Research Output per year
Organization profile
Introduction / mission
The mission of the group is to educate students in the biomechanics of soft tissues with emphasis on both computational as well as experimental methods. This includes development of constitutive models for solids and mixtures, including growth, adaptation and damage development. Experimental techniques involve in-vivo and ex-vivo mechanical testing at multiple scales, microscopic techniques and inverse methods.
Highlighted phrase
understand and predict the behaviour of biological structures and organs
Organisational profile
Biomechanics has always played an important role in biomedical engineering and forms an integral part of a multi-disciplinary approach to clinical and biological problems. Biomechanical modelling became an essential tool to understand and predict the behaviour of biological structures and organs, from the molecular scale up to the full body scale. This involved the solution of solid/fluid interaction problems and the transport of small and large molecules in tissues. A lot of effort was put in dynamical time dependent variations, which are so specific for biological tissues like growth, adaptation and degradation.
The research comprises two related research lines and is a good example of the trend in research methodology that is described above. The first line is aimed at the prevention of Pressure Ulcers (PUs) with three major objectives: 1. Understanding the mechanisms that cause PUs 2. Develop a method to identify patients at risk. 3. Develop a method for early detection of ulcers that start to develop in deep tissue layers near the bony prominences. The second research line involves biomechanics of skin, strongly related to conditions associated with PUs (studies on skin irritation and biomarkers), but also focused on other application areas (interaction of skin with personal care devices and trans-epidermal drug delivery). The above-mentioned applications required detailed knowledge of mechanical properties like stiffness and strength as well as transport properties (diffusion coefficients, permeability) at a very local level in the top layers of the skin.
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Network
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Profiles

Zülal Kizilaslan, MSc
- Department of Biomedical Engineering, Biomechanics of Soft Tissues - Doctoral Candidate
Person: Prom. : doctoral candidate (PhD)

Cees W.J. Oomens
- Department of Biomedical Engineering, Soft Tissue Engineering and Mechanobiology - Full Professor
- Department of Biomedical Engineering, Biomechanics of Soft Tissues - Full Professor
Person: HGL : Professor

Jessica Ralvoni
- Department of Biomedical Engineering, Biomechanics of Soft Tissues - Doctoral Candidate
Person: Prom. : doctoral candidate (PhD)
Research Output 2017 2019
Magnetic resonance elastography of skeletal muscle deep tissue injury
Nelissen, J. L., Sinkus, R., Nicolay, K., Nederveen, A. J., Oomens, C. W. J. & Strijkers, G. J., Jun 2019, In : NMR in Biomedicine. 32, 6, 12 p., e4087.Research output: Contribution to journal › Article › Academic › peer-review
Mechanical and biochemical response of human skin to diverse loading conditions
Soetens, J. F. J., 18 Jun 2019, Eindhoven: Technische Universiteit Eindhoven. 112 p.Research output: Thesis › Phd Thesis 1 (Research TU/e / Graduation TU/e)
Myoglobin and troponin concentrations are increased in early stage deep tissue injury
Traa, W. A., Strijkers, G. J., Bader, D. L. & Oomens, C. W. J., 1 Apr 2019, In : Journal of the Mechanical Behavior of Biomedical Materials. 92, p. 50-57 8 p.Research output: Contribution to journal › Article › Academic › peer-review
Press / Media
-Eindhoven University of Technology: Detecting pressure ulcers in sweat and sebum
18/06/19
1 item of Media coverage
Press/Media: Expert Comment
Detecting pressure ulcers in sweat and sebum
17/06/19
1 item of Media coverage
Press/Media: Expert Comment
TU/e Researchers Develop Expandable, Biodegradable 3D Printed Stents for Pediatric Patients
Cees W.J. Oomens, Frank P.T. Baaijens & Bart Sanders
21/05/17
1 item of Media coverage
Press/Media: Expert Comment
Student theses
Investigation of the cause of heel ulcers for bedridden patients: a finite element study
Author: van Zwam, W., 29 Aug 2019Supervisor: Oomens, C. (Supervisor 1) & van Turnhout, M. (Supervisor 2)
Student thesis: Master