• Postbus 513, Helix Building

    5600 MB Eindhoven

    Netherlands

  • De Groene Loper 3, Helix Building (STO 3.39)

    5612 AE Eindhoven

    Netherlands

Organization profile

Introduction / mission

We develop compartmentalization strategies to construct micro- and nano-capsules for application in nanomedicine and artificial cell research.

Highlighted phrase

Creating minuscule compartments with life-like features

Organisational profile

In our research we combine techniques from protein engineering, polymer chemistry and bioconjugation approaches to create particles with bioactive properties. In the field of nanomedicine, we design smart delivery vehicles that for example cross the blood brain barrier or are used in cancer therapy. We also use nanoparticles as scaffolds for vaccine development. In the field of artificial cell research, we aim to create responsive smart compartments that mimic the behavior of living cells. For instance, we develop nanoreactors that can be incorporated as artificial organelles in living cells, to complement or affect cellular processes.

With advanced synthetic techniques and assembly methods, we can construct particles with control over size, shape, surface charge and functionality. In the field of nanomedicine, these particles are employed in treating brain related (metabolic) diseases, ophthalmology, cancer research and bacterial vaccine development. This is pursued in collaboration with our (international) partners. In the field of artificial cell research, we construct capsules with life-like properties, such as metabolism, organelle-mimetic behavior and cell growth and motility. We are part of the Institute for Complex Molecular Systems (ICMS) and of the Research Center for Functional Molecular Systems (FMS), brought together to complete a single grand challenge: the construction of functional life-like molecular systems.

Fingerprint Dive into the research topics where Bio-Organic Chemistry is active. These topic labels come from the works of this organisation's members. Together they form a unique fingerprint.

Nanoreactors Chemical Compounds
Self assembly Chemical Compounds
Polymers Chemical Compounds
Medical nanotechnology Chemical Compounds
Nanoparticles Medicine & Life Sciences
Viruses Chemical Compounds
Polyethylene glycols Chemical Compounds
Artificial Cells Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2008 2020

Engineering interactive artificial cells

Buddingh, B. C., 20 Jan 2020, Eindhoven: Technische Universiteit Eindhoven. 178 p.

Research output: ThesisPhd Thesis 1 (Research TU/e / Graduation TU/e)

Hybrid bio/supra-molecular polymers as programmable nano-architectures

Magdalena Estirado, E., 13 Jan 2020, Eindhoven: Technische Universiteit Eindhoven. 193 p.

Research output: ThesisPhd Thesis 1 (Research TU/e / Graduation TU/e)

Open Access
File
Ethylene Glycol
Self assembly
Polyethylene glycols
Polymers
Organic solvents

Equipment

Prizes

Artificial endosymbiosis

J.C.M. van Hest (Recipient), 2015

Prize: ERCAdvancedScientific

symbiosis
organelles
cells
synthetic biology
uptake mechanisms

Checkpoint NANO

W.J.M. Mulder (Recipient), Nov 2018

Prize: ERCConsolidatorScientific

Precision Medicine
Immune System
Research
Pharmaceutical Preparations
Immunotherapy

Research Center for Functional Molecular Systems

E.W. Meijer (Recipient), J.C.M. van Hest (Recipient), L. Brunsveld (Recipient), R.A.J. Janssen (Recipient) & R.P. Sijbesma (Recipient), 2013

Prize: NWOGravitationScientific

selection procedure
Ministry of Education
Netherlands
funding
science

Activities 2015 2019

  • 1 Conference
  • 1 Visiting an external academic institution

University of Oxford

Alexander Mason (Visiting researcher), Hagan Bayley (Visiting lecturer)
2019 → …

Activity: Visiting an external institution typesVisiting an external academic institutionScientific

Dutch Peptide Symposium - 2015

Pascal Welzen (Organiser)
27 May 2015

Activity: Participating in or organising an event typesConferenceScientific

Press / Media

ICMS Fellowship for Alex Mason

Jan C.M. Hest, van

9/01/20

1 item of Media coverage

Press/Media: Expert Comment

Learning lessons in nanomedicine

Jan C.M. Hest, van

7/01/20

1 item of Media coverage

Press/Media: Expert Comment

Student theses

Development of Fischer Tropsch foam catalyst and reactor development: diffusion limitations for FTS foam catalyst

Author: van der Linden, C., 1 Sep 2017

Supervisor: de Martino, M. (Supervisor 1)

Student thesis: Master

File

Development of reduction responsive polymersomes for controlled drug delivery

Author: Stam, R., 13 Nov 2018

Supervisor: Pijpers, I. (Supervisor 1), van Hest, J. (Supervisor 2), Brunsveld, L. (Supervisor 2) & Abdelmohsen, L. (Supervisor 2)

Student thesis: Master

Measuring all three vitamin D metabolites on the LC-MS/MS: effects of vitamin D supplementation in pre-dialysis patients

Author: Verbon, I., 27 Nov 2017

Supervisor: van Dongen, J. (Supervisor 1) & Schmitz, E. (Supervisor 2)

Student thesis: Master