• Postbus 513, Helix Building

    5600 MB Eindhoven

    Netherlands

  • De Groene Loper 3, Helix Building (STO 3.39)

    5612 AE Eindhoven

    Netherlands

Research Output 2008 2020

66 Citations (Scopus)

A block copolymer for functionalisation of polymersome surfaces

van Dongen, S. F. M., Nallani, M., Schoffelen, S., Cornelissen, J. J. L. M., Nolte, R. J. M. & van Hest, J. C. M., 18 Feb 2008, In : Macromolecular Rapid Communications. 29, 4, p. 321-325 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Polyethylene glycols
Block copolymers
Polystyrenes
Acetylene
Azides
29 Citations (Scopus)

Accelerated living cationic ring-opening polymerization of a methyl ester functionalized 2-oxazoline monomer

Bouten, P. J. M., Hertsen, D., Vergaelen, M., Monnery, B. D., Boerman, M. A., Goossens, H., Catak, S., van Hest, J. C. M., van Speybroeck, V. & Hoogenboom, R., 28 Jan 2015, In : Polymer Chemistry. 6, 4, p. 514-518 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Cationic polymerization
Ring opening polymerization
Polymerization
Copolymerization
Esters
51 Citations (Scopus)

A compartmentalized out-of-equilibrium enzymatic reaction network for sustained autonomous movement

Nijemeisland, M., Abdelmohsen, L. K. E. A., Huck, W. T. S., Wilson, D. A. & van Hest, J. C. M., 23 Nov 2016, In : ACS Central Science. 2, 11, p. 843-849 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File

Adaptive polymeric assemblies for applications in biomimicry and nanomedicine

Altay, Y., Che, H., Cao, S., Abdelmohsen, L. & van Hest, J., 23 Oct 2019, In : Biomacromolecules. 20, 11, p. 4053-4064 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Medical nanotechnology
Nanostructured materials
Self assembly
Intelligent networks
Complex networks

Adaptive polymersome and micelle morphologies in anticancer nanomedicine: from design rationale to fabrication and proof-of-concept studies

Pijpers, I. A. B., Abdelmohsen, L. K. E. A., Xia, Y., Cao, S., Williams, D. S., Meng, F., van Hest, J. C. M. & Zhong, Z., 1 Dec 2018, In : Advanced Therapeutics. 1, 8, 14 p., 1800068

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Medical nanotechnology
Micelles
Nanoparticles
Fabrication
Drug delivery

Adaptive polymersome nanoreactors

Che, H. & van Hest, J. C. M., 1 Sep 2019, In : ChemNanoMat. 5, 9, p. 1092-1109

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Nanoreactors
Medical nanotechnology
Adaptive systems

A dibenzoazacyclooctyne as a reactive chain stopper for [2]rotaxanes

Hou, Z-Y., Yeniad, B., van Guyse, J., Woisel, P., Mullen, K. M., Rutjes, F. P. J. T., van Hest, J. C. M. & Hoogenboom, R., 8 Jun 2017, In : European Journal of Organic Chemistry. 21, p. 3107-3113 7 p., 21

Research output: Contribution to journalArticleAcademicpeer-review

Rotaxanes
cycloaddition
alkynes
naphthalene
ethers

A filter-free blood-brain barrier model to quantitatively study transendothelial delivery of nanoparticles by fluorescence spectroscopy

De Jong, E., Williams, D. S., Abdelmohsen, L. K. E. A., van Hest, J. C. M. & Zuhorn, I. S., 10 Nov 2018, In : Journal of Controlled Release. 289, p. 14-22 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Fluorescence Spectrometry
Blood-Brain Barrier
Nanoparticles
Transcytosis
Brain

Alendronate-functionalized poly(2-oxazoline)s with tunable affinity for calcium cations

Sánchez-Fernández, M. J., Immers, M. R., Félix Lanao, R. P., Yang, F., Bender, J. C. M. E., Mecinović, J., Leeuwenburgh, S. C. G. & van Hest, J. C. M., 1 Jan 2019, In : Biomacromolecules. 20, 8, p. 2913-2921 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Alendronate
Cations
Calcium
Polymers
Positive ions
2 Citations (Scopus)

Alternative application of an affinity purification tag: hexahistidines in ester hydrolysis

Schoonen, L., van Esterik, K. S., Zhang, C., Ulijn, R. V., Nolte, R. J. M. & van Hest, J. C. M., 7 Nov 2017, In : Scientific Reports. 7, 14772 , 9 p., 14772

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
His-His-His-His-His-His
Purification
Hydrolysis
Esters
Affinity chromatography
1 Citation (Scopus)

An integrated, peptide-based approach to site-specific protein immobilization for detection of biomolecular interactions

Kruis, I. C., Löwik, D. W. P. M., Boelens, W. C., van Hest, J. C. M. & Pruijn, G. J. M., 21 Sep 2016, In : Analyst. 141, 18, p. 5321-5328 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Leucine Zippers
Immobilization
peptide
immobilization
Peptides

A revised modular approach to (–)-trans-Δ 8 -THC and derivatives through late-stage Suzuki–Miyaura cross-coupling reactions

Bloemendal, V. R. L. J., Sondag, D., Elferink, H., Boltje, T. J., van Hest, J. C. M. & Rutjes, F. P. J. T., 31 Mar 2019, In : European Journal of Organic Chemistry. 2019, 12, p. 2289-2296 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
thermohaline circulation
Dronabinol
cross coupling
Derivatives
Scaffolds
123 Citations (Scopus)

Artificial cells: synthetic compartments with life-like functionality and adaptivity

van Hest, J. C. M. & Buddingh, B. C., 17 Jan 2017, In : Accounts of Chemical Research. 50, 4, p. 769–777 4

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Membranes
Biochemistry
Chemotactic Factors
Metabolites
Metabolism
4 Citations (Scopus)

Assembly of protein stacks with in situ synthesized nanoparticle cargo

Manuguri, S., Webster, K., Yewdall, N. A., An, Y., Venugopal, H., Bhugra, V., Turner, A., Domigan, L. J., Gerrard, J. A., Williams, D. E. & Malmström, J., 8 Aug 2018, In : Nano Letters. 18, 8, p. 5138-5145 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

cargo
assembly
Iron
Nanoparticles
proteins

ATP-mediated transient behavior of stomatocyte nanosystems

Che, H., Zhu, J., Song, S., Mason, A. F., Cao, S., Pijpers, I. A. B., Abdelmohsen, L. K. E. A. & van Hest, J. C. M., 2 Jul 2019, In : Angewandte Chemie - International Edition. 58, 37, p. 13113-13118

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Nanosystems
Adenosine Triphosphate
Polylysine
Nanoreactors
Molecular interactions
4 Citations (Scopus)

Biodegradable, drug-loaded nanovectors via direct hydration as a new platform for cancer therapeutics

Ridolfo, R., Ede, B. C., Diamanti, P., White, P. B., Perriman, A. W., van Hest, J. C. M., Blair, A. & Williams, D. S., 12 Jul 2018, In : Small. 14, 12, 10 p., 1703774

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Ethylene Glycol
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Hydration
Nanomedicine
Drug Compounding
9 Citations (Scopus)

Biodegradable synthetic organelles demonstrate ROS shielding in human-complex-I-deficient fibroblasts

van Oppen, L. M. P. E., Abdelmohsen, L. K. E. A., van Emst-de Vries, S. E., Welzen, P. L. W., Wilson, D. A., Smeitink, J. A. M., Koopman, W. J. H., Brock, R., Willems, P. H. G. M., Williams, D. S. & van Hest, J. C. M., 25 Jul 2018, In : ACS Central Science. 4, 7, p. 917-928 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Nanoreactors
Fibroblasts
Shielding
Polyethylene glycols
Carbonates
42 Citations (Scopus)

Bio-inks for 3D bioprinting: recent advances and future prospects

Donderwinkel, I., van Hest, J. C. M. & Cameron, N. R., 20 Aug 2017, In : Polymer Chemistry. 8, 31, p. 4451-4471 21 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Bioprinting
Printing
Ink
Polymers
Biocompatible Materials
2 Citations (Scopus)

Biomorphic engineering of multifunctional polylactide stomatocytes toward therapeutic nano-red blood cells

Shao, J., Pijpers, I. A. B., Cao, S., Williams, D. S., Yan, X., Li, J., Abdelmohsen, L. K. E. A. & van Hest, J. C. M., 1 Jan 2019, In : Advanced Science. 6, 5, 8 p., 1801678

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
erythrocytes
Blood
Erythrocytes
Cells
engineering
2 Citations (Scopus)

Bone-adhesive materials: clinical requirements, mechanisms of action, and future perspective

Sánchez-Fernández, M. J., Hammoudeh, H., Félix Lanao, R. P., van Erk, M., van Hest, J. C. M. & Leeuwenburgh, S. C. G., 22 Feb 2019, In : Advanced Materials Interfaces. 6, 4, 11 p., 1802021

Research output: Contribution to journalReview articleAcademicpeer-review

Adhesives
Bone
Biomaterials
Glues
Tissue
2 Citations (Scopus)

Cell-free microcompartmentalised transcription-translation for the prototyping of synthetic communication networks

Dubuc, E., Pieters, P. A., van der Linden, A. J., van Hest, J. C. M., Huck, W. T. S. & de Greef, T. F. A., 1 Aug 2019, In : Current Opinion in Biotechnology. 58, p. 72-80 9 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
File
Transcription
Telecommunication networks
Communication
Cells
Networks (circuits)
4 Citations (Scopus)

Chemical tools and materials for Biological/Medicinal applications

Yan, X. & van Hest, J. C. M., 15 Oct 2018, In : Chemistry - An Asian Journal. 13, 22, p. 3331-3332

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Research
Therapeutics

Chemoenzymatic synthesis of sialic acid derivatives using immobilized N-acetylneuraminate lyase in a continuous flow reactor

Bloemendal, V. R. L. J., Moons, S. J., Heming, J. J. A., Chayoua, M., Niesink, O., van Hest, J. C. M., Boltje, T. J. & Rutjes, F. P. J. T., 8 May 2019, In : Advanced Synthesis & Catalysis. 361, 11, p. 2443-2447

Research output: Contribution to journalArticleAcademicpeer-review

N-acetylneuraminate lyase
N-Acetylneuraminic Acid
Derivatives
Acids
Sialic Acids
3 Citations (Scopus)

Choice of capping group in tripeptide hydrogels influences viability in the three-dimensional cell culture of tumor spheroids

Wojciechowski, J. P., Martin, A. D., Mason, A. F., Fife, C. M., Sagnella, S. M., Kavallaris, M. & Thordarson, P., 1 Mar 2017, In : chempluschem. 82, 3, p. 383-389 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Hydrogels
Cell culture
Tumors
Bearings (structural)
Gels
6 Citations (Scopus)

Click-MS: tagless protein enrichment using bioorthogonal chemistry for quantitative proteomics

Smits, A. H., Borrmann, A., Roosjen, M., Hest, van, J. C. M. & Vermeulen, M., 19 Sep 2016, In : ACS Chemical Biology. 11, 12, p. 3245–3250 6 p., 12

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Proteomics
Proteins
Cell Extracts
Click Chemistry
Amino Acids
5 Citations (Scopus)

Coiled-coil mediated activation of oligo-arginine cell-penetrating peptides

Bode, S. A., Kruis, I. C., Adams, P. J. H. M., Boelens, W. C., Pruijn, G., van Hest, J. C. M. & Löwik, D. W. P. M., 2017, In : ChemBioChem. 18, 2, p. 185–188 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Cell-Penetrating Peptides
Leucine Zippers
Arginine
Chemical activation
Peptides

Consequences of a cosolvent on the structure and molecular dynamics of supramolecular polymers in water

Lafleur, R. P. M., Lou, X., Pavan, G. M., Palmans, A. R. A. & Meijer, E. W., 1 Jan 2018, In : Chemical Science. 9, 29, p. 6199-6209 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Molecular dynamics
Polymers
Water
Depolymerization
Polymerization
5 Citations (Scopus)

Continuous fabrication of polymeric vesicles and nanotubes with fluidic channe

Peng, F., Deng, N-N., Tu, Y., van Hest, J. C. M. & Wilson, D. A., 21 Apr 2017, In : Nanoscale. 9, 15, p. 4875-4880 15

Research output: Contribution to journalArticleAcademicpeer-review

Polystyrenes
Fluidics
Phase boundaries
Platinum
Laminar flow
10 Citations (Scopus)

Controlling the morphology of copolymeric vectors for next generation nanomedicine

Williams, D. S., Pijpers, I. A. B., Ridolfo, R. & van Hest, J. C. M., 10 Aug 2017, In : Journal of Controlled Release. 259, 10 august 2016, p. 29-39

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Nanomedicine
Research
In Vitro Techniques
Open Access
File
3 Citations (Scopus)

Development of morphologically discrete PEG-PDLLA nanotubes for precision nanomedicine

Wauters, A. C., Pijpers, I. A. B., Mason, A. F., Williams, D. S., Tel, J., Abdelmohsen, L. K. E. A. & van Hest, J. C. M., 1 Jan 2019, In : Biomacromolecules. 20, 1, p. 177-183

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Medical nanotechnology
Nanotubes
Polyethylene glycols
Particle interactions
Nanostructures
9 Citations (Scopus)

Dual-color bioluminescent sensor proteins for therapeutic drug monitoring of antitumor antibodies

van Rosmalen, M., Ni, Y., Vervoort, D. F. M., Arts, R., Ludwig, S. K. J. & Merkx, M., 6 Mar 2018, In : Analytical Chemistry. 90, 5, p. 3592-3599 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Antineoplastic Agents
Color
Antibodies
Monitoring
Sensors

Dynamic assembly of micellar meso‐structures

Altay, Y., Pijpers - Welzen, I., Abdelmohsen, L. & van Hest, J., 28 Oct 2019, (Accepted/In press) In : ChemSystemsChem.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Biological systems
Nanosystems
Micelles
Sulfhydryl Compounds
Disulfides
17 Citations (Scopus)

Dynamic diversity of synthetic supramolecular polymers in water as revealed by hydrogen/deuterium exchange

Lou, X., Lafleur, R. P. M., Leenders, C. M. A., Schoenmakers, S. M. C., Matsumoto, N. M., Baker, M. B., van Dongen, J. L. J., Palmans, A. R. A. & Meijer, E. W., 15 May 2017, In : Nature Communications. 8, 8 p., 15420

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Deuterium
deuterium
Hydrogen
Polymers
Water

Editorial

van Hest, J. C. M., Lavik, E. B., Smith, B. D., Zheng, G. & Rotello, V., 20 Jan 2016, In : Bioconjugate Chemistry. 27, 1, p. 1-2

Research output: Contribution to journalEditorialAcademicpeer-review

Open Access

Editorial 2018

van Hest, J., Lavik, E. B., Smith, B. D., Zheng, G. & Rotello, V. M., 17 Jan 2018, In : Bioconjugate Chemistry. 29, 1, p. 1-3 3 p.

Research output: Contribution to journalEditorialAcademicpeer-review

Open Access

Editorial for virtual issue on polymer bioconjugates in biology and medicine

van Hest, J. C. M., Sumerlin, B., Anseth, K. S., Shoichet, M. & Hammes-Schiffer, S., 13 Feb 2017, In : Biomacromolecules. 18, 2, p. 315 1 p.

Research output: Contribution to journalEditorialAcademicpeer-review

Open Access
1 Citation (Scopus)

Editorial for virtual issue on polymer bioconjugates in biology and medicine

van Hest, J. C. M., Sumerlin, B., Anseth, K. S., Shoichet, M. & Hammes-Schiffer, S., 15 Feb 2017, In : Bioconjugate Chemistry. 28, 2, p. 282 1 p.

Research output: Contribution to journalEditorialAcademicpeer-review

Open Access
1 Citation (Scopus)

Editorial for virtual issue on polymer bioconjugates in biology and medicine

van Hest, J., Sumerlin, B., Anseth, K. S., Shoichet, M. & Hammes-Schiffer, S., 21 Feb 2017, In : ACS Macro Letters. 6, 2, p. 144 1 p.

Research output: Contribution to journalEditorialAcademicpeer-review

Open Access

Editorial for virtual issue on polymer bioconjugates in biology and medicine

van Hest, J. C. M., Sumerlin, B. S., Anseth, K. S., Shoichet, M. & Hammes-Schiffer, S., 14 Feb 2017, In : Macromolecules. 50, 3, p. 713 1 p.

Research output: Contribution to journalEditorialAcademicpeer-review

Open Access

Editorial for Virtual Issue on Polymer Bioconjugates in Biology and Medicine

van Hest, J. C. M., Sumerlin, B. S., Anseth, K. S., Shoichet, M. & Hammes-Schiffer, S., 8 Feb 2017, In : Chemical Reviews. 117, 3, p. 900 1 p.

Research output: Contribution to journalEditorialAcademicpeer-review

Open Access
2 Citations (Scopus)

Effect of formulation and processing parameters on the size of mPEG-b-p(HPMA-Bz) polymeric micelles

Bagheri, M., Bresseleers, J., Varela-Moreira, A., Sandre, O., Meeuwissen, S. A., Schiffelers, R. M., Metselaar, J. M., Van Nostrum, C. F., van Hest, J. C. M. & Hennink, W. E., 12 Nov 2018, In : Langmuir. 34, 50, p. 15495-15506

Research output: Contribution to journalArticleAcademicpeer-review

hydroxypropyl methacrylate
Micelles
micelles
formulations
Processing

Engineering orthogonal polypeptide GalNAc-transferase and UDP-sugar pairs

Choi, J., Wagner, L. J. S., Timmermans, S. B. P. E., Malaker, S. A., Schumann, B., Gray, M. A., Debets, M. F., Takashima, M., Gehring, J. & Bertozzi, C. R., 2 Aug 2019, In : Journal of the American Chemical Society. 141, 34, p. 13442-13453 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Uridine Diphosphate Sugars
Polypeptides
Sugars
Substrate Specificity
Peptides

Engineering protein-based nanoparticle conjugates for nanomedicine applications

van Hest, J., Pille, J., Abdelghani, M., Timmermans, S., Vervoort, D. & Pretto, C., 19 Aug 2018, 256th National Meeting and Exposition of the American-Chemical-Society (ACS) - Nanoscience, Nanotechnology and Beyond .

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

18 Citations (Scopus)

Erythrocyte membrane modified janus polymeric motors for thrombus therapy

Shao, J., Abdelghani, M., Shen, G., Cao, S., Williams, D. S. & van Hest, J. C. M., 22 May 2018, In : ACS Nano. 12, 5, p. 4877-4885 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Janus
erythrocytes
therapy
membranes
Capsules
7 Citations (Scopus)

Evaluation of dextran(ethylene glycol) hydrogel films for giant unilamellar lipid vesicle production and their application for the encapsulation of polymersomes

Mora, N. L., Gao, Y., Gutierrez, M. G., Peruzzi, J., Bakker, I., Peters, R. J. R. W., Siewert, B., Bonnet, S., Kieltyka, R. E., van Hest, J. C. M., Malmstadt, N. & Kros, A., 4 Sep 2017, In : Soft Matter. 13, 33, p. 5580-5588 33

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Unilamellar Liposomes
dextrans
Ethylene Glycol
Dextrans
Encapsulation
2 Citations (Scopus)

Existing self‐replicators can direct the emergence of new ones

Altay, Y., Altay, M. & Otto, S., 2018, In : Chemistry : A European Journal. 24, 46, p. 11911-11915 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Molecules
5 Citations (Scopus)

Expansion of the assembly of cowpea chlorotic mottle virus towards non-native and physiological conditions

Schoonen, L., Maas, R. J. M., Nolte, R. J. M. & van Hest, J. C. M., 17 Aug 2017, In : Tetrahedron. 73, 33, p. 4968-4971 33

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Bromovirus
Viruses
Elastin
Capsid Proteins
Peptides
29 Citations (Scopus)

Feedback-induced temporal control of “breathing” polymersomes to create self-adaptive nanoreactors

Che, H., Cao, S. & van Hest, J. C. M., 4 Apr 2018, In : Journal of the American Chemical Society. 140, 16, p. 5356–5359 16

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Nanoreactors
Horseradish Peroxidase
Respiration
Biocatalysis
Artificial Cells
20 Citations (Scopus)

Formation of non-spherical polymersomes driven by hydrophobic directional aromatic perylene interactions

Wong, C. K., Mason, A. F., Stenzel, M. H. & Thordarson, P., 1 Dec 2017, In : Nature Communications. 8, 1, 1240

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Perylene
Polymers
Synthetic Biology
shape control
membrane structures