• Groene Loper 15, Gemini-Zuid 3.115

    5612 AZ Eindhoven

    Netherlands

Organization profile

Introduction / mission

MRI and MRS offer exciting possibilities for the investigation of a range of structural, functional and metabolic parameters in living systems.

MRI and MRS are non-invasive and therefore ideally suited for repeated studies, in which changes in tissues are followed over time. This non-invasiveness and the richness of the information that is obtained explain the important role of MR in biological and biomedical research. Not surprisingly, MR has also rapidly gained an important position in human healthcare since its first arrival in medical centers in the late 1980’s.

Highlighted phrase

The research and teaching program of the BioMedical NMR group is aimed at the development and use of in vivo magnetic resonance imaging (MRI) and spectroscopy (MRS) techniques. 

Organisational profile

The central aim of our research program is to push the limits of biomedical MR. New techniques are developed and validated by studies on biological preparations in vitro and animal models in vivo, and where possible applied in clinical human research. The technology developments in our group are inspired by important biomedical and healthcare problems:

  1. skeletal muscle disorders, especially type 2 diabetes and decubitus;
  2. cardiovascular disorders, including atherosclerosis and cardiac infarction;
  3. molecular imaging of disease biomarkers and the development of target-specific contrast agents.

These themes were chosen because:

  1. diseases of skeletal muscle and the cardiovascular system have a major socio-economic impact;
  2. MR has the potential to greatly improve the diagnosis and management of these disorders;
  3. novel MRI protocols combined with targeted contrast agents can strongly enhance the specificity and sensitivity of diagnostic MRI.

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Profiles

No photo of Ot Bakermans

Ot Bakermans

Person: OWP : University Teacher / Researcher

20112015
Photo of Holger Grüll
20072018
No photo of Jules L. Nelissen

Jules L. Nelissen

Person: Prom. : doctoral candidate (PhD)

20142018

Research Output 1978 2019

Dynamics in human muscle bioenergetics: in silico and in vivo studies of metabolism during exercise

Hendriks, A., Nabben, M. W., Schmitz, J. P. J., Hilbers, P. A. J., Prompers, J. J. & van Riel, N. A. W., 2019, (In preparation) Eindhoven: Technische Universiteit Eindhoven

Research output: Working paperAcademic

Tetrazine - trans-cyclooctene chemistry applied to fabricate self-assembled fluorescent and radioactive nanoparticles for in vivo dual mode imaging

van Onzen, A. H. A. M., Rossin, R., Schenning, A. P. H. J., Nicolay, K., Milroy, L. G., Robillard, M. S. & Brunsveld, L., 1 Jan 2019, In : Bioconjugate Chemistry. 30, 3, p. 547–551 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Nanoparticles
Imaging techniques
Molecules
Multimodal Imaging
Radioactivity
1 Citation (Scopus)

Accelerated 4D phase contrast MRI in skeletal muscle contraction

Mazzoli, V., Gottwald, L. M., Peper, E. S., Froeling, M., Coolen, B. F., Verdonschot, N., Sprengers, A. M., van Ooij, P., Strijkers, G. J. & Nederveen, A. J., 1 Nov 2018, In : Magnetic Resonance in Medicine. 80, 5, p. 1799-1811 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Muscle Contraction
Skeletal Muscle
Muscles
Volunteers
Leg

Prizes

NWO Veni Award : Changes in the failing heart

M.W. Nabben (Recipient), 2013

Recognition: NWOVeniScientific

Heart Diseases
Heart Failure
Research Personnel
Therapeutics

Press / Media

Skull Surprise

Katrien Vandoorne

30/08/18

1 item of media coverage

Press/Media: Expert Comment

Student theses

Cerebral activation reflects loudness perception rather than physical sound intensity: an fMRI study in normally hearing and hearing-impaired subjects

Author: Schoenmaker, E., 28 Feb 2005

Supervisor: Langers, D. (Supervisor 1), Backes, W. (Supervisor 2), van Dijk, P. (Supervisor 2), Manni, J. (External person) (Supervisor 2), van Engelshoven, J. M. (Supervisor 2) & Nicolay, K. (Supervisor 2)

Student thesis: Master

Machnetic resonance neurograpy of the celiac plexus with motion-compensated 3D SHINKEI

Author: Kok, L., 20 Jun 2017

Supervisor: Strijkers, G. (Supervisor 1), Ferrer, C. (External person) (External coach), Bos, C. (External person) (External coach), van Leeuwen, M. (External person) (External coach) & Lopata, R. (Supervisor 2)

Student thesis: Master