• Postbus 513, Helix Building

    5600 MB Eindhoven

    Netherlands

  • De Groene Loper 5, STO 3.39, Helix Building

    5612 AE Eindhoven

    Netherlands

Organization profile

Introduction / mission

We develop compartmentalization strategies to construct micro- and nano-capsules for application in nanomedicine and artificial cell research.

Highlighted phrase

Creating minuscule compartments with life-like features

Organisational profile

In our research we combine techniques from protein engineering, polymer chemistry and bioconjugation approaches to create particles with bioactive properties. In the field of nanomedicine, we design smart delivery vehicles that for example cross the blood brain barrier or are used in cancer therapy. We also use nanoparticles as scaffolds for vaccine development. In the field of artificial cell research, we aim to create responsive smart compartments that mimic the behavior of living cells. For instance, we develop nanoreactors that can be incorporated as artificial organelles in living cells, to complement or affect cellular processes.

With advanced synthetic techniques and assembly methods, we can construct particles with control over size, shape, surface charge and functionality. In the field of nanomedicine, these particles are employed in treating brain related (metabolic) diseases, ophthalmology, cancer research and bacterial vaccine development. This is pursued in collaboration with our (international) partners. In the field of artificial cell research, we construct capsules with life-like properties, such as metabolism, organelle-mimetic behavior and cell growth and motility. We are part of the Institute for Complex Molecular Systems (ICMS) and of the Research Center for Functional Molecular Systems (FMS), brought together to complete a single grand challenge: the construction of functional life-like molecular systems.

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2008 2019

Open Access
File
Micellization
Surface-Active Agents
self consistent fields
Surface active agents
Salts

Adaptive polymersome and micelle morphologies in anticancer nanomedicine: from design rationale to fabrication and proof-of-concept studies

Pijpers, I. A. B., Abdelmohsen, L. K. E. A., Xia, Y., Cao, S., Williams, D. S., Meng, F., van Hest, J. C. M. & Zhong, Z., 4 Sep 2018, In : Advanced Therapeutics. 1800068

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Medical nanotechnology
Micelles
Nanoparticles
Fabrication
Drug delivery

A filter-free blood-brain barrier model to quantitatively study transendothelial delivery of nanoparticles by fluorescence spectroscopy

De Jong, E., Williams, D. S., Abdelmohsen, L. K. E. A., van Hest, J. C. M. & Zuhorn, I. S., 10 Nov 2018, In : Journal of Controlled Release. 289, p. 14-22 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Fluorescence Spectrometry
Blood-Brain Barrier
Nanoparticles
Transcytosis
Brain

Equipment

Prizes

Artificial endosymbiosis

Jan van Hest (Recipient), 2015

Recognition: ERCAdvancedScientific

symbiosis
organelles
cells
synthetic biology
uptake mechanisms

Checkpoint NANO

Willem Mulder (Recipient), Nov 2018

Recognition: ERCConsolidatorScientific

Precision Medicine
Immune System
Research
Pharmaceutical Preparations
Immunotherapy

Research Center for Functional Molecular Systems

Bert Meijer (Recipient), Jan van Hest (Recipient), Luc Brunsveld (Recipient), Rene Janssen (Recipient) & Rint Sijbesma (Recipient), 2013

Recognition: NWOGravitationScientific

Netherlands
selection procedure
Ministry of Education
funding
organization

Activities 2015 2015

Dutch Peptide Symposium - 2015

Welzen, P. (Organiser)
27 May 2015

Activity: Participating in or organising an eventConferenceScientific

Press / Media

Local entrepreneur challenging more women to own businesses

Gang Wang

16/09/18

1 item of media coverage

Press/Media: Expert Comment

FSU research reveals bias against female CEOs

Gang Wang

10/09/18

1 item of media coverage

Press/Media: Expert Comment

Student theses

Development of Fischer Tropsch foam catalyst and reactor development: diffusion limitations for FTS foam catalyst

Author: van der Linden, C., 1 Sep 2017

Supervisor: de Martino, M. (Supervisor 1)

Student thesis: Master

File

Development of reduction responsive polymersomes for controlled drug delivery

Author: Stam, R., 13 Nov 2018

Supervisor: Pijpers, I. (Supervisor 1), van Hest, J. (Supervisor 2), Brunsveld, L. (Supervisor 2) & Abdelmohsen, L. (Supervisor 2)

Student thesis: Master