• Department of Biomedical Engineering Eindhoven University of Technology, P.O. Box 513

    5600 MB Eindhoven

    Netherlands

  • Eindhoven University of Technology, Building 15, Gemini-South (room 4.115) Groene Loper

    5612 AZ Eindhoven

    Netherlands

Organization profile

Introduction / mission

The mission of the group is to educate students in the biomechanics of soft tissues with emphasis on both computational as well as experimental methods. This includes development of constitutive models for solids and mixtures, including growth, adaptation and damage development. Experimental techniques involve in-vivo and ex-vivo mechanical testing at multiple scales, microscopic techniques and inverse methods.

Highlighted phrase

understand and predict the behaviour of biological structures and organs

Organisational profile

Biomechanics has always played an important role in biomedical engineering and forms an integral part of a multi-disciplinary approach to clinical and biological problems. Biomechanical modelling became an essential tool to understand and predict the behaviour of biological structures and organs, from the molecular scale up to the full body scale. This involved the solution of solid/fluid interaction problems and the transport of small and large molecules in tissues. A lot of effort was put in dynamical time dependent variations, which are so specific for biological tissues like growth, adaptation and degradation.

The research comprises two related research lines and is a good example of the trend in research methodology that is described above.  The first line is aimed at the prevention of Pressure Ulcers (PUs) with three major objectives: 1. Understanding the mechanisms that cause PUs 2. Develop a method to identify patients at risk. 3. Develop a method for early detection of ulcers that start to develop in deep tissue layers near the bony prominences. The second research line involves biomechanics of skin, strongly related to conditions associated with PUs (studies on skin irritation and biomarkers), but also focused on other application areas (interaction of skin with personal care devices and trans-epidermal drug delivery). The above-mentioned applications required detailed knowledge of mechanical properties like stiffness and strength as well as transport properties  (diffusion coefficients, permeability) at a very local level in the top layers of the skin.

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Research Output 2017 2018

3 Citations (Scopus)

Adaptation of a MR imaging protocol into a real-time clinical biometric ultrasound protocol for persons with spinal cord injury at risk for deep tissue injury: A reliability study

Swaine, J. M., Moe, A., Breidahl, W., Bader, D. L., Oomens, C. W. J., Lester, L., O'Loughlin, E., Santamaria, N. & Stacey, M. C., 1 Feb 2018, In : Journal of Tissue Viability. 27, 1, p. 2-9 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Spinal Cord Injuries
Tendons
Skin
Spinal Cord
Wounds and Injuries
1 Citation (Scopus)

A model of human skin under large amplitude oscillatory shear

Soetens, J. F. J., van Vijven, M., Bader, D. L., Peters, G. W. M. & Oomens, C. W. J., 1 Oct 2018, In : Journal of the Mechanical Behavior of Biomedical Materials. 86, p. 423-432 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Skin
Constitutive models
Shear thinning
Parameter estimation
Shear deformation
5 Citations (Scopus)

An advanced magnetic resonance imaging perspective on the etiology of deep tissue injury

Nelissen, J. L., Traa, W. A., de Boer, H. H., de Graaf, L., Mazzoli, V., Savci-Heijink, C. D., Nicolay, K., Froeling, M., Bader, D. L., Nederveen, A. J., Oomens, C. W. J. & Strijkers, G. J., 1 Jun 2018, In : Journal of Applied Physiology. 124, 6, p. 1580-1596 17 p.

Research output: Contribution to journalArticleAcademicpeer-review

Magnetic Resonance Imaging
Wounds and Injuries
Muscles
Edema
Angiography