• Postbus 513, Helix Building

    5600 MB Eindhoven

    Netherlands

  • De Groene Loper 3, Helix Building (STO 3.39)

    5612 AE Eindhoven

    Netherlands

Research Output 2008 2020

2008
66 Citations (Scopus)

A block copolymer for functionalisation of polymersome surfaces

van Dongen, S. F. M., Nallani, M., Schoffelen, S., Cornelissen, J. J. L. M., Nolte, R. J. M. & van Hest, J. C. M., 18 Feb 2008, In : Macromolecular Rapid Communications. 29, 4, p. 321-325 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Polyethylene glycols
Block copolymers
Polystyrenes
Acetylene
Azides
2015
29 Citations (Scopus)

Accelerated living cationic ring-opening polymerization of a methyl ester functionalized 2-oxazoline monomer

Bouten, P. J. M., Hertsen, D., Vergaelen, M., Monnery, B. D., Boerman, M. A., Goossens, H., Catak, S., van Hest, J. C. M., van Speybroeck, V. & Hoogenboom, R., 28 Jan 2015, In : Polymer Chemistry. 6, 4, p. 514-518 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Cationic polymerization
Ring opening polymerization
Polymerization
Copolymerization
Esters

Nanoscale compartmentalization techniques in cascade catalysis

Willemsen, J. S., Rutjes, F. P. J. T. & van Hest, J. C. M., 1 Jan 2015, Enzyme Nanocarriers. Pan Stanford Publishing Pte. Ltd., p. 123-158 36 p.

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Catalysis
Waste Products
Reaction intermediates
Molecules
Biocatalysts
2016
52 Citations (Scopus)

A compartmentalized out-of-equilibrium enzymatic reaction network for sustained autonomous movement

Nijemeisland, M., Abdelmohsen, L. K. E. A., Huck, W. T. S., Wilson, D. A. & van Hest, J. C. M., 23 Nov 2016, In : ACS Central Science. 2, 11, p. 843-849 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
1 Citation (Scopus)

An integrated, peptide-based approach to site-specific protein immobilization for detection of biomolecular interactions

Kruis, I. C., Löwik, D. W. P. M., Boelens, W. C., van Hest, J. C. M. & Pruijn, G. J. M., 21 Sep 2016, In : Analyst. 141, 18, p. 5321-5328 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Leucine Zippers
Immobilization
peptide
immobilization
Peptides
6 Citations (Scopus)

Click-MS: tagless protein enrichment using bioorthogonal chemistry for quantitative proteomics

Smits, A. H., Borrmann, A., Roosjen, M., Hest, van, J. C. M. & Vermeulen, M., 19 Sep 2016, In : ACS Chemical Biology. 11, 12, p. 3245–3250 6 p., 12

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Proteomics
Proteins
Cell Extracts
Click Chemistry
Amino Acids

Editorial

van Hest, J. C. M., Lavik, E. B., Smith, B. D., Zheng, G. & Rotello, V., 20 Jan 2016, In : Bioconjugate Chemistry. 27, 1, p. 1-2

Research output: Contribution to journalEditorialAcademicpeer-review

Open Access
7 Citations (Scopus)

Shape characterization of polymersome morphologies via light scattering techniques

Abdelmohsen, L. K. E. A., Rikken, R. S. M., Christianen, P. C. M., van Hest, J. C. M. & Wilson, D. A., 19 Dec 2016, In : Polymer. 107, p. 445-449 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Light scattering
Phosmet
Elastic scattering
Electron microscopy
Block copolymers
43 Citations (Scopus)

Shaping polymersomes into predictable morphologies via out-of-equilibrium self-assembly

Rikken, R. S. M., Engelkamp, H., Nolte, R. J. M., Maan, J. C., van Hest, J. C. M., Wilson, D. A. & Christianen, P. C. M., 25 Aug 2016, In : Nature Communications. 7, 12606, p. 1-7 12606

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Self assembly
self assembly
Permeability
Nanocapsules
Birefringence
70 Citations (Scopus)

Stimuli-responsive polymersomes and nanoreactors

Che, H. & van Hest, J. C. M., 17 Jul 2016, In : Journal of Materials Chemistry B. 4, 27, p. 4632-4647

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Nanoreactors
Nanocapsules
Polymers
Biomimetic materials
Self assembly
2017

A dibenzoazacyclooctyne as a reactive chain stopper for [2]rotaxanes

Hou, Z-Y., Yeniad, B., van Guyse, J., Woisel, P., Mullen, K. M., Rutjes, F. P. J. T., van Hest, J. C. M. & Hoogenboom, R., 8 Jun 2017, In : European Journal of Organic Chemistry. 21, p. 3107-3113 7 p., 21

Research output: Contribution to journalArticleAcademicpeer-review

Rotaxanes
cycloaddition
alkynes
naphthalene
ethers
2 Citations (Scopus)

Alternative application of an affinity purification tag: hexahistidines in ester hydrolysis

Schoonen, L., van Esterik, K. S., Zhang, C., Ulijn, R. V., Nolte, R. J. M. & van Hest, J. C. M., 7 Nov 2017, In : Scientific Reports. 7, 14772 , 9 p., 14772

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
His-His-His-His-His-His
Purification
Hydrolysis
Esters
Affinity chromatography
126 Citations (Scopus)

Artificial cells: synthetic compartments with life-like functionality and adaptivity

van Hest, J. C. M. & Buddingh, B. C., 17 Jan 2017, In : Accounts of Chemical Research. 50, 4, p. 769–777 4

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Membranes
Biochemistry
Chemotactic Factors
Metabolites
Metabolism
43 Citations (Scopus)

Bio-inks for 3D bioprinting: recent advances and future prospects

Donderwinkel, I., van Hest, J. C. M. & Cameron, N. R., 20 Aug 2017, In : Polymer Chemistry. 8, 31, p. 4451-4471 21 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Bioprinting
Printing
Ink
Polymers
Biocompatible Materials
3 Citations (Scopus)

Choice of capping group in tripeptide hydrogels influences viability in the three-dimensional cell culture of tumor spheroids

Wojciechowski, J. P., Martin, A. D., Mason, A. F., Fife, C. M., Sagnella, S. M., Kavallaris, M. & Thordarson, P., 1 Mar 2017, In : chempluschem. 82, 3, p. 383-389 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Hydrogels
Cell culture
Tumors
Bearings (structural)
Gels
5 Citations (Scopus)

Coiled-coil mediated activation of oligo-arginine cell-penetrating peptides

Bode, S. A., Kruis, I. C., Adams, P. J. H. M., Boelens, W. C., Pruijn, G., van Hest, J. C. M. & Löwik, D. W. P. M., 2017, In : ChemBioChem. 18, 2, p. 185–188 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Cell-Penetrating Peptides
Leucine Zippers
Arginine
Chemical activation
Peptides
5 Citations (Scopus)

Continuous fabrication of polymeric vesicles and nanotubes with fluidic channe

Peng, F., Deng, N-N., Tu, Y., van Hest, J. C. M. & Wilson, D. A., 21 Apr 2017, In : Nanoscale. 9, 15, p. 4875-4880 15

Research output: Contribution to journalArticleAcademicpeer-review

Polystyrenes
Fluidics
Phase boundaries
Platinum
Laminar flow
10 Citations (Scopus)

Controlling the morphology of copolymeric vectors for next generation nanomedicine

Williams, D. S., Pijpers, I. A. B., Ridolfo, R. & van Hest, J. C. M., 10 Aug 2017, In : Journal of Controlled Release. 259, 10 august 2016, p. 29-39

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Nanomedicine
Research
In Vitro Techniques
17 Citations (Scopus)

Dynamic diversity of synthetic supramolecular polymers in water as revealed by hydrogen/deuterium exchange

Lou, X., Lafleur, R. P. M., Leenders, C. M. A., Schoenmakers, S. M. C., Matsumoto, N. M., Baker, M. B., van Dongen, J. L. J., Palmans, A. R. A. & Meijer, E. W., 15 May 2017, In : Nature Communications. 8, 8 p., 15420

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Deuterium
deuterium
Hydrogen
Polymers
Water

Editorial for virtual issue on polymer bioconjugates in biology and medicine

van Hest, J. C. M., Sumerlin, B., Anseth, K. S., Shoichet, M. & Hammes-Schiffer, S., 13 Feb 2017, In : Biomacromolecules. 18, 2, p. 315 1 p.

Research output: Contribution to journalEditorialAcademicpeer-review

Open Access
1 Citation (Scopus)

Editorial for virtual issue on polymer bioconjugates in biology and medicine

van Hest, J. C. M., Sumerlin, B., Anseth, K. S., Shoichet, M. & Hammes-Schiffer, S., 15 Feb 2017, In : Bioconjugate Chemistry. 28, 2, p. 282 1 p.

Research output: Contribution to journalEditorialAcademicpeer-review

Open Access
1 Citation (Scopus)

Editorial for virtual issue on polymer bioconjugates in biology and medicine

van Hest, J., Sumerlin, B., Anseth, K. S., Shoichet, M. & Hammes-Schiffer, S., 21 Feb 2017, In : ACS Macro Letters. 6, 2, p. 144 1 p.

Research output: Contribution to journalEditorialAcademicpeer-review

Open Access

Editorial for virtual issue on polymer bioconjugates in biology and medicine

van Hest, J. C. M., Sumerlin, B. S., Anseth, K. S., Shoichet, M. & Hammes-Schiffer, S., 14 Feb 2017, In : Macromolecules. 50, 3, p. 713 1 p.

Research output: Contribution to journalEditorialAcademicpeer-review

Open Access

Editorial for Virtual Issue on Polymer Bioconjugates in Biology and Medicine

van Hest, J. C. M., Sumerlin, B. S., Anseth, K. S., Shoichet, M. & Hammes-Schiffer, S., 8 Feb 2017, In : Chemical Reviews. 117, 3, p. 900 1 p.

Research output: Contribution to journalEditorialAcademicpeer-review

Open Access
7 Citations (Scopus)

Evaluation of dextran(ethylene glycol) hydrogel films for giant unilamellar lipid vesicle production and their application for the encapsulation of polymersomes

Mora, N. L., Gao, Y., Gutierrez, M. G., Peruzzi, J., Bakker, I., Peters, R. J. R. W., Siewert, B., Bonnet, S., Kieltyka, R. E., van Hest, J. C. M., Malmstadt, N. & Kros, A., 4 Sep 2017, In : Soft Matter. 13, 33, p. 5580-5588 33

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Unilamellar Liposomes
dextrans
Ethylene Glycol
Dextrans
Encapsulation
5 Citations (Scopus)

Expansion of the assembly of cowpea chlorotic mottle virus towards non-native and physiological conditions

Schoonen, L., Maas, R. J. M., Nolte, R. J. M. & van Hest, J. C. M., 17 Aug 2017, In : Tetrahedron. 73, 33, p. 4968-4971 33

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Bromovirus
Viruses
Elastin
Capsid Proteins
Peptides
20 Citations (Scopus)

Formation of non-spherical polymersomes driven by hydrophobic directional aromatic perylene interactions

Wong, C. K., Mason, A. F., Stenzel, M. H. & Thordarson, P., 1 Dec 2017, In : Nature Communications. 8, 1, 1240

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Perylene
Polymers
Synthetic Biology
shape control
membrane structures
24 Citations (Scopus)

Hierarchical self-assembly of a copolymer-stabilized coacervate protocell

Mason, A. F., Buddingh, B. C., Williams, D. S. & van Hest, J. C. M., 6 Dec 2017, In : Journal of the American Chemical Society. 139, 48, p. 17309-17312 4 p., 48

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Artificial Cells
Self assembly
Copolymers
Membranes
Biopolymers
18 Citations (Scopus)

Legomedicine - a versatile chemo-enzymatic approach for the preparation of targeted dual-labeled llama antibody-nanoparticle conjugates

van Lith, S. A. M., van Duijnhoven, S. M. J., Navis, A. C., Leenders, W. P. J., Dolk, E., Wennink, J. W. H., Nostrum, van, C. F. & van Hest, J. C. M., 15 Feb 2017, In : Bioconjugate Chemistry. 28, 2, p. 539-548 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
New World Camelids
Antibodies
Nanoparticles
Tail
Single-Domain Antibodies
12 Citations (Scopus)

Morphology under control: engineering biodegradable stomatocytes

Pijpers, I. A. B., Abdelmohsen, L. K. E. A., Williams, D. S. & van Hest, J. C. M., 1 Nov 2017, In : ACS Macro Letters. 6, 11, p. 1217-1222 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Polyethylene glycols
Membranes
Copolymers
Dialysis
Solvation
13 Citations (Scopus)

Next generation hemostatic materials based on NHS-Ester functionalized poly(2-oxazoline)s

Boerman, M. A., Roozen, E., Sanchez Fernandez, M. J., Keereweer, A. R., Félix Lanao, R. P., Bender, J. C. M. E., Hoogenboom, R., Leeuwenburgh, S. C. G., Jansen, J. A., van Goor, H. & van Hest, J. C. M., 1 Aug 2017, In : Biomacromolecules. 18, 8, p. 2529-2538 8

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Hemostatics
Esters
Polymers
Polyethylene glycols
Blood
1 Citation (Scopus)

Peptide conjugates for biological applications

van Hest, J. C. M., 23 Feb 2017, In : Bioconjugate Chemistry. 28, 3, p. 689-690 2 p.

Research output: Contribution to journalEditorialAcademicpeer-review

Open Access
File
9 Citations (Scopus)

Polymersomes as protocellular constructs

Mason, A. F. & Thordarson, P., 1 Jan 2017, In : Journal of Polymer Science, Part A: Polymer Chemistry. 55, 23, p. 3817-3825 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Polymers
Scaffolds
Membranes
Engineers

Quantitative assessment of prosthetic valve regurgitation after TAVI by angiography and cardiac magnetic resonance imaging

Abdelghani, M., Abdel-Wahab, M., Miyazaki, Y., Holy, E., Merten, C., Zachow, D., Tonino, P., Rutten, M., van de Vosse, F. N., Morel, M. A., Onuma, Y., Serruys, P., Richardt, G. & Soliman, O., Aug 2017, In : European Heart Journal. 38, Issue suppl_1, p. 623-623

Research output: Contribution to journalMeeting AbstractAcademic

Open Access

Science in a global community

van Hest, J. C. M., Lavik, E. B., Smith, B. D., Zheng, G. & Rotello, V. M., 15 Feb 2017, In : Bioconjugate Chemistry. 28, 2, p. 279-281 3 p.

Research output: Contribution to journalEditorialAcademicpeer-review

Open Access
11 Citations (Scopus)

Self-assembling VHH-elastin-like peptides for photodynamic nanomedicine

Pille, J., van Lith, S. A. M., van Hest, J. C. M. & Leenders, W. P. J., 1 Apr 2017, In : Biomacromolecules. 18, 4, p. 1302-1310 4

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Medical nanotechnology
Elastin
Epidermal Growth Factor Receptor
Peptides
Nanoparticles
81 Citations (Scopus)

Self-propelled supramolecular nanomotors with temperature-responsive speed regulation

Tu, Y., Peng, F., Sui, X., Men, Y., White, P. B., van Hest, J. C. M. & Wilson, D. A., 9 May 2017, In : Nature Chemistry. 9, 5, p. 480-486

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Micromotors
Nanosystems
Brushes
Brakes
Fuel consumption
15 Citations (Scopus)

Self-regulated and temporal control of a "breathing" microgel mediated by enzymatic reaction

Che, H., Buddingh, B. C. & van Hest, J. C. M., 2 Oct 2017, In : Angewandte Chemie - International Edition. 56, 41, p. 12581-12585 41

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Urease
Enzymes
Fluorescence
Switches
Feedback
9 Citations (Scopus)

Stabilization of a virus-like particle and its application as a nanoreactor at physiological conditions

Schoonen, L., Maassen, S., Nolte, R. J. M. & van Hest, J. C. M., 20 Jun 2017, In : Biomacromolecules. 18, 11, p. 3492-3497 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Nanoreactors
Viruses
Stabilization
Enzymes
Muramidase
1 Citation (Scopus)

Sub-micron polymeric stomatocytes as promising templates for confined crystallization and diffraction experiments

Adawy, A., Amghouz, Z., van Hest, J. C. M. & Wilson, D. A., 13 Jul 2017, In : Small. 13, 28, p. 1-8 1700642

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Crystallization
Crystallography
Diffraction
Nanoparticles
Nanocrystals
25 Citations (Scopus)

Supramolecular adaptive nanomotors with magnetotaxis behavior

Peng, F., Tu, Y., Men, Y., van Hest, J. C. M. & Wilson, D. A., 10 Feb 2017, In : Advanced Materials. 29, 6, p. 1-7 1604996

Research output: Contribution to journalArticleAcademicpeer-review

2018

Adaptive polymersome and micelle morphologies in anticancer nanomedicine: from design rationale to fabrication and proof-of-concept studies

Pijpers, I. A. B., Abdelmohsen, L. K. E. A., Xia, Y., Cao, S., Williams, D. S., Meng, F., van Hest, J. C. M. & Zhong, Z., 1 Dec 2018, In : Advanced Therapeutics. 1, 8, 14 p., 1800068

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Medical nanotechnology
Micelles
Nanoparticles
Fabrication
Drug delivery

A filter-free blood-brain barrier model to quantitatively study transendothelial delivery of nanoparticles by fluorescence spectroscopy

De Jong, E., Williams, D. S., Abdelmohsen, L. K. E. A., van Hest, J. C. M. & Zuhorn, I. S., 10 Nov 2018, In : Journal of Controlled Release. 289, p. 14-22 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Fluorescence Spectrometry
Blood-Brain Barrier
Nanoparticles
Transcytosis
Brain
4 Citations (Scopus)

Assembly of protein stacks with in situ synthesized nanoparticle cargo

Manuguri, S., Webster, K., Yewdall, N. A., An, Y., Venugopal, H., Bhugra, V., Turner, A., Domigan, L. J., Gerrard, J. A., Williams, D. E. & Malmström, J., 8 Aug 2018, In : Nano Letters. 18, 8, p. 5138-5145 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

cargo
assembly
Iron
Nanoparticles
proteins
4 Citations (Scopus)

Biodegradable, drug-loaded nanovectors via direct hydration as a new platform for cancer therapeutics

Ridolfo, R., Ede, B. C., Diamanti, P., White, P. B., Perriman, A. W., van Hest, J. C. M., Blair, A. & Williams, D. S., 12 Jul 2018, In : Small. 14, 12, 10 p., 1703774

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Ethylene Glycol
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Hydration
Nanomedicine
Drug Compounding
9 Citations (Scopus)

Biodegradable synthetic organelles demonstrate ROS shielding in human-complex-I-deficient fibroblasts

van Oppen, L. M. P. E., Abdelmohsen, L. K. E. A., van Emst-de Vries, S. E., Welzen, P. L. W., Wilson, D. A., Smeitink, J. A. M., Koopman, W. J. H., Brock, R., Willems, P. H. G. M., Williams, D. S. & van Hest, J. C. M., 25 Jul 2018, In : ACS Central Science. 4, 7, p. 917-928 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Nanoreactors
Fibroblasts
Shielding
Polyethylene glycols
Carbonates
4 Citations (Scopus)

Chemical tools and materials for Biological/Medicinal applications

Yan, X. & van Hest, J. C. M., 15 Oct 2018, In : Chemistry - An Asian Journal. 13, 22, p. 3331-3332

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Research
Therapeutics

Consequences of a cosolvent on the structure and molecular dynamics of supramolecular polymers in water

Lafleur, R. P. M., Lou, X., Pavan, G. M., Palmans, A. R. A. & Meijer, E. W., 1 Jan 2018, In : Chemical Science. 9, 29, p. 6199-6209 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Molecular dynamics
Polymers
Water
Depolymerization
Polymerization
Open Access
File
9 Citations (Scopus)

Dual-color bioluminescent sensor proteins for therapeutic drug monitoring of antitumor antibodies

van Rosmalen, M., Ni, Y., Vervoort, D. F. M., Arts, R., Ludwig, S. K. J. & Merkx, M., 6 Mar 2018, In : Analytical Chemistry. 90, 5, p. 3592-3599 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Antineoplastic Agents
Color
Antibodies
Monitoring
Sensors