Department of Biomedical Engineering

Research Output 1962 2020

2020

A metamodeling approach for instant severity assessment and uncertainty quantification of iliac artery stenoses

Heinen, S. G. H., Gashi, K., van den Heuvel, D. A. F., de Vries, J. P. P. M., van de Vosse, F. N., Delhaas, T. & Huberts, W., 1 Jan 2020, In : Journal of Biomechanical Engineering. 142, 1, 8 p., 011010

Research output: Contribution to journalArticleAcademicpeer-review

Iliac Artery
Uncertainty
Pathologic Constriction
Pressure drop
Pressure

Peroxiredoxin proteins as building blocks for nanotechnology

Conroy, F. & Yewdall, A., 2020, Protein Nanotechnology. Gerard, J. & Domigan, L. (eds.). Humana: Springer, p. 39-54 16 p. (Methods in Molecular Biology; vol. 2073)

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Peroxiredoxins
Nanotechnology
Proteins
Transmission Electron Microscopy
Centrifugation
2019

Accelerating implant RF safety assessment using a low-rank inverse update method

Stijnman, P. R. S., Tokaya, J. P., van Gemert, J., Luijten, P. R., Pluim, J. P. W., Brink, W. M., Remis, R. F., van den Berg, C. A. T. & Raaijmakers, A. J. E., 30 Sep 2019, In : Magnetic Resonance in Medicine.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Radio
Safety
Magnetic Fields
Heating
Libraries

A comparative study of geometry-based methods and intra-arterial pressure measurements to assess the hemodynamic significance of equivocal iliac artery stenoses

Heinen, S. G. H., Huberts, W., van den Heuvel, D. A. F., van de Vosse, F. N., de Vries, J. P. P. M. & Delhaas, T., 1 Apr 2019, In : Vascular. 27, 2, p. 119-127 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Iliac Artery
Arterial Pressure
Pathologic Constriction
Hemodynamics
Blood Vessels

A computational approach on sensitivity of left ventricular wall strains to geometry

Barbarotta, L. & Bovendeerd, P., 2019, FIMH 2019: Functional Imaging and Modeling of the Heart . Coudière, Y., Ozenne, V., Vigmond, E. & Zemzemi, N. (eds.). Cham: Springer Nature Switzerland AG, p. 240-248 9 p. (Lecture Notes in Computer Science ; vol. 11504)

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Mode Shape
Atlas
Finite Element Model
Principal Component Analysis
Mechanics

A computational model of postprandial adipose tissue lipid metabolism derived using human arteriovenous stable isotope tracer data

O'Donovan, S. D., Lenz, M., Vink, R. G., Roumans, N. J. T., de Kok, T. M. C. M., Mariman, E. C. M., Peeters, R. L. M., van Riel, N. A. W., van Baak, M. A. & Arts, I. C. W., 3 Oct 2019, In : PLoS Computational Biology. 15, 10, 23 p., e1007400

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Lipid Metabolism
Radioactive tracers
isotope labeling
Isotopes
lipid metabolism

A computational model to predict cell traction-mediated prestretch in the mitral valve

van Kelle, M. A. J., Rausch, M. K., Kuhl, E. & Loerakker, S., 2019, In : Computer Methods in Biomechanics and Biomedical Engineering. 22, 15, p. 1174-1185

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Tissue
Actins
Structural properties
Anisotropy
Fibers

A CRISPR-Cas9 screen identifies essential CTCF anchor sites for estrogen receptor-driven breast cancer cell proliferation

Korkmaz, G., Manber, Z., Lopes, R., Prekovic, S., Schuurman, K., Kim, Y., Teunissen, H., Flach, K., Wit, E. D., Galli, G. G., Zwart, W., Elkon, R. & Agami, R., 10 Oct 2019, In : Nucleic Acids Research. 47, 18, p. 9557-9572 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Clustered Regularly Interspaced Short Palindromic Repeats
Estrogen Receptor alpha
Estrogen Receptors
Cell Proliferation
Breast Neoplasms

Adaptive polymeric assemblies for applications in biomimicry and nanomedicine

Altay, Y., Che, H., Cao, S., Abdelmohsen, L. & van Hest, J., 23 Oct 2019, In : Biomacromolecules. 20, 11, p. 4053-4064 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Medical nanotechnology
Nanostructured materials
Self assembly
Intelligent networks
Complex networks

Adaptive polymersome nanoreactors

Che, H. & van Hest, J. C. M., 1 Sep 2019, In : ChemNanoMat. 5, 9, p. 1092-1109

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Nanoreactors
Medical nanotechnology
Adaptive systems

A deep learning method for image-based subject-specific local SAR assessment

Meliadò, E. F., Raaijmakers, A. J. E., Sbrizzi, A., Steensma, B. R., Maspero, M., Savenije, M. H. F., Luijten, P. R. & van den Berg, C. A. T., 1 Nov 2019, In : Magnetic Resonance in Medicine. 83, 2, p. 695-711

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Learning
Computer Simulation
Safety
Uncertainty
Prostate

Adherence to dabigatran etexilate in atrial fibrillation patients intended to undergo electrical cardioversion

Comuth, W. J., de Maat, M. P. M., van de Kerkhof, D., Malczynski, J., Husted, S., Kristensen, S. D. & Münster, A. M. B., 1 Apr 2019, In : European Heart Journal - Cardiovascular Pharmacotherapy. 5, 2, p. 91-99 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Electric Countershock
Atrial Fibrillation
Medication Adherence
Therapeutics
Dabigatran

A DNA-based synthetic apoptosome

Rosier, B., Markvoort, B., Gumi Audenis, B., Roodhuizen, J., Brunsveld, L. & de Greef, T. F. A., 2019, (Accepted/In press) In : Nature Catalysis.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Apoptosomes
Caspase 9
DNA
Proteins
Enzymes

A geometry-based model for non-invasive estimation of pressure gradients over iliac artery stenoses

Heinen, S. G. H., van den Heuvel, D. A. F., de Vries, J. P. P. M., van de Vosse, F. N., Delhaas, T. & Huberts, W., 19 Jul 2019, In : Journal of Biomechanics. 92, p. 67-75

Research output: Contribution to journalArticleAcademicpeer-review

Iliac Artery
Pressure gradient
Pathologic Constriction
Angiography
Pressure

Alendronate-functionalized poly(2-oxazoline)s with tunable affinity for calcium cations

Sánchez-Fernández, M. J., Immers, M. R., Félix Lanao, R. P., Yang, F., Bender, J. C. M. E., Mecinović, J., Leeuwenburgh, S. C. G. & van Hest, J. C. M., 1 Jan 2019, In : Biomacromolecules. 20, 8, p. 2913-2921 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Alendronate
Cations
Calcium
Polymers
Positive ions
3 Citations (Scopus)

Allosteric small molecule modulators of nuclear receptors

Meijer, F. A., Leijten-van de Gevel, I. A., de Vries, R. M. J. M. & Brunsveld, L., 1 Apr 2019, In : Molecular and Cellular Endocrinology. 485, p. 20-34 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Cytoplasmic and Nuclear Receptors
Allosteric Site
Ligands
Drug Discovery
Pathology
Open Access
File
Intravenous Administration
Theoretical Models
Clinical Decision Support Systems
Mathematical models
Fluids

AMPK and AKT protein kinases hierarchically phosphorylate the N-terminus of the FOXO1 transcription factor, modulating interactions with 14-3-3 proteins

Saline, M., Badertscher, L., Wolter, M., Lau, R., Gunnarsson, A., Jacso, T., Norris, T., Ottmann, C. & Snijder, A., 1 Jan 2019, In : Journal of Biological Chemistry. 294, 35, p. 13106-13116 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

14-3-3 Proteins
Phosphorylation
AMP-Activated Protein Kinases
Protein Kinases
Transcription Factors

A multicenter evaluation of a point of care CRP Test

Scharnhorst, V., Noordzij, P. G., Lutz, A., Graser, U., Püntener, D. & Alquézar-Arbé, A., 1 Sep 2019, In : Clinical Biochemistry. 71, Sept 2019, p. 38-45

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Point-of-Care Systems
C-Reactive Protein
Blood
Serum
Plasmas

A multilayer microfluidic platform for the conduction of prolonged cell-free gene expression

van der Linden, A., Pieters, P., Yelleswarapu, M., Swank, Z., Huck, W. T. S., Maerkl, S. & de Greef, T., 1 Oct 2019, In : Journal of Visualized Experiments (JoVE). 152, 14 p., e59655

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Lab-On-A-Chip Devices
Microfluidics
Transcription
Gene expression
Multilayers
Open Access
Tissue Scaffolds
Tissue Engineering
Scaffold
Microfluidics
Fluidics
3 Citations (Scopus)

Analysis of chemical exchange saturation transfer contributions from brain metabolites to the Z-spectra at various field strengths and pH

Khlebnikov, V., van der Kemp, W. J. M., Hoogduin, H., Klomp, D. W. J. & Prompers, J. J., 31 Jan 2019, In : Scientific Reports. 9, 11 p., 1089

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File

An aptamer-based new method for competitive fluorescence detection of exosomes

Yu, X., He, L., Pentok, M., Yang, H., Yang, Y., Li, Z., He, N., Deng, Y., Li, S., Liu, T., Chen, X. & Luo, H., 7 Sep 2019, In : Nanoscale. 11, 33, p. 15589-15595 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Fluorescence
Biomarkers
Costs
Cells
Proteins

Androgen receptor genomics for patient stratification: from biomarker discovery to mechanisms

Stelloo, S., 1 Jul 2019, Eindhoven: Technische Universiteit Eindhoven. 291 p.

Research output: ThesisPhd Thesis 2 (Research NOT TU/e / Graduation TU/e)Academic

1 Citation (Scopus)

A new class of supramolecular ligands stabilizes 14-3-3 protein-protein interactions by up to two orders of magnitude

Gigante, A., Grad, J. N., Briels, J., Bartel, M., Hoffmann, D., Ottmann, C. & Schmuck, C., 1 Jan 2019, In : Chemical Communications. 55, 1, p. 111-114 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Neurodegenerative diseases
14-3-3 Proteins
Signal transduction
Ligands
Proteins
Open Access
File
Coronary Artery Disease
Percutaneous Coronary Intervention
Coronary Artery Bypass
Myocardium
Angiography
Open Access
File
Percutaneous Coronary Intervention
Coronary Artery Bypass
Transplants
Coronary Artery Disease
Pathologic Constriction
Child Guidance
Scoliosis
Mebendazole
Toes
Polyethylene

An isolated beating pig heart platform for a comprehensive evaluation of intracardiac blood flow with 4D flow MRI: a feasibility study

Peper, E. S., Leopaldi, A. M., van Tuijl, S., Coolen, B. F., Strijkers, G. J., Baan, J., Planken, R. N., de Weger, A., Nederveen, A. J., Marquering, H. A. & van Ooij, P., 1 Dec 2019, In : European Radiology Experimental. 3, 1, 10 p., 40

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Feasibility Studies
Swine
Magnetic Resonance Imaging
Cardiac Output
Abattoirs

An iterative sparse deconvolution method for simultaneous multicolor 19F-MRI of multiple contrast agents

Schoormans, J., Calcagno, C., Daal, M. R. R., Wüst, R. C. I., Faries, C., Maier, A., Teunissen, A. J. P., Naidu, S., Sanchez-Gaytan, B. L., Nederveen, A. J., Fayad, Z. A., Mulder, W. J. M., Coolen, B. F. & Strijkers, G. J., 10 Jul 2019, In : Magnetic Resonance in Medicine. 83, 1, p. 228-239

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Contrast Media
Artifacts
Fluorine
Noise
Cell Tracking
1 Citation (Scopus)

A novel hybrid silk-fibroin/polyurethane three-layered vascular graft: Towards in situ tissue-engineered vascular accesses for haemodialysis

van Uden, S., Vanerio, N., Catto, V., Bonandrini, B., Tironi, M., Figliuzzi, M., Remuzzi, A., Kock, L., Redaelli, A. C. L., Greco, F. G. & Riboldi, S. A., 1 Mar 2019, In : Biomedical Materials. 14, 2, p. 025007 18 p., 025007

Research output: Contribution to journalArticleAcademicpeer-review

Fibroins
Polyurethanes
Silk
Grafts
Tissue

A pipette-tip based method for seeding cells to droplet microfluidic platforms

Sinha, N., Subedi, N., Wimmers, F., Soennichsen, M. & Tel, J., 11 Feb 2019, In : Journal of Visualized Experiments (JoVE). 144, 10 p., e57848

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Cloud seeding
Microfluidics
Encapsulation
Poisson distribution
Poisson Distribution

Approximation of a pipeline of unsupervised retina image analysis methods with a CNN

Heslinga, F., Pluim, J., Dasht Bozorg, B., Berendschot, T., Houben, A. J. H. M., Henry, R. M. A. & Veta, M., 1 Mar 2019, Image Processing: SPIE Medical Imaging, 2019, San Diego, California, United States. Angelini, E. D. & Landman, B. A. (eds.). Bellingham: SPIE, 7 p. 109491N. (Proceedings of SPIE; vol. 10949)

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Biomarkers
Image analysis
Pipelines
Neural networks
Medical problems
Hypothermia
Myocardial Infarction
Temperature
Myocardial Reperfusion
Myocardium

A protocol update of the fractional flow reserve versus angiography for multivessel evaluation (FAME) 3 trial: a comparison of fractional flow reserve–guided percutaneous coronary intervention and coronary artery bypass graft surgery in patients with multivessel coronary artery disease

Zimmermann, F. M., de Bruyne, B., Pijls, N. H. J., Desai, M., Oldroyd, K. G., Reardon, M. J., Wendler, O., Woo, J., Yeung, A. C. & Fearon, W. F., 1 Aug 2019, In : American Heart Journal. 214, p. 156-157 2 p.

Research output: Contribution to journalArticleAcademicpeer-review

A revised modular approach to (–)-trans-Δ 8 -THC and derivatives through late-stage Suzuki–Miyaura cross-coupling reactions

Bloemendal, V. R. L. J., Sondag, D., Elferink, H., Boltje, T. J., van Hest, J. C. M. & Rutjes, F. P. J. T., 31 Mar 2019, In : European Journal of Organic Chemistry. 2019, 12, p. 2289-2296 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
thermohaline circulation
Dronabinol
cross coupling
Derivatives
Scaffolds
1 Citation (Scopus)

Arginine mimetic appended peptide-based probes for fluorescence turn-on detection of 14-3-3 proteins

Maity, D., Gigante, A., Sánchez-Murcia, P. A., Sijbesma, E., Li, M., Bier, D., Mosel, S., Knauer, S., Ottmann, C. & Schmuck, C., 2 Apr 2019, In : Organic & Biomolecular Chemistry. 17, 17, p. 4359-4363 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

14-3-3 Proteins
peptides
Arginine
Fluorescence
proteins

A robust and general approach to quantitatively conjugate enzymes to plasmonic nanoparticles

Wang, Y., van Asdonk, K. & Zijlstra, P., 23 Sep 2019, In : Langmuir. 35, 41, p. 13356−13363 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
enzymes
Enzymes
Nanoparticles
proteins
Proteins

A simple multi-scale model to evaluate left ventricular growth laws

Rondanina, E. & Bovendeerd, P., 2019, FIMH 2019: Functional Imaging and Modeling of the Heart. Coudière, Y., Ozenne, V., Vigmond, E. & Zemzemi, N. (eds.). Cham: Springer Nature Switzerland AG, p. 249-257 9 p. (Lecture Notes in Computer Science; vol. 11504)

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Mechanics
Blood

Association of improvement in fractional flow reserve with outcomes, including symptomatic relief, after percutaneous coronary intervention

Fournier, S., Ciccarelli, G., Toth, G. G., Milkas, A., Xaplanteris, P., Tonino, P. A. L., Fearon, W. F., Pijls, N. H. J., Barbato, E. & de Bruyne, B., 1 Apr 2019, In : JAMA Cardiology. 4, 4, p. 370-374 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Percutaneous Coronary Intervention
Angiography
Coronary Artery Disease
Randomized Controlled Trials
North America

A stirring system using suspended magnetically-actuated pillars for controlled cell clustering

Saberi, A., Zhang, S., van den Bersselaar, C., Kandail, H., den Toonder, J. M. J. & Kurniawan, N. A., 1 Jan 2019, In : Soft Matter. 15, 6, p. 1435-1443 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
stirring
Magnetic scales
Colloids
Research laboratories
cells
4 Citations (Scopus)

A stochastic view on surface inhomogeneity of nanoparticles

Post, R. A. J., van der Zwaag, D., Bet, G., Wijnands, S. P. W., Albertazzi, L., Meijer, E. W. & van der Hofstad, R. W., 10 Apr 2019, In : Nature Communications. 10, 1, 11 p., 1663

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Nanoparticles
inhomogeneity
nanoparticles
Microscopy
Microscopic examination
Open Access
File
Biocompatible Materials
Pyrimidinones
Proteins
Notch1 Receptor
Click Chemistry

A survey of crowdsourcing in medical image analysis

Ørting, S., Doyle, A., Hirth, M., van Hilten, A., Inel, O., Madan, C. R., Mavridis, P., Spiers, H. & Cheplygina, V., 25 Feb 2019, In : arXiv. 12 p., 1902.09159

Research output: Contribution to journalArticleAcademic

Open Access
File
Image analysis
Astrophysics
Medical imaging
Metadata
Learning algorithms

Atherosclerotic carotid bifurcation phantoms with stenotic soft inclusions for ultrasound flow and vessel wall elastography imaging

Chayer, B., van den Hoven, M., Roy Cardinal, M. H., Li, H., Swillens, A., Lopata, R. & Cloutier, G., 2 May 2019, In : Physics in Medicine and Biology. 64, 9, 12 p., 095025

Research output: Contribution to journalArticleAcademicpeer-review

Elasticity Imaging Techniques
Blood Vessels
Elastic Modulus
Internal Carotid Artery
Atherosclerotic Plaques

ATP-mediated transient behavior of stomatocyte nanosystems

Che, H., Zhu, J., Song, S., Mason, A. F., Cao, S., Pijpers, I. A. B., Abdelmohsen, L. K. E. A. & van Hest, J. C. M., 2 Jul 2019, In : Angewandte Chemie - International Edition. 58, 37, p. 13113-13118

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Nanosystems
Adenosine Triphosphate
Polylysine
Nanoreactors
Molecular interactions

Attenuated cardiac function degradation in ex vivo pig hearts

Kappler, B., van Tuijl, S., Ergin, B., Fixsen, L., Stijnen, M., Ince, C. & de Mol, B. A. J. M., 17 Oct 2019, In : International Journal of Artificial Organs.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Blood
Swine
Degradation
Dialysis
Renal Dialysis

Automated clear cell renal carcinoma grade classification with prognostic significance

Tian, K., Rubadue, C. A., Lin, D. I., Veta, M., Pyle, M. E., Irshad, H. & Heng, Y. J., 1 Jan 2019, In : PLoS ONE. 14, 10, 16 p., e0222641

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
kidney cells
Renal Cell Carcinoma
carcinoma
Atlases
Hazards

Automatic cardiac landmark localization by a recurrent neural network

van Zon, M., Veta, M. & Li, S., 1 Jan 2019, Medical Imaging 2019: Image Processing. Landman, B. A. & Angelini, E. D. (eds.). Bellingham: SPIE, 13 p. 1094916. (Proceedings of SPIE; vol. 10949)

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

landmarks
Recurrent neural networks
Mitral Valve
Magnetic Resonance Spectroscopy
Magnetic resonance

Automatic classification of focal liver lesions based on MRI and risk factors

Jansen, M. J. A., Kuijf, H. J., Veldhuis, W. B., Wessels, F. J., Viergever, M. A. & Pluim, J. P. W., 2019, In : PLoS ONE. 14, 5, 13 p., e0217053

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
lesions (animal)
Liver
Magnetic resonance imaging
risk factors
liver