• Postbus 513, Helix Building

    5600 MB Eindhoven

    Netherlands

  • De Groene Loper 3, Helix Building (STO 3.39)

    5612 AE Eindhoven

    Netherlands

Organization profile

Introduction / mission

We develop compartmentalization strategies to construct micro- and nano-capsules for application in nanomedicine and artificial cell research.

Highlighted phrase

Creating minuscule compartments with life-like features

Organisational profile

In our research we combine techniques from protein engineering, polymer chemistry and bioconjugation approaches to create particles with bioactive properties. In the field of nanomedicine, we design smart delivery vehicles that for example cross the blood brain barrier or are used in cancer therapy. We also use nanoparticles as scaffolds for vaccine development. In the field of artificial cell research, we aim to create responsive smart compartments that mimic the behavior of living cells. For instance, we develop nanoreactors that can be incorporated as artificial organelles in living cells, to complement or affect cellular processes.

With advanced synthetic techniques and assembly methods, we can construct particles with control over size, shape, surface charge and functionality. In the field of nanomedicine, these particles are employed in treating brain related (metabolic) diseases, ophthalmology, cancer research and bacterial vaccine development. This is pursued in collaboration with our (international) partners. In the field of artificial cell research, we construct capsules with life-like properties, such as metabolism, organelle-mimetic behavior and cell growth and motility. We are part of the Institute for Complex Molecular Systems (ICMS) and of the Research Center for Functional Molecular Systems (FMS), brought together to complete a single grand challenge: the construction of functional life-like molecular systems.

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  • Network Recent external collaboration on country level. Dive into details by clicking on the dots.

    Research Output

    CD44-targeted vesicles encapsulating granzyme B as artificial killer cells for potent inhibition of human multiple myeloma in mice

    Zhong, Y., Meng, F., Zhang, W., Li, B., van Hest, J. C. M. & Zhong, Z., 3 Feb 2020, In : Journal of Controlled Release. 320, p. 421-430 10 p.

    Research output: Contribution to journalArticleAcademicpeer-review

  • Dithioacetal-mechanized mesoporous nanosensor for Hg(II) determination

    Jimenez-Falcao, S., Villalonga, A., Parra-Nieto, J., Llopis-Lorente, A., Martinez-Ruiz, P., Martinez-Mañez, R. & Villalonga, R., 1 May 2020, In : Microporous and Mesoporous Materials. 297, 7 p., 110054.

    Research output: Contribution to journalArticleAcademicpeer-review

  • Engineering interactive artificial cells

    Buddingh, B. C., 20 Jan 2020, Eindhoven: Technische Universiteit Eindhoven. 178 p.

    Research output: ThesisPhd Thesis 1 (Research TU/e / Graduation TU/e)

    Equipment

    Prizes

    Artificial endosymbiosis

    J.C.M. van Hest (Recipient), 2015

    Prize: ERCAdvancedScientific

  • Checkpoint NANO

    W.J.M. Mulder (Recipient), Nov 2018

    Prize: ERCConsolidatorScientific

  • Research Center for Functional Molecular Systems

    E.W. Meijer (Recipient), J.C.M. van Hest (Recipient), L. Brunsveld (Recipient), R.A.J. Janssen (Recipient) & R.P. Sijbesma (Recipient), 2013

    Prize: NWOGravitationScientific

  • Activities

    • 1 Conference
    • 1 Visiting an external academic institution

    University of Oxford

    Alexander Mason (Visiting researcher), Hagan Bayley (Visiting lecturer)
    2019 → …

    Activity: Visiting an external institution typesVisiting an external academic institutionScientific

    Dutch Peptide Symposium - 2015

    Pascal Welzen (Organiser)
    27 May 2015

    Activity: Participating in or organising an event typesConferenceScientific

    Press / Media

    ICMS Fellowship for Alex Mason

    Jan C.M. Hest, van

    9/01/20

    1 item of Media coverage

    Press/Media: Expert Comment

    Learning lessons in nanomedicine

    Jan C.M. Hest, van

    7/01/20

    1 item of Media coverage

    Press/Media: Expert Comment

    Student theses

    Behaviour and morphology of self-assemblies of pH-responsive polyurethane ionomers

    Author: Song, S., 29 Nov 2017

    Supervisor: Voets, I. K. (Supervisor 1), Sahebali, S. (Supervisor 2), Tuinier, R. (Supervisor 2) & Sijbesma, R. P. (Supervisor 2)

    Student thesis: Master

    Development of Fischer Tropsch foam catalyst and reactor development: diffusion limitations for FTS foam catalyst

    Author: van der Linden, C., 1 Sep 2017

    Supervisor: de Martino, M. (Supervisor 1)

    Student thesis: Master

    File

    Development of reduction responsive polymersomes for controlled drug delivery

    Author: Stam, R., 13 Nov 2018

    Supervisor: Pijpers, I. (Supervisor 1), van Hest, J. (Supervisor 2), Brunsveld, L. (Supervisor 2) & Abdelmohsen, L. (Supervisor 2)

    Student thesis: Master