• Postbus 513, Helix Building

    5600 MB Eindhoven

    Netherlands

  • De Groene Loper 3, Helix Building (STO 3.39)

    5612 AE Eindhoven

    Netherlands

Research Output 2008 2020

2020

Engineering interactive artificial cells

Buddingh, B., 20 Jan 2020, (Accepted/In press) Eindhoven: Technische Universiteit Eindhoven. 178 p.

Research output: ThesisPhd Thesis 1 (Research TU/e / Graduation TU/e)

Hybrid bio/supra-molecular polymers as programmable nano-architectures

Magdalena Estirado, E., 13 Jan 2020, Eindhoven: Technische Universiteit Eindhoven. 193 p.

Research output: ThesisPhd Thesis 1 (Research TU/e / Graduation TU/e)

8 Downloads (Pure)

Peptidic antifreeze materials: from design to potential applications

Suris Valls, R., 16 Jan 2020, Eindhoven: Technische Universiteit Eindhoven. 138 p.

Research output: ThesisPhd Thesis 1 (Research TU/e / Graduation TU/e)

Open Access
File

Peroxiredoxin proteins as building blocks for nanotechnology

Conroy, F. & Yewdall, A., 2020, Protein Nanotechnology. Gerard, J. & Domigan, L. (eds.). Humana: Springer, p. 39-54 16 p. (Methods in Molecular Biology; vol. 2073).

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Peroxiredoxins
Nanotechnology
Proteins
Transmission Electron Microscopy
Centrifugation
2019
1 Citation (Scopus)
12 Downloads (Pure)

Adaptive polymeric assemblies for applications in biomimicry and nanomedicine

Altay, Y., Che, H., Cao, S., Abdelmohsen, L. & van Hest, J., 11 Nov 2019, In : Biomacromolecules. 20, 11, p. 4053-4064 12 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
File
Medical nanotechnology
Nanostructured materials
Self assembly
Intelligent networks
Complex networks
1 Citation (Scopus)
32 Downloads (Pure)

Adaptive polymersome nanoreactors

Che, H. & van Hest, J. C. M., 1 Sep 2019, In : ChemNanoMat. 5, 9, p. 1092-1109 18 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Nanoreactors
Medical nanotechnology
Adaptive systems
5 Downloads (Pure)

Alendronate-functionalized poly(2-oxazoline)s with tunable affinity for calcium cations

Sánchez-Fernández, M. J., Immers, M. R., Félix Lanao, R. P., Yang, F., Bender, J. C. M. E., Mecinović, J., Leeuwenburgh, S. C. G. & van Hest, J. C. M., 12 Aug 2019, In : Biomacromolecules. 20, 8, p. 2913-2921 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Alendronate
Cations
Calcium
Polymers
Positive ions
17 Downloads (Pure)

A revised modular approach to (–)-trans-Δ 8 -THC and derivatives through late-stage Suzuki–Miyaura cross-coupling reactions

Bloemendal, V. R. L. J., Sondag, D., Elferink, H., Boltje, T. J., van Hest, J. C. M. & Rutjes, F. P. J. T., 31 Mar 2019, In : European Journal of Organic Chemistry. 2019, 12, p. 2289-2296 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
thermohaline circulation
Dronabinol
cross coupling
Derivatives
Scaffolds
1 Citation (Scopus)
2 Downloads (Pure)

ATP-mediated transient behavior of stomatocyte nanosystems

Che, H., Zhu, J., Song, S., Mason, A. F., Cao, S., Pijpers, I. A. B., Abdelmohsen, L. K. E. A. & van Hest, J. C. M., 9 Sep 2019, In : Angewandte Chemie - International Edition. 58, 37, p. 13113-13118 6 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
Nanosystems
Adenosine Triphosphate
Polylysine
Nanoreactors
Molecular interactions
4 Citations (Scopus)
22 Downloads (Pure)

Biomorphic engineering of multifunctional polylactide stomatocytes toward therapeutic nano-red blood cells

Shao, J., Pijpers, I. A. B., Cao, S., Williams, D. S., Yan, X., Li, J., Abdelmohsen, L. K. E. A. & van Hest, J. C. M., 6 Mar 2019, In : Advanced Science. 6, 5, 8 p., 1801678.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
erythrocytes
Blood
Erythrocytes
Cells
engineering
3 Citations (Scopus)
1 Downloads (Pure)

Bone-adhesive materials: clinical requirements, mechanisms of action, and future perspective

Sánchez-Fernández, M. J., Hammoudeh, H., Félix Lanao, R. P., van Erk, M., van Hest, J. C. M. & Leeuwenburgh, S. C. G., 22 Feb 2019, In : Advanced Materials Interfaces. 6, 4, 11 p., 1802021.

Research output: Contribution to journalReview articleAcademicpeer-review

Adhesives
Bone
Biomaterials
Glues
Tissue
5 Citations (Scopus)
52 Downloads (Pure)

Cell-free microcompartmentalised transcription-translation for the prototyping of synthetic communication networks

Dubuc, E., Pieters, P. A., van der Linden, A. J., van Hest, J. C. M., Huck, W. T. S. & de Greef, T. F. A., 1 Aug 2019, In : Current Opinion in Biotechnology. 58, p. 72-80 9 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
File
Transcription
Telecommunication networks
Communication
Cells
Networks (circuits)
2 Downloads (Pure)

Chemoenzymatic synthesis of sialic acid derivatives using immobilized N-acetylneuraminate lyase in a continuous flow reactor

Bloemendal, V. R. L. J., Moons, S. J., Heming, J. J. A., Chayoua, M., Niesink, O., van Hest, J. C. M., Boltje, T. J. & Rutjes, F. P. J. T., 6 Jun 2019, In : Advanced Synthesis & Catalysis. 361, 11, p. 2443-2447 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

N-acetylneuraminate lyase
N-Acetylneuraminic Acid
Derivatives
Acids
Sialic Acids
4 Citations (Scopus)
22 Downloads (Pure)

Click to enter: activation of oligo-arginine cell-penetrating peptides by bioorthogonal tetrazine ligations

Bode, S. A., Timmermans, S. B. P. E., Eising, S., van Gemert, S. P. W., Bonger, K. M. & Löwik, D. W. P. M., 21 Jan 2019, In : Chemical Science. 10, 3, p. 701-705 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Cell-Penetrating Peptides
Arginine
Chemical activation
Peptides
Cell membranes
4 Citations (Scopus)
54 Downloads (Pure)

Development of morphologically discrete PEG-PDLLA nanotubes for precision nanomedicine

Wauters, A. C., Pijpers, I. A. B., Mason, A. F., Williams, D. S., Tel, J., Abdelmohsen, L. K. E. A. & van Hest, J. C. M., 14 Jan 2019, In : Biomacromolecules. 20, 1, p. 177-183 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Medical nanotechnology
Nanotubes
Polyethylene glycols
Particle interactions
Nanostructures

Dynamic assembly of micellar mesostructures

Altay, Y., Pijpers - Welzen, I., Abdelmohsen, L. & van Hest, J., 28 Oct 2019, In : ChemSystemsChem. p. 1-5 5 p., e1900049.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Biological systems
Nanosystems
Micelles
Disulfides
Association reactions
Open Access
Ethylene Glycol
Self assembly
Polyethylene glycols
Polymers
Organic solvents
3 Citations (Scopus)
12 Downloads (Pure)
Open Access
File
Terpolymers
Cell membranes
Encapsulation
Cell culture
Self assembly
2 Citations (Scopus)
14 Downloads (Pure)

Molecular programming of biodegradable nanoworms via ionically induced morphology switch toward asymmetric therapeutic carriers

Cao, S., Shao, J., Xia, Y., Che, H., Zhong, Z., Meng, F., van Hest, J. C. M., Abdelmohsen, L. K. E. A. & Williams, D. S., 1 Sep 2019, In : Small. 15, 38, 8 p., 1901849.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Nanostructures
Micelles
Block copolymers
Switches
Nanomedicine

Multifaceted cell mimicry in coacervate-based synthetic cells

Mason, A. & Hest, van, J. C. M., Nov 2019, In : Emerging Topics in Life Sciences. 3, 5, p. 567-571 5.

Research output: Contribution to journalArticleAcademicpeer-review

Natural sciences
Earth (planet)
130 Downloads (Pure)

Myosin II isoforms play distinct roles in adherens junction biogenesis

Heuzé, M. L., Sankara Narayana, G. H. N., D'Alessandro, J., Cellerin, V., Dang, T., Williams, D. S., van Hest, J. C. M., Marcq, P., Mège, R. M. & Ladoux, B., 5 Sep 2019, In : eLife. 8, 30 p., e46599.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Myosin Type II
Adherens Junctions
Actins
Protein Isoforms
pioglitazone
3 Citations (Scopus)
1 Downloads (Pure)

Octa-arginine boosts the penetration of elastin-like polypeptide nanoparticles in 3D cancer models

van Oppen, L. M. P. E., Pille, J., Stuut, C., van Stevendaal, M., van der Vorm, L. N., Smeitink, J. A. M., Koopman, W. J. H., Willems, P. H. G. M., van Hest, J. C. M. & Brock, R., 1 Apr 2019, In : European Journal of Pharmaceutics and Biopharmaceutics. 137, p. 175-184 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Cell-Penetrating Peptides
Elastin
Nanoparticles
Arginine
Peptides
2 Citations (Scopus)
9 Downloads (Pure)
Open Access
File
Artificial Cells
Biochemical Phenomena
Polymers
Membranes
Macromolecules

Scale-up of the manufacturing process to produce docetaxel-loaded mPEG- b-p(HPMA-Bz) block copolymer micelles for pharmaceutical applications

Bresseleers, J., Bagheri, M., Storm, G., Metselaar, J. M., Hennink, W. E., Meeuwissen, S. A. & van Hest, J. C. M., 29 Oct 2019, In : Organic Process Research and Development. 23, p. 2707-2715 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
hydroxypropyl methacrylate
docetaxel
Micelles
block copolymers
Block copolymers

Screening of functional solvent system for automatic aldehyde and ketone separation in aldol reaction: a combined COSMO-RS and experimental approach

Zhang, C., Song, Z., Jin, C., Nijhuis, J., Zhou, T., Noël, T., Gröger, H., Sundmacher, K., van Hest, J. & Hessel, V., 5 Nov 2019, (Accepted/In press) In : Chemical Engineering Journal.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
ketone
aldehyde
Ketones
Aldehydes
Screening
83 Downloads (Pure)

Self-regulated out-of-equilibrium polymer assemblies

Che, H., 20 Sep 2019, Eindhoven: Technische Universiteit Eindhoven. 148 p.

Research output: ThesisPhd Thesis 1 (Research TU/e / Graduation TU/e)

Open Access
File
6 Downloads (Pure)

Single enzyme loaded nanoparticles for combinational ultrasound-guided focused ultrasound ablation and hypoxia-relieved chemotherapy

Zhu, J., Li, Z., Zhang, C., Lin, L., Cao, S., Che, H., Shi, X., Wang, H. & van Hest, J. C. M., 1 Jan 2019, In : Theranostics. 9, 26, p. 8048-8060 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Nanoparticles
Nanomedicine
Drug Therapy
Acoustic Neuroma
Ethylene Glycol

Spatial organization in proteinaceous membrane-stabilized coacervate protocells

Li, J., Liu, X., Abdelmohsen, L. K. E. A., Williams, D. S. & Huang, X., 1 Sep 2019, In : Small. 15, 36, p. e1902893 9 p., 1902893.

Research output: Contribution to journalArticleAcademicpeer-review

Artificial Cells
Membranes
Buoyancy
Static Electricity
Self assembly
6 Downloads (Pure)

Versatile reversible cross-linking strategy to stabilize CCMV virus like particles for efficient siRNA delivery

Pretto, C. & van Hest, J. C. M., 18 Dec 2019, In : Bioconjugate Chemistry. 30, 12, p. 3069-3077 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Bromovirus
Viruses
Virion
Small Interfering RNA
Digestion
2018
3 Downloads (Pure)

Adaptive polymersome and micelle morphologies in anticancer nanomedicine: from design rationale to fabrication and proof-of-concept studies

Pijpers, I. A. B., Abdelmohsen, L. K. E. A., Xia, Y., Cao, S., Williams, D. S., Meng, F., van Hest, J. C. M. & Zhong, Z., 1 Dec 2018, In : Advanced Therapeutics. 1, 8, 14 p., 1800068.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Medical nanotechnology
Micelles
Nanoparticles
Fabrication
Drug delivery
32 Downloads (Pure)

A filter-free blood-brain barrier model to quantitatively study transendothelial delivery of nanoparticles by fluorescence spectroscopy

De Jong, E., Williams, D. S., Abdelmohsen, L. K. E. A., van Hest, J. C. M. & Zuhorn, I. S., 10 Nov 2018, In : Journal of Controlled Release. 289, p. 14-22 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Fluorescence Spectrometry
Blood-Brain Barrier
Nanoparticles
Transcytosis
Brain
4 Citations (Scopus)
41 Downloads (Pure)

Biodegradable, drug-loaded nanovectors via direct hydration as a new platform for cancer therapeutics

Ridolfo, R., Ede, B. C., Diamanti, P., White, P. B., Perriman, A. W., van Hest, J. C. M., Blair, A. & Williams, D. S., 12 Jul 2018, In : Small. 14, 12, 10 p., 1703774.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Ethylene Glycol
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Hydration
Nanomedicine
Drug Compounding
10 Citations (Scopus)
71 Downloads (Pure)

Biodegradable synthetic organelles demonstrate ROS shielding in human-complex-I-deficient fibroblasts

van Oppen, L. M. P. E., Abdelmohsen, L. K. E. A., van Emst-de Vries, S. E., Welzen, P. L. W., Wilson, D. A., Smeitink, J. A. M., Koopman, W. J. H., Brock, R., Willems, P. H. G. M., Williams, D. S. & van Hest, J. C. M., 25 Jul 2018, In : ACS Central Science. 4, 7, p. 917-928 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Nanoreactors
Fibroblasts
Shielding
Polyethylene glycols
Carbonates
5 Citations (Scopus)

Chemical tools and materials for Biological/Medicinal applications

Yan, X. & van Hest, J. C. M., 15 Oct 2018, In : Chemistry - An Asian Journal. 13, 22, p. 3331-3332

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Research
Therapeutics
21 Downloads (Pure)
Open Access
File

Editorial 2018

van Hest, J., Lavik, E. B., Smith, B. D., Zheng, G. & Rotello, V. M., 17 Jan 2018, In : Bioconjugate Chemistry. 29, 1, p. 1-3 3 p.

Research output: Contribution to journalEditorialAcademicpeer-review

Open Access
3 Citations (Scopus)
1 Downloads (Pure)

Effect of formulation and processing parameters on the size of mPEG-b-p(HPMA-Bz) polymeric micelles

Bagheri, M., Bresseleers, J., Varela-Moreira, A., Sandre, O., Meeuwissen, S. A., Schiffelers, R. M., Metselaar, J. M., Van Nostrum, C. F., van Hest, J. C. M. & Hennink, W. E., 12 Nov 2018, In : Langmuir. 34, 50, p. 15495-15506

Research output: Contribution to journalArticleAcademicpeer-review

hydroxypropyl methacrylate
Micelles
micelles
formulations
Processing

Engineering protein-based nanoparticle conjugates for nanomedicine applications

van Hest, J., Pille, J., Abdelghani, M., Timmermans, S., Vervoort, D. & Pretto, C., 19 Aug 2018, 256th National Meeting and Exposition of the American-Chemical-Society (ACS) - Nanoscience, Nanotechnology and Beyond .

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

20 Citations (Scopus)
54 Downloads (Pure)

Erythrocyte membrane modified janus polymeric motors for thrombus therapy

Shao, J., Abdelghani, M., Shen, G., Cao, S., Williams, D. S. & van Hest, J. C. M., 22 May 2018, In : ACS Nano. 12, 5, p. 4877-4885 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Janus
erythrocytes
therapy
membranes
Capsules
32 Citations (Scopus)
94 Downloads (Pure)

Feedback-induced temporal control of “breathing” polymersomes to create self-adaptive nanoreactors

Che, H., Cao, S. & van Hest, J. C. M., 4 Apr 2018, In : Journal of the American Chemical Society. 140, 16, p. 5356–5359 16.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Nanoreactors
Horseradish Peroxidase
Respiration
Biocatalysis
Artificial Cells
1 Citation (Scopus)

Metal ion-induced self-assembly and packaging of CCMV nanocapsules

Schoonen, L., van Eldijk, M. B. & van Hest, J. C. M., 5 Jun 2018, Protein scaffolds: design, synthesis, and applications. Udit, A. K. (ed.). Dordrecht: Springer, p. 57-67 11 p. (Methods in Molecular Biology; vol. 1798).

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Nanocapsules
His-His-His-His-His-His
Capsid Proteins
Viral Proteins
Product Packaging
1 Citation (Scopus)

Modification of CCMV nanocages for enzyme encapsulation

Schoonen, L. & van Hest, J. C. M., 5 Jun 2018, Protein Scaffolds : Design, Synthesis, and Applications. Udit, A. K. (ed.). Dordrecht: Springer, p. 69-83 15 p. (Methods in Molecular Biology; vol. 1798).

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Capsid
Enzymes
Nanoparticles
Peptides
3 Citations (Scopus)
66 Downloads (Pure)

Modular, bioorthogonal strategy for the controlled loading of cargo into a protein nanocage

Schoonen, L., Eising, S., van Eldijk, M. B., Bresseleers, J., Van Der Pijl, M., Nolte, R. J. M., Bonger, K. M. & van Hest, J. C. M., 18 Apr 2018, In : Bioconjugate Chemistry. 29, 4, p. 1186-1193 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Bromovirus
Viruses
Proteins
Capsid
Encapsulation
17 Citations (Scopus)
100 Downloads (Pure)

Nanoreactors for green catalysis

De Martino, M. T., Abdelmohsen, L. K. E. A., Rutjes, F. P. J. T., van Hest, J. C. M. & Hessel, V. (Guest ed.), 29 Mar 2018, In : Beilstein Journal of Organic Chemistry. 14, p. 716–733

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Nanoreactors
Catalysis
Industrial chemicals
Dendrimers
Micelles
6 Citations (Scopus)
38 Downloads (Pure)

PH-induced transformation of biodegradable multilamellar nanovectors for enhanced tumor penetration

Cao, S., Abdelmohsen, L. K. E. A., Shao, J., van den Dikkenberg, J., Mastrobattista, E., Williams, D. S. & van Hest, J. C. M., 20 Nov 2018, In : ACS Macro Letters. 7, 11, p. 1394-1399 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Tumors
Ethylene Glycol
Surface charge
Ethylene glycol
Hydration
3 Citations (Scopus)
1 Downloads (Pure)

Polymers at the interface with biology

Deming, T. J., Klok, H. A., Armes, S. P., Becker, M. L., Champion, J. A., Chen, E. Y. X., Heilshorn, S. C., van Hest, J. C. M., Irvine, D. J., Johnson, J. A., Kiessling, L. L., Maynard, H. D., De La Cruz, M. O., Sullivan, M. O., Tirrell, M. V., Anseth, K. S., Lecommandoux, S., Percec, S., Zhong, Z. & Albertsson, A. C., 13 Aug 2018, In : Biomacromolecules. 19, 8, p. 3151-3162 12 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
Polymers
1 Citation (Scopus)

Residue-specific incorporation of noncanonical amino acids for protein engineering

van Eldijk, M. B. & van Hest, J. C. M., 2018, Noncanonical amino acids: methods and protocols. Lemke, E. A. (ed.). New York: Humana Press, p. 137-145 9 p. (Methods in Molecular Biology; vol. 1728).

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Protein Engineering
Alkynes
Azides
Amino Acids
Cycloaddition Reaction
13 Citations (Scopus)
65 Downloads (Pure)

Self-assembled nanoreactors based on peptides and proteins

Timmermans, S. B. P. E. & van Hest, J. C. M., 1 May 2018, In : Current Opinion in Colloid and Interface Science. 35, p. 26-35 10 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
File
Nanoreactors
Peptides
peptides
proteins
Proteins
2 Citations (Scopus)
12 Downloads (Pure)

Self-assembly and stabilization of hybrid cowpea chlorotic mottle virus particles under nearly physiological conditions

Timmermans, S. B. P. E., Vervoort, D. F. M., Schoonen, L., Nolte, R. J. M. & van Hest, J. C. M., 1 Nov 2018, In : Chemistry - An Asian Journal. 13, 22, p. 3518-3525

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Bromovirus
Capsid
Viruses
Virion
Self assembly
3 Citations (Scopus)
30 Downloads (Pure)

Temperature-induced collapse of elastin-like peptides studied by 2DIR spectroscopy

Selig, O., da Cunha, A. M. D. C. V., van Eldijk, M. B., van Hest, J. C. M., Jansen, T. L. C., Bakker, H. J. & Rezus, Y. L. A., 1 Aug 2018, In : Journal of Physical Chemistry B. 122, 34, p. 8243-8254 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
elastin
Elastin
Peptides
peptides
Spectroscopy