• Postbus 513, Helix Building

    5600 MB Eindhoven

    Netherlands

  • De Groene Loper 3, Helix Building (STO 3.39)

    5612 AE Eindhoven

    Netherlands

Research Output 2008 2020

2020

Peroxiredoxin proteins as building blocks for nanotechnology

Conroy, F. & Yewdall, A., 2020, Protein Nanotechnology. Gerard, J. & Domigan, L. (eds.). Humana: Springer, p. 39-54 16 p. (Methods in Molecular Biology; vol. 2073)

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Peroxiredoxins
Nanotechnology
Proteins
Transmission Electron Microscopy
Centrifugation
2019

Adaptive polymersome nanoreactors

Che, H. & van Hest, J. C. M., 1 Sep 2019, In : ChemNanoMat. 5, 9, p. 1092-1109

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Nanoreactors
Medical nanotechnology
Adaptive systems

Alendronate-functionalized poly(2-oxazoline)s with tunable affinity for calcium cations

Sánchez-Fernández, M. J., Immers, M. R., Félix Lanao, R. P., Yang, F., Bender, J. C. M. E., Mecinović, J., Leeuwenburgh, S. C. G. & van Hest, J. C. M., 1 Jan 2019, In : Biomacromolecules. 20, 8, p. 2913-2921 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Alendronate
Cations
Calcium
Polymers
Positive ions

A revised modular approach to (–)-trans-Δ 8 -THC and derivatives through late-stage Suzuki–Miyaura cross-coupling reactions

Bloemendal, V. R. L. J., Sondag, D., Elferink, H., Boltje, T. J., van Hest, J. C. M. & Rutjes, F. P. J. T., 31 Mar 2019, In : European Journal of Organic Chemistry. 2019, 12, p. 2289-2296 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
thermohaline circulation
Dronabinol
cross coupling
Derivatives
Scaffolds

ATP-mediated transient behavior of stomatocyte nanosystems

Che, H., Zhu, J., Song, S., Mason, A. F., Cao, S., Pijpers, I. A. B., Abdelmohsen, L. K. E. A. & van Hest, J. C. M., 2 Jul 2019, In : Angewandte Chemie - International Edition. 58, 37, p. 13113-13118

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Nanosystems
Adenosine Triphosphate
Polylysine
Nanoreactors
Molecular interactions
2 Citations (Scopus)

Biomorphic engineering of multifunctional polylactide stomatocytes toward therapeutic nano-red blood cells

Shao, J., Pijpers, I. A. B., Cao, S., Williams, D. S., Yan, X., Li, J., Abdelmohsen, L. K. E. A. & van Hest, J. C. M., 1 Jan 2019, In : Advanced Science. 6, 5, 8 p., 1801678

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
erythrocytes
Blood
Erythrocytes
Cells
engineering
2 Citations (Scopus)

Bone-adhesive materials: clinical requirements, mechanisms of action, and future perspective

Sánchez-Fernández, M. J., Hammoudeh, H., Félix Lanao, R. P., van Erk, M., van Hest, J. C. M. & Leeuwenburgh, S. C. G., 22 Feb 2019, In : Advanced Materials Interfaces. 6, 4, 11 p., 1802021

Research output: Contribution to journalReview articleAcademicpeer-review

Adhesives
Bone
Biomaterials
Glues
Tissue
2 Citations (Scopus)

Cell-free microcompartmentalised transcription-translation for the prototyping of synthetic communication networks

Dubuc, E., Pieters, P. A., van der Linden, A. J., van Hest, J. C. M., Huck, W. T. S. & de Greef, T. F. A., 1 Aug 2019, In : Current Opinion in Biotechnology. 58, p. 72-80 9 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
File
Transcription
Telecommunication networks
Communication
Cells
Networks (circuits)

Chemoenzymatic synthesis of sialic acid derivatives using immobilized N-acetylneuraminate lyase in a continuous flow reactor

Bloemendal, V. R. L. J., Moons, S. J., Heming, J. J. A., Chayoua, M., Niesink, O., van Hest, J. C. M., Boltje, T. J. & Rutjes, F. P. J. T., 8 May 2019, In : Advanced Synthesis & Catalysis. 361, 11, p. 2443-2447

Research output: Contribution to journalArticleAcademicpeer-review

N-acetylneuraminate lyase
N-Acetylneuraminic Acid
Derivatives
Acids
Sialic Acids
3 Citations (Scopus)

Development of morphologically discrete PEG-PDLLA nanotubes for precision nanomedicine

Wauters, A. C., Pijpers, I. A. B., Mason, A. F., Williams, D. S., Tel, J., Abdelmohsen, L. K. E. A. & van Hest, J. C. M., 1 Jan 2019, In : Biomacromolecules. 20, 1, p. 177-183

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Medical nanotechnology
Nanotubes
Polyethylene glycols
Particle interactions
Nanostructures

Engineering orthogonal polypeptide GalNAc-transferase and UDP-sugar pairs

Choi, J., Wagner, L. J. S., Timmermans, S. B. P. E., Malaker, S. A., Schumann, B., Gray, M. A., Debets, M. F., Takashima, M., Gehring, J. & Bertozzi, C. R., 2 Aug 2019, In : Journal of the American Chemical Society. 141, 34, p. 13442-13453 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Uridine Diphosphate Sugars
Polypeptides
Sugars
Substrate Specificity
Peptides
Open Access
Ethylene Glycol
Self assembly
Polyethylene glycols
Polymers
Organic solvents
Open Access
File
Micellization
Surface-Active Agents
self consistent fields
Surface active agents
Salts
Open Access
File
Terpolymers
Cell membranes
Encapsulation
Cell culture
Self assembly

Molecular programming of biodegradable nanoworms via ionically induced morphology switch toward asymmetric therapeutic carriers

Cao, S., Shao, J., Xia, Y., Che, H., Zhong, Z., Meng, F., van Hest, J. C. M., Abdelmohsen, L. K. E. A. & Williams, D. S., 5 Aug 2019, In : Small. 1901849

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Nanostructures
Micelles
Block copolymers
Switches
Nanomedicine
7 Citations (Scopus)

Molecular repolarisation of tumour-associated macrophages

van Dalen, F. J., van Stevendaal, M. H. M. E., Fennemann, F. L., Verdoes, M. & Ilina, O., 1 Jan 2019, In : Molecules. 24, 1, 25 p., 9

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
File
macrophages
Macrophages
Tumors
tumors
Neoplasms

Myosin II isoforms play distinct roles in adherens junction biogenesis

Heuzé, M. L., Sankara Narayana, G. H. N., D'Alessandro, J., Cellerin, V., Dang, T., Williams, D. S., van Hest, J. C. M., Marcq, P., Mège, R. M. & Ladoux, B., 5 Sep 2019, In : eLife. 8, 30 p., e46599

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Myosin Type II
Adherens Junctions
Actins
Protein Isoforms
pioglitazone
3 Citations (Scopus)

Nanoimmunotherapy to treat ischaemic heart disease

Duivenvoorden, R., Senders, M. L., van Leent, M. M. T., Pérez-Medina, C., Nahrendorf, M., Fayad, Z. A. & Mulder, W. J. M., 2019, In : Nature Reviews. Cardiology. 16, p. 21-32

Research output: Contribution to journalArticleAcademicpeer-review

Myocardial Ischemia
Atherosclerosis
Inflammation
Lipids
Recurrence
2 Citations (Scopus)

Octa-arginine boosts the penetration of elastin-like polypeptide nanoparticles in 3D cancer models

van Oppen, L. M. P. E., Pille, J., Stuut, C., van Stevendaal, M., van der Vorm, L. N., Smeitink, J. A. M., Koopman, W. J. H., Willems, P. H. G. M., van Hest, J. C. M. & Brock, R., 1 Apr 2019, In : European Journal of Pharmaceutics and Biopharmaceutics. 137, p. 175-184 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Cell-Penetrating Peptides
Elastin
Nanoparticles
Arginine
Peptides
Artificial Cells
Biochemical Phenomena
Polymers
Membranes
Macromolecules

Self-regulated out-of-equilibrium polymer assemblies

Che, H., 20 Sep 2019, Eindhoven: Technische Universiteit Eindhoven. 148 p.

Research output: ThesisPhd Thesis 1 (Research TU/e / Graduation TU/e)Academic

Open Access
File

Solvent impact assessment for the “One-Flow Functional Solvent Factory”

Morales-Gonzalez, O. M., Zhang, C., Li, S. & Hessel, V., 1 Aug 2019, In : Chemical Engineering Science: X. 3, 10 p., 100024

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Industrial plants
Ionic Liquids
Ionic liquids
Solubility
Acids

Spatial organization in proteinaceous membrane-stabilized coacervate protocells

Li, J., Liu, X., Abdelmohsen, L. K. E. A., Williams, D. S. & Huang, X., Jul 2019, In : Small. 15, 36, 9 p., 1902893

Research output: Contribution to journalArticleAcademicpeer-review

Artificial Cells
Membranes
Buoyancy
Static Electricity
Self assembly
1 Citation (Scopus)

Water resistant self-extinguishing low frequency soundproofing polyvinylpyrrolidone based electrospun blankets

Passaro, J., Russo, P., Bifulco, A., De Martino, M. T., Granata, V., Vitolo, B., Iannace, G., Vecchione, A., Marulo, F. & Branda, F., 1 Jul 2019, In : Polymers. 11, 7, 19 p., 1205

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Povidone
Electrospinning
Acoustic waves
Lactams
Water
2018

Adaptive polymersome and micelle morphologies in anticancer nanomedicine: from design rationale to fabrication and proof-of-concept studies

Pijpers, I. A. B., Abdelmohsen, L. K. E. A., Xia, Y., Cao, S., Williams, D. S., Meng, F., van Hest, J. C. M. & Zhong, Z., 1 Dec 2018, In : Advanced Therapeutics. 1, 8, 14 p., 1800068

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Medical nanotechnology
Micelles
Nanoparticles
Fabrication
Drug delivery

A filter-free blood-brain barrier model to quantitatively study transendothelial delivery of nanoparticles by fluorescence spectroscopy

De Jong, E., Williams, D. S., Abdelmohsen, L. K. E. A., van Hest, J. C. M. & Zuhorn, I. S., 10 Nov 2018, In : Journal of Controlled Release. 289, p. 14-22 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Fluorescence Spectrometry
Blood-Brain Barrier
Nanoparticles
Transcytosis
Brain
4 Citations (Scopus)

Assembly of protein stacks with in situ synthesized nanoparticle cargo

Manuguri, S., Webster, K., Yewdall, N. A., An, Y., Venugopal, H., Bhugra, V., Turner, A., Domigan, L. J., Gerrard, J. A., Williams, D. E. & Malmström, J., 8 Aug 2018, In : Nano Letters. 18, 8, p. 5138-5145 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

cargo
assembly
Iron
Nanoparticles
proteins
3 Citations (Scopus)

Biodegradable, drug-loaded nanovectors via direct hydration as a new platform for cancer therapeutics

Ridolfo, R., Ede, B. C., Diamanti, P., White, P. B., Perriman, A. W., van Hest, J. C. M., Blair, A. & Williams, D. S., 12 Jul 2018, In : Small. 14, 12, 10 p., 1703774

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Ethylene Glycol
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Hydration
Nanomedicine
Drug Compounding
7 Citations (Scopus)

Biodegradable synthetic organelles demonstrate ROS shielding in human-complex-I-deficient fibroblasts

van Oppen, L. M. P. E., Abdelmohsen, L. K. E. A., van Emst-de Vries, S. E., Welzen, P. L. W., Wilson, D. A., Smeitink, J. A. M., Koopman, W. J. H., Brock, R., Willems, P. H. G. M., Williams, D. S. & van Hest, J. C. M., 25 Jul 2018, In : ACS Central Science. 4, 7, p. 917-928 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Nanoreactors
Fibroblasts
Shielding
Polyethylene glycols
Carbonates
4 Citations (Scopus)

Chemical tools and materials for Biological/Medicinal applications

Yan, X. & van Hest, J. C. M., 15 Oct 2018, In : Chemistry - An Asian Journal. 13, 22, p. 3331-3332

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Research
Therapeutics

Consequences of a cosolvent on the structure and molecular dynamics of supramolecular polymers in water

Lafleur, R. P. M., Lou, X., Pavan, G. M., Palmans, A. R. A. & Meijer, E. W., 1 Jan 2018, In : Chemical Science. 9, 29, p. 6199-6209 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Molecular dynamics
Polymers
Water
Depolymerization
Polymerization
Open Access
File
7 Citations (Scopus)

Dual-color bioluminescent sensor proteins for therapeutic drug monitoring of antitumor antibodies

van Rosmalen, M., Ni, Y., Vervoort, D. F. M., Arts, R., Ludwig, S. K. J. & Merkx, M., 6 Mar 2018, In : Analytical Chemistry. 90, 5, p. 3592-3599 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Antineoplastic Agents
Color
Antibodies
Monitoring
Sensors

Editorial 2018

van Hest, J., Lavik, E. B., Smith, B. D., Zheng, G. & Rotello, V. M., 17 Jan 2018, In : Bioconjugate Chemistry. 29, 1, p. 1-3 3 p.

Research output: Contribution to journalEditorialAcademicpeer-review

Open Access
2 Citations (Scopus)

Effect of formulation and processing parameters on the size of mPEG-b-p(HPMA-Bz) polymeric micelles

Bagheri, M., Bresseleers, J., Varela-Moreira, A., Sandre, O., Meeuwissen, S. A., Schiffelers, R. M., Metselaar, J. M., Van Nostrum, C. F., van Hest, J. C. M. & Hennink, W. E., 12 Nov 2018, In : Langmuir. 34, 50, p. 15495-15506

Research output: Contribution to journalArticleAcademicpeer-review

hydroxypropyl methacrylate
Micelles
micelles
formulations
Processing

Engineering protein-based nanoparticle conjugates for nanomedicine applications

van Hest, J., Pille, J., Abdelghani, M., Timmermans, S., Vervoort, D. & Pretto, C., 19 Aug 2018, 256th National Meeting and Exposition of the American-Chemical-Society (ACS) - Nanoscience, Nanotechnology and Beyond .

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

16 Citations (Scopus)

Erythrocyte membrane modified janus polymeric motors for thrombus therapy

Shao, J., Abdelghani, M., Shen, G., Cao, S., Williams, D. S. & van Hest, J. C. M., 22 May 2018, In : ACS Nano. 12, 5, p. 4877-4885 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Janus
erythrocytes
therapy
membranes
Capsules
2 Citations (Scopus)

Existing self‐replicators can direct the emergence of new ones

Altay, Y., Altay, M. & Otto, S., 2018, In : Chemistry : A European Journal. 24, 46, p. 11911-11915 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Molecules
26 Citations (Scopus)

Feedback-induced temporal control of “breathing” polymersomes to create self-adaptive nanoreactors

Che, H., Cao, S. & van Hest, J. C. M., 4 Apr 2018, In : Journal of the American Chemical Society. 140, 16, p. 5356–5359 16

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Nanoreactors
Horseradish Peroxidase
Respiration
Biocatalysis
Artificial Cells
1 Citation (Scopus)

Fragmentation of organic ions bearing fixed multiple charges observed in MALDI MS

Lou, X., Li, B., de Waal, B. F. M., Schill, J., Baker, M. B., Bovee, R. A. A., van Dongen, J. L. J., Milroy, L. G. & Meijer, E. W., 1 Jan 2018, In : Journal of Mass Spectrometry. 53, 1, p. 39-47 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Bearings (structural)
Ions
Ionization
Mass spectrometry
Desorption

Imaging tropoelastin in atherosclerosis

Duivenvoorden, R. & Mulder, W. J. M., 1 Aug 2018, In : Circulation. Cardiovascular Imaging. 11, 8, 3 p., e008147

Research output: Contribution to journalEditorialAcademicpeer-review

Open Access
Tropoelastin
Atherosclerosis
2 Citations (Scopus)

Impact of the water-compatible periphery on the dynamic and structural properties of benzene-1,3,5-tricarboxamide based amphiphiles

Schoenmakers, S. M. C., Leenders, C. M. A., Lafleur, R. P. M., Lou, X., Meijer, E. W., Pavan, G. M. & Palmans, A. R. A., 2 Oct 2018, In : Chemical Communications. 54, 79, p. 11128-11131 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

File
Amphiphiles
Structural properties
Benzene
Polymers
Water
14 Citations (Scopus)

Inhibiting inflammation with Myeloid cell-specific nanobiologics promotes organ transplant acceptance

Braza, M. S., van Leent, M. M. T., Lameijer, M., Sanchez-Gaytan, B. L., Arts, R. J. W., Pérez-Medina, C., Conde, P., Garcia, M. R., Gonzalez-Perez, M., Brahmachary, M., Fay, F., Kluza, E., Kossatz, S., Dress, R. J., Salem, F., Rialdi, A., Reiner, T., Boros, P., Strijkers, G. J., Calcagno, C. C. & 13 othersGinhoux, F., Marazzi, I., Lutgens, E., Nicolaes, G. A. F., Weber, C., Swirski, F. K., Nahrendorf, M., Fisher, E. A., Duivenvoorden, R., Fayad, Z. A., Netea, M. G., Mulder, W. J. M. & Ochando, J., 20 Nov 2018, In : Immunity. 49, 5, p. 819-828.e6 17 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Myeloid Cells
HDL Lipoproteins
Allografts
Inflammation
Transplants
11 Citations (Scopus)

Investigating supramolecular systems using Förster resonance energy transfer

Teunissen, A. J. P., Pérez-Medina, C., Meijerink, A. & Mulder, W. J. M., 21 Sep 2018, In : Chemical Society Reviews. 47, 18, p. 7027-7044 18 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Energy transfer
Medical nanotechnology
Biochemistry
Materials science
Conformations

Metal ion-induced self-assembly and packaging of CCMV nanocapsules

Schoonen, L., van Eldijk, M. B. & van Hest, J. C. M., 5 Jun 2018, Protein scaffolds: design, synthesis, and applications. Udit, A. K. (ed.). Dordrecht: Springer, p. 57-67 11 p. (Methods in Molecular Biology; vol. 1798)

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Nanocapsules
His-His-His-His-His-His
Capsid Proteins
Viral Proteins
Product Packaging
1 Citation (Scopus)

Modification of CCMV nanocages for enzyme encapsulation

Schoonen, L. & van Hest, J. C. M., 5 Jun 2018, Protein Scaffolds : Design, Synthesis, and Applications. Udit, A. K. (ed.). Dordrecht: Springer, p. 69-83 15 p. (Methods in Molecular Biology; vol. 1798)

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Capsid
Enzymes
Nanoparticles
Peptides
3 Citations (Scopus)

Modular, bioorthogonal strategy for the controlled loading of cargo into a protein nanocage

Schoonen, L., Eising, S., van Eldijk, M. B., Bresseleers, J., Van Der Pijl, M., Nolte, R. J. M., Bonger, K. M. & van Hest, J. C. M., 18 Apr 2018, In : Bioconjugate Chemistry. 29, 4, p. 1186-1193 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Bromovirus
Viruses
Proteins
Capsid
Encapsulation

Nanoemulsion-based delivery of fluorescent PARP inhibitors in mouse models of small cell lung cancer

Gonzales, J., Kossatz, S., Roberts, S., Pirovano, G., Brand, C., Pérez-Medina, C., Donabedian, P., de la Cruz, M. J., Mulder, W. J. M. & Reiner, T., 24 Oct 2018, In : Bioconjugate Chemistry. 29, 11, p. 3776-3782 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Small Cell Lung Carcinoma
Half-Life
Administrative data processing
Poly(ADP-ribose) Polymerases
Cells
15 Citations (Scopus)

Nanoreactors for green catalysis

De Martino, M. T., Abdelmohsen, L. K. E. A., Rutjes, F. P. J. T., van Hest, J. C. M. & Hessel, V., 29 Mar 2018, In : Beilstein Journal of Organic Chemistry. 14, p. 716–733

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Nanoreactors
Catalysis
Industrial chemicals
Dendrimers
Micelles
1 Citation (Scopus)
Hepcidins
Biomarkers
Assays
formic acid
Proteins