Department of Biomedical Engineering

Research Output 1962 2019

2019

Allosteric small molecule modulators of nuclear receptors

Meijer, F. A., Leijten-van de Gevel, I. A., de Vries, R. M. J. M. & Brunsveld, L., 1 Apr 2019, In : Molecular and Cellular Endocrinology. 485, p. 20-34 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Cytoplasmic and Nuclear Receptors
Allosteric Site
Ligands
Drug Discovery
Pathology
Open Access
Intravenous Administration
Theoretical Models
Clinical Decision Support Systems
Mathematical models
Fluids

A multilayer microfluidic platform for the conduction of prolonged cell-free gene expression

van der Linden, A., Pieters, P., Yelleswarapu, M., Swank, Z., Huck, W. T. S., Maerkl, S. & de Greef, T., 2019, (Accepted/In press) In : Journal of Visualized Experiments (JoVE).

Research output: Contribution to journalArticleAcademicpeer-review

File
Lab-On-A-Chip Devices
Microfluidics
Transcription
Gene expression
Multilayers

A new class of supramolecular ligands stabilizes 14-3-3 protein-protein interactions by up to two orders of magnitude

Gigante, A., Grad, J. N., Briels, J., Bartel, M., Hoffmann, D., Ottmann, C. & Schmuck, C., 1 Jan 2019, In : Chemical Communications. 55, 1, p. 111-114 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Neurodegenerative diseases
14-3-3 Proteins
Signal transduction
Ligands
Proteins

An improved growth guidance system for children with scoliosis: design of a screw guide and spacer

Gabriels, F., 11 Mar 2019, Eindhoven: Technische Universiteit Eindhoven. 59 p.

Research output: ThesisPd Eng ThesisOther research output

Child Guidance
Scoliosis
Mebendazole
Toes
Polyethylene

A novel hybrid silk-fibroin/polyurethane three-layered vascular graft: towards in situ tissue-engineered vascular accesses for haemodialysis

van Uden, S., Vanerio, N., Catto, V., Bonandrini, B., Tironi, M., Figliuzzi, M., Remuzzi, A., Kock, L., Redaelli, A. C. L., Greco, F. G. & Riboldi, S. A., 30 Jan 2019, In : Biomedical Materials. 14, 2, p. 025007 18 p.

Research output: Contribution to journalArticleAcademicpeer-review

Fibroins
Polyurethanes
Silk
Blood Vessels
Renal Dialysis

Approximation of a pipeline of unsupervised retina image analysis methods with a CNN

Heslinga, F., Pluim, J., Dasht Bozorg, B., Berendschot, T., Houben, B., Henry, R. M. A. & Veta, M., 15 Mar 2019, Proc. SPIE 10949: Image Processing. Bellingham: SPIE, 7 p. doi: 10.1117/12.2512393

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Open Access
Biomarkers
Image analysis
Pipelines
Neural networks
Chemical activation

A stirring system using suspended magnetically-actuated pillars for controlled cell clustering

Saberi, A., Zhang, S., van den Bersselaar, C., Kandail, H., den Toonder, J. M. J. & Kurniawan, N. A., 1 Jan 2019, In : Soft Matter. 15, 6, p. 1435-1443 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

stirring
Magnetic scales
Colloids
Research laboratories
cells

A stochastic view on surface inhomogeneity of nanoparticles

Post, R. A. J., van der Zwaag, D., Bet, G., Wijnands, S. P. W., Albertazzi, L., Meijer, E. W. & van der Hofstad, R. W., 1 Dec 2019, In : Nature Communications. 10, 1, 1663

Research output: Contribution to journalArticleAcademicpeer-review

Nanoparticles
inhomogeneity
nanoparticles
Microscopy
Microscopic examination

A survey of crowdsourcing in medical image analysis

Ørting, S., Doyle, A., Hirth, M., van Hilten, A., Inel, O., Madan, C. R., Mavridis, P., Spiers, H. & Cheplygina, V., 25 Feb 2019, In : arXiv. 12 p., 1902.09159

Research output: Contribution to journalArticleAcademic

Open Access
File
Image analysis
Astrophysics
Medical imaging
Metadata
Learning algorithms

A value proposition for trough level-based anti-TNFα drug dosing

Scharnhorst, V., Schmitz, E. M. H., van de Kerkhof, D., Derijks, L. J. J. & Broeren, M. A. C., 1 Feb 2019, In : Clinica Chimica Acta. 489, p. 89-95 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Drug Monitoring
Pharmaceutical Preparations
Cost-Benefit Analysis
Therapeutics
Critical Pathways

A versatile protocol for studying anterior cruciate ligament reconstruction in a rabbit model

Hevesi, M., Crispim, J. F., Paggi, C. A., Dudakovic, A., van Genechten, W., Hewett, T., Kakar, S., Krych, A. J., van Wijnen, A. J. & Saris, D., 19 Mar 2019, In : Tissue Engineering Part C: Methods. 25, 4, p. 191-196 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Anterior Cruciate Ligament Reconstruction
Ligaments
Anterior Cruciate Ligament
Rabbits
Animal Care Committees

Benchmark on automatic 6-month-old infant brain segmentation algorithms: The iSeg-2017 Challenge

Wang, L., Nie, D., Li, G., Puybareau, E., Dolz, J., Zhang, Q., Wang, F., Xia, J., Wu, Z., Chen, J., Thung, K-H., Bui, T. D., Shin, J., Zeng, G., Zheng, G., Fonov, V. S., Doyle, A., Xu, Y., Moeskops, P., Pluim, J. P. W. & 9 othersDesrosiers, C., Ayed, I. B., Sanroma, G., Benkarim, O. M., Casamitjana, A., Vilaplana, V., Lin, W., Li, G. & Shen, D., 27 Feb 2019, In : IEEE Transactions on Medical Imaging.

Research output: Contribution to journalArticleAcademicpeer-review

Benchmarking
Brain
Magnetic resonance
Magnetic Resonance Spectroscopy
Cerebrospinal fluid

Biomorphic engineering of multifunctional polylactide stomatocytes toward therapeutic nano-red blood cells

Shao, J., Pijpers, I. A. B., Cao, S., Williams, D. S., Yan, X., Li, J., Abdelmohsen, L. K. E. A. & van Hest, J. C. M., 1 Jan 2019, (Accepted/In press) In : Advanced Science.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
erythrocytes
Blood
Erythrocytes
Cells
engineering
1 Citation (Scopus)

Carbon nanotube reinforced supramolecular hydrogels for bioapplications

Mihajlovic, M., Mihajlovic, M., Dankers, P. Y. W., Masereeuw, R. & Sijbesma, R. P., 1 Jan 2019, In : Macromolecular Bioscience. 19, 12 p., 1800173

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Carbon Nanotubes
Hydrogels
Nanocomposites
Carbon nanotubes
Hydrogel

Characteristics of the Retinal Microvasculature in Association with Cardiovascular Risk Markers in Children with Overweight, Obesity and Morbid Obesity

Berendschot, T. T. J. M., Rijks, J., Vreugdenhil, A., Dorenbos, E., Karnebeek, K., Joris, P., Mensink, R. & Plat, J., 2019, In : Journal of Vascular Research. 56, p. 13-13

Research output: Contribution to journalMeeting AbstractAcademic

Clinical candidates modulating protein-protein interactions: the fragment-based experience

Valenti, D., Hristeva, S., Tzalis, D. & Ottmann, C., 1 Apr 2019, In : European Journal of Medicinal Chemistry. 167, p. 76-95 20 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Proteins
Modulators
Lead compounds
Drug Discovery
Chemical properties

Computational modelling of energy balance in individuals with Metabolic Syndrome

Rozendaal, Y., Wang, Y., Hilbers, P. & van Riel, N., 26 Feb 2019, In : BMC Systems Biology. 13, 24, 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Computational Modeling
Energy Balance
Energy balance
Energy Metabolism
Energy

Cooperativity basis for small-molecule stabilization of protein-protein interactions

de Vink, P. J., Andrei, S. A., Higuchi, Y., Ottmann, C., Milroy, L-G. & Brunsveld, L., 2019, In : Chemical Science. 10, 10, p. 2869-2874 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Stabilization
Molecules
Proteins
14-3-3 Proteins
Fluorescence
3 Citations (Scopus)

Cortical and trabecular bone microarchitecture as an independent predictor of incident fracture risk in older women and men in the Bone Microarchitecture International Consortium (BoMIC): a prospective study

Samelson, E. J., Broe, K. E., Xu, H., Yang, L., Boyd, S., Biver, E., Szulc, P., Adachi, J., Amin, S., Atkinson, E., Berger, C., Burt, L., Chapurlat, R., Chevalley, T., Ferrari, S., Goltzman, D., Hanley, D. A., Hannan, M. T., Khosla, S., Liu, C-T. & 13 othersLorentzon, M., Mellstrom, D., Merle, B., Nethander, M., Rizzoli, R., Sornay-Rendu, E., van Rietbergen, B., Sundh, D., Wong, A. K. O., Ohlsson, C., Demissie, S., Kiel, D. P. & Bouxsein, M. L., 1 Jan 2019, In : Lancet Diabetes & Endocrinology. 7, 1, p. 34-43 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Bone Density
Prospective Studies
Bone and Bones
Femur Neck
Tibia

Counterion dependent mechanisms of DNA origami nanostructure stabilization revealed by atomistic molecular simulation

Roodhuizen, J., Hendrikx, P. J. T. M., Hilbers, P. A. J., de Greef, T. & Markvoort, B., 2019, (Accepted/In press) In : ACS Nano.

Research output: Contribution to journalArticleAcademicpeer-review

Deep learning networks to segment and detect breast terminal duct lobular units, acini, and adipose tissue: a step toward the automated analysis of lobular involution as a marker for breast cancer risk

Onken, A., Wetstein, S., Pyle, M., Pluim, J., Schnitt, S., Baker, G., Collins, L., Tamimi, R., Veta, M. & Heng, Y., 2019, (Accepted/In press) United States and Canadian Academy of Pathology (USCAP).

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademic

Adipose Tissue
Breast
Learning
Breast Neoplasms
Physiological Phenomena

Detection of acini in histopathology slides: towards automated prediction of breast cancer risk

Wetstein, S., Onken, A., Baker, G., Pyle, M., Pluim, J., Tamimi, R., Heng, Y. & Veta, M., 18 Mar 2019, SPIE Medical Imaging: Digital Pathology. Bellingham, Vol. 10956, 7 p. 109560Q

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Ducts
Labels
Masks
Health
Biomarkers
1 Citation (Scopus)

Development of morphologically discrete PEG-PDLLA nanotubes for precision nanomedicine

Wauters, A. C., Pijpers, I. A. B., Mason, A. F., Williams, D. S., Tel, J., Abdelmohsen, L. K. E. A. & van Hest, J. C. M., 1 Jan 2019, In : Biomacromolecules. 20, 1, p. 177-183

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Medical nanotechnology
Nanotubes
Polyethylene glycols
Particle interactions
Nanostructures

DNA-based communication in populations of synthetic protocells

Joesaar, A. H., Yang, S., Bögels, B. W. A., van der Linden, A. J., Pieters, P. A., Kumar, P., Dachau, N., Phillips, A., Mann, S. & de Greef, T. F. A., 1 Apr 2019, In : Nature Nanotechnology. 14, p. 369-378

Research output: Contribution to journalArticleAcademicpeer-review

DNA
deoxyribonucleic acid
communication
Communication
Networks (circuits)

DNA-functionalized supramolecular polymers: dynamic multicomponent assemblies with emergent properties

Wijnands, S. P. W., Meijer, E. W. & Merkx, M., 1 Jan 2019, In : Bioconjugate Chemistry.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
Polymers
DNA
Hybrid systems

Dynamics in human muscle bioenergetics: in silico and in vivo studies of metabolism during exercise

Hendriks, A., Nabben, M. W., Schmitz, J. P. J., Hilbers, P. A. J., Prompers, J. J. & van Riel, N. A. W., 2019, (In preparation) Eindhoven: Technische Universiteit Eindhoven

Research output: Working paperAcademic

Early Phacoemulsification After Acute Angle Closure in Patients With Coexisting Cataract

Romkens, H. C. S., Beckers, H. J. M., Schouten, J. S. A. G., Nuijts, R. M. M. A., Berendschot, T. T. J. M., Breusegem, C. M. & Webers, C. A. B., Feb 2019, In : Journal of Glaucoma. 28, 2, p. E34-E35

Research output: Contribution to journalLetterAcademicpeer-review

Engineered cardiac microenvironments based on supramolecular biomaterials

Spaans, S., 13 Mar 2019, Eindhoven: Technische Universiteit Eindhoven. 175 p.

Research output: ThesisPhd Thesis 1 (Research TU/e / Graduation TU/e)Academic

Biocompatible Materials

Engineering stabilizers of 14-3-3 protein-protein interactions

Andrei, S., 9 May 2019, (Accepted/In press) Eindhoven: Technische Universiteit Eindhoven. 192 p.

Research output: ThesisPhd Thesis 1 (Research TU/e / Graduation TU/e)Academic

Environmental stimuli for controlled bone tissue engineering applications

Melke, J., 14 Mar 2019, Eindhoven: Technische Universiteit Eindhoven. 172 p.

Research output: ThesisPhd Thesis 1 (Research TU/e / Graduation TU/e)Academic

Tissue engineering
Bone
2 Citations (Scopus)

Epileptic seizure detection in EEG signals using sparse multiscale radial basis function networks and the Fisher vector approach

Li, Y., Cui, W. G., Huang, H., Guo, Y. Z., Li, K. & Tan, T., 15 Jan 2019, In : Knowledge-Based Systems. 164, p. 96-106

Research output: Contribution to journalArticleAcademicpeer-review

Radial basis function networks
Electroencephalography
Statistical tests
Model structures
Particle swarm optimization (PSO)

Evaluating aetiological processes for monitoring and detection of deep tissue injury

Traa, W. A., 19 Feb 2019, Eindhoven: Technische Universiteit Eindhoven. 140 p.

Research output: ThesisPhd Thesis 1 (Research TU/e / Graduation TU/e)Academic

Open Access
File

First generation versus second generation toric calculator for toric IOL implantations

Webers, V. S. C., Bauer, N. J. C., Visser, N., Berendschot, T. T. T. J. M., Saelens, I. E. Y., Beckers, H. J. M. & Nuijts, R. M. M. A., Mar 2019, In : Acta Ophthalmologica. 97, S262, p. 36-37 2 p.

Research output: Contribution to journalMeeting AbstractAcademic

1 Citation (Scopus)

Fourier transform on the homogeneous space of 3D positions and orientations for exact solutions to linear PDEs

Duits, R., Bekkers, E. J. & Mashtakov, A., 8 Jan 2019, In : Entropy. 21, 1, 38 p., 38

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
pulse detonation engines
quotients
rigid structures
robotics
image analysis

Het fundament van maatwerk

Zwart, W., 10 May 2019, (Accepted/In press) Eindhoven: Technische Universiteit Eindhoven.

Research output: Book/ReportInaugural speechOther research output

Identification of topographical architectures supporting the phenotype of rat tenocytes

Vermeulen, S., Vasilevich, A., Tsiapalis, D., Roumans, N., Vroemen, P., Beijer, N. R. M., Dede Eren, A., Zeugolis, D. & de Boer, J., 1 Jan 2019, In : Acta Biomaterialia. 83, p. 277-290 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Topography
Rats
Tendons
Phenotype
Screening

Impairment of cyclo-oxygenase-2 function results in abnormal growth plate development and bone microarchitecture but does not affect longitudinal growth of the long bones in skeletally immature mice

Caron, M. M. J., Castermans, T. M. R., van Rietbergen, B., Haartmans, M. J. J., van Rhijn, L. W., Witlox, A. M. A. & Welting, T. J. M., 1 Jan 2019, In : Cartilage.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Celecoxib
Growth Plate
Bone Development
Prostaglandin-Endoperoxide Synthases
Growth and Development

Including surrounding tissue improves ultrasound-based 3D mechanical characterization of abdominal aortic aneurysms

Petterson, N. J., van Disseldorp, E. M. J., van Sambeek, M. R. H. M., van de Vosse, F. N. & Lopata, R. G. P., 6 Mar 2019, In : Journal of Biomechanics. 85, p. 126-133

Research output: Contribution to journalArticleAcademicpeer-review

Abdominal Aortic Aneurysm
Spine
Ultrasonics
Tissue
Aorta

Increased cell traction-induced prestress in dynamically cultured microtissues

van Kelle, M. A. J., Khalil, N., Foolen, J., Loerakker, S. & Bouten, C. V. C., 12 Mar 2019, In : Frontiers in Bioengineering and Biotechnology. 7, 11 p., 41

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File

In reply: early phacoemulsification after acute angle closure in patients with coexisting cataract

Romkens, H. C. S., Beckers, H. J. M., Schouten, J. S. A. G., Nuijts, R. M. M. A., Berendschot, T. T. J. M., Breusegem, C. M. & Webers, C. A. B., Mar 2019, In : Journal of Glaucoma. 28, 3, p. e51-e51

Research output: Contribution to journalLetterAcademicpeer-review

Insights into the kinetics of supramolecular copolymerization in water

Lafleur, R., Schoenmakers, S., Madhikar, P., Bochicchio, D., Baumeier, B., Palmans, A., Pavan, G. & Meijer, B., 2019, (Accepted/In press) In : Macromolecules.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Copolymerization
Polymers
Kinetics
Water
Monomers

In vitro test-retest repeatability of invasive physiological indices to assess coronary flow

Picard, F., Alansari, O., Mogi, S., van 't Veer, M., Varenne, O. & Adjedj, J., 6 Mar 2019, In : Catheterization and Cardiovascular Interventions.

Research output: Contribution to journalArticleAcademicpeer-review

Reproducibility of Results
Blood Vessels
Pathologic Constriction
Catheters
In Vitro Techniques

Macrophage-driven in situ cardiovascular tissue engineering: balancing biomaterial and neo-tissue formation

Wissing, T., 14 May 2019, (Accepted/In press) Eindhoven: Technische Universiteit Eindhoven. 259 p.

Research output: ThesisPhd Thesis 1 (Research TU/e / Graduation TU/e)Academic

Markers of Microvascular Dysfunction Are Associated with Incident Depressive Symptoms: The Maastricht Study

Geraets, A., Van Agtmaal, M., Stehouwer, C. D. A., Sorensen, B., Berendschot, T., Schouten, J., Schaper, N., Henry, R., van der Kallen, C., Koster, A., Eussen, S., Kohler, S., Schram, M. T. & Houben, A. J. H. M., 2019, In : Journal of Vascular Research. 56, p. 38-39

Research output: Contribution to journalMeeting AbstractAcademic

Maternal hemoglobin level and its relation to fetal distress, mode of delivery, and short-term neonatal outcome: a retrospective cohort study

Bullens, L. M., Smith, J. S., Truijens, S. E. M., van der Hout-van der Jagt, M. B., van Runnard Heimel, P. J. & Oei, S. G., 31 Jan 2019, In : Journal of Maternal-Fetal and Neonatal Medicine. p. 1-7 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Fetal Distress
Hemoglobins
Cohort Studies
Retrospective Studies
Mothers

Mechanical analysis of aortic aneurysms using 3D ultrasound : towards patient-specific risk assessment

van Disseldorp, E. M. J., 10 Jan 2019, Eindhoven: Technische Universiteit Eindhoven. 178 p.

Research output: ThesisPhd Thesis 1 (Research TU/e / Graduation TU/e)Academic

Open Access
File
Risk assessment
Ultrasonics

Mechanically driven adaptation in engineered cardiovascular tissues

van Kelle, A. J., 31 Jan 2019, Eindhoven: Technische Universiteit Eindhoven. 134 p.

Research output: ThesisPhd Thesis 1 (Research TU/e / Graduation TU/e)Academic

Heart Valves
Blood Vessels
Open Access
File
Micellization
Surface-Active Agents
self consistent fields
Surface active agents
Salts

Micro-scaled topographies direct differentiation of human epidermal stem cells

Zijl, S., Vasilevich, A. S., Viswanathan, P., Helling, A. L., Beijer, N. R. M., Walko, G., Chiappini, C., de Boer, J. & Watt, F. M., 15 Jan 2019, In : Acta Biomaterialia. 84, p. 133-145 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File