Projects per year
Organisation profile
Introduction / mission
The research is performed in close collaboration with material scientists, life scientists, clinicians, and medtech spin-offs within national and international consortia in the field of Regenerative Medicine and Tissue Engineering
Organisation profile
The research group investigates the interplay between living cells and the mechanobiological cues originating from the extracellular matrix under conditions of tissue growth, adaptation, regeneration and degeneration. For this, the group uses ‘living’ model systems (cell, cell-matrix, engineered tissue, native tissue) to quantify and understand these aspects at different levels of complexity. The obtained fundamental knowledge is translated into engineering approaches to restore or regenerate living tissues, in particular for the human heart. A prominent example is the development of a synthetic, biodegradable heart valve prosthesis that seduces the body to create a new, living heart valve at the site of implantation. Along this line, novel developments concentrate on the in situ tissue engineering of coronary arteries and vascular access grafts
Another important research topic focuses on restoring tissue organization in compromised myocardium and other soft tissues. This research aims to understand extracellular matrix synthesis and remodeling under mechanical loading conditions and in the presence of degradable scaffolds using platforms of miniaturized heart tissues.
Highlighted phrase
We investigate how living cells shape and adapt their own environment in order to rationally design regenerative implants for the heart
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Collaborations and top research areas from the last five years
Profiles
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Sofia Artamonova
- Biomedical Engineering, Cell-Matrix Interactions in Cardiovascular Tissue Regeneration - Doctoral Candidate
Person: Prom. : doctoral candidate (PhD)
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Jordy G.M. van Asten
- Biomedical Engineering, Cell-Matrix Interactions in Cardiovascular Tissue Regeneration - Former Doctoral Candidate
- Biomedical Engineering, Modeling in Mechanobiology - Former Doctoral Candidate
Person: Prom. : doctoral candidate (PhD)
Projects
- 1 Finished
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Advaessel: Ad vanced materials processing and design for regenerating blodd vessels
Kurniawan, N. A. (Project Manager) & Castilho, M. (Project member)
1/11/20 → 30/11/21
Project: Research direct
Research output
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2.5D Model for Ex Vivo Mechanical Characterization of Sprouting Angiogenesis in Living Tissue
Grolleman, J., Pijnenburg, I. M. T., Bouten, C. V. C., Conte, V. (Corresponding author) & Sahlgren, C. M. (Corresponding author-nrf), 28 Feb 2025, In: Journal of Visualized Experiments (JoVE). 216, 22 p., e67641 .Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile24 Downloads (Pure) -
A call for standardization: evaluating different methodologies to induce in vitro foreign body giant cell formation for biomaterials research and design
Conner, T. S., Baaijens, F. P. T., Bouten, C. V. C., Angeloni, L. & Smits, A. I. P. M. (Corresponding author), 1 Mar 2025, In: Acta Biomaterialia. 194, p. 20-37 18 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile17 Downloads (Pure) -
Applications of electrospun scaffolds: Using a supramolecular approach to improve material-tissue interactions
Arts, B., 20 Mar 2025, Eindhoven: Eindhoven University of Technology. 259 p.Research output: Thesis › Phd Thesis 1 (Research TU/e / Graduation TU/e)
Open AccessFile
Equipment
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Alveole protein printer 'Primo'
Janssen-van den Broek, W. J. T. (Manager)
Departmental Office BMTFacility/equipment: Equipment
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Autoclaves
Janssen-van den Broek, W. J. T. (Manager)
Biomedical EngineeringFacility/equipment: Equipment
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BioTek Synergy HTX Plate reader
Janssen-van den Broek, W. J. T. (Manager)
Departmental Office BMTFacility/equipment: Equipment
Datasets
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Source data for the publication: A Cell Pre-Wrapping Seeding Technique for Hydrogel-Based Tubular Organ-On-A-Chip
Nie, J. (Creator), Lou, S. (Creator), Pollet, A. (Creator), van Vegchel, M. (Creator), Bouten, C. V. C. (Creator) & den Toonder, J. M. J. (Creator), 4TU.Centre for Research Data, 15 Nov 2024
DOI: 10.4121/6b6afa04-cf9c-4273-8150-8eb34c22b138, https://data.4tu.nl/datasets/6b6afa04-cf9c-4273-8150-8eb34c22b138 and one more link, https://data.4tu.nl/datasets/6b6afa04-cf9c-4273-8150-8eb34c22b138/1 (show fewer)
Dataset
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Microfluidic Models of Metastasis: In vitro approaches to study the tumor microenvironment - supplementary design and video files
Sleeboom, J. (Creator), Sahlgren, C. M. (Creator) & den Toonder, J. M. J. (Creator), 4TU.Centre for Research Data, 21 Aug 2020
DOI: 10.4121/uuid:08ac69b6-6430-4ffa-a33e-40da88821dc6
Dataset
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Data underlying the publication "A biomimetic microfluidic model to study signalling between endothelial and vascular smooth muscle cells under hemodynamic conditions"
van Engeland, N. C. A. (Contributor), Pollet, A. (Creator), den Toonder, J. M. J. (Contributor), Bouten, C. V. C. (Creator), Stassen, O. M. J. A. (Creator) & Sahlgren, C. M. (Creator), 4TU.Centre for Research Data, 2 Sept 2020
DOI: 10.4121/12854756, https://data.4tu.nl/articles/_/12854756
Dataset
Prizes
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Annual BME Research Day Poster Prize
van Kelle, M. (Recipient), 8 Apr 2016
Prize: Other › Career, activity or publication related prizes (lifetime, best paper, poster etc.) › Scientific
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Control cell communication and tissue regeneration
Kurniawan, N. (Recipient), 2019
Prize: ERC › Starting › Scientific
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ESB Best Doctoral Thesis Award
Ristori, T. (Recipient), 10 Jul 2019
Prize: Other › Discipline related › Scientific
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A Photoresponsive Hydrogel to Investigate Cell Responses to Dynamically Changing Topographies
Bril, M. (Speaker)
1 Dec 2022Activity: Talk or presentation types › Contributed talk › Scientific
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A Photoresponsive Hydrogel to Investigate Cell Responses to Dynamically Changing Topographies
Bril, M. (Speaker)
15 Nov 2022Activity: Talk or presentation types › Contributed talk › Scientific
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A Photoresponsive Hydrogel to Investigate Cell Responses to Dynamically Changing Topographies
Bril, M. (Speaker)
11 Oct 2022Activity: Talk or presentation types › Contributed talk › Scientific
Press/Media
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Experts warn Oklahoma college DEI programs likely illegal
19/10/23 → 1/11/23
2 items of Media coverage
Press/Media: Expert Comment
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Movement finds way to keep Black history alive
8/10/23
1 item of Media coverage
Press/Media: Expert Comment
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Black history 'Underground Railroad' forms across US after DeSantis, others ban books
30/09/23
5 items of Media coverage
Press/Media: Expert Comment
Student theses
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A brain chip to investigate neurite outgrowth by trapping cell-laden hydrogel beads in microsieves
Labeur, T. (Author), Bouten, C. (Supervisor 1), Luttge, R. (Supervisor 2), Kurniawan, N. (Supervisor 2) & Bastiaens, A. (Supervisor 2), 29 Aug 2019Student thesis: Master
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A droplet-based platform for assessing NK cell mediated cytotoxicity in real time
Houben, L. (Author), Subedi, N. (Supervisor 1), Conte, V. (Supervisor 2), Merkx, M. (Supervisor 2) & Smits, A. I. P. M. (Supervisor 2), 19 Apr 2021Student thesis: Master
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A microengineering approach to studying galvanotaxis
van Katwijk, W. H. (Author), Kurniawan, N. A. (Supervisor 1) & Saberi, A. (Supervisor 2), 23 May 2024Student thesis: Master