• Postbus 513, Helix Building

    5600 MB Eindhoven

    Netherlands

  • De Groene Loper 5, STO 3.39, Helix Building

    5612 AE Eindhoven

    Netherlands

Organization profile

Introduction / mission

We develop compartmentalization strategies to construct micro- and nano-capsules for application in nanomedicine and artificial cell research.

Highlighted phrase

Creating minuscule compartments with life-like features

Organisational profile

In our research we combine techniques from protein engineering, polymer chemistry and bioconjugation approaches to create particles with bioactive properties. In the field of nanomedicine, we design smart delivery vehicles that for example cross the blood brain barrier or are used in cancer therapy. We also use nanoparticles as scaffolds for vaccine development. In the field of artificial cell research, we aim to create responsive smart compartments that mimic the behavior of living cells. For instance, we develop nanoreactors that can be incorporated as artificial organelles in living cells, to complement or affect cellular processes.

With advanced synthetic techniques and assembly methods, we can construct particles with control over size, shape, surface charge and functionality. In the field of nanomedicine, these particles are employed in treating brain related (metabolic) diseases, ophthalmology, cancer research and bacterial vaccine development. This is pursued in collaboration with our (international) partners. In the field of artificial cell research, we construct capsules with life-like properties, such as metabolism, organelle-mimetic behavior and cell growth and motility. We are part of the Institute for Complex Molecular Systems (ICMS) and of the Research Center for Functional Molecular Systems (FMS), brought together to complete a single grand challenge: the construction of functional life-like molecular systems.

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Profiles

Photo of Mona Abdelghani

Mona Abdelghani

Person: Prom. : doctoral candidate (PhD)

20182018
Photo of Loai K.E.A. Abdelmohsen

Loai K.E.A. Abdelmohsen

Person: UD : Assistant Professor

20142019
Photo of Yigit Altay

Yigit Altay

Person: OWP : University Teacher / Researcher

20102018

Research Output 2008 2019

Biomorphic engineering of multifunctional polylactide stomatocytes toward therapeutic nano-red blood cells

Shao, J., Pijpers, I. A. B., Cao, S., Williams, D. S., Yan, X., Li, J., Abdelmohsen, L. K. E. A. & van Hest, J. C. M., 1 Jan 2019, (Accepted/In press) In : Advanced Science.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
erythrocytes
Blood
Erythrocytes
Cells
engineering
1 Citations

Development of morphologically discrete PEG-PDLLA nanotubes for precision nanomedicine

Wauters, A. C., Pijpers, I. A. B., Mason, A. F., Williams, D. S., Tel, J., Abdelmohsen, L. K. E. A. & van Hest, J. C. M., 1 Jan 2019, In : Biomacromolecules. 20, 1, p. 177-183

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Medical nanotechnology
Nanotubes
Polyethylene glycols
Particle interactions
Nanostructures
Open Access
File
Micellization
Surface-Active Agents
self consistent fields
Surface active agents
Salts

Equipment

Prizes

Artificial endosymbiosis

Jan van Hest (Recipient), 2015

Recognition: ERCAdvancedScientific

symbiosis
organelles
cells
synthetic biology
uptake mechanisms

Checkpoint NANO

Willem Mulder (Recipient), Nov 2018

Recognition: ERCConsolidatorScientific

Precision Medicine
Immune System
Research
Pharmaceutical Preparations
Immunotherapy

Research Center for Functional Molecular Systems

Bert Meijer (Recipient), Jan van Hest (Recipient), Luc Brunsveld (Recipient), Rene Janssen (Recipient) & Rint Sijbesma (Recipient), 2013

Recognition: NWOGravitationScientific

Netherlands
selection procedure
Ministry of Education
funding
organization

Activities 2015 2015

Dutch Peptide Symposium - 2015

Pascal Welzen (Organiser)
27 May 2015

Activity: Participating in or organising an event typesConferenceScientific

Research areas

Bioluminescent sensors for point-of-care diagnostics

Marjo van Hoof (Content manager), Lieke van Gorp (Content manager), Amy Broeders (Content manager)

Impact: Research Topic/Theme (at group level)

FRET and BRET sensors for intracellular imaging

Marjo van Hoof (Content manager), Lieke van Gorp (Content manager), Amy Broeders (Content manager)

Impact: Research Topic/Theme (at group level)

Protein sensing and actuation using DNA-based molecular circuits

Marjo van Hoof (Content manager), Lieke van Gorp (Content manager), Amy Broeders (Content manager)

Impact: Research Topic/Theme (at group level)

Student theses

Development of Fischer Tropsch foam catalyst and reactor development: diffusion limitations for FTS foam catalyst

Author: van der Linden, C., 1 Sep 2017

Supervisor: de Martino, M. (Supervisor 1)

Student thesis: Master

File

Development of reduction responsive polymersomes for controlled drug delivery

Author: Stam, R., 13 Nov 2018

Supervisor: Pijpers, I. (Supervisor 1), van Hest, J. (Supervisor 2), Brunsveld, L. (Supervisor 2) & Abdelmohsen, L. (Supervisor 2)

Student thesis: Master