Department of Biomedical Engineering

Research Output 1962 2020

2019

Adherence to dabigatran etexilate in atrial fibrillation patients intended to undergo electrical cardioversion

Comuth, W. J., de Maat, M. P. M., van de Kerkhof, D., Malczynski, J., Husted, S., Kristensen, S. D. & Münster, A. M. B., 1 Apr 2019, In : European Heart Journal - Cardiovascular Pharmacotherapy. 5, 2, p. 91-99 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Electric Countershock
Atrial Fibrillation
Medication Adherence
Therapeutics
Dabigatran
2 Downloads (Pure)

A geometry-based model for non-invasive estimation of pressure gradients over iliac artery stenoses

Heinen, S. G. H., van den Heuvel, D. A. F., de Vries, J. P. P. M., van de Vosse, F. N., Delhaas, T. & Huberts, W., 19 Jul 2019, In : Journal of Biomechanics. 92, p. 67-75 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Iliac Artery
Pressure gradient
Pathologic Constriction
Angiography
Pressure
5 Downloads (Pure)

Alendronate-functionalized poly(2-oxazoline)s with tunable affinity for calcium cations

Sánchez-Fernández, M. J., Immers, M. R., Félix Lanao, R. P., Yang, F., Bender, J. C. M. E., Mecinović, J., Leeuwenburgh, S. C. G. & van Hest, J. C. M., 12 Aug 2019, In : Biomacromolecules. 20, 8, p. 2913-2921 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Alendronate
Cations
Calcium
Polymers
Positive ions
5 Citations (Scopus)
115 Downloads (Pure)

Allosteric small molecule modulators of nuclear receptors

Meijer, F. A., Leijten-van de Gevel, I. A., de Vries, R. M. J. M. & Brunsveld, L., 5 Apr 2019, In : Molecular and Cellular Endocrinology. 485, p. 20-34 15 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
File
Cytoplasmic and Nuclear Receptors
Allosteric Site
Ligands
Drug Discovery
Pathology
26 Downloads (Pure)
Open Access
File
Intravenous Administration
Theoretical Models
Clinical Decision Support Systems
Mathematical models
Fluids

A microfluidic oxygen gradient device to assess EMT state and migrational responses of cancer cells

Sleeboom, J., van der Doelen, K., Kruyt, F., Sahlgren, C. M. & den Toonder, J. M. J., Jul 2019.

Research output: Contribution to conferencePosterAcademic

3 Downloads (Pure)

A microfluidic oxygen gradient device to assess EMT state and migrational responses of cancer cells

Sleeboom, J., van der Doelen, K., Kruyt, F., Sahlgren, C. M. & den Toonder, J. M. J., Jun 2019.

Research output: Contribution to conferencePosterAcademic

File
1 Citation (Scopus)

AMPK and AKT protein kinases hierarchically phosphorylate the N-terminus of the FOXO1 transcription factor, modulating interactions with 14-3-3 proteins

Saline, M., Badertscher, L., Wolter, M., Lau, R., Gunnarsson, A., Jacso, T., Norris, T., Ottmann, C. & Snijder, A., 30 Aug 2019, In : Journal of Biological Chemistry. 294, 35, p. 13106-13116 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

14-3-3 Proteins
Phosphorylation
AMP-Activated Protein Kinases
Protein Kinases
Transcription Factors
35 Downloads (Pure)

A multicenter evaluation of a point of care CRP Test

Scharnhorst, V., Noordzij, P. G., Lutz, A., Graser, U., Püntener, D. & Alquézar-Arbé, A., 1 Sep 2019, In : Clinical Biochemistry. 71, Sept 2019, p. 38-45 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Point-of-Care Systems
C-Reactive Protein
Blood
Serum
Plasmas
71 Downloads (Pure)

A multilayer microfluidic platform for the conduction of prolonged cell-free gene expression

van der Linden, A., Pieters, P., Yelleswarapu, M., Swank, Z., Huck, W. T. S., Maerkl, S. & de Greef, T., 1 Oct 2019, In : Journal of Visualized Experiments (JoVE). 152, 14 p., e59655.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Lab-On-A-Chip Devices
Microfluidics
Transcription
Gene expression
Multilayers
1 Citation (Scopus)
6 Downloads (Pure)
Open Access
File
Tissue Scaffolds
Tissue Engineering
Scaffold
Microfluidics
Fluidics
3 Citations (Scopus)
7 Downloads (Pure)

Analysis of chemical exchange saturation transfer contributions from brain metabolites to the Z-spectra at various field strengths and pH

Khlebnikov, V., van der Kemp, W. J. M., Hoogduin, H., Klomp, D. W. J. & Prompers, J. J., 31 Jan 2019, In : Scientific Reports. 9, 1, 11 p., 1089.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
2 Citations (Scopus)
1 Downloads (Pure)

An aptamer-based new method for competitive fluorescence detection of exosomes

Yu, X., He, L., Pentok, M., Yang, H., Yang, Y., Li, Z., He, N., Deng, Y., Li, S., Liu, T., Chen, X. & Luo, H., 7 Sep 2019, In : Nanoscale. 11, 33, p. 15589-15595 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Fluorescence
Biomarkers
Costs
Cells
Proteins
4 Downloads (Pure)

Androgen receptor genomics for patient stratification: from biomarker discovery to mechanisms

Stelloo, S., 1 Jul 2019, Eindhoven: Technische Universiteit Eindhoven. 291 p.

Research output: ThesisPhd Thesis 2 (Research NOT TU/e / Graduation TU/e)

1 Citation (Scopus)

A new class of supramolecular ligands stabilizes 14-3-3 protein-protein interactions by up to two orders of magnitude

Gigante, A., Grad, J. N., Briels, J., Bartel, M., Hoffmann, D., Ottmann, C. & Schmuck, C., 4 Jan 2019, In : Chemical Communications. 55, 1, p. 111-114 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Neurodegenerative diseases
14-3-3 Proteins
Signal transduction
Ligands
Proteins
34 Downloads (Pure)
Open Access
File
Percutaneous Coronary Intervention
Coronary Artery Bypass
Transplants
Coronary Artery Disease
Pathologic Constriction
30 Downloads (Pure)
Open Access
File
Coronary Artery Disease
Percutaneous Coronary Intervention
Coronary Artery Bypass
Myocardium
Angiography
Child Guidance
Scoliosis
Polyethylene
Mebendazole
Weights and Measures
4 Downloads (Pure)

An isolated beating pig heart platform for a comprehensive evaluation of intracardiac blood flow with 4D flow MRI: a feasibility study

Peper, E. S., Leopaldi, A. M., van Tuijl, S., Coolen, B. F., Strijkers, G. J., Baan, J., Planken, R. N., de Weger, A., Nederveen, A. J., Marquering, H. A. & van Ooij, P., 1 Dec 2019, In : European Radiology Experimental. 3, 1, 10 p., 40.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Feasibility Studies
Swine
Magnetic Resonance Imaging
Cardiac Output
Abattoirs
6 Downloads (Pure)

An iterative sparse deconvolution method for simultaneous multicolor 19F-MRI of multiple contrast agents

Schoormans, J., Calcagno, C., Daal, M. R. R., Wüst, R. C. I., Faries, C., Maier, A., Teunissen, A. J. P., Naidu, S., Sanchez-Gaytan, B. L., Nederveen, A. J., Fayad, Z. A., Mulder, W. J. M., Coolen, B. F. & Strijkers, G. J., 10 Jul 2019, In : Magnetic Resonance in Medicine. 83, 1, p. 228-239 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Contrast Media
Artifacts
Fluorine
Noise
Cell Tracking
1 Citation (Scopus)
2 Downloads (Pure)

A novel hybrid silk-fibroin/polyurethane three-layered vascular graft: Towards in situ tissue-engineered vascular accesses for haemodialysis

van Uden, S., Vanerio, N., Catto, V., Bonandrini, B., Tironi, M., Figliuzzi, M., Remuzzi, A., Kock, L., Redaelli, A. C. L., Greco, F. G. & Riboldi, S. A., 1 Mar 2019, In : Biomedical Materials. 14, 2, p. 025007 18 p., 025007.

Research output: Contribution to journalArticleAcademicpeer-review

Fibroins
Polyurethanes
Silk
Grafts
Tissue
2 Citations (Scopus)
20 Downloads (Pure)

A pipette-tip based method for seeding cells to droplet microfluidic platforms

Sinha, N., Subedi, N., Wimmers, F., Soennichsen, M. & Tel, J., 11 Feb 2019, In : Journal of Visualized Experiments (JoVE). 144, 10 p., e57848.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Cloud seeding
Microfluidics
Encapsulation
Poisson distribution
Poisson Distribution
11 Downloads (Pure)

Approximation of a pipeline of unsupervised retina image analysis methods with a CNN

Heslinga, F., Pluim, J., Dasht Bozorg, B., Berendschot, T., Houben, A. J. H. M., Henry, R. M. A. & Veta, M., 1 Mar 2019, Image Processing: SPIE Medical Imaging, 2019, San Diego, California, United States. Angelini, E. D. & Landman, B. A. (eds.). Bellingham: SPIE, 7 p. 109491N. (Proceedings of SPIE; vol. 10949).

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Open Access
File
Biomarkers
Image analysis
Pipelines
Neural networks
Medical problems
2 Downloads (Pure)

A predictive computational model to estimate myocardial temperature during intracoronary hypothermia in acute myocardial infarction

van Willigen, B., Otterspoor, L. C., van 't Veer, M., Rosalina, T., Pijls, N. & van de Vosse, F., 1 Jun 2019, In : Medical Engineering & Physics. 68, June 2019, p. 65-75 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Hypothermia
Myocardial Infarction
Temperature
Myocardial Reperfusion
Myocardium

A protocol update of the fractional flow reserve versus angiography for multivessel evaluation (FAME) 3 trial: a comparison of fractional flow reserve–guided percutaneous coronary intervention and coronary artery bypass graft surgery in patients with multivessel coronary artery disease

Zimmermann, F. M., de Bruyne, B., Pijls, N. H. J., Desai, M., Oldroyd, K. G., Reardon, M. J., Wendler, O., Woo, J., Yeung, A. C. & Fearon, W. F., 1 Aug 2019, In : American Heart Journal. 214, p. 156-157 2 p.

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)
17 Downloads (Pure)

A revised modular approach to (–)-trans-Δ 8 -THC and derivatives through late-stage Suzuki–Miyaura cross-coupling reactions

Bloemendal, V. R. L. J., Sondag, D., Elferink, H., Boltje, T. J., van Hest, J. C. M. & Rutjes, F. P. J. T., 31 Mar 2019, In : European Journal of Organic Chemistry. 2019, 12, p. 2289-2296 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
thermohaline circulation
Dronabinol
cross coupling
Derivatives
Scaffolds
1 Citation (Scopus)
2 Downloads (Pure)

Arginine mimetic appended peptide-based probes for fluorescence turn-on detection of 14-3-3 proteins

Maity, D., Gigante, A., Sánchez-Murcia, P. A., Sijbesma, E., Li, M., Bier, D., Mosel, S., Knauer, S., Ottmann, C. & Schmuck, C., 2 Apr 2019, In : Organic & Biomolecular Chemistry. 17, 17, p. 4359-4363 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

14-3-3 Proteins
peptides
Arginine
Fluorescence
proteins
12 Downloads (Pure)

A robust and general approach to quantitatively conjugate enzymes to plasmonic nanoparticles

Wang, Y., van Asdonk, K. & Zijlstra, P., 23 Sep 2019, In : Langmuir. 35, 41, p. 13356−13363 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
enzymes
Enzymes
Nanoparticles
proteins
Proteins

A simple multi-scale model to evaluate left ventricular growth laws

Rondanina, E. & Bovendeerd, P., 2019, Functional Imaging and Modeling of the Heart - 10th International Conference, FIMH 2019, Proceedings. Zemzemi, N., Coudière, Y., Ozenne, V. & Vigmond, E. (eds.). Cham: Springer Nature Switzerland AG, p. 249-257 9 p. (Lecture Notes in Computer Science; vol. 11504).

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Blood

Assessment of graft maturity after anterior cruciate ligament reconstruction: a systematic review

van Groningen, B., van der Steen, M. C., Janssen, D. M., van Rhijn, L. W., van der Linden, T. & Janssen, R. P. A., 2019.

Research output: Contribution to conferencePaperAcademic

2 Citations (Scopus)

Association of improvement in fractional flow reserve with outcomes, including symptomatic relief, after percutaneous coronary intervention

Fournier, S., Ciccarelli, G., Toth, G. G., Milkas, A., Xaplanteris, P., Tonino, P. A. L., Fearon, W. F., Pijls, N. H. J., Barbato, E. & de Bruyne, B., 1 Apr 2019, In : JAMA Cardiology. 4, 4, p. 370-374 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Percutaneous Coronary Intervention
Angiography
Coronary Artery Disease
Randomized Controlled Trials
North America
1 Citation (Scopus)
8 Downloads (Pure)

A stirring system using suspended magnetically-actuated pillars for controlled cell clustering

Saberi, A., Zhang, S., van den Bersselaar, C., Kandail, H., den Toonder, J. M. J. & Kurniawan, N. A., 14 Feb 2019, In : Soft Matter. 15, 6, p. 1435-1443 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
stirring
Magnetic scales
Colloids
Research laboratories
cells
5 Citations (Scopus)
39 Downloads (Pure)

A stochastic view on surface inhomogeneity of nanoparticles

Post, R. A. J., van der Zwaag, D., Bet, G., Wijnands, S. P. W., Albertazzi, L., Meijer, E. W. & van der Hofstad, R. W., 10 Apr 2019, In : Nature Communications. 10, 1, 11 p., 1663.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Nanoparticles
inhomogeneity
nanoparticles
Microscopy
Microscopic examination
3 Downloads (Pure)

A study on the effect of synthetic α-to-β3-amino acid mutations on the binding of phosphopeptides to 14-3-3 proteins

Andrei, S. A., Thijssen, V., Brunsveld, L., Ottmann, C. & Milroy, L-G., 5 Dec 2019, In : Chemical Communications. 55, 98, p. 14809-14812 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
14-3-3 Proteins
Phosphopeptides
Amino acids
Substitution reactions
Proteins
10 Downloads (Pure)
Open Access
File
Biocompatible Materials
Pyrimidinones
Proteins
Notch1 Receptor
Click Chemistry
13 Downloads (Pure)

A survey of crowdsourcing in medical image analysis

Ørting, S., Doyle, A., Hirth, M., van Hilten, A., Inel, O., Madan, C. R., Mavridis, P., Spiers, H. & Cheplygina, V., 25 Feb 2019, In : arXiv. 12 p., 1902.09159.

Research output: Contribution to journalArticleAcademic

Open Access
File
Image analysis
Astrophysics
Medical imaging
Metadata
Learning algorithms
1 Citation (Scopus)

Atherosclerotic carotid bifurcation phantoms with stenotic soft inclusions for ultrasound flow and vessel wall elastography imaging

Chayer, B., van den Hoven, M., Roy Cardinal, M. H., Li, H., Swillens, A., Lopata, R. & Cloutier, G., 2 May 2019, In : Physics in Medicine and Biology. 64, 9, 12 p., 095025.

Research output: Contribution to journalArticleAcademicpeer-review

Elasticity Imaging Techniques
Blood Vessels
Elastic Modulus
Internal Carotid Artery
Atherosclerotic Plaques
1 Citation (Scopus)
2 Downloads (Pure)

ATP-mediated transient behavior of stomatocyte nanosystems

Che, H., Zhu, J., Song, S., Mason, A. F., Cao, S., Pijpers, I. A. B., Abdelmohsen, L. K. E. A. & van Hest, J. C. M., 9 Sep 2019, In : Angewandte Chemie - International Edition. 58, 37, p. 13113-13118 6 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
Nanosystems
Adenosine Triphosphate
Polylysine
Nanoreactors
Molecular interactions

Attenuated cardiac function degradation in ex vivo pig hearts

Kappler, B., van Tuijl, S., Ergin, B., Fixsen, L., Stijnen, M., Ince, C. & de Mol, B. A. J. M., 17 Oct 2019, In : International Journal of Artificial Organs.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Blood
Swine
Degradation
Dialysis
Renal Dialysis
8 Downloads (Pure)

Automated clear cell renal carcinoma grade classification with prognostic significance

Tian, K., Rubadue, C. A., Lin, D. I., Veta, M., Pyle, M. E., Irshad, H. & Heng, Y. J., 1 Jan 2019, In : PLoS ONE. 14, 10, 16 p., e0222641.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
kidney cells
Renal Cell Carcinoma
carcinoma
Atlases
Hazards

Automatic cardiac landmark localization by a recurrent neural network

van Zon, M., Veta, M. & Li, S., 1 Jan 2019, Medical Imaging 2019: Image Processing. Landman, B. A. & Angelini, E. D. (eds.). Bellingham: SPIE, 13 p. 1094916. (Proceedings of SPIE; vol. 10949).

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

landmarks
Recurrent neural networks
Mitral Valve
Magnetic Resonance Spectroscopy
Magnetic resonance
23 Downloads (Pure)

Automatic classification of focal liver lesions based on MRI and risk factors

Jansen, M. J. A., Kuijf, H. J., Veldhuis, W. B., Wessels, F. J., Viergever, M. A. & Pluim, J. P. W., May 2019, In : PLoS ONE. 14, 5, 13 p., e0217053.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
lesions (animal)
Liver
Magnetic resonance imaging
risk factors
liver

A value proposition for trough level-based anti-TNFα drug dosing

Scharnhorst, V., Schmitz, E. M. H., van de Kerkhof, D., Derijks, L. J. J. & Broeren, M. A. C., 1 Feb 2019, In : Clinica Chimica Acta. 489, p. 89-95 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Drug Monitoring
Tumor Necrosis Factor-alpha
Pharmaceutical Preparations
Cost-Benefit Analysis
Therapeutics
1 Citation (Scopus)

A versatile protocol for studying anterior cruciate ligament reconstruction in a rabbit model

Hevesi, M., Crispim, J. F., Paggi, C. A., Dudakovic, A., van Genechten, W., Hewett, T., Kakar, S., Krych, A. J., van Wijnen, A. J. & Saris, D., 19 Mar 2019, In : Tissue Engineering. Part C: Methods. 25, 4, p. 191-196 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Anterior Cruciate Ligament Reconstruction
Ligaments
Anterior Cruciate Ligament
Rabbits
Animal Care Committees

Benchmark on automatic 6-month-old infant brain segmentation algorithms: The iSeg-2017 Challenge

Wang, L., Nie, D., Li, G., Puybareau, E., Dolz, J., Zhang, Q., Wang, F., Xia, J., Wu, Z., Chen, J., Thung, K-H., Bui, T. D., Shin, J., Zeng, G., Zheng, G., Fonov, V. S., Doyle, A., Xu, Y., Moeskops, P., Pluim, J. P. W. & 9 others, Desrosiers, C., Ayed, I. B., Sanroma, G., Benkarim, O. M., Casamitjana, A., Vilaplana, V., Lin, W., Li, G. & Shen, D., 27 Feb 2019, In : IEEE Transactions on Medical Imaging. 38, 9, p. 2219-2230

Research output: Contribution to journalArticleAcademicpeer-review

Benchmarking
Brain
Magnetic resonance
Magnetic Resonance Spectroscopy
Cerebrospinal fluid
4 Citations (Scopus)

Bi-layered micro-fibre reinforced hydrogels for articular cartilage regeneration

Castilho, M., Mouser, V., Chen, M., Malda, J. & Ito, K., 1 Sep 2019, In : Acta Biomaterialia. 95, Sept 2019, p. 297-306 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Hydrogels
Cartilage
Articular Cartilage
Regeneration
Fibers
52 Downloads (Pure)

Bioactive glass as bone graft substitute: in vitro assessment of the mechanical and biological properties

van Gestel, N. A. P., 31 Oct 2019, Eindhoven: Technische Universiteit Eindhoven. 181 p.

Research output: ThesisPhd Thesis 1 (Research TU/e / Graduation TU/e)

Open Access
File
Bone Substitutes
Glass
Transplants
In Vitro Techniques
4 Downloads (Pure)

Biomechanics and modeling of tissue-engineered heart valves

Ristori, T., van Kelle, A. J. M., Baaijens, F. & Loerakker, S., 9 Apr 2019, Advances in heart valve biomechanics: valvular physiology, mechanobiology, and bioengineering. Sacks, M. & Liao, J. (eds.). Cham: Springer, p. 413-446 34 p.

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

Biomechanics
Tissue engineering
Tissue
Collagen
Heart valve prostheses
2 Citations (Scopus)
58 Downloads (Pure)

Biomedical applications of photo- and sono-activated Rose Bengal: a review

Vanerio, N., Stijnen, M., de Mol, B. A. J. M. & Kock, L. M., 1 Jul 2019, In : Photobiomodulation, Photomedicine, and Laser Surgery. 37, 7, p. 383-394 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Rose Bengal
Oncology
Xanthenes
Photodynamic therapy
Oxygen