• Department of Biomedical Engineering Eindhoven University of Technology, P.O. Box 513

    5600 MB Eindhoven


  • Eindhoven University of Technology, Building 15, Gemini-South (room 4.115) Groene Loper

    5612 AZ Eindhoven


Organization profile

Introduction / mission

The mission of the group is to educate students in the biomechanics of soft tissues with emphasis on both computational as well as experimental methods. This includes development of constitutive models for solids and mixtures, including growth, adaptation and damage development. Experimental techniques involve in-vivo and ex-vivo mechanical testing at multiple scales, microscopic techniques and inverse methods.

Highlighted phrase

understand and predict the behaviour of biological structures and organs

Organisational profile

Biomechanics has always played an important role in biomedical engineering and forms an integral part of a multi-disciplinary approach to clinical and biological problems. Biomechanical modelling became an essential tool to understand and predict the behaviour of biological structures and organs, from the molecular scale up to the full body scale. This involved the solution of solid/fluid interaction problems and the transport of small and large molecules in tissues. A lot of effort was put in dynamical time dependent variations, which are so specific for biological tissues like growth, adaptation and degradation.

The research comprises two related research lines and is a good example of the trend in research methodology that is described above.  The first line is aimed at the prevention of Pressure Ulcers (PUs) with three major objectives: 1. Understanding the mechanisms that cause PUs 2. Develop a method to identify patients at risk. 3. Develop a method for early detection of ulcers that start to develop in deep tissue layers near the bony prominences. The second research line involves biomechanics of skin, strongly related to conditions associated with PUs (studies on skin irritation and biomarkers), but also focused on other application areas (interaction of skin with personal care devices and trans-epidermal drug delivery). The above-mentioned applications required detailed knowledge of mechanical properties like stiffness and strength as well as transport properties  (diffusion coefficients, permeability) at a very local level in the top layers of the skin.

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    Research Output

    • 17 Article
    • 1 Phd Thesis 1 (Research TU/e / Graduation TU/e)

    Magnetic resonance elastography of skeletal muscle deep tissue injury

    Nelissen, J. L., Sinkus, R., Nicolay, K., Nederveen, A. J., Oomens, C. W. J. & Strijkers, G. J., Jun 2019, In : NMR in Biomedicine. 32, 6, 12 p., e4087.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
  • 1 Citation (Scopus)
    32 Downloads (Pure)

    Mechanical and biochemical response of human skin to diverse loading conditions

    Soetens, J. F. J., 18 Jun 2019, Eindhoven: Technische Universiteit Eindhoven. 112 p.

    Research output: ThesisPhd Thesis 1 (Research TU/e / Graduation TU/e)

    Open Access
  • Myoglobin and troponin concentrations are increased in early stage deep tissue injury

    Traa, W. A., Strijkers, G. J., Bader, D. L. & Oomens, C. W. J., 1 Apr 2019, In : Journal of the Mechanical Behavior of Biomedical Materials. 92, p. 50-57 8 p.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
  • 2 Citations (Scopus)
    32 Downloads (Pure)

    Student theses

    Evaluation of bone metabolism around the Symax hip stem prosthesis after Total Hip Arthroplasty using 18F-fluoride PET/CT in patients

    Author: ter Voert, C., 27 Feb 2020

    Supervisor: van Rietbergen, B. (Supervisor 1), Peters, M. (External coach), ten Broeke, R. H. (External person) (External coach), Arts, J. (. (Supervisor 2) & Oomens, C. W. (Supervisor 2)

    Student thesis: Master

    Investigation of the cause of heel ulcers for bedridden patients: a finite element study

    Author: van Zwam, W., 29 Aug 2019

    Supervisor: Oomens, C. (Supervisor 1) & van Turnhout, M. (Supervisor 2)

    Student thesis: Master

    Scaling effects in effective mechanical properties of skin during indentation

    Author: van den Boogaert, L., 26 Mar 2020

    Supervisor: Oomens, C. W. (Supervisor 1), van Turnhout, M. C. (Supervisor 2), Bovendeerd, P. H. (Supervisor 2) & van Rietbergen, B. (Supervisor 2)

    Student thesis: Master