• Postbus 513, Helix Building

    5600 MB Eindhoven

    Netherlands

  • De Groene Loper 3, Helix Building (STO 3.39)

    5612 AE Eindhoven

    Netherlands

Research Output

Article

A block copolymer for functionalisation of polymersome surfaces

van Dongen, S. F. M., Nallani, M., Schoffelen, S., Cornelissen, J. J. L. M., Nolte, R. J. M. & van Hest, J. C. M., 18 Feb 2008, In : Macromolecular Rapid Communications. 29, 4, p. 321-325 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

68 Citations (Scopus)

Accelerated living cationic ring-opening polymerization of a methyl ester functionalized 2-oxazoline monomer

Bouten, P. J. M., Hertsen, D., Vergaelen, M., Monnery, B. D., Boerman, M. A., Goossens, H., Catak, S., van Hest, J. C. M., van Speybroeck, V. & Hoogenboom, R., 28 Jan 2015, In : Polymer Chemistry. 6, 4, p. 514-518 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

33 Citations (Scopus)

A compartmentalized out-of-equilibrium enzymatic reaction network for sustained autonomous movement

Nijemeisland, M., Abdelmohsen, L. K. E. A., Huck, W. T. S., Wilson, D. A. & van Hest, J. C. M., 23 Nov 2016, In : ACS Central Science. 2, 11, p. 843-849 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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59 Citations (Scopus)
98 Downloads (Pure)

Adaptive polymersome and micelle morphologies in anticancer nanomedicine: from design rationale to fabrication and proof-of-concept studies

Pijpers, I. A. B., Abdelmohsen, L. K. E. A., Xia, Y., Cao, S., Williams, D. S., Meng, F., van Hest, J. C. M. & Zhong, Z., 1 Dec 2018, In : Advanced Therapeutics. 1, 8, 14 p., 1800068.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
3 Downloads (Pure)

Adaptive polymersome nanoreactors

Che, H. & van Hest, J. C. M., 1 Sep 2019, In : ChemNanoMat. 5, 9, p. 1092-1109 18 p.

Research output: Contribution to journalArticleAcademicpeer-review

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3 Citations (Scopus)
49 Downloads (Pure)

A dibenzoazacyclooctyne as a reactive chain stopper for [2]rotaxanes

Hou, Z-Y., Yeniad, B., van Guyse, J., Woisel, P., Mullen, K. M., Rutjes, F. P. J. T., van Hest, J. C. M. & Hoogenboom, R., 8 Jun 2017, In : European Journal of Organic Chemistry. 2017, 21, p. 3107-3113 7 p., 21.

Research output: Contribution to journalArticleAcademicpeer-review

A filter-free blood-brain barrier model to quantitatively study transendothelial delivery of nanoparticles by fluorescence spectroscopy

De Jong, E., Williams, D. S., Abdelmohsen, L. K. E. A., van Hest, J. C. M. & Zuhorn, I. S., 10 Nov 2018, In : Journal of Controlled Release. 289, p. 14-22 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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1 Citation (Scopus)
38 Downloads (Pure)

Alendronate-functionalized poly(2-oxazoline)s with tunable affinity for calcium cations

Sánchez-Fernández, M. J., Immers, M. R., Félix Lanao, R. P., Yang, F., Bender, J. C. M. E., Mecinović, J., Leeuwenburgh, S. C. G. & van Hest, J. C. M., 12 Aug 2019, In : Biomacromolecules. 20, 8, p. 2913-2921 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

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11 Downloads (Pure)

Alternative application of an affinity purification tag: hexahistidines in ester hydrolysis

Schoonen, L., van Esterik, K. S., Zhang, C., Ulijn, R. V., Nolte, R. J. M. & van Hest, J. C. M., 1 Dec 2017, In : Scientific Reports. 7, 1, 9 p., 14772.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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3 Citations (Scopus)
84 Downloads (Pure)

An integrated, peptide-based approach to site-specific protein immobilization for detection of biomolecular interactions

Kruis, I. C., Löwik, D. W. P. M., Boelens, W. C., van Hest, J. C. M. & Pruijn, G. J. M., 21 Sep 2016, In : Analyst. 141, 18, p. 5321-5328 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)
2 Downloads (Pure)

A revised modular approach to (–)-trans-Δ 8 -THC and derivatives through late-stage Suzuki–Miyaura cross-coupling reactions

Bloemendal, V. R. L. J., Sondag, D., Elferink, H., Boltje, T. J., van Hest, J. C. M. & Rutjes, F. P. J. T., 31 Mar 2019, In : European Journal of Organic Chemistry. 2019, 12, p. 2289-2296 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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3 Citations (Scopus)
30 Downloads (Pure)

Artificial cells: synthetic compartments with life-like functionality and adaptivity

van Hest, J. C. M. & Buddingh, B. C., 17 Jan 2017, In : Accounts of Chemical Research. 50, 4, p. 769–777 9 p., 4.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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146 Citations (Scopus)
140 Downloads (Pure)

Biodegradable, drug-loaded nanovectors via direct hydration as a new platform for cancer therapeutics

Ridolfo, R., Ede, B. C., Diamanti, P., White, P. B., Perriman, A. W., van Hest, J. C. M., Blair, A. & Williams, D. S., 9 Aug 2018, In : Small. 14, 32, 10 p., 1703774.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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4 Citations (Scopus)
51 Downloads (Pure)

Biodegradable synthetic organelles demonstrate ROS shielding in human-complex-I-deficient fibroblasts

van Oppen, L. M. P. E., Abdelmohsen, L. K. E. A., van Emst-de Vries, S. E., Welzen, P. L. W., Wilson, D. A., Smeitink, J. A. M., Koopman, W. J. H., Brock, R., Willems, P. H. G. M., Williams, D. S. & van Hest, J. C. M., 25 Jul 2018, In : ACS Central Science. 4, 7, p. 917-928 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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12 Citations (Scopus)
83 Downloads (Pure)

Biomorphic engineering of multifunctional polylactide stomatocytes toward therapeutic nano-red blood cells

Shao, J., Pijpers, I. A. B., Cao, S., Williams, D. S., Yan, X., Li, J., Abdelmohsen, L. K. E. A. & van Hest, J. C. M., 6 Mar 2019, In : Advanced Science. 6, 5, 8 p., 1801678.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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5 Citations (Scopus)
32 Downloads (Pure)

CD44-targeted vesicles encapsulating granzyme B as artificial killer cells for potent inhibition of human multiple myeloma in mice

Zhong, Y., Meng, F., Zhang, W., Li, B., van Hest, J. C. M. & Zhong, Z., 10 Apr 2020, In : Journal of Controlled Release. 320, p. 421-430 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Chemoenzymatic synthesis of sialic acid derivatives using immobilized N-acetylneuraminate lyase in a continuous flow reactor

Bloemendal, V. R. L. J., Moons, S. J., Heming, J. J. A., Chayoua, M., Niesink, O., van Hest, J. C. M., Boltje, T. J. & Rutjes, F. P. J. T., 6 Jun 2019, In : Advanced Synthesis & Catalysis. 361, 11, p. 2443-2447 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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5 Downloads (Pure)

Click-MS: tagless protein enrichment using bioorthogonal chemistry for quantitative proteomics

Smits, A. H., Borrmann, A., Roosjen, M., Hest, van, J. C. M. & Vermeulen, M., 19 Sep 2016, In : ACS Chemical Biology. 11, 12, p. 3245–3250 6 p., 12.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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8 Citations (Scopus)
178 Downloads (Pure)

Click to enter: activation of oligo-arginine cell-penetrating peptides by bioorthogonal tetrazine ligations

Bode, S. A., Timmermans, S. B. P. E., Eising, S., van Gemert, S. P. W., Bonger, K. M. & Löwik, D. W. P. M., 21 Jan 2019, In : Chemical Science. 10, 3, p. 701-705 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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4 Citations (Scopus)
35 Downloads (Pure)

Coiled-coil mediated activation of oligo-arginine cell-penetrating peptides

Bode, S. A., Kruis, I. C., Adams, P. J. H. M., Boelens, W. C., Pruijn, G., van Hest, J. C. M. & Löwik, D. W. P. M., 17 Jan 2017, In : ChemBioChem. 18, 2, p. 185–188 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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6 Citations (Scopus)
112 Downloads (Pure)

Compartmentalized cross-linked enzymatic nano -aggregates (c -CLE n A) for efficient in-flow biocatalysis

de Martino, M. T., Tonin, F., Yewdall, N. A., Abdelghani, M., Williams, D. S., Hanefeld, U., Rutjes, F. P. J. T., Abdelmohsen, L. K. E. A. & van Hest, J. C. M., 14 Mar 2020, In : Chemical Science. 11, 10, p. 2765-2769 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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8 Downloads (Pure)

Continuous fabrication of polymeric vesicles and nanotubes with fluidic channels

Peng, F., Deng, N-N., Tu, Y., van Hest, J. C. M. & Wilson, D. A., 21 Apr 2017, In : Nanoscale. 9, 15, p. 4875-4880 6 p., 15.

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

Controlling the morphology of copolymeric vectors for next generation nanomedicine

Williams, D. S., Pijpers, I. A. B., Ridolfo, R. & van Hest, J. C. M., 10 Aug 2017, In : Journal of Controlled Release. 259, 10 august 2016, p. 29-39 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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16 Citations (Scopus)
112 Downloads (Pure)

Development of morphologically discrete PEG-PDLLA nanotubes for precision nanomedicine

Wauters, A. C., Pijpers, I. A. B., Mason, A. F., Williams, D. S., Tel, J., Abdelmohsen, L. K. E. A. & van Hest, J. C. M., 14 Jan 2019, In : Biomacromolecules. 20, 1, p. 177-183 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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5 Citations (Scopus)
76 Downloads (Pure)

Dithioacetal-mechanized mesoporous nanosensor for Hg(II) determination

Jimenez-Falcao, S., Villalonga, A., Parra-Nieto, J., Llopis-Lorente, A., Martinez-Ruiz, P., Martinez-Mañez, R. & Villalonga, R., 1 May 2020, In : Microporous and Mesoporous Materials. 297, 7 p., 110054.

Research output: Contribution to journalArticleAcademicpeer-review

Dynamic assembly of micellar mesostructures

Altay, Y., Pijpers - Welzen, I., Abdelmohsen, L. & van Hest, J., 28 Oct 2019, In : ChemSystemsChem. 2, 2, 5 p., e1900049.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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2 Downloads (Pure)

Effect of formulation and processing parameters on the size of mPEG-b-p(HPMA-Bz) polymeric micelles

Bagheri, M., Bresseleers, J., Varela-Moreira, A., Sandre, O., Meeuwissen, S. A., Schiffelers, R. M., Metselaar, J. M., Van Nostrum, C. F., van Hest, J. C. M. & Hennink, W. E., 18 Dec 2018, In : Langmuir. 34, 50, p. 15495-15506 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)
1 Downloads (Pure)

Erythrocyte membrane modified janus polymeric motors for thrombus therapy

Shao, J., Abdelghani, M., Shen, G., Cao, S., Williams, D. S. & van Hest, J. C. M., 22 May 2018, In : ACS Nano. 12, 5, p. 4877-4885 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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28 Citations (Scopus)
61 Downloads (Pure)

Evaluation of dextran(ethylene glycol) hydrogel films for giant unilamellar lipid vesicle production and their application for the encapsulation of polymersomes

Mora, N. L., Gao, Y., Gutierrez, M. G., Peruzzi, J., Bakker, I., Peters, R. J. R. W., Siewert, B., Bonnet, S., Kieltyka, R. E., van Hest, J. C. M., Malmstadt, N. & Kros, A., 4 Sep 2017, In : Soft Matter. 13, 33, p. 5580-5588 9 p., 33.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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8 Citations (Scopus)
84 Downloads (Pure)

Expansion of the assembly of cowpea chlorotic mottle virus towards non-native and physiological conditions

Schoonen, L., Maas, R. J. M., Nolte, R. J. M. & van Hest, J. C. M., 17 Aug 2017, In : Tetrahedron. 73, 33, p. 4968-4971 4 p., 33.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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8 Citations (Scopus)
86 Downloads (Pure)

Feedback-induced temporal control of “breathing” polymersomes to create self-adaptive nanoreactors

Che, H., Cao, S. & van Hest, J. C. M., 25 Apr 2018, In : Journal of the American Chemical Society. 140, 16, p. 5356–5359 4 p., 16.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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42 Citations (Scopus)
109 Downloads (Pure)

Hierarchical self-assembly of a copolymer-stabilized coacervate protocell

Mason, A. F., Buddingh, B. C., Williams, D. S. & van Hest, J. C. M., 6 Dec 2017, In : Journal of the American Chemical Society. 139, 48, p. 17309-17312 4 p., 48.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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29 Citations (Scopus)
117 Downloads (Pure)

Hyperthermia-Triggered On-Demand Biomimetic Nanocarriers for Synergetic Photothermal and Chemotherapy

Gao, J., Wang, F., Wang, S., Liu, L., Liu, K., Ye, Y., Wang, Z., Wang, H., Chen, B., Jiang, J., Ou, J., van Hest, J. C. M., Peng, F. & Tu, Y., 1 Jan 2020, (Accepted/In press) In : Advanced Science. 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Influence of surface charge on the formulation of elongated PEG-b-PDLLA nanoparticles

Ridolfo, R., Williams, D. S. & van Hest, J. C. M., 28 Apr 2020, In : Polymer Chemistry. 11, 16, p. 2775-2780 6 p.

Research output: Contribution to journalArticleAcademic

Open Access

Intercellular communication between artificial cells by allosteric amplification of a molecular signal

Buddingh', B. C., Elzinga, J. & van Hest, J. C. M., 3 Apr 2020, In : Nature Communications. 11, 1, 10 p., 1652.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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8 Downloads (Pure)
Open Access
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2 Citations (Scopus)
14 Downloads (Pure)

Legomedicine - a versatile chemo-enzymatic approach for the preparation of targeted dual-labeled llama antibody-nanoparticle conjugates

van Lith, S. A. M., van Duijnhoven, S. M. J., Navis, A. C., Leenders, W. P. J., Dolk, E., Wennink, J. W. H., Nostrum, van, C. F. & van Hest, J. C. M., 15 Feb 2017, In : Bioconjugate Chemistry. 28, 2, p. 539-548 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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20 Citations (Scopus)
82 Downloads (Pure)
Open Access
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7 Citations (Scopus)
27 Downloads (Pure)

Modular, bioorthogonal strategy for the controlled loading of cargo into a protein nanocage

Schoonen, L., Eising, S., van Eldijk, M. B., Bresseleers, J., Van Der Pijl, M., Nolte, R. J. M., Bonger, K. M. & van Hest, J. C. M., 18 Apr 2018, In : Bioconjugate Chemistry. 29, 4, p. 1186-1193 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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4 Citations (Scopus)
76 Downloads (Pure)

Molecular programming of biodegradable nanoworms via ionically induced morphology switch toward asymmetric therapeutic carriers

Cao, S., Shao, J., Xia, Y., Che, H., Zhong, Z., Meng, F., van Hest, J. C. M., Abdelmohsen, L. K. E. A. & Williams, D. S., 1 Sep 2019, In : Small. 15, 38, 8 p., 1901849.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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4 Citations (Scopus)
30 Downloads (Pure)

Morphology under control: engineering biodegradable stomatocytes

Pijpers, I. A. B., Abdelmohsen, L. K. E. A., Williams, D. S. & van Hest, J. C. M., 21 Nov 2017, In : ACS Macro Letters. 6, 11, p. 1217-1222 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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18 Citations (Scopus)
104 Downloads (Pure)

Multifaceted cell mimicry in coacervate-based synthetic cells

Mason, A. & Hest, van, J. C. M., Nov 2019, In : Emerging Topics in Life Sciences. 3, 5, p. 567-571 5.

Research output: Contribution to journalArticleAcademicpeer-review

Multifunctional PVCL nanogels with redox-responsiveness enable enhanced MR imaging and ultrasound-promoted tumor chemotherapy

Xu, F., Zhu, J., Lin, L., Zhang, C., Sun, W., Fan, Y., Yin, F., van Hest, J. C. M., Wang, H., Du, L. & Shi, X., 1 Jan 2020, In : Theranostics. 10, 10, p. 4349-4358 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Myosin II isoforms play distinct roles in adherens junction biogenesis

Heuzé, M. L., Sankara Narayana, G. H. N., D'Alessandro, J., Cellerin, V., Dang, T., Williams, D. S., van Hest, J. C. M., Marcq, P., Mège, R. M. & Ladoux, B., 5 Sep 2019, In : eLife. 8, 30 p., e46599.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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5 Citations (Scopus)
147 Downloads (Pure)

Nanoreactors for green catalysis

De Martino, M. T., Abdelmohsen, L. K. E. A., Rutjes, F. P. J. T., van Hest, J. C. M. & Hessel, V. (Guest ed.), 29 Mar 2018, In : Beilstein Journal of Organic Chemistry. 14, p. 716–733 18 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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19 Citations (Scopus)
108 Downloads (Pure)

Next generation hemostatic materials based on NHS-Ester functionalized poly(2-oxazoline)s

Boerman, M. A., Roozen, E., Sanchez Fernandez, M. J., Keereweer, A. R., Félix Lanao, R. P., Bender, J. C. M. E., Hoogenboom, R., Leeuwenburgh, S. C. G., Jansen, J. A., van Goor, H. & van Hest, J. C. M., 14 Aug 2017, In : Biomacromolecules. 18, 8, p. 2529-2538 8.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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17 Citations (Scopus)
79 Downloads (Pure)

Octa-arginine boosts the penetration of elastin-like polypeptide nanoparticles in 3D cancer models

van Oppen, L. M. P. E., Pille, J., Stuut, C., van Stevendaal, M., van der Vorm, L. N., Smeitink, J. A. M., Koopman, W. J. H., Willems, P. H. G. M., van Hest, J. C. M. & Brock, R., 1 Apr 2019, In : European Journal of Pharmaceutics and Biopharmaceutics. 137, p. 175-184 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)
1 Downloads (Pure)

Pathway dependent shape-transformation of azide-decorated polymersomes

Che, H., de Windt, L. N. J., Zhu, J., Pijpers, I. A. B., Mason, A. F., Abdelmohsen, L. K. E. A. & van Hest, J. C. M., 18 Feb 2020, In : Chemical Communications. 56, 14, p. 2127-2130 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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9 Downloads (Pure)

PH-induced transformation of biodegradable multilamellar nanovectors for enhanced tumor penetration

Cao, S., Abdelmohsen, L. K. E. A., Shao, J., van den Dikkenberg, J., Mastrobattista, E., Williams, D. S. & van Hest, J. C. M., 20 Nov 2018, In : ACS Macro Letters. 7, 11, p. 1394-1399 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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7 Citations (Scopus)
48 Downloads (Pure)

Physicochemical characterization of polymer-stabilized coacervate protocells

Yewdall, N. A., Buddingh, B. C., Altenburg, W. J., Timmermans, S. B. P. E., Vervoort, D. F. M., Abdelmohsen, L. K. E. A., Mason, A. F. & van Hest, J., 15 Oct 2019, In : ChemBioChem. 20, 20, p. 2643-2652 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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2 Citations (Scopus)
17 Downloads (Pure)