• Groene Loper, Building 15, Gemini South (room 2.106)

    5612 AZ Eindhoven

    Netherlands

Organization profile

Introduction / mission

Constructing computational models to improve the knowledge of diseases, biomedical processes and structures

Highlighted phrase

Describing, understanding and ultimately controlling life's processes

Organisational profile

The research group Computational Biology develops computational models that help to obtain qualitative and quantitative knowledge of diseases, biomedical processes and structures. The computational models are developed based on a thorough understanding of molecular modeling methods, data analysis techniques,  machine learning, systems biology, and parameter estimation techniques. Next to data obtained through collaborations and partnerships with other university groups, companies and hospitals, within the Synthetic Biology arena data is also achieved by own experiments. Topics of research are, amongst others, biomembranes, protein interactions, complex biochemical networks, and diseases like metabolic syndrome, diabetes mellitus and cancer. The group also puts efforts in enhancing the shift from ‘describing’ life’s processes to ‘understanding’ them and ‘capturing’ them in validated predictive models, and even ‘managing’ or ‘controlling’ them in real life. Research themes of the group are Molecular Simulations, Systems Biology, Synthetic Biology, Bioinformatics and Mathematical Modeling.

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  • Network Recent external collaboration on country level. Dive into details by clicking on the dots.

    Profiles

    Photo of Gizem Aktas

    Gizem Aktas, MSc

    Person: Prom. : doctoral candidate (PhD)

    20172019
    No photo of Mart Bartelds

    Mart Bartelds, MSc

    Person: OWP : University Teacher / Researcher

    Photo of Bas Bögels
    20192019

    Projects

    NWO/Complexity/MATRyOSka

    van Riel, N. A. W., Aktas, G., O'Donovan, S. D., Arts, I. C. W. & Afman, L.

    1/10/1731/12/22

    Project: Research direct

    Research Output

    Open Access
  • Dynamic modulation of proximity-induced enzyme activity using supramolecular polymers

    Magdalena Estirado, E., Rosier, B. J. H. M., de Greef, T. F. A. & Brunsveld, L., 28 May 2020, In : Chemical Communications. 56, 43, p. 5747-5750 4 p.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
  • Engineered living materials based on adhesin-mediated trapping of programmable cells

    Guo, S., Dubuc, E., Rave, Y., Verhagen, M., Twisk, S. A. E., van der Hek, T., Oerlemans, G. J. M., van den Oetelaar, M. C. M., van Hazendonk, L. S., Brüls, M., Eijkens, B. V., Joostens, P. L., Keij, S. R., Xing, W., Nijs, M., Stalpers, J., Sharma, M., Gerth, M., Boonen, R. J. E. A., Verduin, K. & 3 others, Merkx, M., Voets, I. K. & De Greef, T. F. A., 20 Mar 2020, In : ACS Synthetic Biology. 9, 3, p. 475-485 11 p.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    File
  • 9 Downloads (Pure)

    Prizes

    AMC Principal Investigator

    Natal van Riel (Recipient), 1 May 2016

    Prize: OtherCareer, activity or publication related prizes (lifetime, best paper, poster etc.)Scientific

    Best poster award

    Yvonne Rozendaal (Recipient), 28 Oct 2016

    Prize: OtherCareer, activity or publication related prizes (lifetime, best paper, poster etc.)Scientific

  • Activities

    Personalized modelling of bile acid metabolism: predicting metabolic effects of bariatric surgery

    Natal van Riel (Speaker)
    6 Jul 2018

    Activity: Talk or presentation typesInvited talkScientific

    A physiology based glucose-insulin-GLP-1 model: explaining changes observed after Roux-en-Y gastric bypass

    L.C.P. Thijssen (Speaker), Natal van Riel (Member)
    15 May 2018

    Activity: Talk or presentation typesContributed talkScientific

    4th Dutch Bioinformatics & Systems Biology Conference

    Natal van Riel (Organiser)
    15 May 201816 May 2018

    Activity: Participating in or organising an event typesConferenceScientific

    Research areas

    Bioinformatics

    Rina van Dijck - Postma (Content manager), Sylvia van Beek - Verschure (Content manager), Lieke van Gorp (Content manager), Amy Broeders (Content manager)

    Impact: Research Topic/Theme (at group level)

    Brain Image Analysis

    Josien P.W. Pluim (Content manager), Rina van Dijck - Postma (Content manager), Sylvia van Beek - Verschure (Content manager), Lieke van Gorp (Content manager), Amy Broeders (Content manager)

    Impact: Research Topic/Theme (at group level)

    Cardiovascular Image Analysis

    Josien P.W. Pluim (Content manager), Rina van Dijck - Postma (Content manager), Sylvia van Beek - Verschure (Content manager), Lieke van Gorp (Content manager), Amy Broeders (Content manager)

    Impact: Research Topic/Theme (at group level)

    Student theses

    A computational biology framework: a data analysis tool to support biomedical engineers in their research

    Author: Beishuizen, T., 29 Nov 2018

    Supervisor: Bosnacki, D. (Supervisor 1), Cheplygina, V. (Supervisor 2), Hilbers, P. (Supervisor 2), Fletcher, G. (Supervisor 2) & Vanschoren, J. (Supervisor 2)

    Student thesis: Master

    A physiology based glucose-insulin-GLP-1 model: explaining changes observed after Roux-en-Y gastric bypass

    Author: Thijssen, L., 30 Aug 2018

    Supervisor: Sips, F. (Supervisor 1), Yildirim, V. (Supervisor 2), van Riel, N. (Supervisor 2) & Hilbers, P. (Supervisor 2)

    Student thesis: Master

    Biomarkers as predictor of quality of life in bariatric patients

    Author: Schouten, J., 31 Jan 2019

    Supervisor: Hilbers, P. (Supervisor 1), van Riel, N. (Supervisor 2), Scharnhorst, V. (Supervisor 2), van Loon, S. (Supervisor 2) & Deneer, R. (Supervisor 2)

    Student thesis: Master