Content available in repository
Content available in repository
Organisation profile
Introduction / mission
In this group, research deals with chemical biology approaches to study protein-protein interactions.
Highlighted phrase
supramolecular architecture and drug discovery
Organisation profile
The Chemical Biology group is a research group within the department of Biomedical Engineering. The group is supervized by Prof.dr.ir. Luc Brunsveld.
In this group, research deals with chemical biology approaches to study protein-protein interactions. The two general lines that are being followed are supramolecular architecture and drug discovery.
UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. Our work contributes towards the following SDG(s):
Fingerprint
Dive into the research topics where Chemical Biology is active. These topic labels come from the works of this organisation's members. Together they form a unique fingerprint.
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Profiles
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Blaž Andlovic, MSc
- Biomedical Engineering, Chemical Biology - Former Doctoral Candidate
Person: Prom. : doctoral candidate (PhD)
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Arjen-Kars Boer
- Biomedical Engineering, Chemical Biology - University Researcher
- EAISI Health - University Researcher
- Biomedical Engineering, Computational Biology - University Researcher
Person: OWP : University Teacher / Researcher
Research output
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14-3-3 Protein-Protein Interactions: From Mechanistic Understanding to Their Small-Molecule Stabilization
Somsen, B. A., Cossar, P. J., Arkin, M. R., Brunsveld, L. & Ottmann, C. (Corresponding author), 15 Jul 2024, In: ChemBioChem. 25, 14, 14 p., e202400214.Research output: Contribution to journal › Review article › peer-review
Open AccessFile21 Downloads (Pure) -
14-3-3τ as a Modulator of Early α-Synuclein Multimerization and Amyloid Formation
Heesink, G., van den Oetelaar, M. C. M., Semerdzhiev, S. A., Ottmann, C., Brunsveld, L., Blum, C. (Corresponding author) & Claessens, M. M. A. E. (Corresponding author), 1 May 2024, In: ACS Chemical Neuroscience. 15, 9, p. 1926-1936 11 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile32 Downloads (Pure) -
A Generic Antibody-Blocking Protein That Enables pH-Switchable Activation of Antibody Activity
Biewenga, L., Vermathen, R., Rosier, B. J. H. M. & Merkx, M. (Corresponding author), 19 Jan 2024, In: ACS Chemical Biology. 19, 1, p. 48-57 10 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile2 Citations (Scopus)63 Downloads (Pure)
Equipment
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Laboratory for Chemical Biology
Brunsveld, L. (Manager)
Chemical BiologyFacility/equipment: Research lab
Datasets
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CCDC 2183728: Experimental Crystal Structure Determination
Maurya, G. P. (Contributor), Verma, D. (Contributor), Sinha, A. (Contributor), Brunsveld, L. (Contributor) & Haridas, V. (Contributor), Cambridge Crystallographic Data Centre, 4 Jul 2022
DOI: 10.5517/ccdc.csd.cc2c9bvw
Dataset
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Supplementary Material for: Visual Analysis of Biomarkers Reveals Differences in Lipid Profiles and Liver Enzymes before and after Gastric Sleeve and Bypass
Scharnhorst, V. (Contributor), Van Loon, S. L. M. (Contributor), van Berckel, M. M. G. (Contributor), Nienhuijs, S. W. (Contributor) & Boer, A.-K. (Contributor), Figshare Academic Research System, 5 Feb 2021
DOI: 10.6084/m9.figshare.13720693, https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Visual_Analysis_of_Biomarkers_Reveals_Differences_in_Lipid_Profiles_and_Liver_Enzymes_before_and_after_Gastric_Sleeve_and_Bypass/13720693
Dataset
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Traversing Chemical Space with Active Deep Learning: A Computational Framework for Low-data Drug Discovery
van Tilborg, D. (Creator) & Grisoni, F. (Creator), Zenodo, 23 Nov 2023
DOI: 10.5281/zenodo.10781477, https://zenodo.org/records/10781477
Dataset
Prizes
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Golden Medal Royal Dutch Chemical Society 2012
Brunsveld, L. (Recipient), 2012
Prize: Other › Career, activity or publication related prizes (lifetime, best paper, poster etc.) › Scientific
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NWO Vici Award : Synthetic Supramolecular Signalling Systems
Brunsveld, L. (Recipient), 2014
Prize: NWO › Vici › Scientific
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NWO Vidi Award : Pieces of plastic with biological properties?
Dankers, P. Y. W. (Recipient), 2016
Prize: NWO › Vidi › Scientific
Press/Media
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Reports from University of Newcastle Add New Data to Findings in Pancreatic Cancer (Novel Piperazine-1,2,3-triazole Leads for the Potential Treatment of Pancreatic Cancer)
11/10/23
1 item of Media coverage
Press/Media: Expert Comment
Research areas
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14-3-3 Protein-Protein Interactions
(Content manager), (Content manager) & (Content manager)
Impact: Research Topic/Theme (at group level)
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Nuclear Receptor-Cofactor Interaction
(Content manager), (Content manager) & (Content manager)
Impact: Research Topic/Theme (at group level)
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Supramolecular Architectures
(Content manager), (Content manager) & (Content manager)
Impact: Research Topic/Theme (at group level)
Student theses
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1,4,7-triazacyclononane functionalized BTA: a supramolecular polymer for cooperative catalysis
Robeerst, C. J. (Author), Mabesoone, M. (Supervisor 1), Su, L. (Supervisor 2), Meijer, B. (Supervisor 2), Palmans, A. (Supervisor 2) & Schenning, A. (Supervisor 2), 26 Jun 2019Student thesis: Master
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Active learning for drug discovery using graph neural networks
Rossen, L. (Author), Brunsveld, L. (Supervisor 1), Grisoni, F. (Supervisor 2), Markvoort, A. J. (Supervisor 2) & van Tilborg, D. (Supervisor 2), 30 Nov 2023Student thesis: Master
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A general framework for straightforward model construction of multi-component thermodynamic equilibrium systems
Geertjens, N. H. J. (Author), Wezeman, T. (Supervisor 1) & Brunsveld, L. (Supervisor 2), 28 Feb 2022Student thesis: Master