Biological Materials Chemistry: Bone structure characterization in genetic disorder disease

  • Nina Romme-van Moll (Content manager)

Impact: Research Topic/Theme (at group level)

Description of impact

Osteogenesis imperfecta (OI), also known as brittle bone disease, is a genetic disorder that affects the way collagen type I is folded and assembled into fibrils. The malfunctioning in collagen assembly directly affects the mineralization process of collagen fibrils, leading to hyper mineralization and resulting in poor mechanical properties. By combining advanced electron microscopy techniques and Raman spectroscopy we aim to understand the collagen organization and mineral formation in OI bone samples, from the molecular level up to the macroscopic level where the phenotypic effects are observed. The insights obtained will be the first step towards a comprehensive understanding of OI and will open the way to new approaches for future treatments.
Category of impactResearch Topic/Theme (at group level)