, C. A. T. & Raaijmakers, A. J. E., 30 Sep 2019, In : Magnetic Resonance in Medicine.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Radio
Safety
Magnetic Fields
Heating
Libraries

A comparative study of geometry-based methods and intra-arterial pressure measurements to assess the hemodynamic significance of equivocal iliac artery stenoses

Heinen, S. G. H., Huberts, W., van den Heuvel, D. A. F., van de Vosse, F. N., de Vries, J. P. P. M. & Delhaas, T., 1 Apr 2019, In : Vascular. 27, 2, p. 119-127 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Iliac Artery
Arterial Pressure
Pathologic Constriction
Hemodynamics
Blood Vessels

A computational model of postprandial adipose tissue lipid metabolism derived using human arteriovenous stable isotope tracer data

O'Donovan, S. D., Lenz, M., Vink, R. G., Roumans, N. J. T., de Kok, T. M. C. M., Mariman, E. C. M., Peeters, R. L. M., van Riel, N. A. W., van Baak, M. A. & Arts, I. C. W., 3 Oct 2019, In : PLoS Computational Biology. 15, 10, 23 p., e1007400

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Lipid Metabolism
Radioactive tracers
isotope labeling
Isotopes
lipid metabolism

A computational model to predict cell traction-mediated prestretch in the mitral valve

van Kelle, M. A. J., Rausch, M. K., Kuhl, E. & Loerakker, S., 2019, In : Computer Methods in Biomechanics and Biomedical Engineering. 22, 15, p. 1174-1185

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Tissue
Actins
Structural properties
Anisotropy
Fibers
1 Citation (Scopus)

A CRISPR-Cas9 screen identifies essential CTCF anchor sites for estrogen receptor-driven breast cancer cell proliferation

Korkmaz, G., Manber, Z., Lopes, R., Prekovic, S., Schuurman, K., Kim, Y., Teunissen, H., Flach, K., Wit, E. D., Galli, G. G., Zwart, W., Elkon, R. & Agami, R., 10 Oct 2019, In : Nucleic Acids Research. 47, 18, p. 9557-9572 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Clustered Regularly Interspaced Short Palindromic Repeats
Estrogen Receptor alpha
Estrogen Receptors
Cell Proliferation
Breast Neoplasms

Adaptive polymeric assemblies for applications in biomimicry and nanomedicine

Altay, Y., Che, H., Cao, S., Abdelmohsen, L. & van Hest, J., 23 Oct 2019, In : Biomacromolecules. 20, 11, p. 4053-4064 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Medical nanotechnology
Nanostructured materials
Self assembly
Intelligent networks
Complex networks

Adaptive polymersome nanoreactors

Che, H. & van Hest, J. C. M., 1 Sep 2019, In : ChemNanoMat. 5, 9, p. 1092-1109

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Nanoreactors
Medical nanotechnology
Adaptive systems

A deep learning method for image-based subject-specific local SAR assessment

Meliadò, E. F., Raaijmakers, A. J. E., Sbrizzi, A., Steensma, B. R., Maspero, M., Savenije, M. H. F., Luijten, P. R. & van den Berg, C. A. T., 1 Nov 2019, In : Magnetic Resonance in Medicine. 83, 2, p. 695-711

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Learning
Computer Simulation
Safety
Uncertainty
Prostate

Adherence to dabigatran etexilate in atrial fibrillation patients intended to undergo electrical cardioversion

Comuth, W. J., de Maat, M. P. M., van de Kerkhof, D., Malczynski, J., Husted, S., Kristensen, S. D. & Münster, A. M. B., 1 Apr 2019, In : European Heart Journal - Cardiovascular Pharmacotherapy. 5, 2, p. 91-99 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Electric Countershock
Atrial Fibrillation
Medication Adherence
Therapeutics
Dabigatran

A DNA-based synthetic apoptosome

Rosier, B., Markvoort, B., Gumi Audenis, B., Roodhuizen, J., Brunsveld, L. & de Greef, T. F. A., 2019, (Accepted/In press) In : Nature Catalysis.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Apoptosomes
Caspase 9
DNA
Proteins
Enzymes

A geometry-based model for non-invasive estimation of pressure gradients over iliac artery stenoses

Heinen, S. G. H., van den Heuvel, D. A. F., de Vries, J. P. P. M., van de Vosse, F. N., Delhaas, T. & Huberts, W., 19 Jul 2019, In : Journal of Biomechanics. 92, p. 67-75

Research output: Contribution to journalArticleAcademicpeer-review

Iliac Artery
Pressure gradient
Pathologic Constriction
Angiography
Pressure

Alendronate-functionalized poly(2-oxazoline)s with tunable affinity for calcium cations

Sánchez-Fernández, M. J., Immers, M. R., Félix Lanao, R. P., Yang, F., Bender, J. C. M. E., Mecinović, J., Leeuwenburgh, S. C. G. & van Hest, J. C. M., 1 Jan 2019, In : Biomacromolecules. 20, 8, p. 2913-2921 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Alendronate
Cations
Calcium
Polymers
Positive ions
3 Citations (Scopus)

Allosteric small molecule modulators of nuclear receptors

Meijer, F. A., Leijten-van de Gevel, I. A., de Vries, R. M. J. M. & Brunsveld, L., 1 Apr 2019, In : Molecular and Cellular Endocrinology. 485, p. 20-34 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Cytoplasmic and Nuclear Receptors
Allosteric Site
Ligands
Drug Discovery
Pathology
Open Access
File
Intravenous Administration
Theoretical Models
Clinical Decision Support Systems
Mathematical models
Fluids

AMPK and AKT protein kinases hierarchically phosphorylate the N-terminus of the FOXO1 transcription factor, modulating interactions with 14-3-3 proteins

Saline, M., Badertscher, L., Wolter, M., Lau, R., Gunnarsson, A., Jacso, T., Norris, T., Ottmann, C. & Snijder, A., 1 Jan 2019, In : Journal of Biological Chemistry. 294, 35, p. 13106-13116 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

14-3-3 Proteins
Phosphorylation
AMP-Activated Protein Kinases
Protein Kinases
Transcription Factors

A multicenter evaluation of a point of care CRP Test

Scharnhorst, V., Noordzij, P. G., Lutz, A., Graser, U., Püntener, D. & Alquézar-Arbé, A., 1 Sep 2019, In : Clinical Biochemistry. 71, Sept 2019, p. 38-45

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Point-of-Care Systems
C-Reactive Protein
Blood
Serum
Plasmas

A multilayer microfluidic platform for the conduction of prolonged cell-free gene expression

van der Linden, A., Pieters, P., Yelleswarapu, M., Swank, Z., Huck, W. T. S., Maerkl, S. & de Greef, T., 1 Oct 2019, In : Journal of Visualized Experiments (JoVE). 152, 14 p., e59655

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Lab-On-A-Chip Devices
Microfluidics
Transcription
Gene expression
Multilayers
Open Access
Tissue Scaffolds
Tissue Engineering
Scaffold
Microfluidics
Fluidics
3 Citations (Scopus)

Analysis of chemical exchange saturation transfer contributions from brain metabolites to the Z-spectra at various field strengths and pH

Khlebnikov, V., van der Kemp, W. J. M., Hoogduin, H., Klomp, D. W. J. & Prompers, J. J., 31 Jan 2019, In : Scientific Reports. 9, 11 p., 1089

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
1 Citation (Scopus)

An aptamer-based new method for competitive fluorescence detection of exosomes

Yu, X., He, L., Pentok, M., Yang, H., Yang, Y., Li, Z., He, N., Deng, Y., Li, S., Liu, T., Chen, X. & Luo, H., 7 Sep 2019, In : Nanoscale. 11, 33, p. 15589-15595 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Fluorescence
Biomarkers
Costs
Cells
Proteins
1 Citation (Scopus)

A new class of supramolecular ligands stabilizes 14-3-3 protein-protein interactions by up to two orders of magnitude

Gigante, A., Grad, J. N., Briels, J., Bartel, M., Hoffmann, D., Ottmann, C. & Schmuck, C., 1 Jan 2019, In : Chemical Communications. 55, 1, p. 111-114 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Neurodegenerative diseases
14-3-3 Proteins
Signal transduction
Ligands
Proteins

An isolated beating pig heart platform for a comprehensive evaluation of intracardiac blood flow with 4D flow MRI: a feasibility study

Peper, E. S., Leopaldi, A. M., van Tuijl, S., Coolen, B. F., Strijkers, G. J., Baan, J., Planken, R. N., de Weger, A., Nederveen, A. J., Marquering, H. A. & van Ooij, P., 1 Dec 2019, In : European Radiology Experimental. 3, 1, 10 p., 40

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Feasibility Studies
Swine
Magnetic Resonance Imaging
Cardiac Output
Abattoirs

An iterative sparse deconvolution method for simultaneous multicolor 19F-MRI of multiple contrast agents

Schoormans, J., Calcagno, C., Daal, M. R. R., Wüst, R. C. I., Faries, C., Maier, A., Teunissen, A. J. P., Naidu, S., Sanchez-Gaytan, B. L., Nederveen, A. J., Fayad, Z. A., Mulder, W. J. M., Coolen, B. F. & Strijkers, G. J., 10 Jul 2019, In : Magnetic Resonance in Medicine. 83, 1, p. 228-239

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Contrast Media
Artifacts
Fluorine
Noise
Cell Tracking
1 Citation (Scopus)

A novel hybrid silk-fibroin/polyurethane three-layered vascular graft: Towards in situ tissue-engineered vascular accesses for haemodialysis

van Uden, S., Vanerio, N., Catto, V., Bonandrini, B., Tironi, M., Figliuzzi, M., Remuzzi, A., Kock, L., Redaelli, A. C. L., Greco, F. G. & Riboldi, S. A., 1 Mar 2019, In : Biomedical Materials. 14, 2, p. 025007 18 p., 025007

Research output: Contribution to journalArticleAcademicpeer-review

Fibroins
Polyurethanes
Silk
Grafts
Tissue

A pipette-tip based method for seeding cells to droplet microfluidic platforms

Sinha, N., Subedi, N., Wimmers, F., Soennichsen, M. & Tel, J., 11 Feb 2019, In : Journal of Visualized Experiments (JoVE). 144, 10 p., e57848

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Cloud seeding
Microfluidics
Encapsulation
Poisson distribution
Poisson Distribution
Hypothermia
Myocardial Infarction
Temperature
Myocardial Reperfusion
Myocardium

A protocol update of the fractional flow reserve versus angiography for multivessel evaluation (FAME) 3 trial: a comparison of fractional flow reserve–guided percutaneous coronary intervention and coronary artery bypass graft surgery in patients with multivessel coronary artery disease

Zimmermann, F. M., de Bruyne, B., Pijls, N. H. J., Desai, M., Oldroyd, K. G., Reardon, M. J., Wendler, O., Woo, J., Yeung, A. C. & Fearon, W. F., 1 Aug 2019, In : American Heart Journal. 214, p. 156-157 2 p.

Research output: Contribution to journalArticleAcademicpeer-review

A revised modular approach to (–)-trans-Δ 8 -THC and derivatives through late-stage Suzuki–Miyaura cross-coupling reactions

Bloemendal, V. R. L. J., Sondag, D., Elferink, H., Boltje, T. J., van Hest, J. C. M. & Rutjes, F. P. J. T., 31 Mar 2019, In : European Journal of Organic Chemistry. 2019, 12, p. 2289-2296 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
thermohaline circulation
Dronabinol
cross coupling
Derivatives
Scaffolds
1 Citation (Scopus)

Arginine mimetic appended peptide-based probes for fluorescence turn-on detection of 14-3-3 proteins

Maity, D., Gigante, A., Sánchez-Murcia, P. A., Sijbesma, E., Li, M., Bier, D., Mosel, S., Knauer, S., Ottmann, C. & Schmuck, C., 2 Apr 2019, In : Organic & Biomolecular Chemistry. 17, 17, p. 4359-4363 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

14-3-3 Proteins
peptides
Arginine
Fluorescence
proteins

A robust and general approach to quantitatively conjugate enzymes to plasmonic nanoparticles

Wang, Y., van Asdonk, K. & Zijlstra, P., 23 Sep 2019, In : Langmuir. 35, 41, p. 13356−13363 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
enzymes
Enzymes
Nanoparticles
proteins
Proteins

Association of improvement in fractional flow reserve with outcomes, including symptomatic relief, after percutaneous coronary intervention

Fournier, S., Ciccarelli, G., Toth, G. G., Milkas, A., Xaplanteris, P., Tonino, P. A. L., Fearon, W. F., Pijls, N. H. J., Barbato, E. & de Bruyne, B., 1 Apr 2019, In : JAMA Cardiology. 4, 4, p. 370-374 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Percutaneous Coronary Intervention
Angiography
Coronary Artery Disease
Randomized Controlled Trials
North America

A stirring system using suspended magnetically-actuated pillars for controlled cell clustering

Saberi, A., Zhang, S., van den Bersselaar, C., Kandail, H., den Toonder, J. M. J. & Kurniawan, N. A., 1 Jan 2019, In : Soft Matter. 15, 6, p. 1435-1443 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
stirring
Magnetic scales
Colloids
Research laboratories
cells
4 Citations (Scopus)

A stochastic view on surface inhomogeneity of nanoparticles

Post, R. A. J., van der Zwaag, D., Bet, G., Wijnands, S. P. W., Albertazzi, L., Meijer, E. W. & van der Hofstad, R. W., 10 Apr 2019, In : Nature Communications. 10, 1, 11 p., 1663

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Nanoparticles
inhomogeneity
nanoparticles
Microscopy
Microscopic examination
Open Access
File
Biocompatible Materials
Pyrimidinones
Proteins
Notch1 Receptor
Click Chemistry

A survey of crowdsourcing in medical image analysis

Ørting, S., Doyle, A., Hirth, M., van Hilten, A., Inel, O., Madan, C. R., Mavridis, P., Spiers, H. & Cheplygina, V., 25 Feb 2019, In : arXiv. 12 p., 1902.09159

Research output: Contribution to journalArticleAcademic

Open Access
File
Image analysis
Astrophysics
Medical imaging
Metadata
Learning algorithms

Atherosclerotic carotid bifurcation phantoms with stenotic soft inclusions for ultrasound flow and vessel wall elastography imaging

Chayer, B., van den Hoven, M., Roy Cardinal, M. H., Li, H., Swillens, A., Lopata, R. & Cloutier, G., 2 May 2019, In : Physics in Medicine and Biology. 64, 9, 12 p., 095025

Research output: Contribution to journalArticleAcademicpeer-review

Elasticity Imaging Techniques
Blood Vessels
Elastic Modulus
Internal Carotid Artery
Atherosclerotic Plaques
1 Citation (Scopus)

ATP-mediated transient behavior of stomatocyte nanosystems

Che, H., Zhu, J., Song, S., Mason, A. F., Cao, S., Pijpers, I. A. B., Abdelmohsen, L. K. E. A. & van Hest, J. C. M., 2 Jul 2019, In : Angewandte Chemie - International Edition. 58, 37, p. 13113-13118

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Nanosystems
Adenosine Triphosphate
Polylysine
Nanoreactors
Molecular interactions

Attenuated cardiac function degradation in ex vivo pig hearts

Kappler, B., van Tuijl, S., Ergin, B., Fixsen, L., Stijnen, M., Ince, C. & de Mol, B. A. J. M., 17 Oct 2019, In : International Journal of Artificial Organs.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Blood
Swine
Degradation
Dialysis
Renal Dialysis

Automated clear cell renal carcinoma grade classification with prognostic significance

Tian, K., Rubadue, C. A., Lin, D. I., Veta, M., Pyle, M. E., Irshad, H. & Heng, Y. J., 1 Jan 2019, In : PLoS ONE. 14, 10, 16 p., e0222641

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
kidney cells
Renal Cell Carcinoma
carcinoma
Atlases
Hazards

Automatic classification of focal liver lesions based on MRI and risk factors

Jansen, M. J. A., Kuijf, H. J., Veldhuis, W. B., Wessels, F. J., Viergever, M. A. & Pluim, J. P. W., 2019, In : PLoS ONE. 14, 5, 13 p., e0217053

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
lesions (animal)
Liver
Magnetic resonance imaging
risk factors
liver

A value proposition for through level-based anti-TNFα drug dosing

Scharnhorst, V., Schmitz, E. M. H., van de Kerkhof, D., Derijks, L. J. J. & Broeren, M. A. C., 1 Feb 2019, In : Clinica Chimica Acta. 489, p. 89-95 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Drug Monitoring
Pharmaceutical Preparations
Cost-Benefit Analysis
Therapeutics
Critical Pathways

A versatile protocol for studying anterior cruciate ligament reconstruction in a rabbit model

Hevesi, M., Crispim, J. F., Paggi, C. A., Dudakovic, A., van Genechten, W., Hewett, T., Kakar, S., Krych, A. J., van Wijnen, A. J. & Saris, D., 19 Mar 2019, In : Tissue Engineering. Part C: Methods. 25, 4, p. 191-196 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Anterior Cruciate Ligament Reconstruction
Ligaments
Anterior Cruciate Ligament
Rabbits
Animal Care Committees

Benchmark on automatic 6-month-old infant brain segmentation algorithms: The iSeg-2017 Challenge

Wang, L., Nie, D., Li, G., Puybareau, E., Dolz, J., Zhang, Q., Wang, F., Xia, J., Wu, Z., Chen, J., Thung, K-H., Bui, T. D., Shin, J., Zeng, G., Zheng, G., Fonov, V. S., Doyle, A., Xu, Y., Moeskops, P., Pluim, J. P. W. & 9 othersDesrosiers, C., Ayed, I. B., Sanroma, G., Benkarim, O. M., Casamitjana, A., Vilaplana, V., Lin, W., Li, G. & Shen, D., 27 Feb 2019, In : IEEE Transactions on Medical Imaging. 38, 9, p. 2219-2230

Research output: Contribution to journalArticleAcademicpeer-review

Benchmarking
Brain
Magnetic resonance
Magnetic Resonance Spectroscopy
Cerebrospinal fluid
2 Citations (Scopus)

Bi-layered micro-fibre reinforced hydrogels for articular cartilage regeneration

Castilho, M., Mouser, V., Chen, M., Malda, J. & Ito, K., 1 Sep 2019, In : Acta Biomaterialia. 95, Sept 2019, p. 297-306

Research output: Contribution to journalArticleAcademicpeer-review

Hydrogels
Cartilage
Articular Cartilage
Regeneration
Fibers
2 Citations (Scopus)

Biomedical applications of photo- and sono-activated Rose Bengal: a review

Vanerio, N., Stijnen, M., de Mol, B. A. J. M. & Kock, L. M., 1 Jul 2019, In : Photobiomodulation, Photomedicine, and Laser Surgery. 37, 7, p. 383-394 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Rose Bengal
Oncology
Xanthenes
Photodynamic therapy
Oxygen
3 Citations (Scopus)

Biomorphic engineering of multifunctional polylactide stomatocytes toward therapeutic nano-red blood cells

Shao, J., Pijpers, I. A. B., Cao, S., Williams, D. S., Yan, X., Li, J., Abdelmohsen, L. K. E. A. & van Hest, J. C. M., 1 Jan 2019, In : Advanced Science. 6, 5, 8 p., 1801678

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
erythrocytes
Blood
Erythrocytes
Cells
engineering

Bone microarchitecture and distal radius fracture pattern complexity

Daniels, A. M., Theelen, L. M. A., Wyers, C. E., Janzing, H. M. J., van Rietbergen, B., Vranken, L., van der Velde, R. Y., Geusens, P. P. M. M., Kaarsemaker, S., Poeze, M. & van den Bergh, J. P., 10 Jul 2019, In : Journal of Orthopaedic Research. 37, 8, p. 1690-1697

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Radius Fractures
Bone Density
Bone and Bones
Joints
Odds Ratio
9 Citations (Scopus)

Carbon nanotube reinforced supramolecular hydrogels for bioapplications

Mihajlovic, M., Mihajlovic, M., Dankers, P. Y. W., Masereeuw, R. & Sijbesma, R. P., 1 Jan 2019, In : Macromolecular Bioscience. 19, 12 p., 1800173

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Carbon Nanotubes
Hydrogels
Nanocomposites
Carbon nanotubes
Hydrogel

Cardiomyocyte contractile force changes in response to AGRWE detected by AFM

Qu, Y. M., Zhao, F., Wang, X., Liu, J., Li, J., Song, Z. & Wang, Z., 2 May 2019, In : Micro & Nano Letters. 14, 5, p. 511-514 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

atomic force microscopy
Water
water
synchronism
heart rate