Department of Biomedical Engineering

Research Output 1962 2019

2018

Mechanical properties of bioactive glasses

van Gestel, N. A. P., Gabriels, F., van Rietbergen, B., Arts, J. J. C. & Hofmann, S., 2018, Bioactive glasses: materials, properties and applications. Ylänen, H. (ed.). 2nd ed. Kidlington: Woodhead, p. 87-102 (Woodhead publishing series in biomaterials)

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Bioactive glass
Mechanical properties
Mechanical testing
Tissue

Mechanics of growth and remodeling in native and engineered cardiovascular tissues

Oomen, P. J. A., 15 Oct 2018, Eindhoven: Technische Universiteit Eindhoven. 144 p.

Research output: ThesisPhd Thesis 1 (Research TU/e / Graduation TU/e)Academic

Open Access
File
Mechanics
Growth
3 Citations (Scopus)

Mechanobiology of the cell–matrix interplay: catching a glimpse of complexity via minimalistic models

Kurniawan, N. A. & Bouten, C. V. C., 1 Apr 2018, In : Extreme Mechanics Letters. 20, p. 59-64 6 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
File
Tissue
Tissue regeneration
Biomechanics
Biocompatible Materials
Biomaterials
4 Citations (Scopus)

Mechanosensitivity of Jagged–Notch signaling can induce a switch-type behavior in vascular homeostasis

Loerakker, S., Stassen, O. M. J. A., ter Huurne, F. M., Boareto, M., Bouten, C. V. C. & Sahlgren, C. M., 17 Apr 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 16, p. E3682-E3691 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Blood Vessels
Homeostasis
Vascular Smooth Muscle
Smooth Muscle Myocytes
Hemodynamics
1 Citation (Scopus)

MEG-guided analysis of 7T-MRI in patients with epilepsy

Colon, A. J., van Osch, M. J. P., Buijs, M., van de Grond, J., Hillebrand, A., Schijns, O., Wagner, G. J., Ossenblok, P., Hofman, P., Buchem, M. A. V. & Boon, P., 1 Aug 2018, In : Seizure. 60, p. 29-38 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Epilepsy
Partial Epilepsy
3 Citations (Scopus)

Melt electrowriting allows tailored microstructural and mechanical design of scaffolds to advance functional human myocardial tissue formation

Castilho, M., van Mil, A., Maher, M., Metz, C. H. G., Hochleitner, G., Groll, J., Doevendans, P. A., Ito, K., Sluijter, J. P. G. & Malda, J., 13 Aug 2018, In : Advanced Functional Materials. 28, 40, 10 p., 1803151

Research output: Contribution to journalArticleAcademicpeer-review

Scaffolds
stem cells
Tissue
Stem cells
fibers
5 Citations (Scopus)

Mesoscale substrate curvature overrules nanoscale contact guidance to direct bone marrow stromal cell migration

Werner, M., Kurniawan, N. A., Korus, G., Bouten, C. V. C. & Petersen, A., 8 Aug 2018, In : Journal of Royal Society Interface. 15, 145, 20180162

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Mesenchymal Stromal Cells
Cell Movement
Bone
Cues
Collagen

Metal ion-induced self-assembly and packaging of CCMV nanocapsules

Schoonen, L., van Eldijk, M. B. & van Hest, J. C. M., 5 Jun 2018, Protein scaffolds: design, synthesis, and applications. Udit, A. K. (ed.). Dordrecht: Springer, p. 57-67 11 p. (Methods in Molecular Biology; vol. 1798)

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Nanocapsules
His-His-His-His-His-His
Capsid Proteins
Viral Proteins
Product Packaging
12 Citations (Scopus)

Metastasis in context: modeling the tumor microenvironment with cancer-on-a-chip approaches

Sleeboom, J. J. F., Amirabadi, H. E., Nair, P., Sahlgren, C. M. & Den Toonder, J. M. J., 1 Mar 2018, In : Disease Models & Mechanisms. 11, 3, 033100

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
File
Tumor Microenvironment
Tumors
Neoplasm Metastasis
Neoplasms
Mechanics

Microfabricated tuneable and transferable porous PDMS membranes for Organs-on-Chips

Quirós-Solano, W. F., Gaio, N., Stassen, O. M. J. A., Arik, Y. B., Silvestri, C., van Engeland, N. C. A., van der Meer, A., Passier, R., Sahlgren, C. M., Bouten, C. V. C., van den Berg, A., Dekker, R. & Sarro, P. M., 10 Sep 2018, In : Scientific Reports. 8, 1, 11 p., 13524

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Membranes
Cell Survival
Umbilicus
Porosity
Silicon
2 Citations (Scopus)

Microvascular networks from endothelial cells and mesenchymal stromal cells from adipose tissue and bone marrow: A comparison

Pill, K., Melke, J., Mühleder, S., Pultar, M., Rohringer, S., Priglinger, E., Redl, H. R., Hofmann, S. & Holnthoner, W., 25 Oct 2018, In : Frontiers in Bioengineering and Biotechnology. 6, 10 p., 156

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Endothelial cells
Microvessels
Mesenchymal Stromal Cells
Adipose Tissue
Bone

Minimally invasive glaucoma surgery with the InnFocus MicroShunt (R) in the Netherlands

Kujovic-Aleksov, S., Webers, C. A. B., Berendschot, T. T. J. M. & Beckers, H. J. M., Mar 2018, In : Acta Ophthalmologica. 96, p. 22-23

Research output: Contribution to journalMeeting AbstractAcademic

Open Access
File

Minimal mechanical load and tissue culture conditions preserve native cell phenotype and morphology in tendon - A novel ex vivo mouse explant model

Wunderli, S. L., Widmer, J., Amrein, N., Foolen, J., Silvan, U., Leupin, O. & Snedeker, J. G., 1 May 2018, In : Journal of Orthopaedic Research. 36, 5, p. 1383-1390

Research output: Contribution to journalArticleAcademicpeer-review

Tendons
Phenotype
Tail
Homeostasis
Serum-Free Culture Media
6 Citations (Scopus)

Model-based analysis of postprandial glycemic response dynamics for different types of food

Rozendaal, Y. J., Maas, A. H., van Pul, C., Cottaar, E. J. E., Haak, H. R., Hilbers, P. A. J. & van Riel, N. A., Jun 2018, In : Clinical Nutrition Experimental. 19, p. 32-45

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Insulin
Glucose
Food
Meals
Glycemic Index

Modeling of intracerebral interictal epileptic discharges: evidence for network interactions

Meesters, S., Ossenblok, P., Colon, A., Wagner, L., Schijns, O., Boon, P., Florack, L. & Fuster, A., 1 Jun 2018, In : Clinical Neurophysiology. 129, 6, p. 1276-1290 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Electroencephalography
Epilepsy
Brain
Cluster Analysis
Linear Models
2 Citations (Scopus)

Modeling regulation of vascular tone following muscle contraction: model development, validation and global sensitivity analysis

Keijsers, J. M. T., Leguy, C. A. D., Narracott, A. J., Rittweger, J., van de Vosse, F. N. & Huberts, W., Jan 2018, In : Journal of Computational Science. 24, p. 143-159

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Global Analysis
Muscle
Sensitivity analysis
Sensitivity Analysis
Contraction

Modeling the effect of blue light irradiation on inflammatory skin diseases

Felix Garza, Z. C., 6 Nov 2018, Eindhoven: Technische Universiteit Eindhoven. 145 p.

Research output: ThesisPhd Thesis 1 (Research TU/e / Graduation TU/e)Academic

Open Access
File
Phototherapy
Skin Diseases
Light
1 Citation (Scopus)

Modeling the interference between shear and longitudinal waves under high intensity focused ultrasound propagation in bone

Modena, D., Baragona, M., Bošnački, D., Breuer, B. J. T., Elevelt, A., Maessen, R. T. H., Hilbers, P. A. J. & ten Eikelder, H. M. M., 4 Dec 2018, In : Physics in Medicine and Biology. 63, 23, 12 p., 235024

Research output: Contribution to journalArticleAcademicpeer-review

Bone and Bones
Temperature
Thermogenesis
Hot Temperature
Magnetic Resonance Spectroscopy
1 Citation (Scopus)

Modelling the combined effects of collagen and cyclic strain on cellular orientation in collagenous tissues

Ristori, T., Notermans, T. M. W., Foolen, J., Kurniawan, N. A., Bouten, C. V. C., Baaijens, F. P. T. & Loerakker, S., 1 Dec 2018, In : Scientific Reports. 8, 1, 14 p., 8518

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Collagen
Heart Valves
Cues
Arteries
Gels
1 Citation (Scopus)

Modification of CCMV nanocages for enzyme encapsulation

Schoonen, L. & van Hest, J. C. M., 5 Jun 2018, Protein Scaffolds : Design, Synthesis, and Applications. Udit, A. K. (ed.). Dordrecht: Springer, p. 69-83 15 p. (Methods in Molecular Biology; vol. 1798)

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Capsid
Enzymes
Nanoparticles
Peptides
2 Citations (Scopus)

Modular, bioorthogonal strategy for the controlled loading of cargo into a protein nanocage

Schoonen, L., Eising, S., van Eldijk, M. B., Bresseleers, J., Van Der Pijl, M., Nolte, R. J. M., Bonger, K. M. & van Hest, J. C. M., 18 Apr 2018, In : Bioconjugate Chemistry. 29, 4, p. 1186-1193 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Bromovirus
Viruses
Proteins
Capsid
Encapsulation
6 Citations (Scopus)

Modulation of macrophage phenotype and protein secretion via heparin-IL-4 functionalized supramolecular elastomers

Bonito, V., Smits, A. I. P. M., Goor, O. J. G. M., Ippel, B. D., Driessen-Mol, A., Münker, T. J. A. G., Bosman, A. W., Mes, T., Dankers, P. Y. W. & Bouten, C. V. C., 15 Apr 2018, In : Acta Biomaterialia. 71, p. 247-260

Research output: Contribution to journalArticleAcademicpeer-review

Elastomers
Macrophages
Interleukin-4
Heparin
Pyrimidinones
30 Citations (Scopus)

Modulators of 14-3-3 protein-protein interactions

Stevers, L. M., Sijbesma, E., Botta, M., Mackintosh, C., Obsil, T., Landrieu, I., Cau, Y., Wilson, A. J., Karawajczyk, A., Eickhoff, J., Davis, J., Hann, M., O'Mahony, G., Doveston, R. G., Brunsveld, L. & Ottmann, C., 10 May 2018, In : Journal of Medicinal Chemistry. 61, 9, p. 3755-3778 24 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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14-3-3 Proteins
Proteins
Biological Products
3 Citations (Scopus)

Molecular underpinnings of enzalutamide resistance

Prekovic, S., van den Broeck, T., Linder, S., van Royen, M. E., Houtsmuller, A. B., Handle, F., Joniau, S., Zwart, W. & Claessens, F., 1 Nov 2018, In : Endocrine-related cancer. 25, 11, p. R545-R557 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Prostatic Neoplasms
Androgen Receptors
Second Primary Neoplasms
Therapeutics
Hormones

Monitoring in het JBZ: ontwerp van efficiëntere en veiligere monitoringprocessen door inzet van (nieuwe) technologie

Nijskens - Derikx, L. C. E. M., 18 Dec 2018, Eindhoven: Technische Universiteit Eindhoven. 70 p.

Research output: ThesisPd Eng ThesisAcademic

2 Citations (Scopus)

Mono- and bivalent 14-3-3 inhibitors for characterizing supramolecular “Lysine Wrapping” of oligoethylene glycol (OEG) moieties in proteins

Yilmaz, E., Bier, D., Guillory, X., Briels, J., Ruiz-Blanco, Y. B., Sanchez-Garcia, E., Ottmann, C. & Kaiser, M., 20 Jun 2018, In : Chemistry : A European Journal. 24, 52, p. 13807-13814

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Glycols
Lysine
Polyethylene glycols
Proteins
14-3-3 Proteins
1 Citation (Scopus)

MRI based 3D finite element modelling to investigate deep tissue injury

Traa, W. A., van Turnhout, M. C., Moerman, K. M., Nelissen, J. L., Nederveen, A. J., Strijkers, G. J., Bader, D. L. & Oomens, C. W. J., 2018, In : Computer Methods in Biomechanics and Biomedical Engineering. 21, 14, p. 760-769

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Magnetic resonance imaging
Tissue
Animals
Indentation
Muscle

MR imaging and elastography of deformation-induced skeletal muscle damage

Nelissen, J. L., 5 Jun 2018, Eindhoven: Technische Universiteit Eindhoven. 133 p.

Research output: ThesisPhd Thesis 1 (Research TU/e / Graduation TU/e)Academic

5 Citations (Scopus)

MRI visualization of injectable ureidopyrimidinone hydrogelators by supramolecular contrast agent labeling

Bakker, M. H., Tseng, C. C. S., Keizer, H. M., Seevinck, P. R., Janssen, H. M., van Slochteren, F. J., Chamuleau, S. A. J. & Dankers, P. Y. W., 1 Jun 2018, In : Advanced Healthcare Materials. 7, 11, 8 p., 1701139

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Hydrogel
Magnetic resonance
Hydrogels
Labeling
Contrast Media
4 Citations (Scopus)

Multi-modal and multi-vendor retina image registration

Li, Z., Huang, F., Zhang, J., Dashtbozorg, B., Abbasi-Sureshjani, S., Sun, Y., Long, X., Yu, Q., ter Haar Romeny, B. M. & Tan, T., 1 Feb 2018, In : Biomedical Optics Express. 9, 2, p. 410-422 13 p., #306658

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
retina
Retina
retinal images
registers
Ophthalmoscopes
8 Citations (Scopus)

Multimodal pore formation in calcium phosphate cements

Lodoso-Torrecilla, I., van Gestel, N. A. P., Diaz-Gomez, L., Grosfeld, E. C., Laperre, K., Wolke, J. G. C., Smith, B. T., Arts, J. J., Mikos, A. G., Jansen, J. A., Hofmann, S. & van den Beucken, J. J. J. P., Feb 2018, In : Journal of Biomedical Materials Research, Part A. 106, 2, p. 500-509 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

glycolic acid
Calcium phosphate
Cements
Sugar (sucrose)
Degradation
8 Citations (Scopus)

Multi-omics profiling of the tumor microenvironment: Paving the way to precision immuno-oncology

Finotello, F. & Eduati, F., 5 Oct 2018, In : Frontiers in Oncology. 8, OCT, 9 p., 430

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
File
Tumor Microenvironment
Neoplasms
Ecosystem
Immunity
Therapeutics
16 Citations (Scopus)

Multiple instance learning: a survey of problem characteristics and applications

Carbonneau, M-A., Cheplygina, V., Granger, E. & Gagnon, G., 2018, In : Pattern Recognition. 77, p. 329-353 25 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Learning algorithms
Labels
Supervised learning
Benchmarking
Computer vision

Multi-wavelength photoacoustic imaging of the atherosclerotic carotid artery: a preclinical feasibility study

Arabul, M. Ü., 7 Dec 2018, Eindhoven: Technische Universiteit Eindhoven. 115 p.

Research output: ThesisPhd Thesis 1 (Research TU/e / Graduation TU/e)Academic

Feasibility Studies
Carotid Arteries
2 Citations (Scopus)

Mutually exclusive cellular uptake of combinatorial supramolecular copolymers

van Dun, S., Schill, J., Milroy, L. G. & Brunsveld, L., 2 Nov 2018, In : Chemistry : A European Journal. 24, 61, p. 16445-16451

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Biocompatible Materials
Biomaterials
Polymers
Copolymers
Tuning

Nanoemulsion-based delivery of fluorescent PARP inhibitors in mouse models of small cell lung cancer

Gonzales, J., Kossatz, S., Roberts, S., Pirovano, G., Brand, C., Pérez-Medina, C., Donabedian, P., de la Cruz, M. J., Mulder, W. J. M. & Reiner, T., 24 Oct 2018, In : Bioconjugate Chemistry. 29, 11, p. 3776-3782 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Small Cell Lung Carcinoma
Half-Life
Administrative data processing
Poly(ADP-ribose) Polymerases
Cells
13 Citations (Scopus)

Nanoreactors for green catalysis

De Martino, M. T., Abdelmohsen, L. K. E. A., Rutjes, F. P. J. T., van Hest, J. C. M. & Hessel, V., 29 Mar 2018, In : Beilstein Journal of Organic Chemistry. 14, p. 716–733

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Nanoreactors
Catalysis
Industrial chemicals
Dendrimers
Micelles
3 Citations (Scopus)

Nanoscale interparticle distance within dimers in solution measured by light scattering

van Vliembergen, R. W. L., van Ijzendoorn, L. J. & Prins, M. W. J., 9 Jan 2018, In : Langmuir. 34, 1, p. 179-186 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Colloids
Ionic strength
Dimers
Light scattering
Large scale systems
11 Citations (Scopus)

Nanoscale mapping functional sites on nanoparticles by points accumulation for imaging in nanoscale topography (PAINT)

Delcanale, P., Miret-Ontiveros, B., Arista-Romero, M., Pujals, S. & Albertazzi, L., 26 Jul 2018, In : ACS Nano. 12, 8, p. 7629-7637

Research output: Contribution to journalArticleAcademicpeer-review

Topography
topography
DNA
deoxyribonucleic acid
Nanoparticles
5 Citations (Scopus)

Nanostructuring lipophilic dyes in water using stable vesicles, quatsomes, as scaffolds and their use as probes for bioimaging

Ardizzone, A., Kurhuzenkau, S., Illa-Tuset, S., Faraudo, J., Bondar, M., Hagan, D., Van Stryland, E. W., Painelli, A., Sissa, C., Feiner, N., Albertazzi, L., Veciana, J. & Ventosa, N., 19 Apr 2018, In : Small. 14, 16, 6 p., 1703851

Research output: Contribution to journalArticleAcademicpeer-review

Scaffolds
Nanoparticles
Coloring Agents
Dyes
Carbocyanines

Neu3CA-RT: a framework for real-time fMRI analysis

Heunis, S., Besseling, R., Lamerichs, R., de Louw, A., Breeuwer, M., Aldenkamp, B. & Bergmans, J., 30 Dec 2018, In : Psychiatry Research - Neuroimaging. 282, p. 90-102

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Magnetic Resonance Imaging
Brain
Linear Models
Multivariate Analysis
Research Personnel

Notochordal cell matrix: An inhibitor of neurite and blood vessel growth?

de Vries, S. A. H., van Doeselaar, M., Meij, B. P., Tryfonidou, M. A. & Ito, K., 1 Dec 2018, In : Journal of Orthopaedic Research. 36, 12, p. 3188-3195

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Neurites
Conditioned Culture Medium
Blood Vessels
Growth
Human Umbilical Vein Endothelial Cells

Notochordal cell matrix as a bioactive lubricant for the osteoarthritic joint

De Vries, S. A. H., Van Doeselaar, M., Kaper, H. J., Sharma, P. K. & Ito, K., 1 Dec 2018, In : Scientific Reports. 8, 1, 11 p., 8875

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Lubricants
Joints
Chondrocytes
Friction
Hyaluronic Acid

Not-so-supervised: a survey of semi-supervised, multi-instance, and transfer learning in medical image analysis

Cheplygina, V., de Bruijne, M. & Pluim, J. P. W., 17 Apr 2018, In : arXiv. 1804.06353

Research output: Contribution to journalArticleAcademic

Open Access
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Medical imaging
Image analysis
Learning algorithms
Learning systems

Novel in situ gelling hydrogels loaded with recombinant collagen peptide microspheres as a slow-release system induce ectopic bone formation

Fahmy-Garcia, S., Mumcuoglu, D., de Miguel, L., Dieleman, V., Witte-Bouma, J., van der Eerden, B. C. J., van Driel, M., Eglin, D., Verhaar, J. A. N., Kluijtmans, S. G. J. M., van Osch, G. J. V. M. & Farrell, E., 7 Nov 2018, In : Advanced Healthcare Materials. 7, 21, 14 p., e1800507

Research output: Contribution to journalArticleAcademicpeer-review

Hydrogels
Microspheres
Collagen
Osteogenesis
Peptides
2 Citations (Scopus)

Novel polyelectrolyte membranes for fuel and flow batteries: insights from simulations

Sengupta, S., Kritikos, G., Karatasos, K., Venkatnathan, A., Pant, R., Komarov, P. & Lyulin, A. V., 11 Jul 2018, 9th International Conference on Times of Polymers and Composites: From Aerospace to Nanotechnology. American Institute of Physics, 4 p. 020004. (AIP Conference Proceedings; vol. 1981, no. 1)

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

electric batteries
membranes
acids
hydration
simulation

Offset-free model predictive control for enhancing MR-HIFU hyperthermia in cancer treatment

Deenen, D. A., Maljaars, E., Sebeke, L., de Jager, B., Heijman, E., Grüll, H. & Heemels, W. P. M. H., 22 Nov 2018, In : IFAC-PapersOnLine. 51, 20, p. 191-196 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Oncology
Model predictive control
Tumors
Magnetic resonance
Temperature control

On the interaction between feature selection and parameter determination in fuzzy modelling

Chen, P., Fuchs, C., Wilbik, A., Chan, T. M., van Loon, S., Boer, A. K., Lu, X., Scharnhorst, V. & Kaymak, U., 1 Jan 2018, Information Processing and Management of Uncertainty in Knowledge-Based Systems. Applications - 17th International Conference, IPMU 2018, Proceedings: 17th International Conference, IPMU 2018, Cádiz, Spain, June 11-15, 2018, Proceedings, Part III. Medina, J., Perfilieva, I. & Yager, R. R. (eds.). Dordrecht: Springer, p. 150-161 12 p. (Communications in Computer and Information Science; vol. 855)

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Fuzzy Modeling
Feature Selection
Feature extraction
Interaction
Model

Ontwikkeling van de functie 'expert medische technologie' in het AMC

Siemerink, K. M., 30 Jun 2018, Eindhoven: Technische Universiteit Eindhoven. 56 p.

Research output: ThesisPd Eng ThesisAcademic

Optical scattering of rotating dimers for biosensing applications

van Vliembergen, R. W. L., 31 Oct 2018, Eindhoven: Technische Universiteit Eindhoven. 102 p.

Research output: ThesisPhd Thesis 1 (Research TU/e / Graduation TU/e)Academic

Open Access
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