Department of Biomedical Engineering

Research Output 1962 2020

Article
13 Citations (Scopus)

Allosteric inhibition of Taspase1's pathobiological activity by enforced dimerization in vivo

Bier, C., Knauer, S. K., Wünsch, D., Kunst, L., Scheiding, S., Kaiser, M., Ottmann, C., Krämer, O. H. & Stauber, R. H., 2012, In : The FASEB Journal. 26, 8, p. 3421-3429

Research output: Contribution to journalArticleAcademicpeer-review

Dimerization
Myeloid-Lymphoid Leukemia Protein
Leukemia
Peptide Hydrolases
Fusion reactions
57 Citations (Scopus)

Allosteric regulation of proteases

Hauske, P., Ottmann, C., Meltzer, M., Ehrmann, M. & Kaiser, M., 2008, In : ChemBioChem. 8, 18, p. 2920-2980

Research output: Contribution to journalArticleAcademicpeer-review

Allosteric Regulation
Pharmaceutical Chemistry
Protease Inhibitors
Peptide Hydrolases
Molecules
5 Citations (Scopus)
64 Downloads (Pure)

All-printed cell counting chambers with on-chip sample preparation for point-of-care CD4 counting

Wasserberg, D., Zhang, X., Breukers, C., Connell, B. J., Baeten, E., van den Blink, D., Solà Benet, È., Bloem, A. C., Nijhuis, M., Wensing, A. M. J., Terstappen, L. W. M. M. & Beck, M., 15 Oct 2018, In : Biosensors and Bioelectronics. 117, p. 659-668 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Point-of-Care Systems
Antibodies
Microfluidics
Tissue Donors
HIV
19 Citations (Scopus)

Alterations in femoral and acetabular bone strains immediately following cementless total hip arthroplasty: an in vitro canine study.

Page, A., Jasty, M., Bragdon, C., Ito, K. & Harris, W. H., 1991, In : Journal of Orthopaedic Research. 9, 5, p. 738-748

Research output: Contribution to journalArticleAcademicpeer-review

Thigh
Acetabulum
Arthroplasty
Canidae
Hip
37 Citations (Scopus)
80 Downloads (Pure)

Alterations of bone microstructure and strength in end-stage renal failure

Trombetti, A., Stoermann, C., Chevalley, T., Rietbergen, van, B., Hermann, F. R., Martin, P. Y. & Rizzoli, R., 2013, In : Osteoporosis International. 24, 5, p. 1721-1732 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Chronic Kidney Failure
Bone and Bones
Tibia
Finite Element Analysis
Porosity
27 Citations (Scopus)
5 Downloads (Pure)

Alterations to the subchondral bone architecture during osteoarthritis : bone adaptation versus endochondral bone formation

Cox, L. G. E., Donkelaar, van, C. C., Rietbergen, van, B., Emans, P. J. & Ito, K., 2013, In : Osteoarthritis and Cartilage. 21, 2, p. 331-338 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Osteogenesis
Osteoarthritis
Bone
Bone and Bones
Cartilage
42 Citations (Scopus)
1 Downloads (Pure)

Altered calcium handling is an early sign of streptozotocin-induced diabetic cardiomyopathy

Ligeti, L., Szenczi, O., Prestia, C. M., Szabo, C., Horvath, K., Marcsek, Z. L., Stiphout, van, R. G. P. M., Riel, van, N. A. W., Op den Buijs, J., Vusse, van der, G. & Ivanics, T., 2006, In : International Journal of Molecular Medicine. 17, 6, p. 1035-1043 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Diabetic Cardiomyopathies
Streptozocin
Ryanodine Receptor Calcium Release Channel
Calcium
Poly(ADP-ribose) Polymerases
13 Citations (Scopus)
92 Downloads (Pure)

Altered energetics of exercise explain risk of rhabdomyolysis in very long-chain acyl-coa dehydrogenase deficiency

Diekman, E. F., Visser, G., Schmitz, J. P. J., Nievelstein, R. A. J., De Sain-van Der Velden, M., Wardrop, M., Van Der Pol, W. L., Houten, S. M., van Riel, N. A. W., Takken, T. & Jeneson, J. A. L., 16 Feb 2016, In : PLoS ONE. 11, 2, 18 p., e0147818.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Long-Chain Acyl-CoA Dehydrogenase
acyl-CoA dehydrogenase
rhabdomyolysis
Rhabdomyolysis
Oxidoreductases
6 Citations (Scopus)

Altered joint kinematics and increased electromyographic muscle activity during walking in patients with intermittent claudication

Gommans, L. N. M., Smid, A. T., Scheltinga, M. R. M., Brooijmans, F. A. M., van Disseldorp, E. M. J., van der Linden, F. T. P. M., Meijer, K. & Teijink, J. A. W., Mar 2016, In : Journal of Vascular Surgery. 63, 3, p. 664-672 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Intermittent Claudication
Biomechanical Phenomena
Joints
Muscles
Walking
14 Citations (Scopus)
93 Downloads (Pure)

Alternation and tunable composition in hydrogen bonded supramolecular copolymers

Felder, T. M., Greef, de, T. F. A., Nieuwenhuizen, M. M. L. & Sijbesma, R. P., 2014, In : Chemical Communications. 50, 19, p. 2455-2457 3 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Hydrogen
Copolymers
Monomers
Chemical analysis
Hydrogen bonds
2 Citations (Scopus)
76 Downloads (Pure)

Alternative application of an affinity purification tag: hexahistidines in ester hydrolysis

Schoonen, L., van Esterik, K. S., Zhang, C., Ulijn, R. V., Nolte, R. J. M. & van Hest, J. C. M., 7 Nov 2017, In : Scientific Reports. 7, 14772 , 9 p., 14772.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
His-His-His-His-His-His
Purification
Hydrolysis
Esters
Affinity chromatography
17 Citations (Scopus)
7 Downloads (Pure)
Blood Pressure
Arteries
Velocity Profile
Blood Flow
Electric Impedance
23 Citations (Scopus)
7 Downloads (Pure)

A lumped parameter model of cerebral blood flow control combining cerebral autoregualation and neurovascular coupling

Spronck, B., Martens, E. G. H. J., Gommer, E. D. & Vosse, van de, F. N., 2012, In : American Journal of Physiology : Heart and Circulatory Physiology. 303, 9, p. H1143-H1153 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Cerebrovascular Circulation
Homeostasis
Posterior Cerebral Artery
Photic Stimulation
Blood Flow Velocity
3 Citations (Scopus)

A machine-learning based analysis for the recognition of progressive central hypovolemia

Bennis, F. C., van der Ster, B. J. P., van Lieshout, J. J., Andriessen, P. & Delhaas, T., 21 Aug 2017, In : Physiological Measurement. 38, 9, p. 1791-1801 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Hypovolemia
Syncope
Learning systems
Blood pressure
Neurons
13 Citations (Scopus)
3 Downloads (Pure)
Cardiotocography
Deceleration
Fetal Heart Rate
Theoretical Models
Personnel
46 Citations (Scopus)
2 Downloads (Pure)

A mathematical model to evaluate control strategies for mechanical circulatory support

Cox, L. G. E., Loerakker, S., Rutten, M. C. M., Mol, de, B. A. J. M. & Vosse, van de, F. N., 2009, In : Artificial Organs. 33, 8, p. 593-603

Research output: Contribution to journalArticleAcademicpeer-review

Heart-Assist Devices
Theoretical Models
Mathematical models
Computer Simulation
Heart Ventricles
27 Downloads (Pure)
Open Access
File
Intravenous Administration
Theoretical Models
Clinical Decision Support Systems
Mathematical models
Fluids
4 Citations (Scopus)
53 Downloads (Pure)

A mathematical model to simulate the cardiotocogram during labor. Part A: model setup and simulation of late decelerations

Jongen, G. J. L. M., van der Hout-van der Jagt, M. B., van de Vosse, F. N., Oei, S. G. & Bovendeerd, P. H. M., 16 Aug 2016, In : Journal of Biomechanics. 49, 12, p. 2466–2473

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Cardiotocography
Fetal Heart Rate
Deceleration
Uterine Contraction
Theoretical Models
3 Citations (Scopus)
72 Downloads (Pure)

A mathematical model to simulate the cardiotocogram during labor. Part B: parameter estimation and simulation of variable decelerations

Jongen, G. J. L. M., van der Hout, M. B., van de Vosse, F. N., Oei, S. G. & Bovendeerd, P. H. M., 16 Aug 2016, In : Journal of Biomechanics. 49, 12, p. 2474–2480

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Cardiotocography
Uterine Contraction
Fetal Heart Rate
Deceleration
Parameter estimation
40 Citations (Scopus)

A mechanical analysis of the closed Hancock heart valve prosthesis

Rousseau, E. P. M., Steenhoven, van, A. A., Janssen, J. D. & Huysmans, H. A., 1988, In : Journal of Biomechanics. 21, 7, p. 545-562 18 p.

Research output: Contribution to journalArticleAcademicpeer-review

Heart valve prostheses
Heart Valve Prosthesis
Prostheses and Implants
Membranes
Pressure
167 Citations (Scopus)

A mechanically active heterotypic E-cadherin/N-cadherin adhesion enables fibroblasts to drive cancer cell invasion

Labernadie, A., Kato, T., Brugués, A., Serra-Picamal, X., Derzsi, S., Arwert, E., Weston, A., González-Tarragó, V., Elosegui-Artola, A., Albertazzi, L., Alcaraz, J., Roca-Cusachs, P., Sahai, E. & Trepat, X., 1 Mar 2017, In : Nature Cell Biology. 19, 3, p. 224-237 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Cadherins
Fibroblasts
Neoplasms
Catenins
Vinculin
23 Citations (Scopus)
76 Downloads (Pure)

A mechanism for rotation restraints in the knee joint

Blankevoort, L. & Huiskes, H. W. J., 1996, In : Journal of Orthopaedic Research. 14, 4, p. 676-679

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Knee Joint
Ligaments
Collateral Ligaments
Articular Ligaments
Joints
102 Citations (Scopus)

A mechano-regulatory bone-healing model incorporating cell-phenotype specific activity

Isaksson, H. E., Donkelaar, van, C. C., Huiskes, R. & Ito, K., 2008, In : Journal of Theoretical Biology. 252, 2, p. 230-246

Research output: Contribution to journalArticleAcademicpeer-review

Bone
Phenotype
bones
phenotype
Bone and Bones
13 Citations (Scopus)
86 Downloads (Pure)

A membrane-anchored aptamer sensor for probing IFNγ secretion by single cells

Qiu, L., Wimmers, F., Weiden, J., Heus, H. A., Tel, J. & Figdor, C. G., 2017, In : Chemical Communications. 53, 57, p. 8066-8069 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Cytokines
Membranes
Immune system
Sensors
Cell membranes
9 Citations (Scopus)
76 Downloads (Pure)

A membrane-based microfluidic device for mechano-chemical cell manipulation

Ravetto, A., Hoefer, I. E., den Toonder, J. M. J. & Bouten, C. V. C., Apr 2016, In : Biomedical Microdevices. 18, 2, p. 1-11 11 p., 31.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Lab-On-A-Chip Devices
Microfluidics
Membranes
Drug interactions
Chemical compounds
9 Citations (Scopus)
4 Downloads (Pure)
Tissue Engineering
Scaffolds (biology)
Tissue engineering
Scaffolds
Hemodynamics
3 Downloads (Pure)

A metamodeling approach for instant severity assessment and uncertainty quantification of iliac artery stenoses

Heinen, S. G. H., Gashi, K., van den Heuvel, D. A. F., de Vries, J. P. P. M., van de Vosse, F. N., Delhaas, T. & Huberts, W., 1 Jan 2020, In : Journal of Biomechanical Engineering. 142, 1, 8 p., 011010.

Research output: Contribution to journalArticleAcademicpeer-review

Iliac Artery
Uncertainty
Pathologic Constriction
Pressure drop
Pressure
34 Citations (Scopus)

A method for the quantification of the pressure dependent 3D collagen configuration in the arterial adventitia

Schrauwen, J. T. C., Vilanova, A., Rezakhaniha, R., Stergiopulos, N., Vosse, van de, F. N. & Bovendeerd, P. H. M., 2012, In : Journal of Structural Biology. 180, 2, p. 335-342

Research output: Contribution to journalArticleAcademicpeer-review

Adventitia
Collagen
Pressure
Weight-Bearing
Mechanics
9 Citations (Scopus)
1 Downloads (Pure)

A method for time-resolved measurements of the mechanics of phagocytic cups

Irmscher, M., Jong, de, A. M., Kress, H. & Prins, M. W. J., 6 May 2013, In : Journal of Royal Society Interface. 10, 82, 9 p., 20121048.

Research output: Contribution to journalArticleAcademicpeer-review

Time measurement
Mechanics
Stiffness
Phagocytosis
Mechanical Phenomena
28 Citations (Scopus)
112 Downloads (Pure)

A microfluidics platform for combinatorial drug screening on cancer biopsies

Eduati, F., Utharala, R., Madhavan, D., Neumann, U. P., Longerich, T., Cramer, T., Saez-Rodriguez, J. & Merten, C. A., 22 Jun 2018, In : Nature Communications. 9, 1, 13 p., 2434.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Preclinical Drug Evaluations
Microfluidics
Biopsy
Drug Combinations
Tumors
2 Citations (Scopus)
114 Downloads (Pure)

A microscale pulsatile flow device for dynamic cross-slot rheometry.

Burgt, van der, R. C. H., Anderson, P. D., Toonder, den, J. M. J. & Vosse, van de, F. N., 2014, In : Sensors and Actuators, A: Physical. 220, p. 221-229 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
1 Citation (Scopus)
85 Downloads (Pure)

A microstructural study of load distribution in cartilage : a comparison of stress relaxation versus creep loading

Thambyah, A., van Heeswijk, V. M., Donkelaar, van, C. C. & Broom, N., 2015, In : Advances in Materials Science and Engineering. 2015, p. 952879-1/11 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Cartilage
Stress relaxation
Creep
Bearings (structural)
Tissue
11 Citations (Scopus)

Amide proton transfer imaging of high intensity focused ultrasound-treated tumor tissue

Hectors, S. J. C. G., Jacobs, I., Strijkers, G. J. & Nicolay, K., 2014, In : Magnetic Resonance in Medicine. 72, 4, p. 1113-1122 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Amides
Protons
Neoplasms
Biomarkers
Control Groups
3 Citations (Scopus)

A minicyclotron for a scanning proton muprobe

van der Heide, J. A., de Regt, R. J. L. J., Gudden, W. A. M., Magendans, P., Hagedoorn, H. L., Mutsaers, P. H. A., Mangnus, A. V. G., Aendenroomer, A. J. R., de Folter, L. C. & de Voigt, M. J. A., 2 Feb 1992, In : Nuclear Instruments and Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms. 64, 1-4, p. 336-341 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Protons
Scanning
scanning
protons
Cyclotrons
4 Citations (Scopus)
85 Downloads (Pure)

A mix-and-read drop-based in vitro two-hybrid method for screening high-affinity peptide binders

Cui, N., Zhang, H., Schneider, N., Tao, Y., Asahara, H., Sun, Z., Cai, Y., Koehler, S. A., de Greef, T. F. A., Abbaspourrad, A., Weitz, D. A. & Chong, S., 4 Mar 2016, In : Scientific Reports. 6, 10 p., 22575.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Two-Hybrid System Techniques
Microfluidics
Gene Library
Peptides
Libraries
139 Citations (Scopus)
176 Downloads (Pure)

A mixture approach to the mechanics of skin

Oomens, C. W. J., Campen, van, D. H. & Grootenboer, H. J., 1987, In : Journal of Biomechanics. 20, 9, p. 877-885

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Mechanics
Skin
Fluids
16 Citations (Scopus)
8 Downloads (Pure)

A mock circulation model for cardiovascular device evalutation

Schampaert, S., Pennings, K. A. M. A., Molengraft, van de, M. J. G., Pijls, N. H. J., Vosse, van de, F. N. & Rutten, M. C. M., 2014, In : Physiological Measurement. 35, 4, p. 687-702 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

Cardiovascular Models
Heart Rate
Equipment and Supplies
Pressure
Coronary Circulation
25 Citations (Scopus)

A model for arterial adaptation combining microstructural collagen remodeling and 3D tissue growth

Machyshyn, I., Bovendeerd, P. H. M., Ven, van de, A. A. F., Rongen, P. M. J. & Vosse, van de, F. N., 2010, In : Biomechanics and Modeling in Mechanobiology. 9, 6, p. 671-87

Research output: Contribution to journalArticleAcademicpeer-review

Remodeling
Collagen
Aneurysm
Tissue
Arteries
53 Citations (Scopus)

A model for ion-irradiation induced hydrogen loss from organic materials

de Jong, M. P., Maas, A. J. H., van IJzendoorn, L. J., Klein, S. S. & de Voigt, M. J. A., 1 Aug 1997, In : Journal of Applied Physics. 82, 3, p. 1058-1064 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

organic materials
ion irradiation
hydrogen
degradation
polymers
14 Citations (Scopus)

A model for the deposition of a-C: H using an expanding thermal arc

Kessels, W. M. M., Gielen, J. W. A. M., Van De Sanden, M. C. M., Van Ijzendoorn, L. J., Dekempeneer, E. H. A. & Schram, D. C., 1998, In : Surface and Coatings Technology. 98, 1-3, p. 1584-1589 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

arcs
Acetylene
Argon
thermal plasmas
Carbon films
70 Citations (Scopus)
1 Downloads (Pure)

A model of heart rate changes to detect seizures in severe epilepsy

Elmpt, van, W. J. C., Nijsen, T. M. E., Griep, P. A. M. & Arends, J. B. A. M., 2006, In : Seizure. 15, 6, p. 366-375 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Epilepsy
Seizures
Heart Rate
Electroencephalography
5 Citations (Scopus)
84 Downloads (Pure)

A model of human skin under large amplitude oscillatory shear

Soetens, J. F. J., van Vijven, M., Bader, D. L., Peters, G. W. M. & Oomens, C. W. J., 1 Oct 2018, In : Journal of the Mechanical Behavior of Biomedical Materials. 86, p. 423-432 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Skin
Constitutive models
Shear thinning
Parameter estimation
Shear deformation
13 Citations (Scopus)
51 Downloads (Pure)

A model of the human knee, derived from kinematic principles and its relevance for endoprosthesis design

Huson, A., Spoor, C. W. & Verbout, A. J., 1989, In : Acta Morphologica Neerlando-Scandinavica. 27, p. 45-62

Research output: Contribution to journalArticlePopular

Open Access
File
14 Citations (Scopus)
80 Downloads (Pure)

A model study of muscle forces and joint-force direction in normal and dysplastic neonatal hips

Spoor, C. W., Leeuwen, van, J. L., Windt, de, F. H. J. & Huson, A., 1989, In : Journal of Biomechanics. 22, 8-9, p. 873-884

Research output: Contribution to journalArticlePopular

Open Access
File
16 Citations (Scopus)

A model to predict patient temperature during cardiac surgery

Severens, N. M. W., Marken Lichtenbelt, van, W., Frijns, A. J. H., Steenhoven, van, A. A., Mol, de, B. A. J. M. & Sessler, D. I., 2007, In : Physics in Medicine and Biology. 52, 17, p. 5131-5145

Research output: Contribution to journalArticleAcademicpeer-review

Thoracic Surgery
Temperature
Anesthesia
Hot Temperature
Computer Simulation
44 Citations (Scopus)
2 Downloads (Pure)

A modified PAS stain combined with immunofluorescence for quantitative analyses of glycogen in muscle sections

Schaart, G., Hesselink, R. P., Keizer, H., Kranenburg, van, G., Drost, M. R. & Hesselink, M. K. C., 2004, In : Histochemistry and Cell Biology. 122, 2, p. 161-169

Research output: Contribution to journalArticleAcademicpeer-review

Succinate Dehydrogenase
Glycogen
Fluorescent Antibody Technique
Coloring Agents
Muscles
2 Citations (Scopus)
3 Downloads (Pure)

A molecular dynamics boundary condition for heat exchange between walls and a fluid

Akker, van den, E. A. T., Frijns, A. J. H., Hilbers, P. A. J. & Steenhoven, van, A. A., 2011, In : Molecular Simulation. 37, 10, p. 855-864 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Dynamic Boundary Conditions
Molecular Dynamics
Molecular dynamics
Heat
Boundary conditions
32 Citations (Scopus)

Amorphous hydrogenated carbon nitride films deposited via an expanding thermal plasma at high growth rates

Graaf, de, A., Dinescu, G., Longueville, J. L., Sanden, van de, M. C. M., Schram, D. C., Kempeneer, E. H. A. & IJzendoorn, van, L. J., 1998, In : Thin Solid Films. 333, 1-2, p. 29-34 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Plasma Gases
carbon nitrides
Carbon nitride
thermal plasmas
Plasmas
1 Citation (Scopus)

AMPK and AKT protein kinases hierarchically phosphorylate the N-terminus of the FOXO1 transcription factor, modulating interactions with 14-3-3 proteins

Saline, M., Badertscher, L., Wolter, M., Lau, R., Gunnarsson, A., Jacso, T., Norris, T., Ottmann, C. & Snijder, A., 30 Aug 2019, In : Journal of Biological Chemistry. 294, 35, p. 13106-13116 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

14-3-3 Proteins
Phosphorylation
AMP-Activated Protein Kinases
Protein Kinases
Transcription Factors
9 Citations (Scopus)
119 Downloads (Pure)

A MRI-compatible combined mechanical loading and mr elastography setup to study deformation-induced skeletal muscle damage in rats

Nelissen, J. L., De Graaf, L., Traa, W. A., Schreurs, T. J. L., Moerman, K. M., Nederveen, A. J., Sinkus, R., Oomens, C. W. J., Nicolay, K. & Strijkers, G. J., 1 Jan 2017, In : PLoS ONE. 12, 1, e0169864.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Elasticity Imaging Techniques
Magnetic resonance imaging
Muscle
skeletal muscle
Rats