• Groene Loper, Building 15, Gemini South (room 2.106)

    5612 AZ Eindhoven

    Netherlands

Organization profile

Introduction / mission

Constructing computational models to improve the knowledge of diseases, biomedical processes and structures

Highlighted phrase

Describing, understanding and ultimately controlling life's processes

Organisational profile

The research group Computational Biology develops computational models that help to obtain qualitative and quantitative knowledge of diseases, biomedical processes and structures. The computational models are developed based on a thorough understanding of molecular modeling methods, data analysis techniques,  machine learning, systems biology, and parameter estimation techniques. Next to data obtained through collaborations and partnerships with other university groups, companies and hospitals, within the Synthetic Biology arena data is also achieved by own experiments. Topics of research are, amongst others, biomembranes, protein interactions, complex biochemical networks, and diseases like metabolic syndrome, diabetes mellitus and cancer. The group also puts efforts in enhancing the shift from ‘describing’ life’s processes to ‘understanding’ them and ‘capturing’ them in validated predictive models, and even ‘managing’ or ‘controlling’ them in real life. Research themes of the group are Molecular Simulations, Systems Biology, Synthetic Biology, Bioinformatics and Mathematical Modeling.

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1982 2019

A multilayer microfluidic platform for the conduction of prolonged cell-free gene expression

van der Linden, A., Pieters, P., Yelleswarapu, M., Swank, Z., Huck, W. T. S., Maerkl, S. & de Greef, T., 2019, (Accepted/In press) In : Journal of Visualized Experiments (JoVE).

Research output: Contribution to journalArticleAcademicpeer-review

File
Lab-On-A-Chip Devices
Microfluidics
Transcription
Gene expression
Multilayers
2 Citations (Scopus)

Cell-free microcompartmentalised transcription-translation for the prototyping of synthetic communication networks

Dubuc, E., Pieters, P. A., van der Linden, A. J., van Hest, J. C. M., Huck, W. T. S. & de Greef, T. F. A., 1 Aug 2019, In : Current Opinion in Biotechnology. 58, p. 72-80 9 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
File
Transcription
Telecommunication networks
Communication
Cells
Networks (circuits)

Characterization of disease-specific cellular abundance profiles of chronic inflammatory skin conditions from deconvolution of biopsy samples

Félix Garza, Z. C., Lenz, M., Liebmann, J., Ertaylan, G., Born, M., Arts, I. C. W., Hilbers, P. A. J. & Van Riel, N. A. W., 17 Aug 2019, In : BMC Medical Genomics. 12, 1, 14 p., 121

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Biopsy
Skin
Atopic Dermatitis
Psoriasis
Skin Diseases

Prizes

AMC Principal Investigator

Natal van Riel (Recipient), 1 May 2016

Recognition: OtherCareer, activity or publication related prizes (lifetime, best paper, poster etc.)Scientific

Best poster award

Yvonne Rozendaal (Recipient), 28 Oct 2016

Recognition: OtherCareer, activity or publication related prizes (lifetime, best paper, poster etc.)Scientific

Heart Neoplasms
Practice Guidelines
Chronic Disease
Stroke
Myocardial Infarction

Activities 1999 2018

Personalized modelling of bile acid metabolism: predicting metabolic effects of bariatric surgery

Natal van Riel (Speaker)
6 Jul 2018

Activity: Talk or presentation typesInvited talkScientific

A physiology based glucose-insulin-GLP-1 model: explaining changes observed after Roux-en-Y gastric bypass

L.C.P. Thijssen (Speaker), Natal van Riel (Member)
15 May 2018

Activity: Talk or presentation typesContributed talkScientific

4th Dutch Bioinformatics & Systems Biology Conference

Natal van Riel (Organiser)
15 May 201816 May 2018

Activity: Participating in or organising an event typesConferenceScientific

Press / Media

New Device Enables Test for Cancer Drug Combinations on Tumor Biopsies

Federica Eduati

25/06/18

1 item of media coverage

Press/Media: Expert Comment

Miniature Testing of Drug Pairs on Tumour Biopsies

Federica Eduati

25/06/18

1 item of media coverage

Press/Media: Expert Comment

Research areas

Bioinformatics

Rina van Dijck - Postma (Content manager), Sylvia van Beek - Verschure (Content manager), Lieke van Gorp (Content manager), Amy Broeders (Content manager)

Impact: Research Topic/Theme (at group level)

Brain Image Analysis

Josien P.W. Pluim (Content manager), Rina van Dijck - Postma (Content manager), Sylvia van Beek - Verschure (Content manager), Lieke van Gorp (Content manager), Amy Broeders (Content manager)

Impact: Research Topic/Theme (at group level)

Cardiovascular Image Analysis

Josien P.W. Pluim (Content manager), Rina van Dijck - Postma (Content manager), Sylvia van Beek - Verschure (Content manager), Lieke van Gorp (Content manager), Amy Broeders (Content manager)

Impact: Research Topic/Theme (at group level)

Student theses

A computational biology framework: a data analysis tool to support biomedical engineers in their research

Author: Beishuizen, T., 29 Nov 2018

Supervisor: Bosnacki, D. (Supervisor 1), Cheplygina, V. (Supervisor 2), Hilbers, P. (Supervisor 2), Fletcher, G. (Supervisor 2) & Vanschoren, J. (Supervisor 2)

Student thesis: Master

A physiology based glucose-insulin-GLP-1 model: explaining changes observed after Roux-en-Y gastric bypass

Author: Thijssen, L., 30 Aug 2018

Supervisor: Sips, F. (Supervisor 1), Yildirim, V. (Supervisor 2), van Riel, N. (Supervisor 2) & Hilbers, P. (Supervisor 2)

Student thesis: Master

Biomarkers as predictor of quality of life in bariatric patients

Author: Schouten, J., 31 Jan 2019

Supervisor: Hilbers, P. (Supervisor 1), van Riel, N. (Supervisor 2), Scharnhorst, V. (Supervisor 2), van Loon, S. (Supervisor 2) & Deneer, R. (Supervisor 2)

Student thesis: Master