Organization profile

Introduction / mission

Our mission is to make things move at small scales: fluids, particles, molecules, solid structures. We do this by carrying out research in our Microfab/lab, where we develop innovative technological concepts and fabrication methods to create novel microfluidic devices and microactuators, serving a wide range of applications.

Highlighted phrase

We make things move at small scales!

Organisational profile

In microfluidic systems, active control of fluids and species is essential. Examples are fluid pumping, mixing, mechanical actuation, sorting of cells and particles, and biomolecule capture for diagnostics. We develop and apply micro-actuators, responsive surfaces, and magnetic bead actuation systems, to realize these functions. Our approaches are often biologically inspired, translating principles from nature into technological innovations.

As an important application of our microfluidic systems, and in collaboration with biological, biomedical, and clinical groups, we develop biomedical microdevices to study and understand the behavior of cells, tissues, and organs. This work is aimed at learning about health and disease, and eventually developing novel therapies and medicines. Specifically, we develop organs-on-chips as in-vitro disease models focusing on cancer, we study mechanical properties of single cells, and we develop technologies for in-vitro diagnostics. In addition, we develop biomedical devices that can be applied to treat patients non-invasively, such as a glaucoma eye implant.

We also develop new concepts for microactuators that combine electrical, optical and/or mechanical functionalities, for other applications, from lithography machines to new display principles to air quality monitoring to microrobotics.

Fingerprint Dive into the research topics where den Toonder is active. These topic labels come from the works of this organisation's members. Together they form a unique fingerprint.

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Profiles

Eva A. van Aalen

e.a.v.aalen@tue.nl

Department of Biomedical Engineering, Protein Engineering - Doctoral Candidate
den Toonder

Person: Prom. : doctoral candidate (PhD)

Inês Figueiredo Pereira, MSc

i.c.figueiredo.pereira@tue.nl

Microsystems - Doctoral Candidate
den Toonder

Person: Prom. : doctoral candidate (PhD)

F.G.A. (Erik) Homburg

f.g.a.homburg@tue.nl

Microsystems - Assistant Professor
den Toonder

Person: UD : Assistant Professor

Research Output

27 Article
22 Poster
20 Conference contribution
4 Review article
5 More

3D sugar printing of networks mimicking the vasculature

Pollet, A. M. A. O., Homburg, E. F. G. A., Cardinaels, R. & den Toonder, J. M. J., 1 Jan 2020, In : Micromachines. 11, 1, 22 p., 43.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

1 Citation (Scopus)

26 Downloads (Pure)

A concise review of microfluidic particle manipulation methods

Zhang, S., Wang, Y., Onck, P. R. & den Toonder, J. M. J., 1 Apr 2020, In : Microfluidics and Nanofluidics. 24, 4, p. 1-20 20 p., 24.

Research output: Contribution to journal › Review article › Academic › peer-review

Open Access

File

1 Citation (Scopus)

15 Downloads (Pure)

A new microfluidic model that allows monitoring of complex vascular structures and cell interactions in a 3D biological matrix

van Dijk, C. G. M., Brandt, M. M., Poulis, N., Anten, J., van der Moolen, M., Kramer, L., Homburg, E. F. G. A., Louzao-Martinez, L., Pei, J., Krebber, M. M., van Balkom, B. W. M., de Graaf, P., Duncker, D. J., Verhaar, M. C., Luttge, R. & Cheng, C., 21 May 2020, In : Lab on a Chip. 20, 10, p. 1827-1844 18 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access